LOCUS       NM_029604                925 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Mus musculus ciliary microtubule associated protein 3 (Cimap3),
            transcript variant 2, mRNA.
ACCESSION   NM_029604 XM_003084536 XM_131115
VERSION     NM_029604.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 925)
  AUTHORS   Xiong,Y., Scerbo,M.J., Seelig,A., Volta,F., O'Brien,N., Dicker,A.,
            Padula,D., Lickert,H., Gerdes,J.M. and Berggren,P.O.
  TITLE     Islet vascularization is regulated by primary endothelial cilia via
            VEGF-A-dependent signaling
  JOURNAL   Elife 9, e56914 (2020)
   PUBMED   33200981
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 925)
  AUTHORS   Li,S., Jin,S. and Jin,C.
  TITLE     The correlative hypotheses between Pitchfork and Kif3a in palate
            development
  JOURNAL   Med Hypotheses 126, 23-25 (2019)
   PUBMED   31010494
  REMARK    GeneRIF: there may be a potential correlation between Pitchfork and
            Kif3a that could regulate primary cilia disassembly during palate
            development
REFERENCE   3  (bases 1 to 925)
  AUTHORS   Jung,B., Padula,D., Burtscher,I., Landerer,C., Lutter,D., Theis,F.,
            Messias,A.C., Geerlof,A., Sattler,M., Kremmer,E., Boldt,K.,
            Ueffing,M. and Lickert,H.
  TITLE     Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for
            Hedgehog Pathway Activation
  JOURNAL   PLoS One 11 (2), e0149477 (2016)
   PUBMED   26901434
  REMARK    GeneRIF: Pitchfork and Gprasp2 Target Smoothened to the Primary
            Cilium for Hedgehog Pathway Activation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 925)
  AUTHORS   Jin,C., Lee,J.M., Tang,Q., Li,L., Lee,M.J., Baik,H.S. and Jung,H.S.
  TITLE     Morphological and molecular changes associated with Pitchfork
            during mouse palate development
  JOURNAL   Cell Tissue Res 358 (2), 385-393 (2014)
   PUBMED   25080064
  REMARK    GeneRIF: The proper expression levels of Pitchfork might play a
            pivotal role in normal secondary palate morphogenesis.
REFERENCE   5  (bases 1 to 925)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   6  (bases 1 to 925)
  AUTHORS   Kinzel,D., Boldt,K., Davis,E.E., Burtscher,I., Trumbach,D.,
            Diplas,B., Attie-Bitach,T., Wurst,W., Katsanis,N., Ueffing,M. and
            Lickert,H.
  TITLE     Pitchfork regulates primary cilia disassembly and left-right
            asymmetry
  JOURNAL   Dev Cell 19 (1), 66-77 (2010)
   PUBMED   20643351
  REMARK    GeneRIF: Pitchfork (Pifo) associates with ciliary targeting
            complexes and accumulates at the basal body during cilia
            disassembly. Haploinsufficiency causes a unique node cilia
            duplication phenotype, left-right asymmetry defects, and heart
            failure.
REFERENCE   7  (bases 1 to 925)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 925)
  AUTHORS   McClintock,T.S., Glasser,C.E., Bose,S.C. and Bergman,D.A.
  TITLE     Tissue expression patterns identify mouse cilia genes
  JOURNAL   Physiol Genomics 32 (2), 198-206 (2008)
   PUBMED   17971504
  REMARK    GeneRIF: 1700027A23Rik is most abundantly expressed in tissues rich
            in highly ciliated cells, such as olfactory sensory neurons, and is
            predicted to be important to cilia.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006407.1, AW519725.1 and AW492850.1.
            
            On or before Jan 15, 2011 this sequence version replaced
            XM_003084536.1, NM_029604.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The encoded isoform
            (b) has a distinct N-terminus and is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK006407.1, HM237137.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AK006407.1         2-302
            302-777             AW519725.1         14-489
            778-925             AW492850.1         1-148               c
FEATURES             Location/Qualifiers
     source          1..925
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.47 cM"
     gene            1..925
                     /gene="Cimap3"
                     /gene_synonym="1700027A23Rik; Pifo"
                     /note="ciliary microtubule associated protein 3"
                     /db_xref="GeneID:100503311"
                     /db_xref="MGI:MGI:1923670"
     exon            1..171
                     /gene="Cimap3"
                     /gene_synonym="1700027A23Rik; Pifo"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..734
                     /gene="Cimap3"
                     /gene_synonym="1700027A23Rik; Pifo"
                     /note="isoform b is encoded by transcript variant 2;
                     pitchfork; protein pitchfork; primary cilia formation"
                     /codon_start=1
                     /product="ciliary microtubule-associated protein 3 isoform
                     b"
                     /protein_id="NP_083880.2"
                     /db_xref="CCDS:CCDS51037.1"
                     /db_xref="GeneID:100503311"
                     /db_xref="MGI:MGI:1923670"
                     /translation="MNTEEIPVAPPLRGVTPALQWKVNNYSFGTRQARKLFPHYHPPT
                     WLGNLYLPLRGMPHTGPGCYAAATDWNGLAYNLSKVPTSTKGYAIGARTAVRFKPISK
                     DVTPYPGMYQKVDTLSEKHKKSFAPFNILMPRFRSAAKGDSYPGPGTYNPEMKSVPKV
                     TWPMKFGSPDWSQVPCLEKRTLKAELSADKDFRKHRSRVAYFSLYYQ"
     exon            172..317
                     /gene="Cimap3"
                     /gene_synonym="1700027A23Rik; Pifo"
                     /inference="alignment:Splign:2.1.0"
     exon            318..416
                     /gene="Cimap3"
                     /gene_synonym="1700027A23Rik; Pifo"
                     /inference="alignment:Splign:2.1.0"
     exon            417..547
                     /gene="Cimap3"
                     /gene_synonym="1700027A23Rik; Pifo"
                     /inference="alignment:Splign:2.1.0"
     exon            548..665
                     /gene="Cimap3"
                     /gene_synonym="1700027A23Rik; Pifo"
                     /inference="alignment:Splign:2.1.0"
     exon            666..908
                     /gene="Cimap3"
                     /gene_synonym="1700027A23Rik; Pifo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacagagcta atcctagcac cctgcaggat gtgcttcagc agaataggta aggagagtag
       61 cagagattta cagagcagac agcagaagaa gggtaagaag agcaggagag atgaacacgg
      121 aggaaatacc ggttgctcct ccgctccgtg gagttacacc tgctttacaa tggaaggtga
      181 ataattactc ctttggaaca cgtcaagcga ggaaactctt tcctcactac catcccccaa
      241 cctggctggg gaacctgtat ctccctctta ggggaatgcc ccacacaggc cctgggtgtt
      301 atgcagcagc aacagattgg aatggtttgg catataatct atcgaaagtc ccaaccagta
      361 cgaaaggcta tgctattgga gccaggacag ctgtgaggtt taagccaatc agcaaggatg
      421 tgacaccata cccagggatg tatcagaaag ttgatacttt gagtgaaaaa cacaaaaaaa
      481 gctttgctcc atttaatatc ttgatgcctc gatttaggag tgcagcaaag ggtgattctt
      541 accccggccc tggcacatac aatccagaga tgaagtcagt cccaaaagtt acttggccaa
      601 tgaaatttgg atctccagac tggtctcagg ttccatgtct agagaaaagg actctaaagg
      661 ctgagctgtc cgcagacaag gactttagaa agcatcgtag ccgtgtggcc tactttagcc
      721 tatattacca gtgaaatgta ggcactgtct tcacgtgctg tcctgaccac agagtctcca
      781 gaactgagga cataattgct cctgtatttc tgtgttcctc ggccctcttg tctgcccatt
      841 tcgtgtccag agagggacag ggtctcattg tcaccctcca aatacataaa ggctggttca
      901 gaatgttcaa aaaaaaaaaa aaaaa
//
