LOCUS       NM_029285                739 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Mus musculus ciliary microtubule inner protein 2C (Cimip2c),
            transcript variant 1, mRNA.
ACCESSION   NM_029285
VERSION     NM_029285.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 739)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 739)
  AUTHORS   Tai,L., Yin,G., Huang,X., Sun,F. and Zhu,Y.
  TITLE     In-cell structural insight into the stability of sperm microtubule
            doublet
  JOURNAL   Cell Discov 9 (1), 116 (2023)
   PUBMED   37989994
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 739)
  AUTHORS   Zhou,L., Liu,H., Liu,S., Yang,X., Dong,Y., Pan,Y., Xiao,Z.,
            Zheng,B., Sun,Y., Huang,P., Zhang,X., Hu,J., Sun,R., Feng,S.,
            Zhu,Y., Liu,M., Gui,M. and Wu,J.
  TITLE     Structures of sperm flagellar doublet microtubules expand the
            genetic spectrum of male infertility
  JOURNAL   Cell 186 (13), 2897-2910 (2023)
   PUBMED   37295417
REFERENCE   4  (bases 1 to 739)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 739)
  AUTHORS   Stauber,M., Weidemann,M., Dittrich-Breiholz,O., Lobschat,K.,
            Alten,L., Mai,M., Beckers,A., Kracht,M. and Gossler,A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   6  (bases 1 to 739)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157761.6.
            
            On Mar 13, 2023 this sequence version replaced NM_029285.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060996.1, AK005574.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC157761.6         81119-81252         c
            135-405             AC157761.6         66648-66918         c
            406-518             AC157761.6         65115-65227         c
            519-739             AC157761.6         63215-63435         c
FEATURES             Location/Qualifiers
     source          1..739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.57 cM"
     gene            1..739
                     /gene="Cimip2c"
                     /gene_synonym="1700001C02Rik; 1700047H18Rik; Fam166c"
                     /note="ciliary microtubule inner protein 2C"
                     /db_xref="GeneID:75434"
                     /db_xref="MGI:MGI:1922684"
     exon            1..134
                     /gene="Cimip2c"
                     /gene_synonym="1700001C02Rik; 1700047H18Rik; Fam166c"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..663
                     /gene="Cimip2c"
                     /gene_synonym="1700001C02Rik; 1700047H18Rik; Fam166c"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0573 protein C2orf70 homolog; protein FAM166C; family
                     with sequence similarity 166, member C"
                     /codon_start=1
                     /product="ciliary microtubule inner protein 2C isoform 1"
                     /protein_id="NP_083561.1"
                     /db_xref="CCDS:CCDS19158.1"
                     /db_xref="GeneID:75434"
                     /db_xref="MGI:MGI:1922684"
                     /translation="MAFRSAGTLMTEFNAAFVPPALMPGYKGHVPGVASSFGSSYGNT
                     TFKYFQDLRNTGLEKSYALLSGGCFPTIFSPNSPLVLTDNSQNWDRWLHQPTYSRSNQ
                     DNGRTTELTNFYKTVQQQRKYYQDKTGILSRVPYFVLPVKEPDRYPLPTDLPPLSEKS
                     KWNLLRLSPDYKRTYQTFPSGKRVSSQERQRRDLYFEFRA"
     exon            135..405
                     /gene="Cimip2c"
                     /gene_synonym="1700001C02Rik; 1700047H18Rik; Fam166c"
                     /inference="alignment:Splign:2.1.0"
     exon            406..518
                     /gene="Cimip2c"
                     /gene_synonym="1700001C02Rik; 1700047H18Rik; Fam166c"
                     /inference="alignment:Splign:2.1.0"
     exon            519..739
                     /gene="Cimip2c"
                     /gene_synonym="1700001C02Rik; 1700047H18Rik; Fam166c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      717..722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cimip2c"
                     /gene_synonym="1700001C02Rik; 1700047H18Rik; Fam166c"
                     /note="hexamer: AATAAA"
     polyA_site      739
                     /gene="Cimip2c"
                     /gene_synonym="1700001C02Rik; 1700047H18Rik; Fam166c"
                     /note="major polyA site"
ORIGIN      
        1 agctggctgt ttaccgcagg gctgagccga gccaccgcgc cggggctcgc agcacccacc
       61 atggccttcc gtagcgcggg cacactaatg accgaattta atgccgcctt cgtgccccca
      121 gctctcatgc ccgggtacaa aggccatgtt cccggtgtgg cttcctcctt tggctcttct
      181 tatggcaaca ccaccttcaa gtacttccag gacctccgca acacaggctt ggagaagagc
      241 tatgcgctcc tcagtggggg ttgctttccc accatcttct cccctaactc ccccctggtt
      301 ctgactgata actcacagaa ctgggatcga tggctgcacc agcccaccta cagccgatcc
      361 aaccaggaca acgggcgcac cactgagctc actaactttt acaagacagt ccagcagcag
      421 cggaagtatt accaagacaa gactggcatt ctgtcccgtg ttccttactt tgtacttcct
      481 gtgaaggagc cggaccggta ccccctaccc accgacctgc ctcctctgag tgagaagagt
      541 aagtggaacc tactaagatt atcccctgac tacaagagga cctaccagac cttcccatca
      601 gggaagagag tttcctctca agagcgccaa aggcgggacc tttacttcga gttcagagcc
      661 tgaaaccagg tggttgaccc cagggaacct tggcctgacc aggctggctt gcttgtaata
      721 aaatcttcag ccacaacca
//
