LOCUS       NM_007702               1164 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus cell death-inducing DNA fragmentation factor, alpha
            subunit-like effector A (Cidea), mRNA.
ACCESSION   NM_007702
VERSION     NM_007702.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1164)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   2  (bases 1 to 1164)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1164)
  AUTHORS   Li,Q., Wang,W., Duan,F., Wang,Y., Chen,S., Shi,K., Xia,Y., Li,X.,
            Gao,Y. and Liu,G.
  TITLE     DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS
            via Inhibiting CIDEA Expression
  JOURNAL   Cell Mol Gastroenterol Hepatol 17 (1), 59-77 (2024)
   PUBMED   37703946
  REMARK    GeneRIF: DNMT3B Alleviates Liver Steatosis Induced by Chronic
            Low-grade LPS via Inhibiting CIDEA Expression.
REFERENCE   4  (bases 1 to 1164)
  AUTHORS   Li,L., Zhou,H., Wang,J., Li,J., Lyu,X., Wang,W., Luo,C., Huang,H.,
            Zhou,D., Chen,X., Xu,L. and Li,P.
  TITLE     Metabolic switch from glycogen to lipid in the liver maintains
            glucose homeostasis in neonatal mice
  JOURNAL   J Lipid Res 64 (10), 100440 (2023)
   PUBMED   37826876
REFERENCE   5  (bases 1 to 1164)
  AUTHORS   Park,A., Kim,K.E., Park,I., Lee,S.H., Park,K.Y., Jung,M., Li,X.,
            Sleiman,M.B., Lee,S.J., Kim,D.S., Kim,J., Lim,D.S., Woo,E.J.,
            Lee,E.W., Han,B.S., Oh,K.J., Lee,S.C., Auwerx,J., Mun,J.Y.,
            Rhee,H.W., Kim,W.K., Bae,K.H. and Suh,J.M.
  TITLE     Mitochondrial matrix protein LETMD1 maintains thermogenic capacity
            of brown adipose tissue in male mice
  JOURNAL   Nat Commun 14 (1), 3746 (2023)
   PUBMED   37353518
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1164)
  AUTHORS   Li,P.
  TITLE     Cidea, brown fat and obesity
  JOURNAL   Mech Ageing Dev 125 (4), 337-338 (2004)
   PUBMED   15063110
  REMARK    GeneRIF: First protein known to directly modulate Ucp1 activity in
            regulation of thermogenesis and development of obesity and
            diabetes. Review.
            Review article
REFERENCE   7  (bases 1 to 1164)
  AUTHORS   Zhou,Z., Yon Toh,S., Chen,Z., Guo,K., Ng,C.P., Ponniah,S.,
            Lin,S.C., Hong,W. and Li,P.
  TITLE     Cidea-deficient mice have lean phenotype and are resistant to
            obesity
  JOURNAL   Nat Genet 35 (1), 49-56 (2003)
   PUBMED   12910269
  REMARK    GeneRIF: a role for Cidea in regulating energy balance and
            adiposity
REFERENCE   8  (bases 1 to 1164)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   9  (bases 1 to 1164)
  AUTHORS   Inohara,N., Koseki,T., Chen,S., Benedict,M.A. and Nunez,G.
  TITLE     Identification of regulatory and catalytic domains in the apoptosis
            nuclease DFF40/CAD
  JOURNAL   J Biol Chem 274 (1), 270-274 (1999)
   PUBMED   9867840
REFERENCE   10 (bases 1 to 1164)
  AUTHORS   Inohara,N., Koseki,T., Chen,S., Wu,X. and Nunez,G.
  TITLE     CIDE, a novel family of cell death activators with homology to the
            45 kDa subunit of the DNA fragmentation factor
  JOURNAL   EMBO J 17 (9), 2526-2533 (1998)
   PUBMED   9564035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ554477.1, BB614324.1 and BQ554476.1.
            
            On Dec 11, 2007 this sequence version replaced NM_007702.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF041376.1, BC096649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-533               BQ554477.1         10-542
            534-811             BB614324.1         309-586
            812-1164            BQ554476.1         1-353               c
FEATURES             Location/Qualifiers
     source          1..1164
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 39.94 cM"
     gene            1..1164
                     /gene="Cidea"
                     /note="cell death-inducing DNA fragmentation factor, alpha
                     subunit-like effector A"
                     /db_xref="GeneID:12683"
                     /db_xref="MGI:MGI:1270845"
     exon            1..277
                     /gene="Cidea"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..893
                     /gene="Cidea"
                     /note="cell death activator CIDE-A; cell death-inducing
                     DFFA-like effector A"
                     /codon_start=1
                     /product="lipid transferase CIDEA"
                     /protein_id="NP_031728.2"
                     /db_xref="CCDS:CCDS37846.1"
                     /db_xref="GeneID:12683"
                     /db_xref="MGI:MGI:1270845"
                     /translation="METARDYAGALIRPLTFMGLQTKKVLLTPLIHPARPFRVSNHDR
                     SSRRGVMASSLQELISKTLDVLVITTGLVTLVLEEDGTVVDTEEFFQTLRDNTHFMIL
                     EKGQKWTPGSKYVPVCKQPKKSGIARVTFDLYRLNPKDFLGCLNVKATMYEMYSVSYD
                     IRCTSFKAVLRNLLRFMSYAAQMTGQFLVYAGTYMLRVLGDTEEQPSPKPSTKGWFM"
     exon            278..422
                     /gene="Cidea"
                     /inference="alignment:Splign:2.1.0"
     exon            423..569
                     /gene="Cidea"
                     /inference="alignment:Splign:2.1.0"
     exon            570..751
                     /gene="Cidea"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1164
                     /gene="Cidea"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1125..1130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cidea"
                     /note="hexamer: AATAAA"
     polyA_site      1153
                     /gene="Cidea"
                     /note="major polyA site"
ORIGIN      
        1 ccagaagaga aaaacaaact gacaagagcc accaacatca ccaaatcctg gggttttggg
       61 ccctcggtac cgtttgcgca cgaaggggcg tggccccggg acccaggcca gggagccaga
      121 actattcgct gctcgcagga gcgcagcctg tcgccaaggt cgggtcaagt cgtcgcgggg
      181 cgtggctgat agggcagtga tttaagagac gcggctttgg gacaggagga cccgcaccaa
      241 tggagaccgc cagggactac gcgggagccc tcatcaggcc cctgacattc atgggattgc
      301 agactaagaa ggtcctactg acccccctca tacatccagc tcgccctttt cgagtttcaa
      361 accatgaccg aagtagccgg cgtggggtga tggccagcag cctgcaggaa cttatcagca
      421 agactctgga tgtcttagtc atcacaactg gcctggttac gctggtgctg gaggaggacg
      481 gcaccgtggt ggacacagag gagttctttc agaccttaag ggacaacacg catttcatga
      541 tcttggaaaa gggacagaaa tggacaccgg gtagtaagta tgtcccagtc tgcaagcaac
      601 caaagaaatc gggaatagcc agagtcacct tcgacctata caggctgaac cccaaggact
      661 tcctcggctg tctcaatgtc aaagccacga tgtacgagat gtactcggtg tcctacgaca
      721 tccgatgcac aagcttcaag gccgtgttaa ggaatctgct gaggtttatg tcctatgctg
      781 cacagatgac gggacagttc ctggtctatg cgggcacata catgctccga gtactgggcg
      841 atacagaaga gcagccatcc cccaagccta gcaccaaagg ctggttcatg taaccagggc
      901 acagctacag aggcccaggg accctgctct ctgttatagg ctgtgggatg ccaggggaag
      961 gaatgggggc ttgggggtgg tacccagtgc agggctgagt agcaggattc ctgcaaagga
     1021 aaggcggcag aggggccttt caagcgcttt aggaagggat caacagcgga gtgtgtggga
     1081 actgcgtgga tacgaatcag tttctttgga tccttacata ctgtaataaa ccagtcacat
     1141 gagtcgtctt tgatacttcc ttgc
//
