LOCUS       NM_173735               4116 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus CLOCK interacting protein, circadian (Cipc),
            transcript variant 1, mRNA.
ACCESSION   NM_173735
VERSION     NM_173735.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4116)
  AUTHORS   Zheng,J., Lou,J., Li,Y., Qian,P., He,W., Hao,Y., Xue,T., Li,Y. and
            Song,Y.H.
  TITLE     Satellite cell-specific deletion of Cipc alleviates myopathy in mdx
            mice
  JOURNAL   Cell Rep 39 (11), 110939 (2022)
   PUBMED   35705041
  REMARK    GeneRIF: Satellite cell-specific deletion of Cipc alleviates
            myopathy in mdx mice.
REFERENCE   2  (bases 1 to 4116)
  AUTHORS   Qu,Z., Wang,X., Liu,D., Gao,X. and Xu,Y.
  TITLE     Inactivation of Cipc alters the expression of Per1 but not
            circadian rhythms in mice
  JOURNAL   Sci China Life Sci 58 (4), 368-372 (2015)
   PUBMED   25862660
  REMARK    GeneRIF: mRNA expression profiles of core clock genes in the liver
            of Cipc (-/-) mice showed no significant differences from that in
            wild-type mice except for Per1
REFERENCE   3  (bases 1 to 4116)
  AUTHORS   Yoshitane,H., Takao,T., Satomi,Y., Du,N.H., Okano,T. and Fukada,Y.
  TITLE     Roles of CLOCK phosphorylation in suppression of E-box-dependent
            transcription
  JOURNAL   Mol Cell Biol 29 (13), 3675-3686 (2009)
   PUBMED   19414601
REFERENCE   4  (bases 1 to 4116)
  AUTHORS   Zhao,W.N., Malinin,N., Yang,F.C., Staknis,D., Gekakis,N., Maier,B.,
            Reischl,S., Kramer,A. and Weitz,C.J.
  TITLE     CIPC is a mammalian circadian clock protein without invertebrate
            homologues
  JOURNAL   Nat Cell Biol 9 (3), 268-275 (2007)
   PUBMED   17310242
REFERENCE   5  (bases 1 to 4116)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF530959.1, AC153147.7, AK122546.1 and BI202419.1.
            
            On Apr 30, 2010 this sequence version replaced NM_173735.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Both variants 1 and 3 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122546.1, BC026384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                CF530959.1         1-39
            40-40               AC153147.7         73888-73888
            41-71               CF530959.1         40-70
            72-3471             AK122546.1         1-3400
            3472-4116           BI202419.1         1-645               c
FEATURES             Location/Qualifiers
     source          1..4116
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 41.13 cM"
     gene            1..4116
                     /gene="Cipc"
                     /gene_synonym="2310044G17Rik"
                     /note="CLOCK interacting protein, circadian"
                     /db_xref="GeneID:217732"
                     /db_xref="MGI:MGI:1919185"
     exon            1..157
                     /gene="Cipc"
                     /gene_synonym="2310044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            158..345
                     /gene="Cipc"
                     /gene_synonym="2310044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1403
                     /gene="Cipc"
                     /gene_synonym="2310044G17Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     CLOCK-interacting circadian protein; CLOCK-interacting
                     pacemaker"
                     /codon_start=1
                     /product="CLOCK-interacting pacemaker isoform a"
                     /protein_id="NP_776096.2"
                     /db_xref="CCDS:CCDS56849.1"
                     /db_xref="GeneID:217732"
                     /db_xref="MGI:MGI:1919185"
                     /translation="MQRVPVLRLPAILDMERKIPSRESPRRLSAKPGRGTEMKKLARP
                     LGVVAADSDKDSGFSDGSSECLSSAEQMESEDMLSALGCKREDKRRQPSKAADTALPT
                     LPPMVVMKSVLVKQGSSSSQLQSWTVQPSFEVISAQPQLFVLHPPVPSPVSSCQTGEK
                     KSESRNYLPILNSYTKIAPHPGKRGLNSEDRGTSGVSKKLCTERPGPSLSSSEPAKTG
                     RVLSSPSTPAPPSSKLTEDSTLQGVPSLGAGGSPQTLQPVSSSHVAKAPSLTLASPAS
                     PVCASDSTLHGLESSSPLSPLSASYTSPLWAAEHLCRSPDIFSEQRQNKHRRFQNTLV
                     VLHKSGLLEITLKTKELIRQNQATQAELDQLKEQTQMFIEATKSRAPQAWAKLQASLT
                     SGSSHSGSDLDTLSDHPDV"
     exon            346..515
                     /gene="Cipc"
                     /gene_synonym="2310044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            516..4100
                     /gene="Cipc"
                     /gene_synonym="2310044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4075..4080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cipc"
                     /gene_synonym="2310044G17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4100
                     /gene="Cipc"
                     /gene_synonym="2310044G17Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctgtcgtgga ggcggaggga ggagaaatgg gcgggaggcc tcggggatag ctcgagaccc
       61 ggcgaatacc aggttgtcat ggagtcgtgg ggaccggctc gcgcatgcgc ctgctaaccc
      121 gccgggctgg tcatggagcg gcgaccctgg cccttagagt aatccatatg caaagagtac
      181 ctgtgctccg tcttccggcc atcttagaca tggagaggaa aatcccatcc agagagagcc
      241 ccagaagact gtccgccaag ccaggccgag gcacggagat gaagaagcta gcgcgaccac
      301 ttggcgtggt ggcagctgac tcagacaagg actctggctt ctcagatggg agctcagaat
      361 gtttgagctc cgcagagcag atggagtcag aggacatgct gagcgccttg ggctgcaaga
      421 gagaagacaa gcggaggcag ccctccaaag ctgcggacac tgccctcccc acgctgcccc
      481 ctatggtcgt catgaagagc gtgctggtca agcagggcag cagctcctcc cagcttcagt
      541 cctggactgt ccagccctcc tttgaagtga tctcagcgca gccacagctc tttgtccttc
      601 atccacctgt gccatctcct gtcagctcat gccagactgg tgagaaaaag tcagaatcca
      661 gaaactactt gcccattcta aattcttata ccaaaatagc cccccaccca ggcaagaggg
      721 gcctcaattc agaagacaga ggaacaagtg gggtatcgaa gaaactctgc acggagagac
      781 cggggccaag cctgtcttcc agtgagccag ccaagactgg ccgagtatta tccagtcctt
      841 ccactccagc cccacccagc tccaaactca ctgaggactc cactctgcaa ggagttccct
      901 cccttggggc tggcggaagt ccacagactc ttcagcctgt gtccagcagc catgtggcta
      961 aagctcccag tctgactttg gcttcgcccg ccagccctgt gtgtgcgtca gacagcactc
     1021 tgcatggcct agagagcagc tcccctctct ccccactgtc agccagttac acttcacctc
     1081 tgtgggctgc ggagcacctc tgccgcagcc cagacatctt ctccgagcag aggcagaaca
     1141 agcataggcg ctttcagaat accttagtgg tcctccacaa gtctggtttg ctggagatca
     1201 ctctgaaaac caaggagttg attcgtcaga accaagcaac tcaggcagag ctggaccagc
     1261 tgaaggagca aacccagatg tttatagagg ccaccaagag cagggctcct caggcatggg
     1321 ccaagttgca ggcatcacta acatctgggt ccagtcattc aggcagtgac ctagacacgt
     1381 tgtctgatca cccagacgta tagcacagaa acattttcca gttatttgag ttaactcctt
     1441 tactattaca actacccttg ttttccacag cctatttaag agcttttctt tctaaactca
     1501 cccacaaagc cacgtgccag tccctggctg ttgtcttagt ctgtggtccg tgcacaggtt
     1561 aagtgtgtta agttcctctg aggaactcca gctggaagta tctgtgagtc ccttttccct
     1621 gacctgcagg cacttagctg gatcttggga caagggagag atggctgtgt gtgtctttca
     1681 gctgttcctt cccatcctcc tcctcactgt ccagggtcag ggaacagtga catggatgag
     1741 tgtacacagt gacacttgtc caaccaagga gtaggtgacc taaggatccc ttcactgtcc
     1801 tccctcaagt atgttagtca cagagaaaga gacgaggata cgtttgcatc taccaggcct
     1861 tgtgcctgtg agtgaaacct aaagtgcttt gggcgcaggt gcctgggtgc aagcacttac
     1921 cacctaaggc tttgttcctt acccgagaaa gttaaagggg aaagggcaac gccatctggc
     1981 tcacacactg accacacact agatctcacc tatacaagta ggcaatactt cagattttaa
     2041 catatagaat ggatttaata ctgtctggaa ttgtatttga tgaattgctt ttttgattta
     2101 agggtcaaag aagccagcat ttttggtcac tagctggaag gttttgttca tttatacttg
     2161 aaatagcaca gactatctaa aaggcttgag atggggctgc aggatggctc agtgaggaaa
     2221 ggtgcttgct gccagtgacc tgaatttgat cccctgaacc cacatgagag aaagagaatt
     2281 tactactgca gattgtccat caaatgtgca cacacgcaca cacacgataa ataaactaat
     2341 ctaaaattaa aattacaagc tatcatcaac atcaaaacaa ggtaaaacaa tcaaaagctt
     2401 gagatgactt cagtgggtcc tcagggtctc gtgtaagtcc accctctgtt gtctcttgtc
     2461 tgtgcctctc ccagttgttt ctgtgaggga aaaatgattg tgttatacat ttaaatgaaa
     2521 taaaacccaa ggccacaaca atcagaaagg atccttccct gttctcacat tgggttctca
     2581 cgcatgccct gtacgatggg gctgccgtgg agcggtcttg catctggtgt tagatgtggg
     2641 cagcagagct gaagtgtggt gtccctctca gaggcgggtc ttagggtgaa gagcctgagg
     2701 agtctccatg tcttcggttt ccctgtgccg gtaacgaagt gtctaaatgg taacgatcca
     2761 aaggcttgta tcctctgtta taattttcat cctcctggaa atctttgttc tttatgaatt
     2821 aacttggttt tttttgacca gtatcttttt ctgcagagag aataaatgtt cttgggggct
     2881 ttagtaggtc aggagttaaa ggatcccatt tattacagag ttggttgtga ttctaacata
     2941 atttaaaaag tataagactc aggttggctc tactctgttc ataaagatat atgacttaga
     3001 tatgattggt ttaaaaataa tcaacttggt aaaatctcta ttctttggtt aacatagaac
     3061 tgttacctgc tgtttgcttt ctgaaagttt ccaaaatcag agtcggcgtt tctgggcagg
     3121 cttggctcct cgtgctgtgc tcccccgaat ctgcatggta tggtggacat tctgcacccc
     3181 actaggaagc ggcctttgtg gcagaacatt tggcaggaaa gctgtagaga caggtgcatt
     3241 cagagcagcc tgggcaccac cgtgaggctt accgcgtgtc agaaggctgg aagcacttgc
     3301 tgggagccaa atatattact ccactggaaa agccctctag tgctctaagc ctcttggtct
     3361 cctcttctta gatttgggtt tttatttccc ttcctgtccc catgaaagat gatgaaagcc
     3421 accatggatc ctcgctgccg agtggtggga gggttagcgc cccccacctc tacccccagt
     3481 cactgctcct ctgtgatctt agaggcacag ctgcaagtct ctaggctgtt agcgtagcgc
     3541 tctgttcctg gtgcagctgg aagcaggtgg actccaggag agaagctaga tcttagaagg
     3601 agcactcctt tgaggccaga ggccagacca gcacttggag gaagtcctga gtggactgga
     3661 ggagtcttca ttggttgccc aaggctgtaa gtagcagagg cctctgcatg gtatgagctc
     3721 ttacgaagcg ttatgtagga ctgctgcctc cccaaggtga gaagttgatt tttaactcgg
     3781 atcaacccac aggagtacct ttgtattggc aatattgaaa cacatttaga aaggttcctg
     3841 gctgagattg gctctagaac ttgctgtcgt ttgtaattta ctgttttctt attgattgtg
     3901 gtacctctga cttttcttct ctagtatgat tccttcagca tacaagttac tcttacacac
     3961 atacggaagt ggctttttag ccatatcctc cttagggtag agactattta ccaaatgtga
     4021 attcttctaa gtgtgaagtt atgtagaaat tgactgtgaa atgtcaaaga aaaaaataaa
     4081 agtcacttac ttgaaagcaa aaaaaaaaaa aaaaaa
//
