LOCUS       NM_172616               3974 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus cell proliferation regulating inhibitor of protein
            phosphatase 2A (Cip2a), mRNA.
ACCESSION   NM_172616
VERSION     NM_172616.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3974)
  AUTHORS   Wang,Z., Zhang,L., Yang,J., Zeng,Y., Su,C., Yao,M., Zhang,H.,
            Hu,W., Liu,Y., Lai,Y., Wang,X., Zeng,J. and Liu,R.
  TITLE     Chronic stress induces Alzheimer's disease-like pathologies through
            DNA damage-Chk1-CIP2A signaling
  JOURNAL   Aging (Albany NY) 16 (10), 9168-9187 (2024)
   PUBMED   38819231
  REMARK    GeneRIF: Chronic stress induces Alzheimer's disease-like
            pathologies through DNA damage-Chk1-CIP2A signaling.
REFERENCE   2  (bases 1 to 3974)
  AUTHORS   Leem,J., Kim,J.S. and Oh,J.S.
  TITLE     Oocytes can repair DNA damage during meiosis via a
            microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from
            spindle pole to chromosomes
  JOURNAL   Nucleic Acids Res 51 (10), 4899-4913 (2023)
   PUBMED   36999590
  REMARK    GeneRIF: Oocytes can repair DNA damage during meiosis via a
            microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from
            spindle pole to chromosomes.
REFERENCE   3  (bases 1 to 3974)
  AUTHORS   Zhang,H., Zhu,Y., Jin,C., Shi,L., Xie,Y., Sun,X., Li,P., Zhu,X.,
            Dai,Q., Yang,F., Xie,X. and Qin,L.
  TITLE     Oct4 reduction contributes to testicular injury of unilateral
            testicular torsion in mice model and apoptotic death of Sertoli
            cells through mediating CIP2A expression
  JOURNAL   Gene 860, 147214 (2023)
   PUBMED   36690227
  REMARK    GeneRIF: Oct4 reduction contributes to testicular injury of
            unilateral testicular torsion in mice model and apoptotic death of
            Sertoli cells through mediating CIP2A expression.
REFERENCE   4  (bases 1 to 3974)
  AUTHORS   Hu,W.T., Liuyang,Z.Y., Tian,Y., Liang,J.W., Zhang,X.L., Zhang,H.L.,
            Wang,G., Huo,Y., Shentu,Y.P., Wang,J.Z., Wang,X.C., Lu,Y.M.,
            Westermarck,J., Man,H.Y. and Liu,R.
  TITLE     CIP2A deficiency promotes depression-like behaviors in mice through
            inhibition of dendritic arborization
  JOURNAL   EMBO Rep 23 (12), e54911 (2022)
   PUBMED   36305233
  REMARK    GeneRIF: CIP2A deficiency promotes depression-like behaviors in
            mice through inhibition of dendritic arborization.
REFERENCE   5  (bases 1 to 3974)
  AUTHORS   Hu,W., Wang,Z., Zhang,H., Mahaman,Y.A.R., Huang,F., Meng,D.,
            Zhou,Y., Wang,S., Jiang,N., Xiong,J., Westermarck,J., Lu,Y.,
            Wang,J., Wang,X., Shentu,Y. and Liu,R.
  TITLE     Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and
            Cognitive Dysfunction Through CIP2A/PP2A Signaling
  JOURNAL   Neurotherapeutics 19 (2), 570-591 (2022)
   PUBMED   35286657
  REMARK    GeneRIF: Chk1 Inhibition Ameliorates Alzheimer's Disease
            Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A
            Signaling.
REFERENCE   6  (bases 1 to 3974)
  AUTHORS   Laine,A., Sihto,H., Come,C., Rosenfeldt,M.T., Zwolinska,A.,
            Niemela,M., Khanna,A., Chan,E.K., Kahari,V.M.,
            Kellokumpu-Lehtinen,P.L., Sansom,O.J., Evan,G.I., Junttila,M.R.,
            Ryan,K.M., Marine,J.C., Joensuu,H. and Westermarck,J.
  TITLE     Senescence sensitivity of breast cancer cells is defined by
            positive feedback loop between CIP2A and E2F1
  JOURNAL   Cancer Discov 3 (2), 182-197 (2013)
   PUBMED   23306062
  REMARK    Erratum:[Cancer Discov. 2020 May;10(5):746. doi:
            10.1158/2159-8290.CD-20-0347.. PMID: 32357970]
REFERENCE   7  (bases 1 to 3974)
  AUTHORS   Ventela,S., Come,C., Makela,J.A., Hobbs,R.M., Mannermaa,L.,
            Kallajoki,M., Chan,E.K., Pandolfi,P.P., Toppari,J. and
            Westermarck,J.
  TITLE     CIP2A promotes proliferation of spermatogonial progenitor cells and
            spermatogenesis in mice
  JOURNAL   PLoS One 7 (3), e33209 (2012)
   PUBMED   22461891
  REMARK    GeneRIF: Data show that CIP2A expression can be systematically
            inhibited without severe consequences to normal mouse development
            and viability may have clinical relevance regarding targeting of
            oncogenic CIP2A for future cancer therapies.
REFERENCE   8  (bases 1 to 3974)
  AUTHORS   Kerosuo,L., Fox,H., Perala,N., Ahlqvist,K., Suomalainen,A.,
            Westermarck,J., Sariola,H. and Wartiovaara,K.
  TITLE     CIP2A increases self-renewal and is linked to Myc in neural
            progenitor cells
  JOURNAL   Differentiation 80 (1), 68-77 (2010)
   PUBMED   20447748
  REMARK    GeneRIF: Loss of CIP2A in Myc-overexpressing neural progenitor
            cells significantly reduces the ability of Myc to increase
            self-renewal and proliferation.
REFERENCE   9  (bases 1 to 3974)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 3974)
  AUTHORS   Soo Hoo,L., Zhang,J.Y. and Chan,E.K.
  TITLE     Cloning and characterization of a novel 90 kDa 'companion'
            auto-antigen of p62 overexpressed in cancer
  JOURNAL   Oncogene 21 (32), 5006-5015 (2002)
   PUBMED   12118381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK049356.1, AK160639.1, AV113368.2 and BY453073.1.
            
            On Feb 16, 2007 this sequence version replaced NM_172616.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049356.1, SRR1660817.309715.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AK049356.1         2-26
            26-737              AK049356.1         28-739
            738-1568            AK160639.1         724-1554
            1569-2184           AK049356.1         1571-2186
            2185-2952           AK160639.1         2172-2939
            2953-3179           AK049356.1         2955-3181
            3180-3518           AV113368.2         666-1004
            3519-3521           AK049356.1         3521-3523
            3522-3971           AK049356.1         3525-3974
            3972-3974           BY453073.1         412-414
FEATURES             Location/Qualifiers
     source          1..3974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 30.75 cM"
     gene            1..3974
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /note="cell proliferation regulating inhibitor of protein
                     phosphatase 2A"
                     /db_xref="GeneID:224171"
                     /db_xref="MGI:MGI:2146335"
     exon            1..192
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..2814
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /note="cancerous inhibitor of PP2A; p90 autoantigen
                     homolog"
                     /codon_start=1
                     /product="protein CIP2A"
                     /protein_id="NP_766204.2"
                     /db_xref="CCDS:CCDS49867.1"
                     /db_xref="GeneID:224171"
                     /db_xref="MGI:MGI:2146335"
                     /translation="MDSTACLKSLLLSISQYKAVKSEANATQLLRHLEVVSGQKLTRL
                     FTSHQILPSECLSCLVELLEDPNISASLILSIISLLSQLAIDNETRDCLQNIYNLNSV
                     LSGVVCRSSACHNDSVFLQCIQLLQRLTYNAKFFHSGAHIDDLITFLIGHVQSSEDEL
                     TMPCLGLLANLCRHNLSVQTQIKTLSNVKSFYRTLISFLAHSSLTVVVFALSILSSLT
                     LNEEVGEKLFHARNIHQTFQLIFNILINGDGTLTRKYSVDLLMDLLKNPKIADYLTRY
                     EHFSSCLSQVLGLLNAKDPDSSSKVLELLLAFCAVTQLRHVLSQMMFEQSPSGNILGS
                     RPKSLEPTAALLRWLSQPLDGAENCSVLALELFKEIFEDVIDTGNCSSTDHFVTLLLP
                     TILDQLQFKEQNLDETLVRNKCERMVKAIEVLLTLCGDDSLKMHVVKILTTLKCTTLI
                     EQQFTYGKIDLGFGTKVADSELCKLAADVILKTLTLMNKLKQLVPGMEVSFYKILQDP
                     RLITPLAFALTSDNREQVQSGLGILLEASPLPDFPAFVLGESIAANNVYRQQETEHLP
                     RKMTFQPLNHGFSTSAKCLTPPPSKDNAPALNIEDLIEKLQAGVMVKDQISDIRISDI
                     MDVYEMKLSTLASKESRLQDLLEAKALALAQADRLIAQYRCQRTQAETEARTLAGMLR
                     EVERKNEELSVLLKSQQLESERAQNDIEHLFQHSKKLESVAAEHEILTKSYMELVQRN
                     EATEKKNTDLQTTCESLNKHIETMKKLNEALKQQNEKTIAQLIEKEEQRKEVQSQLAD
                     RECKLSNLHKIAKSQEEKLNVLQKEKEDKQETIDILRKELSRTEQIRKELSIKASSLE
                     MHKAQLEGRLEEKESLLKLQQEELNKHSHMIAMIHSLSGGKISPETVNLSI"
     exon            193..340
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            341..453
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            454..548
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            549..645
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            646..768
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            769..914
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            915..990
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1206
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1366
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1508
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1608
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1727
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1923
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..1998
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2109
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2306
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            2307..2420
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2503
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2643
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     exon            2644..3974
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3495..3500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /note="hexamer: ATTAAA"
     polyA_site      3520
                     /gene="Cip2a"
                     /gene_synonym="C330027C09Rik; Kiaa1524"
                     /note="major polyA site"
ORIGIN      
        1 ggggcttaaa aaaaatcaaa aaatgcgcgg cgaccgctga agacagaggg tggctggtgt
       61 cggtggtcgc tgacaggccg gctcgtcggc atggattcca ccgcctgctt gaagtccctg
      121 ctcctgagca tcagtcagta caaggccgtt aagtcggagg cgaacgccac tcagctgctg
      181 aggcacttgg aggtagtttc tggacaaaag ctcacacgac tgtttacatc acatcagata
      241 ttaccaagtg aatgcttgag ctgccttgta gaacttctcg aagacccaaa cataagtgct
      301 tcactgatct taagtattat cagtttgctg tctcaactgg ctatagataa tgaaacccga
      361 gactgtcttc agaatatata caatctgaat agtgtgctgt caggagtggt ttgtcggagc
      421 agcgcttgcc acaatgattc cgtgttttta cagtgcattc aactgctgca aaggttaaca
      481 tataatgcca aatttttcca ttctggtgcc catatagatg acttaattac attcttgatt
      541 ggtcatgttc agtcttctga agatgagcta acaatgcctt gtctaggact attggcaaat
      601 ctttgtcggc acaatctttc tgttcaaaca caaataaaaa ctttgagtaa tgtgaaatct
      661 ttttaccgaa ctctcataag cttcctagca cacagcagtc tgactgtggt tgtgtttgca
      721 ctttcaatat tatccagttt aacactaaat gaagaagtgg gagaaaagct atttcatgct
      781 cgaaacattc atcagacttt ccaattaata tttaatattc tcataaatgg tgatggtacc
      841 ctaacaagaa agtactcagt tgacctactg atggatctcc ttaaaaaccc taaaattgct
      901 gattatctga ccaggtatga gcacttttct tcatgtctta gtcaagtact aggacttcta
      961 aatgcaaaag accctgattc ttcttccaag gttttagaat tacttcttgc cttctgtgca
     1021 gtgactcagc tgcgccatgt actcagtcag atgatgtttg aacagtctcc atctggcaac
     1081 attctgggaa gccgtcctaa gagcttagag cctactgcgg ctctacttcg ctggttaagc
     1141 caacccttgg atggagctga aaactgttct gtgttagcat tggagttgtt caaggaaatc
     1201 ttcgaggatg tcattgatac tggtaactgt tcctcaactg accattttgt gacccttctg
     1261 cttcctacaa ttcttgatca gcttcagttc aaagaacaaa atctggatga gaccttagta
     1321 agaaataagt gtgaaaggat ggtcaaagcc attgaagttt tattaactct gtgtggagac
     1381 gactctctga aaatgcatgt tgtaaaaata ttgactactc taaagtgcac cacgcttata
     1441 gagcagcagt ttacatatgg caagattgac ctggggtttg gaacaaaggt agccgattct
     1501 gagttgtgca aacttgctgc tgatgtaatt ttgaaaactc ttactttgat gaacaaactt
     1561 aaacagttgg tccctggtat ggaagtaagc ttctacaaaa tccttcagga tccgcggttg
     1621 attactcctt tagcttttgc tttaacgtca gataatagag agcaagtcca gtctggattg
     1681 ggaatactgc ttgaagcctc tcccctgccc gatttccctg ccttcgtact tggagaaagt
     1741 atagcagcaa acaatgtata cagacagcaa gaaactgagc atctgcccag gaaaatgact
     1801 ttccagccct taaatcatgg tttttcaaca tcagcaaagt gcttaacgcc tcctccttca
     1861 aaagataatg ctcctgcgtt gaacattgag gacctcatag agaaactgca ggctggagtg
     1921 atggtaaagg atcagattag tgatataaga atatctgaca tcatggatgt ttatgagatg
     1981 aaactttcca cattagcctc taaagagagc aggttacaag atctcctgga agcaaaagcc
     2041 ctggctcttg cacaggctga cagactgatc gctcagtatc gctgtcagag aacgcaagca
     2101 gagacagagg cacgaacact tgcgggtatg ttacgagaag ttgagagaaa aaatgaagag
     2161 cttagtgtgt tgctgaagtc acaacagctc gagtcagaaa gagcccaaaa tgatattgag
     2221 catctctttc aacacagtaa gaagctggaa tctgtagctg cagaacatga aatactgaca
     2281 aagtcctaca tggaacttgt tcaaagaaat gaagctactg aaaagaagaa tactgactta
     2341 cagactacct gtgaatctct gaataaacac attgagacaa tgaaaaaatt gaacgaggcg
     2401 ctcaagcaac aaaatgaaaa aactattgct cagttgatag agaaagaaga gcagagaaaa
     2461 gaagtccaga gccagttagc agaccgagaa tgtaaactat caaatttgca taaaatagca
     2521 aaatcccaag aagaaaaact taatgtttta caaaaggaaa aggaagataa gcaggaaacc
     2581 attgatatcc ttagaaaaga attaagcaga acagaacaga taaggaaaga gttgagcatt
     2641 aaggcttcct ccctagaaat gcacaaggct caattagaag gtcgtttgga agagaaggag
     2701 tctttgttga aacttcagca agaggagttg aacaaacatt ctcacatgat agcaatgatc
     2761 cacagtttaa gtggtggaaa aataagccca gaaactgtga accttagtat ataaacattc
     2821 tggctttggg gaatttgtgc atgaatactt ttgttgtatt tatatgttgg aagtggcagt
     2881 aaacggagga aatcgtgact tcaaaacagt tatcatttgt ttgctatcta acttagtaaa
     2941 gatcataatt gcattgatgt tttatttatt ctttgggaga tttttagatt ttggtttttt
     3001 ttaatgttta ctcttacata ttctcatgta tgattatagt catggattac ttaatatcaa
     3061 ccatgaataa atttacataa atgtgctttt taagcccttt gtgaacatgc tagaatagac
     3121 acacagctat caggaataca gggtctttag gctgtatcat cttttgcaac tatggtaata
     3181 aaaatatgac ctatcattaa ctaaaatatc atcaccatta ccaagtggtg atatagttgt
     3241 taagtagttt tcttgatcca gcagccttac agattaattg attaagatca acaagtaaaa
     3301 aatgttctga tactactcag gaagtttttt tctaaaggta acagaaaata gactgaaaga
     3361 actttattac tgcatttaag atgaaacaat atatagccta aattgtaaat ttggaaacag
     3421 tgctgtagct atcagaaata atgtttaaaa atggagagta tccattatgt taaatgattt
     3481 catagtctcc taaaattaaa aattgtataa ttatttgcaa ctttcttttg ttctttgctt
     3541 ttttttctca cgttctgttc ttattttttg ctattgttct ttaattttgt tatttgcttt
     3601 atagaacaca gtttctcttt ctatcctagg ctaatcttga gcttactgtg gacctcatgt
     3661 gtcttaactc ccagtgatct cctcttgtaa tccaggcact aggattacaa gtggtttcta
     3721 ctatatcagt ataaatataa ctatttctta aaatgttgta tgttgaaaaa cctatcatcg
     3781 ctttcaagag taattggatt tctattctag ctaatcagaa atgttatttc ttgtagtata
     3841 atacacattt aacgtattca attgagccat tgaattttat ataaaagtta tgtatccttg
     3901 ttttggtatt tcattcatac tagagaattt tagtactttt catttaaata aaacataagt
     3961 gtgatatgtt taag
//
