LOCUS       NM_001302618            5438 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus class II transactivator (Ciita), transcript variant 4,
            mRNA.
ACCESSION   NM_001302618
VERSION     NM_001302618.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5438)
  AUTHORS   Specht,C.A., Wang,R., Oliveira,L.V.N., Hester,M.M., Gomez,C.,
            Mou,Z., Carlson,D., Lee,C.K., Hole,C.R., Lam,W.C., Upadhya,R.,
            Lodge,J.K. and Levitz,S.M.
  TITLE     Immunological correlates of protection mediated by a whole
            organism, Cryptococcus neoformans, vaccine deficient in chitosan
  JOURNAL   mBio 15 (8), e0174624 (2024)
   PUBMED   38980038
REFERENCE   2  (bases 1 to 5438)
  AUTHORS   Santharam,M.A., Shukla,A., Levesque,D., Kufer,T.A., Boisvert,F.M.,
            Ramanathan,S. and Ilangumaran,S.
  TITLE     NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I
            Expression and Antitumor Immunity
  JOURNAL   Int J Mol Sci 24 (8), 7206 (2023)
   PUBMED   37108368
  REMARK    GeneRIF: NLRC5-CIITA Fusion Protein as an Effective Inducer of
            MHC-I Expression and Antitumor Immunity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5438)
  AUTHORS   Hos,B.J., Tondini,E., Camps,M.G.M., Rademaker,W., van den Bulk,J.,
            Ruano,D., Janssen,G.M.C., de Ru,A.H., van den Elsen,P.J., de
            Miranda,N.F.C.C., van Veelen,P.A. and Ossendorp,F.
  TITLE     Cancer-specific T helper shared and neo-epitopes uncovered by
            expression of the MHC class II master regulator CIITA
  JOURNAL   Cell Rep 41 (2), 111485 (2022)
   PUBMED   36223747
  REMARK    GeneRIF: Cancer-specific T helper shared and neo-epitopes uncovered
            by expression of the MHC class II master regulator CIITA.
            Erratum:[Cell Rep. 2022 Nov 22;41(8):111680. doi:
            10.1016/j.celrep.2022.111680.. PMID: 36417866]
REFERENCE   4  (bases 1 to 5438)
  AUTHORS   Gunaydin,C., Celik,Z.B. and Bilge,S.S.
  TITLE     CIITA expression is regulated by histone deacetylase enzymes and
            has a role in alpha-synuclein pre-formed fibril-induced antigen
            presentation in murine microglial cell line
  JOURNAL   Immunopharmacol Immunotoxicol 44 (3), 447-455 (2022)
   PUBMED   35291899
  REMARK    GeneRIF: CIITA expression is regulated by histone deacetylase
            enzymes and has a role in alpha-synuclein pre-formed fibril-induced
            antigen presentation in murine microglial cell line.
REFERENCE   5  (bases 1 to 5438)
  AUTHORS   Lopes,N., Boucherit,N., Santamaria,J.C., Provin,N., Charaix,J.,
            Ferrier,P., Giraud,M. and Irla,M.
  TITLE     Thymocytes trigger self-antigen-controlling pathways in immature
            medullary thymic epithelial stages
  JOURNAL   Elife 11, e69982 (2022)
   PUBMED   35188458
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5438)
  AUTHORS   Kobayashi,K.S. and van den Elsen,P.J.
  TITLE     NLRC5: a key regulator of MHC class I-dependent immune responses
  JOURNAL   Nat Rev Immunol 12 (12), 813-820 (2012)
   PUBMED   23175229
  REMARK    Review article
REFERENCE   7  (bases 1 to 5438)
  AUTHORS   Ramassar,V., Goes,N., Hobart,M. and Halloran,P.F.
  TITLE     Evidence for the in vivo role of class II transactivator in basal
            and IFN-gamma induced class II expression in mouse tissue
  JOURNAL   Transplantation 62 (12), 1901-1907 (1996)
   PUBMED   8990384
REFERENCE   8  (bases 1 to 5438)
  AUTHORS   Chang,C.H., Guerder,S., Hong,S.C., van Ewijk,W. and Flavell,R.A.
  TITLE     Mice lacking the MHC class II transactivator (CIITA) show
            tissue-specific impairment of MHC class II expression
  JOURNAL   Immunity 4 (2), 167-178 (1996)
   PUBMED   8624807
REFERENCE   9  (bases 1 to 5438)
  AUTHORS   Panelli,M.C., Wang,E., Shen,S., Schluter,S.F., Bernstein,R.M.,
            Hersh,E.M., Stopeck,A., Gangavalli,R., Barber,J., Jolly,D. and
            Akporiaye,E.T.
  TITLE     Interferon gamma (IFNgamma) gene transfer of an EMT6 tumor that is
            poorly responsive to IFNgamma stimulation: increase in tumor
            immunogenicity is accompanied by induction of a mouse class II
            transactivator and class II MHC
  JOURNAL   Cancer Immunol Immunother 42 (2), 99-107 (1996)
   PUBMED   8620527
REFERENCE   10 (bases 1 to 5438)
  AUTHORS   Elliott,E.A., Drake,J.R., Amigorena,S., Elsemore,J., Webster,P.,
            Mellman,I. and Flavell,R.A.
  TITLE     The invariant chain is required for intracellular transport and
            function of major histocompatibility complex class II molecules
  JOURNAL   J Exp Med 179 (2), 681-694 (1994)
   PUBMED   8294875
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK143956.1, AK138822.1,
            AK153609.1, BC107330.1, BE850370.1 and AI182240.1.
            
            Summary: This gene encodes a member of the NOD-like receptor
            protein family. This protein acts as a transcriptional coactivator
            and component of the enhanceosome complex to stimulate
            transcription of MHC class II genes in the adaptive immune
            response. This protein may also regulate the transcription of MHC
            class I genes. Mutations in the human gene have been linked to a
            rare immunodeficiency, bare lymphocyte syndrome, and homozygous
            knockout mice exhibit many features of this disease. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest isoform (4).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3162              AK143956.1         2-3163
            3163-3163           AK138822.1         3082-3082
            3164-3728           AK143956.1         3165-3729
            3729-4302           AK153609.1         3555-4128
            4303-5266           BC107330.1         834-1797
            5267-5351           BE850370.1         176-260
            5352-5438           AI182240.1         398-484
FEATURES             Location/Qualifiers
     source          1..5438
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 5.65 cM"
     gene            1..5438
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /note="class II transactivator"
                     /db_xref="GeneID:12265"
                     /db_xref="MGI:MGI:108445"
     exon            1..355
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..3540
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /EC_number="2.7.11.1"
                     /note="isoform 4 is encoded by transcript variant 4; MHC
                     class II transactivator"
                     /codon_start=1
                     /product="MHC class II transactivator isoform 4"
                     /protein_id="NP_001289547.1"
                     /db_xref="CCDS:CCDS88875.1"
                     /db_xref="GeneID:12265"
                     /db_xref="MGI:MGI:108445"
                     /translation="MNHFQAILAQVQTLLSSQKPRQVRALLDGLLEEELLSREYHCAL
                     LHEPDGDALARKISLTLLEKGDLDLTFLSWVCNSLQAPTVERGTSYRDHGDHSLCATM
                     DLGSPEGSYLELLNSDADPLHLYHLYDQMDLAGEEEIELSSEPDTDTINCDQFSKLLQ
                     DMELDEETREAYANIAELDQYVFQDTQLEGLSKDLFIEHIGAEEGFGENIEIPVEAGQ
                     KPQKRRFPEEHAMDSKHRKLVPTSRTSLNYLDLPTGHIQIFTTLPQGLWQISGAGTGL
                     SSVLIYHGEMPQVNQVLPSSSLSIPSLPESPDRPGSTSPFTPSAADLPSMPEPALTSR
                     VNETEDTSPSPCQEGPESSIKLPKWPEAVERFQHSLQDKYKALPQSPRGPLVAVELVR
                     ARLERGSNKSQERELATPDWTERQLAHGGLAEVLQVVSDCRRPGETQVVAVLGKAGQG
                     KSHWARTVSHTWACGQLLQYDFVFYVPCHCLDRPGDTYHLRDLLCPPSLQPLAMDDEV
                     LDYIVRQPDRVLLILDAFEELEAQDGLLHGPCGSLSPEPCSLRGLLAGIFQRKLLRGC
                     TLLLTARPRGRLAQSLSKADAIFEVPSFSTKQAKTYMRHYFENSGTAGNQDKALGLLE
                     GQPLLCSYSHSPVVCRAVCQLSKALLEQGTEAQLPCTLTGLYVSLLGPAAQNSPPGAL
                     VELAKLAWELGRRHQSTLQETRFSSVEVKTWAVTQGLMQQTLETTEAQLAFSSFLLQC
                     FLGAVWLAQCNEIKDKELPQYLALTPRKKRPYDNWLEGVPRFLAGLVFQPRAHCLGAL
                     VEPAVAAVADRKQKVLTRYLKRLKLGTLRAGRLLELLHCAHETQQPGIWEHVAHQLPG
                     HLSFLGTRLTPPDVYVLGRALETASQDFSLDLRQTGVEPSGLGNLVGLSCVTSFRASL
                     SDTMALWESLQQQGEAQLLQAAEEKFTIEPFKAKSPKDVEDLDRLVQTQRLRNPSEDA
                     AKDLPAIRDLKKLEFALGPILGPQAFPTLAKILPAFSSLQHLDLDSLSENKIGDKGVS
                     KLSATFPQLKALETLNLSQNNITDVGACKLAEALPALAKSLLRLSLYNNCICDKGAKS
                     LAQVLPDMVSLRVMDVQFNKFTAAGAQQLASSLQKCPQVETLAMWTPTIPFGVQEHLQ
                     QLDARISLR"
     exon            356..502
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            503..598
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            599..661
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            662..742
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            743..787
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            788..922
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1087
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1153
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..2804
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2963
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3035
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3116
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3209
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            3210..3296
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3380
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            3381..3464
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3561
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..5438
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4069..4074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /note="hexamer: CATAAA"
     polyA_site      4091
                     /gene="Ciita"
                     /gene_synonym="C2ta; EG669998; Gm9475; Mhc2ta"
                     /note="major polyA site"
ORIGIN      
        1 acttcatgtt ttggatgctg caaggctgga tgagaggcga ctccaggcag caggcagcct
       61 cagagcactg ccatgaacca cttccaggcc atcctggccc aagtacagac actgctctcc
      121 agccagaagc ccaggcaggt gcgggccctc ctggatggcc tgctggaaga agagctgctc
      181 tcacgggaat accactgtgc cttgctgcat gagcctgatg gtgatgccct ggcccggaag
      241 atttccctga ccctgctgga gaaaggggac ttagacttga ctttcttgag ctgggtctgc
      301 aacagtctgc aggctcccac ggtagagagg ggcaccagct acagggacca tggagaccat
      361 agtctgtgtg ccaccatgga tctgggatct ccagagggca gctacctgga actccttaac
      421 agtgatgccg accccctaca tctctaccac ctctatgacc agatggacct ggctggggag
      481 gaggagatcg aactcagctc agagccagac acagatacca tcaactgcga ccagttcagc
      541 aagctgttgc aggacatgga actggatgaa gagacccggg aggcctatgc caacattgcg
      601 gaactggatc agtacgtgtt ccaggatacc cagctcgagg gcctgagcaa ggacctcttc
      661 atagagcaca ttggagcaga ggaaggcttt ggtgagaaca tagagatccc tgtagaagca
      721 ggacagaagc ctcagaagag acgcttcccg gaagagcatg ctatggactc aaagcacagg
      781 aagctagtgc ccacctctag gacctcactg aactatttgg atctccccac tgggcacatc
      841 cagatcttca ccactctgcc ccagggactc tggcaaatct caggggctgg cacaggtctc
      901 tccagtgtcc taatctacca cggtgagatg ccccaggtca accaagtgct cccttcaagc
      961 agcctcagta tccccagtct ccccgagtcc ccagaccggc ctggctccac cagccccttc
     1021 acaccatctg cagctgacct gcccagcatg cccgaacctg cgctgacctc ccgtgtaaat
     1081 gagacagagg acacatctcc ctccccatgc caagagggtc ccgagtcttc catcaagctt
     1141 ccaaaatggc cagaggctgt ggagcgattc cagcactccc tacaggacaa atacaaggca
     1201 ttgccccaga gcccaagggg tcctctggtg gccgtggagc tggtacgggc caggctggaa
     1261 agaggcagca acaagagcca ggaaagggag ctggccactc ccgactggac agagcgccag
     1321 ctagcccacg gtggtctggc agaggtactt caggttgtca gtgactgcag gcgaccagga
     1381 gagacacagg tggtcgctgt gctgggcaag gctggccagg gaaagagcca ctgggccagg
     1441 acagtgagtc acacctgggc atgtggccag ttgctacaat atgactttgt cttctatgtc
     1501 ccctgtcatt gcttggatcg tcccggggac acctaccacc tgcgggatct gctctgtccc
     1561 ccgagcctgc agccactggc catggatgac gaggtccttg attatatcgt gaggcagcca
     1621 gaccgtgttc tgctcatcct agatgctttc gaggagctag aggcccaaga tggcctcctg
     1681 cacggaccct gtggatctct gtccccagag ccctgctccc tccgaggact gctggctggg
     1741 atcttccagc ggaagctact gcgaggctgc acactgctcc tcacagcccg gccccggggc
     1801 cgcctggctc agagcctgag caaggcagat gccatctttg aggtgcccag cttctctacc
     1861 aagcaggcca agacttacat gaggcactac tttgagaact cagggacagc ggggaaccaa
     1921 gacaaggccc tgggcctcct ggagggccag cctcttctct gcagctatag tcacagccct
     1981 gttgtgtgca gggctgtgtg ccagctctcc aaggccctgc tagaacaggg cacagaggcc
     2041 cagctacctt gtacacttac aggactctat gtcagcctgc taggtcctgc agctcagaac
     2101 agtcctcccg gagccttagt cgagctggcc aagctggcct gggagctggg acgaagacac
     2161 caaagcacct tgcaagaaac ccggttttca tccgtggagg tgaaaacctg ggcagtgacc
     2221 caaggcttga tgcagcagac cctggagacc acggaggctc aactggcctt ctccagtttt
     2281 ctgctacagt gtttcctggg tgctgtgtgg ctggcacagt gcaatgaaat caaagacaag
     2341 gagctgccac agtacctggc cttgactccg aggaagaaga gaccctatga caactggctg
     2401 gagggtgtac cacgctttct ggctggatta gttttccagc ctcgagccca ctgcctggga
     2461 gctctggtgg agcctgcagt ggctgcagtg gcggatagga aacagaaggt tcttaccagg
     2521 tacctgaagc gcctgaagct ggggacactc cgggcaggga ggctgctgga gctgctccac
     2581 tgtgcccacg agacacagca acctgggata tgggagcatg ttgcacacca gctccctggc
     2641 cacctctcct tcctgggcac ccggctcaca cccccagatg tgtatgtgct gggcagggcc
     2701 ttggagacag ccagccagga cttctccttg gaccttcgtc agactggcgt tgagccttct
     2761 ggactgggaa acctcgtggg actcagctgt gtcaccagtt tcagggcctc cttgagtgat
     2821 acaatggcat tatgggagtc ccttcagcag cagggagaag cccagctact ccaggcggca
     2881 gaggagaagt tcaccattga gccatttaaa gccaaatccc caaaggatgt ggaagacctg
     2941 gatcgtctcg tgcagaccca gaggctgaga aacccctcag aagatgcagc caaggatctt
     3001 cctgccatcc gggaccttaa gaagctagag tttgcgttgg gccccatctt gggcccccag
     3061 gctttcccca cactggcaaa gatccttcca gccttctctt ctctgcaaca cctggacctg
     3121 gactcactta gtgagaacaa gatcggagac aagggtgtgt cgaagctctc agccaccttc
     3181 cctcagctga aggccctgga gacgctcaac ttgtcccaaa acaacatcac tgatgtgggt
     3241 gcctgcaagc ttgcagaagc tctgccagcc ctagccaagt ccctcctaag gctgagcttg
     3301 tacaataact gcatctgtga caaaggagcc aagagcctgg cacaagtact tccggacatg
     3361 gtgtccctgc gtgtgatgga tgtccagttc aacaagttca cggctgccgg tgcccagcaa
     3421 ctggcctcca gccttcagaa gtgccctcag gtggaaacac tggcaatgtg gacacccact
     3481 atcccctttg gggttcagga acacctgcag cagctggatg ccaggatcag tctgagatga
     3541 ccctgctgta ctctggacaa gaatgtactc tgggaacact gaccatgctg gaccttgaac
     3601 tgggtactgt ggactcagct tttctgtggg ccatagccca taagagtcaa catcccatca
     3661 ccctgcccct gcaggctcag agttgggccc tgcctacacg aggaaaggac acaagtcttg
     3721 ctcttctgaa ggccccaaga ccagctccag gcccttacag caccaggtac aaagacagcc
     3781 ccactctgcg gccgtgagcg ctggtagaca gaactggggc tgccttccgt gggttcaccc
     3841 gggaggacaa aggccttctc ttcgacactc caggacagaa cgaggaacag aagcatccaa
     3901 gtgcctgctt gtccagacca gggccagcct ggtgagaaag catgtcttcc tgctgctccc
     3961 aacagggcca cctagaggct ctgaagacgc taagggcaac actggcctgc aaatctctag
     4021 atgtgacagg gagcctatgg tagctctttc tacttgtggc actgtttcca taaactttag
     4081 gtcaaagctg agtcgggcct ggcccagacc ctgggtgtga accaaaaggc agggagtggt
     4141 ctgcttcggg gctgtggcgg ggagttcttc tggcttcacc ttcacggtca ctacacttaa
     4201 aatgcatcag ctacgttcac tgaagctctg gggcttggtt tatcccacaa gtcccatctg
     4261 gggacatctt ctgccccatc taatgcaaaa caaaacaaaa cgaaacaaaa caaaacaaaa
     4321 caaaacaaaa caaaacaaaa caaaaccaaa ccaaaccagc cgaactataa taacttgaaa
     4381 caatccacac tccgctggcc aggcaggctc agcagtgccc accaacccag aagtcaggct
     4441 ggaatcatct tgagtgtggg tctagcatgt gacacaagtt gctgtctggg agccctgagt
     4501 ccttaatggg acagctggct ggggcttgcc ctccccgtag cattatagtt atgttatagg
     4561 ggggacaccc agagaggaga aagtgaggag cccggccagc agagacagtc tgtagactgc
     4621 tcagagcagg gctcaaagcc acacagtatt gtttctacaa cactctgcat gcgcccgtgt
     4681 gcccaccata cagcccacca ctgcctagat cctgtcttca ctgcaaagat ctttgtagct
     4741 tccaaagatg cagtgaaaag ttcttactcc tgcacccgag gactgaagca gtgaccactg
     4801 tacagagtgg agtgctctct cctactgccc tgctgcatcc tgggagcagt tctgtatagc
     4861 cacattggtc agccttggct acagctagcc caaaagggct tggcagcacc agtgccgctg
     4921 ctcctgtttc ctctgggaca ccccctttga gctcaggcac cacccatccc tccatcgaga
     4981 cagtgacagc ttgctttctt gtcttggcag agggagctgt gtggctccac catgccagcc
     5041 ctgatgccag caggactggc acatcctagg aagtgggagc tgggctagag ggcctggggc
     5101 cggggtggtc tgcatggctg ctgggggcga ttcttaaaga gacaggtcca gctgcagctc
     5161 aggcttacat tatgaactgt taggaccttg ggctcagggt ggcacatgga agtcccattt
     5221 ctgtggccac cagggacagc actgaggcac tctccaaggc aggcatctgc tgtacctgtc
     5281 aggagaaagg cagatctgta tcgctcgctg cctttggtct gtctggaaat gccaaaaaat
     5341 gtctctcatt actctgtgtt gatgatggct gccatctttt aatgagctga ttaggtaagg
     5401 cactcactat agtgctgggg acatcactga ttcttgat
//
