LOCUS       NM_001301295            1720 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cell death-inducing DFFA-like effector c (Cidec),
            transcript variant 2, mRNA.
ACCESSION   NM_001301295 XM_006505532
VERSION     NM_001301295.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1720)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1720)
  AUTHORS   Qian,K., Tol,M.J., Wu,J., Uchiyama,L.F., Xiao,X., Cui,L.,
            Bedard,A.H., Weston,T.A., Rajendran,P.S., Vergnes,L., Shimanaka,Y.,
            Yin,Y., Jami-Alahmadi,Y., Cohn,W., Bajar,B.T., Lin,C.H., Jin,B.,
            DeNardo,L.A., Black,D.L., Whitelegge,J.P., Wohlschlegel,J.A.,
            Reue,K., Shivkumar,K., Chen,F.J., Young,S.G., Li,P. and Tontonoz,P.
  TITLE     CLSTN3beta enforces adipocyte multilocularity to facilitate lipid
            utilization
  JOURNAL   Nature 613 (7942), 160-168 (2023)
   PUBMED   36477540
REFERENCE   3  (bases 1 to 1720)
  AUTHORS   Huang,L., Liao,Q., Pan,T., Sun,Y., Aluo,Z., Xiao,L., Yu,J., Liu,S.,
            Xiao,Y., Yang,Y., Li,Y. and Zhou,L.
  TITLE     Small Intestine-specific Knockout of CIDEC Improves Obesity and
            Hepatic Steatosis by Inhibiting Synthesis of Phosphatidic Acid
  JOURNAL   Int J Biol Sci 18 (15), 5740-5752 (2022)
   PUBMED   36263170
  REMARK    GeneRIF: Small Intestine-specific Knockout of CIDEC Improves
            Obesity and Hepatic Steatosis by Inhibiting Synthesis of
            Phosphatidic Acid.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1720)
  AUTHORS   Lyu,X., Wang,J., Wang,J., Yin,Y.S., Zhu,Y., Li,L.L., Huang,S.,
            Peng,S., Xue,B., Liao,R., Wang,S.Q., Long,M., Wohland,T.,
            Chua,B.T., Sun,Y., Li,P., Chen,X.W., Xu,L., Chen,F.J. and Li,P.
  TITLE     A gel-like condensation of Cidec generates lipid-permeable plates
            for lipid droplet fusion
  JOURNAL   Dev Cell 56 (18), 2592-2606 (2021)
   PUBMED   34508658
REFERENCE   5  (bases 1 to 1720)
  AUTHORS   Li,P., Lu,M., Shi,J., Gong,Z., Hua,L., Li,Q., Lim,B., Zhang,X.H.,
            Chen,X., Li,S., Shultz,L.D. and Ren,G.
  TITLE     Lung mesenchymal cells elicit lipid storage in neutrophils that
            fuel breast cancer lung metastasis
  JOURNAL   Nat Immunol 21 (11), 1444-1455 (2020)
   PUBMED   32958928
REFERENCE   6  (bases 1 to 1720)
  AUTHORS   Puri,V., Konda,S., Ranjit,S., Aouadi,M., Chawla,A., Chouinard,M.,
            Chakladar,A. and Czech,M.P.
  TITLE     Fat-specific protein 27, a novel lipid droplet protein that
            enhances triglyceride storage
  JOURNAL   J Biol Chem 282 (47), 34213-34218 (2007)
   PUBMED   17884815
  REMARK    GeneRIF: FSP27/Cidec as a novel adipocyte lipid droplet protein
            that negatively regulates lipolysis and promotes triglyceride
            accumulation.
REFERENCE   7  (bases 1 to 1720)
  AUTHORS   Zhou,Z., Yon Toh,S., Chen,Z., Guo,K., Ng,C.P., Ponniah,S.,
            Lin,S.C., Hong,W. and Li,P.
  TITLE     Cidea-deficient mice have lean phenotype and are resistant to
            obesity
  JOURNAL   Nat Genet 35 (1), 49-56 (2003)
   PUBMED   12910269
REFERENCE   8  (bases 1 to 1720)
  AUTHORS   Liang,L., Zhao,M., Xu,Z., Yokoyama,K.K. and Li,T.
  TITLE     Molecular cloning and characterization of CIDE-3, a novel member of
            the cell-death-inducing DNA-fragmentation-factor (DFF45)-like
            effector family
  JOURNAL   Biochem J 370 (Pt 1), 195-203 (2003)
   PUBMED   12429024
REFERENCE   9  (bases 1 to 1720)
  AUTHORS   Inohara,N., Koseki,T., Chen,S., Benedict,M.A. and Nunez,G.
  TITLE     Identification of regulatory and catalytic domains in the apoptosis
            nuclease DFF40/CAD
  JOURNAL   J Biol Chem 274 (1), 270-274 (1999)
   PUBMED   9867840
REFERENCE   10 (bases 1 to 1720)
  AUTHORS   Danesch,U., Hoeck,W. and Ringold,G.M.
  TITLE     Cloning and transcriptional regulation of a novel
            adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein
            (C/EBP) and C/EBP-like proteins interact with sequences required
            for differentiation-dependent expression
  JOURNAL   J Biol Chem 267 (10), 7185-7193 (1992)
   PUBMED   1339452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153910.6.
            
            On Aug 1, 2014 this sequence version replaced XM_006505532.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR.
            Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no single transcript from the reference strain was
            available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M61737.1, SRR5189685.24517.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC153910.6         110855-110901       c
            48-125              AC153910.6         109576-109653       c
            126-279             AC153910.6         108201-108354       c
            280-438             AC153910.6         103536-103694       c
            439-629             AC153910.6         103262-103452       c
            630-1720            AC153910.6         99775-100865        c
FEATURES             Location/Qualifiers
     source          1..1720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 52.76 cM"
     gene            1..1720
                     /gene="Cidec"
                     /gene_synonym="CIDE-3; Fsp27"
                     /note="cell death-inducing DFFA-like effector c"
                     /db_xref="GeneID:14311"
                     /db_xref="MGI:MGI:95585"
     exon            1..47
                     /gene="Cidec"
                     /gene_synonym="CIDE-3; Fsp27"
                     /inference="alignment:Splign:2.1.0"
     exon            48..125
                     /gene="Cidec"
                     /gene_synonym="CIDE-3; Fsp27"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..792
                     /gene="Cidec"
                     /gene_synonym="CIDE-3; Fsp27"
                     /note="isoform 1 is encoded by transcript variant 2; fat
                     specific gene 27; cell death activator CIDE-3;
                     fat-specific protein FSP27; cell death-inducing DFFA-like
                     effector protein C; CIDE-3alpha; lipid transferase CIDEC"
                     /codon_start=1
                     /product="lipid transferase CIDEC isoform 1"
                     /protein_id="NP_001288224.1"
                     /db_xref="CCDS:CCDS20418.1"
                     /db_xref="GeneID:14311"
                     /db_xref="MGI:MGI:95585"
                     /translation="MDYAMKSLSLLYPRSLSRHVAVSTAVVTQQLVSKPSRETPRARP
                     CRVSTADRKVRKGIMAHSLEDLLNKVQDILKLKDKPFSLVLEEDGTIVETEEYFQALA
                     KDTMFMVLLKGQKWKPPSEQRKKRAQLALSQKPTKKIDVARVTFDLYKLNPQDFIGCL
                     NVKATLYDTYSLSYDLHCYKAKRIVKEMLRWTLFSMQATGHMLLGTSSYMQQFLDATE
                     EEQPAKAKPSSLLPACLKMLQ"
     exon            126..279
                     /gene="Cidec"
                     /gene_synonym="CIDE-3; Fsp27"
                     /inference="alignment:Splign:2.1.0"
     exon            280..438
                     /gene="Cidec"
                     /gene_synonym="CIDE-3; Fsp27"
                     /inference="alignment:Splign:2.1.0"
     exon            439..629
                     /gene="Cidec"
                     /gene_synonym="CIDE-3; Fsp27"
                     /inference="alignment:Splign:2.1.0"
     exon            630..1720
                     /gene="Cidec"
                     /gene_synonym="CIDE-3; Fsp27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1695..1700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cidec"
                     /gene_synonym="CIDE-3; Fsp27"
                     /note="hexamer: AGTAAA"
     polyA_site      1720
                     /gene="Cidec"
                     /gene_synonym="CIDE-3; Fsp27"
                     /note="major polyA site"
ORIGIN      
        1 gtgcctggcc acgcggtatt gccaggaggc tgggaggtga gggggaggtc caacacaatc
       61 caactgacaa ggatggacta cgccatgaag tctctcagcc tcctgtaccc caggtcgctg
      121 tccaggcatg tggcagtgag cacggcagtg gtgacccaac agctggtgtc taagcccagc
      181 cgggagaccc cgagggccag gccctgtcgt gttagcaccg cagatcggaa ggttcgcaaa
      241 ggcatcatgg ctcacagctt ggaggacctc ctgaacaagg tccaggacat cttgaaactt
      301 aaagacaagc ccttctccct ggtgctggag gaagatggca caatcgtgga gacagaagaa
      361 tacttccaag ccctggcaaa agataccatg ttcatggtcc tgctgaaggg gcagaagtgg
      421 aagcccccat cagaacagcg caagaagaga gcccagctag ccctttccca gaagccaact
      481 aagaagatcg atgtggcccg ggtaaccttc gacctgtaca agctgaaccc tcaggacttt
      541 attggctgcc tgaacgtgaa ggcaaccctc tatgacacat actcgctttc ctatgacctg
      601 cactgctaca aggccaagcg catcgtgaag gagatgctcc gctggaccct cttcagcatg
      661 caggccaccg gtcacatgct gcttggcacc tccagctaca tgcagcagtt cctggatgcc
      721 accgaggaag aacagcctgc caaggccaag ccctcctccc tcctcccagc ctgtctgaag
      781 atgctgcaat gaagacccga gtcctcagag gccttccttg ggccatggat gtgaccgggg
      841 accctgcgct cggctagcag cacccatgag cctggcagcc agacagcttc tcacctgcct
      901 gcgcctccct cacagcacag caccaaggaa attgcaggaa gggctggagc cctggggtgg
      961 gctggtcaca ggaggacttc ctagcctggc ccagttcctt cctttctgtc tcaggtagct
     1021 tagaggacta acacttagcc ctggcaggca caaagtctgc ccctgtgtcc acttgtgccg
     1081 tcttccgtgc cactccctct ctggtgcacc ccaccatccc cggtcctggc tgcccacact
     1141 catcatgcag tagacattat tatggtggcc cccatcatac cttggcctga atcaagacaa
     1201 ccaagcgagc agcatgccac agcaccaact atgtctatga ccatggtgcc agagtggtta
     1261 gcactctgta gtagaagaaa aggaggtggg ggcttcgggg gtctctcacc tgggactctg
     1321 atcactccct cctagccccc agctgcacat gatcatgagg tgtgcgagag agtgttagag
     1381 gtggagatta actaaagccg gcatgccagg gatgcagatc tggggggtcc tcacctgtgc
     1441 cagggatgca gatctggggg gtcctcacct gtgccaggga gggaccttag ggaatgcaga
     1501 tgattctgag tcacccaggc ccctcctgta agtaacctaa aagctcatag attcaccaag
     1561 ctggacttgg gtgaaaccgc ggcttagcct ctcattgcct gaatggacac agttcctgtt
     1621 ctcctgggaa aggcatgcag ctgcctctct tgttctcatt tttccacgaa tgagtgaatg
     1681 gtattagagt ctgcagtaaa ctatttatgc tgatacctca
//
