LOCUS       NM_009894               1186 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cell death-inducing DNA fragmentation factor, alpha
            subunit-like effector B (Cideb), mRNA.
ACCESSION   NM_009894
VERSION     NM_009894.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1186)
  AUTHORS   Su,L., Zhou,L., Chen,F.J., Wang,H., Qian,H., Sheng,Y., Zhu,Y.,
            Yu,H., Gong,X., Cai,L., Yang,X., Xu,L., Zhao,T.J., Li,J.Z.,
            Chen,X.W. and Li,P.
  TITLE     Cideb controls sterol-regulated ER export of SREBP/SCAP by
            promoting cargo loading at ER exit sites
  JOURNAL   EMBO J 38 (8) (2019)
   PUBMED   30858281
REFERENCE   2  (bases 1 to 1186)
  AUTHORS   Sun,C., Zhao,Y., Gao,X., Yuan,Y., Wang,C., Wang,Y., Zhang,L.,
            Gu,Y., Zhang,F., Hu,P., Wang,Z., Li,Z., Shi,J., Li,S., Cao,K.,
            Ren,B., Yu,M., Liang,W., Li,Z. and Ye,J.
  TITLE     Cideb Deficiency Aggravates Dextran Sulfate Sodium-induced
            Ulcerative Colitis in Mice by Exacerbating the Oxidative Burden in
            Colonic Mucosa
  JOURNAL   Inflamm Bowel Dis 23 (8), 1338-1347 (2017)
   PUBMED   28719542
  REMARK    GeneRIF: High Cideb expression is associated with Ulcerative
            Colitis.
REFERENCE   3  (bases 1 to 1186)
  AUTHORS   Svandova,E.B., Vesela,B., Lesot,H., Poliard,A. and Matalova,E.
  TITLE     Expression of Fas, FasL, caspase-8 and other factors of the
            extrinsic apoptotic pathway during the onset of interdigital tissue
            elimination
  JOURNAL   Histochem Cell Biol 147 (4), 497-510 (2017)
   PUBMED   27709293
REFERENCE   4  (bases 1 to 1186)
  AUTHORS   Xu,W., Wu,L., Yu,M., Chen,F.J., Arshad,M., Xia,X., Ren,H., Yu,J.,
            Xu,L., Xu,D., Li,J.Z., Li,P. and Zhou,L.
  TITLE     Differential Roles of Cell Death-inducing DNA Fragmentation
            Factor-alpha-like Effector (CIDE) Proteins in Promoting Lipid
            Droplet Fusion and Growth in Subpopulations of Hepatocytes
  JOURNAL   J Biol Chem 291 (9), 4282-4293 (2016)
   PUBMED   26733203
  REMARK    GeneRIF: Data (including data from studies in knockout mice)
            suggest Cideb promotes lipid storage as droplets in hepatocytes
            under normal diet conditions; Cidea/Cidec promote fusion of lipid
            droplets leading to liver steatosis in fasting (16h) and obese
            mice.
REFERENCE   5  (bases 1 to 1186)
  AUTHORS   Barneda,D., Planas-Iglesias,J., Gaspar,M.L., Mohammadyani,D.,
            Prasannan,S., Dormann,D., Han,G.S., Jesch,S.A., Carman,G.M.,
            Kagan,V., Parker,M.G., Ktistakis,N.T., Klein-Seetharaman,J.,
            Dixon,A.M., Henry,S.A. and Christian,M.
  TITLE     The brown adipocyte protein CIDEA promotes lipid droplet fusion via
            a phosphatidic acid-binding amphipathic helix
  JOURNAL   Elife 4, e07485 (2015)
   PUBMED   26609809
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1186)
  AUTHORS   Li,J.Z., Ye,J., Xue,B., Qi,J., Zhang,J., Zhou,Z., Li,Q., Wen,Z. and
            Li,P.
  TITLE     Cideb regulates diet-induced obesity, liver steatosis, and insulin
            sensitivity by controlling lipogenesis and fatty acid oxidation
  JOURNAL   Diabetes 56 (10), 2523-2532 (2007)
   PUBMED   17646209
  REMARK    GeneRIF: Cideb is a novel important regulator in lipid metabolism
            in the liver and may thus represent a new therapeutic target for
            the treatment of obesity, diabetes, and liver steatosis
REFERENCE   7  (bases 1 to 1186)
  AUTHORS   Reed,J.C., Doctor,K., Rojas,A., Zapata,J.M., Stehlik,C.,
            Fiorentino,L., Damiano,J., Roth,W., Matsuzawa,S., Newman,R.,
            Takayama,S., Marusawa,H., Xu,F., Salvesen,G. and Godzik,A.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Comparative analysis of apoptosis and inflammation genes of mice
            and humans
  JOURNAL   Genome Res 13 (6B), 1376-1388 (2003)
   PUBMED   12819136
REFERENCE   8  (bases 1 to 1186)
  AUTHORS   Liang,L., Zhao,M., Xu,Z., Yokoyama,K.K. and Li,T.
  TITLE     Molecular cloning and characterization of CIDE-3, a novel member of
            the cell-death-inducing DNA-fragmentation-factor (DFF45)-like
            effector family
  JOURNAL   Biochem J 370 (Pt 1), 195-203 (2003)
   PUBMED   12429024
REFERENCE   9  (bases 1 to 1186)
  AUTHORS   Inohara,N., Koseki,T., Chen,S., Benedict,M.A. and Nunez,G.
  TITLE     Identification of regulatory and catalytic domains in the apoptosis
            nuclease DFF40/CAD
  JOURNAL   J Biol Chem 274 (1), 270-274 (1999)
   PUBMED   9867840
REFERENCE   10 (bases 1 to 1186)
  AUTHORS   Inohara,N., Koseki,T., Chen,S., Wu,X. and Nunez,G.
  TITLE     CIDE, a novel family of cell death activators with homology to the
            45 kDa subunit of the DNA fragmentation factor
  JOURNAL   EMBO J 17 (9), 2526-2533 (1998)
   PUBMED   9564035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK003968.1, CB600615.1 and BQ175754.1.
            
            On Dec 8, 2007 this sequence version replaced NM_009894.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046340.1, AK003968.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               AK003968.1         38-280
            244-729             CB600615.1         221-706
            730-1186            BQ175754.1         1-457               c
FEATURES             Location/Qualifiers
     source          1..1186
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..1186
                     /gene="Cideb"
                     /gene_synonym="1110030C18Rik; CIDE-B"
                     /note="cell death-inducing DNA fragmentation factor, alpha
                     subunit-like effector B"
                     /db_xref="GeneID:12684"
                     /db_xref="MGI:MGI:1270844"
     exon            1..173
                     /gene="Cideb"
                     /gene_synonym="1110030C18Rik; CIDE-B"
                     /inference="alignment:Splign:2.1.0"
     exon            174..318
                     /gene="Cideb"
                     /gene_synonym="1110030C18Rik; CIDE-B"
                     /inference="alignment:Splign:2.1.0"
     exon            319..465
                     /gene="Cideb"
                     /gene_synonym="1110030C18Rik; CIDE-B"
                     /inference="alignment:Splign:2.1.0"
     exon            466..656
                     /gene="Cideb"
                     /gene_synonym="1110030C18Rik; CIDE-B"
                     /inference="alignment:Splign:2.1.0"
     exon            657..1176
                     /gene="Cideb"
                     /gene_synonym="1110030C18Rik; CIDE-B"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1143
                     /gene="Cideb"
                     /gene_synonym="1110030C18Rik; CIDE-B"
     regulatory      1154..1159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cideb"
                     /gene_synonym="1110030C18Rik; CIDE-B"
                     /note="hexamer: AATAAA"
     polyA_site      1176
                     /gene="Cideb"
                     /gene_synonym="1110030C18Rik; CIDE-B"
                     /note="major polyA site"
ORIGIN      
        1 cagagtccac gcttgactca cctctcactt taccagggct aagatctcag ctttatacaa
       61 aaaagcaaga acaacagaga agcacccagc cccaaagcaa cagggagaga gtcacctccc
      121 ccatccctct gcatggagta cctttcagcc ttcaacccca atggcctgct aaggtcagta
      181 tccactgtga gctcggagtt aagccgtagg gtctggaact cagctcctcc acctcagcga
      241 cccttccgtg tctgtgatca taagcggaca gtccggaaag gactgacagc tgccagcctc
      301 caagaactgc tagataaggt cctggagacc ttgctgctac gtggagtgct aacactggtc
      361 ctggaggagg atgggactgc tgtggacagt gaggacttct tccagctgct ggaggacgac
      421 acgtgcttga tggtgcttga gcagggccag agctggagcc ccaagagtgg gatgttgtca
      481 tacggcctag gacgggagaa gccaaaacac agcaaggaca tcgcccgcat caccttcgat
      541 gtgtacaagc aaaatccccg agacctcttt ggcagcctca acgtgaaagc tacattctat
      601 ggactctact ccatgagctg tgatttccaa ggagttggcc ctaaaagagt actcagggag
      661 ctcctccgtt ggacttcctc gctgctgcaa ggcctgggcc atatgctgct gggcatctcc
      721 tccacccttc gccatgtggt ggagggggct gatcgatggc agtggcacgg gcagagacac
      781 ctccactcct aatgagatca tgctttgagc ctgtgctgaa agactggttc catgtgacac
      841 aggagggtag taaaggcacc atcaggcttg gggtctgcag tgtaccctag gtaaccaagc
      901 tgactccatc ctaacagatc tgcacactgc cttgttcctc tggcctgtac atcttcctga
      961 agaatgctac ctgtcttccc tccactcctg ccttccacat accctgcaga accacagcct
     1021 tgtcccctgc atcctgatcc caccgtaatc gctgcttcat ctaggttctt actgacgcct
     1081 acccctaaga tcctgcatac caacggccac tgtccctagc tttactacaa gataactttc
     1141 ccctaaaaaa taaaataaaa atatttccaa gaaaaaaaaa aaaaaa
//
