LOCUS       NM_001302811            8244 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus capicua transcriptional repressor (Cic), transcript
            variant 4, mRNA.
ACCESSION   NM_001302811 XM_006540366
VERSION     NM_001302811.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8244)
  AUTHORS   Hendrickson,P.G., Oristian,K.M., Browne,M.R., Luo,L., Ma,Y.,
            Cardona,D.M., Nash,J.O., Ballester,P.L., Davidson,S., Shlien,A.,
            Linardic,C.M. and Kirsch,D.G.
  TITLE     Spontaneous expression of the CIC::DUX4 fusion oncoprotein from a
            conditional allele potently drives sarcoma formation in genetically
            engineered mice
  JOURNAL   Oncogene 43 (16), 1223-1230 (2024)
   PUBMED   38413794
REFERENCE   2  (bases 1 to 8244)
  AUTHORS   Coffin,S.L., Durham,M.A., Nitschke,L., Xhako,E., Brown,A.M.,
            Revelli,J.P., Villavicencio Gonzalez,E., Lin,T., Handler,H.P.,
            Dai,Y., Trostle,A.J., Wan,Y.W., Liu,Z., Sillitoe,R.V., Orr,H.T. and
            Zoghbi,H.Y.
  TITLE     Disruption of the ATXN1-CIC complex reveals the role of additional
            nuclear ATXN1 interactors in spinocerebellar ataxia type 1
  JOURNAL   Neuron 111 (4), 481-492 (2023)
   PUBMED   36577402
  REMARK    Erratum:[Neuron. 2023 Mar 15;111(6):915. doi:
            10.1016/j.neuron.2023.02.030. PMID: 36924764]
REFERENCE   3  (bases 1 to 8244)
  AUTHORS   Hong,H. and Lee,Y.
  TITLE     Generation of hematopoietic lineage cell-specific chimeric mice
            using retrovirus-transduced fetal liver cells
  JOURNAL   STAR Protoc 3 (3), 101526 (2022)
   PUBMED   35779265
REFERENCE   4  (bases 1 to 8244)
  AUTHORS   Hong,H., Lee,J., Park,G.Y., Kim,S., Park,J., Park,J.S., Song,Y.,
            Lee,S., Kim,T.J., Lee,Y.J., Roh,T.Y., Kwok,S.K., Kim,S.W., Tan,Q.
            and Lee,Y.
  TITLE     Postnatal regulation of B-1a cell development and survival by the
            CIC-PER2-BHLHE41 axis
  JOURNAL   Cell Rep 38 (7), 110386 (2022)
   PUBMED   35172136
  REMARK    GeneRIF: Postnatal regulation of B-1a cell development and survival
            by the CIC-PER2-BHLHE41 axis.
REFERENCE   5  (bases 1 to 8244)
  AUTHORS   Kim,S., Park,G.Y., Park,J.S., Park,J., Hong,H. and Lee,Y.
  TITLE     Regulation of positive and negative selection and TCR signaling
            during thymic T cell development by capicua
  JOURNAL   Elife 10, e71769 (2021)
   PUBMED   34895467
  REMARK    GeneRIF: Regulation of positive and negative selection and TCR
            signaling during thymic T cell development by capicua.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8244)
  AUTHORS   Lam,Y.C., Bowman,A.B., Jafar-Nejad,P., Lim,J., Richman,R.,
            Fryer,J.D., Hyun,E.D., Duvick,L.A., Orr,H.T., Botas,J. and
            Zoghbi,H.Y.
  TITLE     ATAXIN-1 interacts with the repressor Capicua in its native complex
            to cause SCA1 neuropathology
  JOURNAL   Cell 127 (7), 1335-1347 (2006)
   PUBMED   17190598
REFERENCE   7  (bases 1 to 8244)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 8244)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 8244)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Hara,Y., Nagase,T.,
            Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   10 (bases 1 to 8244)
  AUTHORS   Lee,C.J., Chan,W.I., Cheung,M., Cheng,Y.C., Appleby,V.J., Orme,A.T.
            and Scotting,P.J.
  TITLE     CIC, a member of a novel subfamily of the HMG-box superfamily, is
            transiently expressed in developing granule neurons
  JOURNAL   Brain Res Mol Brain Res 106 (1-2), 151-156 (2002)
   PUBMED   12393275
  REMARK    GeneRIF: Results describe the identification and characterization
            of a new gene, Cic, in both human and mouse genomes, that is
            implicated in granule cell development.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147535.1, AC156992.13 and BF455793.1.
            
            On Nov 18, 2014 this sequence version replaced XM_006540366.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR, uses an
            alternate promoter, an alternate start codon, and has multiple
            differences in the coding region compared to variant 1. It encodes
            isoform CIC-L (PMID: 17190598), which has a distinct N-terminus and
            is longer than isoform CIC-S.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK147535.1         2-5
            5-5                 AC156992.13        110256-110256       c
            6-3335              AK147535.1         7-3336
            3336-3336           AC156992.13        92456-92456         c
            3337-3890           AK147535.1         3338-3891
            3891-3891           AC156992.13        90983-90983         c
            3892-6535           AK147535.1         3893-6536
            6536-6536           AC156992.13        86221-86221         c
            6537-8209           AK147535.1         6538-8210
            8210-8225           AC156992.13        83801-83816         c
            8226-8244           BF455793.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..8244
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.73 cM"
     gene            1..8244
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /note="capicua transcriptional repressor"
                     /db_xref="GeneID:71722"
                     /db_xref="MGI:MGI:1918972"
     exon            1..58
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            59..2857
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..7602
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /note="isoform CIC-L is encoded by transcript variant 4;
                     protein capicua homolog"
                     /codon_start=1
                     /product="protein capicua homolog isoform CIC-L"
                     /protein_id="NP_001289740.1"
                     /db_xref="CCDS:CCDS80678.1"
                     /db_xref="GeneID:71722"
                     /db_xref="MGI:MGI:1918972"
                     /translation="MKPMKKACPGLAGSASGSKSPPATRAKALRRRGAGEGDKPEEEE
                     EAQPQEQAGPEEAEEGEEEEAERDPGAEGTHPELQPNDPTPGLTEDPKGDGEAGRWEP
                     SLSRKTATFKSRAPKKKYVEEHGTGNVGVVGAPEERERTPEDASALGVPPRPPTSTRS
                     SSTDTASEHSADLEDEPPEACGPGPWPSTGTSEGYDLRQLRSQRVLARRGDGLFLPAV
                     VRQVRRSQDLGVQFPGDRALTFYEGVPGGGVDVVLDVTPPPGALMVGTAVCTCVEPGV
                     AAYREGVVVEVATKPAAYKVRLSPGPSSHAGPPGTLPQAQQTLHREPEEAVWVTRSSL
                     RLLRPPWEPGALLRKHPAGPEEEQAEPGPALPPCPSSVEPKQPEDAEVSNISFGSNLG
                     TRCEEGEEKHPPSLGTPVLLPLPPPQLLSPPPKSPAFGGPGRPSEQPSPCQEGSQGGS
                     RSSSVASLEKGAAPAARARTPLTAAQQKYKKGDVVCTPNGIRKKFNGKQWRRLCSRDG
                     CMKESQRRGYCSRHLSMRTKEMEGLADSGPGGTGRPAGVAAREGSTEFDWGDETSRDS
                     EASSVAARGDSRPRLVAPADLSRFEFDECEAAVMLVSLGSSRSGTPSFSPVSTQSPFS
                     PAPSPSPSPLFGFRPANFSPINASPVIQRTAVRSRHLSASTPKAGVLTPPDLGPHPPP
                     PAPRERHSSGILPTFQTNLTFTVPISPGRRKTELLPHPGTLGASGAGGGGAAPDFPKS
                     DSLDSGVDSVSHTPTPSTPAGFRAVSPAVPFSRSRQPSPLLLLPPPAGLTSDPGPSVR
                     RVPAVQRDSPVIVRNPDVPLPSKFPGEVGTAGEARAGGPGRSCRETPVPPGVASGKPG
                     LPPPLPAPVPITVPPAAPTAVAQPMPTLGLASSPFQPVAFHPSPAALLPVLVPSSYPS
                     HPAPKKEVIMGRPGTVWTNVEPRSVAVFPWHSLVPFLAPSQPDPSVQPSEAQQPASHP
                     VASNQSKEPAESAAVAHEQPPGGTGGADPGRPPGAVCPESPGPGPPLTLGGVDPGKSL
                     PPTTEEEAPGPPGEPRLDSETESDHDDAFLSIMSPEIQLPLPPGKRRTQSLSALPKER
                     DSSSEKDGRSPNKREKDHIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWY
                     ALGPKEKQKYHDLAFQVKEAHFKAHPDWKWCNKDRKKSSSEAKPASLGLAGGHKETRE
                     RSMSETGTAAAPGVSSELLSVAAQTLLSSDTKVPGSGPCGAERLHAVGAPGSARPRAF
                     SHSGVHSLDGGEVDSQALQELTQMVSGPASYSGPKPSPQYGAPGSFAAPGEGGTLATS
                     GRPPLLPSRASRSQRAASEDMTSDEERMVICEEEGDDDVIADDSFGTTDIDLKCKERV
                     TDSESGDSSGEDPEGNKGFGRKVFSPVIRSSFTHCRPTLDPEPPGPPDPPAAFSKGYG
                     PTPSSSSSPASTSVSVSTSFSLGSGTFKTQESGQGSTAVPLRPPPPGAGGPATPSKAT
                     RFPPTDSATFRRKRPESVGSLEAPGPSVIAAPPSGGGNLLQTLVLPPSKEDREGTRVP
                     SAPAPPLAYGAPAAPLCRPAATMVTNVVRPVSSTPVPIASKPFPTSGRAEASSNDIAG
                     ARTEMGTGSRVPGGSPMGVSLVYSDKKSAAAATSPAPHLVAGPLLGTVGKAPATVTNL
                     LVGTPGYGAPASPAVQFIAQGAPGSATPAGSGASTGSGPNGPVPLGILQPGALGKAGG
                     ITQVQYILPTLPQQLQVAPAPAPAPGTKAAAPSGPAPTTSIRFTLPPGTSTNGKVLAA
                     TAPTAGIPILQSVPSAPPPKAQSVSPVQATPSGGSAQLLPGKVLVPLAAPSMSVRGGG
                     AGQPLPLVSSPFSVPVQNGAQQPSKIIQLTPVPVSTPSGLVPPLSPATMPGPTSQPQK
                     VLLPSSTRITYVQSAGGHTLPLGTSSACSQTGTVTSYGPTSSVALGFTSLGPSGPAFV
                     QPLLSGQAPLLAPGQVGVSPVPSPQLPPACTASGGPVITAFYPGSPAPTSAPLGPPSQ
                     APPSLVYTVATSTTPPAATILPKGPPASATATPAPTSPFPSATGSMTYSLVAPKAQRP
                     SPKAPQKVKAAIASIPVGSFESGTTGRPGSTPRQSSDSGVAREPAAPESELEGQPTPP
                     APPPPTETWPPTARSSPPPPLPAEERPGTKGPETASKFPSSSSDWRVPGLGLESRGEP
                     PTPPSPAPATGPSGSSSGSSEGSSGRAAGDTPERKEVTSSGKKMKVRPPPLKKTFDSV
                     DKVLSEVDFEERFAELPEFRPEEVLPSPTLQSLATSPRAILGSYRKKRKNSTDLDSAP
                     EDPTSPKRKMRRRSSCSSEPNTPKSAKCEGDIFTFDRTGTETEDVLGELEYEKVPYSS
                     LRRTLDQRRALVMQLFQDHGFFPSAQATAAFQARYADIFPSKVCLQLKIREVRQKIMQ
                     AATPTEQPPGAEAPLPGPPPTGMAATPVPTPSPAGGPDPTSPGSDSGTAQVAPPLPPP
                     PEPGPGQPGWEGAPQPSPPPSGPSTAATGR"
     exon            2858..3007
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3242
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3372
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            3373..3555
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3721
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3924
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            3925..4150
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            4151..4254
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            4255..5482
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            5483..5670
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            5671..5792
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            5793..5959
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            5960..6247
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            6248..6567
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            6568..6818
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            6819..6970
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            6971..7102
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            7103..7234
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     exon            7235..8226
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8194..8199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /note="hexamer: ATTAAA"
     polyA_site      8212
                     /gene="Cic"
                     /gene_synonym="1200010B10Rik; mKIAA0306"
                     /note="major polyA site"
ORIGIN      
        1 gtgccgctac agccgcctca gcgaggagcc actggcgacg ccagagccag caatccgggt
       61 ggacagacga tgaagccaat gaagaaggca tgccctggcc ttgcaggttc cgccagtggc
      121 agcaagtccc caccagctac cagggccaag gctttgagac ggcgaggggc cggggagggt
      181 gacaagccag aggaggagga ggaggcacag ccacaggagc aggcagggcc agaagaggct
      241 gaagagggtg aggaagagga ggctgagcgg gaccctggag ctgagggaac acatccagag
      301 ctgcagccca atgatcctac tccaggccta actgaggacc ctaaggggga tggggaggca
      361 ggccgctggg agccctcact cagtcgcaag acagccacat tcaagtctcg ggccccgaag
      421 aagaaatatg tggaggagca tggcactgga aatgttggtg tggtaggagc ccctgaagag
      481 cgggagcgga cgcctgagga cgccagtgcc ctgggtgtgc ctcctcggcc acccacctcc
      541 actcggtcct cctctactga cacggccagt gagcactcag ccgacctgga ggacgagccc
      601 cctgaggctt gtggtccagg cccctggccc tctacaggca ccagtgaagg ctatgacctg
      661 cggcaactga ggtctcagcg ggtgctggct cggcgtggtg atggcctctt cctgcctgca
      721 gtcgtgcgcc aggtgcgccg tagccaggac ttgggtgtgc agttccctgg ggaccgtgcc
      781 ttgactttct atgaaggagt acccggtggt ggtgtggacg ttgttttgga tgtcacacca
      841 cctccaggtg cactgatggt gggcacggct gtctgcactt gtgtggaacc tggtgtggct
      901 gcctaccgag agggtgtagt ggtggaagtg gccactaaac cagctgccta taaggtccgc
      961 ctcagccctg gccccagctc ccatgcaggc ccaccaggca cactgccaca agcccaacag
     1021 acactgcacc gtgagcctga ggaggctgtc tgggttactc gctctagcct gcgcctgctt
     1081 cggcccccct gggaacctgg ggccttgctg aggaagcacc ctgcaggccc agaggaggag
     1141 caggcagagc ctgggcccgc tttgcctcct tgtccttctt ccgtggagcc caagcaacct
     1201 gaggatgctg aggtctccaa catcagcttt ggtagcaacc tggggactcg ctgcgaggag
     1261 ggggaggaga agcacccacc atccctgggc acccctgtcc tgctcccact gcctccaccc
     1321 cagctcctgt caccaccccc gaagtcccca gcctttggtg gccctggccg ccctagtgag
     1381 cagccttcgc cctgccagga agggagccag ggtggcagcc gcagtagcag tgtggcctca
     1441 ctggagaagg gagctgcacc agcagcccgt gctcgcacgc cattgacagc cgcccagcag
     1501 aagtacaaga agggcgacgt ggtctgcacg cccaatggca tccgaaagaa gttcaatggc
     1561 aagcagtggc gccggctgtg ctctcgggat ggctgcatga aggagtccca gcggcgcggg
     1621 tactgctcgc gccacttgtc catgagaacc aaagagatgg agggcctggc agacagtggg
     1681 ccaggtggga ctgggcggcc tgcgggtgtg gcagcccggg aaggaagcac tgagtttgac
     1741 tggggcgatg agacttcgag ggacagtgag gccagcagtg tggcagcccg gggagactcc
     1801 cgcccacgtc tagtggcgcc tgctgacctg tcacgcttcg agtttgatga gtgtgaggcg
     1861 gctgtgatgt tggtgtcact tggcagctcc cgctcaggca caccttcctt ctctccggtc
     1921 tctacacagt cgcccttctc tccagccccc tctccctcac cctcgccgct ctttggcttc
     1981 cgccctgcca atttcagccc cataaatgcc tcacctgtca tccaacgcac tgctgttcgc
     2041 agccgccacc tgagcgccag cacccctaag gcaggcgtgc tgacaccacc agacctgggc
     2101 ccccacccac cgccacctgc ccctcgtgag cgccattcct ctggcatcct acccaccttc
     2161 cagaccaacc taacctttac tgtgcccatt agccctgggc ggaggaagac agaactgctg
     2221 ccccatccag ggacattggg ggcctccgga gcaggaggtg ggggagccgc cccagacttc
     2281 cccaagagtg acagcttaga ctctggagtg gactccgtgt cccacacacc taccccctcc
     2341 acaccggctg gcttccgagc tgtgtcaccg gctgtgccct tctctcgctc ccgccagcct
     2401 tcaccattgc tgctgttgcc cccacctgct ggactcacct cagatccagg gccctctgtg
     2461 cgaagggtac ccgccgtgca gcgggactca cctgtcattg tccgcaaccc cgatgtgcca
     2521 ctgccttcca aattccctgg agaggtgggc actgccggtg aggcacgggc cgggggacct
     2581 ggacggagtt gccgtgagac cccagtgccc cctggggtgg ccagcgggaa acctggcctg
     2641 cctccacctc tgcctgcccc tgtgcccatc actgtgcctc cagccgcacc gactgctgtg
     2701 gcccagccga tgcccacctt gggcctggct tcttcaccct tccagcccgt ggcctttcac
     2761 ccttcacctg ctgccctgtt gccagttcta gtgccgagca gctatcccag ccaccctgcc
     2821 cccaagaagg aagtcatcat gggcaggccc ggaacagtgt ggacaaatgt cgaacctcgt
     2881 tctgtggctg tgttcccctg gcactcctta gtccccttcc tggcacccag ccagcccgac
     2941 ccctctgtgc agcctagtga ggcccagcaa cctgccagcc accctgtggc ctccaaccag
     3001 agcaaagaac ctgctgagtc tgctgctgtt gctcatgagc agccaccagg agggacgggg
     3061 ggtgctgacc ctggacggcc ccctggagca gtgtgccctg agagcccagg gcctggacct
     3121 ccacttactt tgggtggtgt ggatcctggt aaaagtctcc cccccaccac tgaggaggag
     3181 gctcctggcc ctccaggaga gccccggctg gacagtgaga ccgagagtga tcatgatgat
     3241 gccttcctct ccatcatgtc tcctgagatt cagttgcctc tgccacctgg aaagcgccgc
     3301 acccagtctc tgagtgcctt gcccaaggaa cgagactcat cttctgaaaa ggatggacga
     3361 agtcctaaca agcgggagaa ggaccatatt cgtcggccca tgaatgcctt catgatcttc
     3421 agcaagcggc accgggcctt ggtccaccag cggcacccca accaggacaa ccggactgtc
     3481 agcaagatcc tgggcgagtg gtggtacgcc ctggggccca aagagaagca gaaataccac
     3541 gacctggcct tccaggtgaa agaggcccac ttcaaggccc acccagattg gaaatggtgc
     3601 aacaaggacc gaaagaagtc cagctcagag gccaagcctg cgagcctggg tctggcagga
     3661 gggcacaagg agacgcggga acggagcatg tcggagacgg gaactgctgc tgcccctggg
     3721 gtgtcttctg agctcctgtc tgttgctgcc cagacacttt tgagctcgga caccaaggtt
     3781 ccagggagtg gcccctgtgg agcagaacgg ctacacgcag ttggggcacc tggctcagcc
     3841 cgacccagag ccttctccca cagtggggtg cacagtcttg atggtgggga agtagacagc
     3901 caagcacttc aagaactgac ccagatggtt tctggccccg catcatactc cggcccaaag
     3961 ccttcccccc agtatggtgc tccaggatct tttgcagctc ctggtgaagg aggtaccttg
     4021 gccactagtg ggcggcctcc actgttgccc tcccgagcct ctcgttccca gcgtgcagcc
     4081 agtgaggaca tgaccagtga tgaggagcgg atggtcatct gtgaggaaga aggggatgat
     4141 gatgtcattg ctgatgacag ctttggcacc accgacattg atctcaagtg caaggaacga
     4201 gtgactgaca gtgaaagtgg agacagctct ggggaggacc cagagggtaa caagggcttt
     4261 ggccgtaagg tgttctcacc tgtcatccgc tcctccttta cccattgccg tccaaccctg
     4321 gaccctgagc ctccagggcc cccggatcca cctgcagcct tcagcaaagg ctacggtccc
     4381 accccatcat cctcctcttc acctgcttcc acctcagtct cagtctccac ctccttttca
     4441 ctgggctctg gaacctttaa gacccaggag tctggtcagg gcagcacagc ggtgccacta
     4501 cggcccccac cccctggagc cgggggccca gcaacacctt ccaaggccac tcggtttcct
     4561 cctacggatt ctgccacctt tcggcgcaag agacctgaaa gtgttggtag ccttgaagca
     4621 ccaggcccct ctgtcattgc agcacctccc agtgggggag gaaaccttct gcagacactg
     4681 gttctgcctc cgagcaagga ggatcgggag ggtacacgag tgccctcagc cccagcccca
     4741 ccactggctt atggggctcc cgcagcccct ctgtgccgcc ctgctgccac catggtcacc
     4801 aatgtggtac ggcctgtcag cagcactcct gtgcccattg cctctaagcc ctttcccacc
     4861 tctggtcggg ctgaggcatc ttcaaatgac atagcaggtg ccaggactga aatgggcaca
     4921 ggatcccggg tgcctggggg ctccccaatg ggtgtcagtt tagtgtattc agataagaag
     4981 tcagcagcag cagccacctc gccagctcca catttggtag ctggaccttt attgggcact
     5041 gtggggaagg cacctgctac tgtcaccaac ttgctggtag gcaccccagg ctatggggct
     5101 cctgcatcgc ctgctgttca gtttattgcc cagggagccc caggcagtgc aacccctgca
     5161 ggctcaggag caagtactgg gagtggcccc aatgggccag tacccctggg catcctgcag
     5221 ccaggtgccc taggcaaggc tgggggaatc acacaggtgc agtacatcct gcccacactg
     5281 ccccagcagc ttcaagtggc acctgcccca gcaccagccc ctgggaccaa ggcagcagct
     5341 cccagtggcc ctgcacccac caccagcatc cgtttcaccc tccctccggg cacctcgacc
     5401 aacggcaagg tcctggctgc cactgcaccc actgctggca tccctatcct gcagtccgta
     5461 ccctcagccc caccccctaa agcccagtca gtttctcctg tccaggccac accttcaggt
     5521 ggctcagccc agctgctgcc tgggaaggtg ctagtccccc tggctgcccc tagcatgtca
     5581 gttcgaggtg gaggggctgg tcagccactg cccctggtta gctcgccttt ctcagtacct
     5641 gtccaaaatg gtgcccaaca acctagcaag attatccagc tgactcctgt gcctgtgagc
     5701 acacctagtg gcctggtacc acccctgagc ccagctacaa tgccgggacc cacatcacag
     5761 cctcagaagg tcctgttgcc ctcttccaca agaatcacct atgtacagtc agcaggtggg
     5821 cacactctgc ctctaggcac cagttctgca tgcagtcaga ctggaacagt gacctcatat
     5881 gggcccacca gctctgtagc tctgggcttc acatctttgg ggcccagtgg tcctgccttt
     5941 gtacagcctc tgctctcagg ccaagctcct ttgctggctc ctggccaggt gggcgtgtca
     6001 cctgtgccta gtccccagtt gcctcctgcc tgtacagcct ctggaggtcc tgtcataaca
     6061 gcattttacc ctggcagccc tgcacccact tcagcacccc tgggcccacc ttcccaagct
     6121 ccgccaagcc tggtctacac tgtagccacc agtaccactc cacctgctgc taccattctg
     6181 cccaagggcc caccagcctc tgccactgcc actccagccc ctactagtcc tttccctagc
     6241 gccacaggct ccatgaccta cagcttagtg gctcccaaag ctcagcgacc cagcccaaaa
     6301 gctccccaga aagtaaaggc agccattgcc agcattcctg tggggtcttt tgaatcgggt
     6361 actactgggc ggcctggatc tacaccccga cagtcttcag actctggcgt agccagagag
     6421 cctgctgccc cagaatcaga acttgagggg cagcccacac ccccagctcc cccacccccc
     6481 acagagacct ggcctcccac tgcccggagc agtcccccac cccccttgcc tgctgaggag
     6541 cgacctggca ctaaaggccc tgagactgcc agcaaattcc ccagctcatc ttcagactgg
     6601 cgagttcctg ggctgggcct ggagagtcgt ggggagcctc ctacccctcc cagcccagct
     6661 ccagccacag gccccagtgg aagcagcagt ggcagcagcg agggcagtag tgggagggca
     6721 gctggggaca cacccgagcg caaggaagtc actagttctg gcaagaagat gaaggtgcgg
     6781 cccccacccc tgaagaagac ctttgactct gtggacaagg tcctgtcaga agtggacttt
     6841 gaagagcggt ttgctgagct gccggagttt agaccagagg aggtgctgcc ctcacccacc
     6901 ctgcagtctc tggccacctc gcctcgggct atcctcggct cctaccgaaa gaagaggaag
     6961 aattccacgg acctagactc agcacctgaa gatcccacct cacccaagcg caagatgagg
     7021 agacgttcga gctgcagctc agagcccaac acccccaaga gtgccaagtg cgagggggac
     7081 atcttcacct ttgaccgcac aggtactgag acagaggatg tgctcgggga gctggagtat
     7141 gagaaggtgc cctactcatc actgcggcgc accctggacc aacggcgggc cctggtcatg
     7201 cagctcttcc aggaccatgg cttcttccca tcagcccagg ccacagcagc cttccaggcc
     7261 cgctacgcag acatcttccc atccaaggtg tgtctgcaat taaagatccg agaggtccgc
     7321 cagaagatca tgcaggcagc cactcccaca gagcagcccc ctggggctga agcccccctc
     7381 cctggaccac cccctactgg catggctgct actcctgtcc ccactcccag ccctgctggg
     7441 ggccctgacc ccacctctcc aggctcggac tctggcactg cccaagttgc cccgccactg
     7501 cctccacccc cagagcctgg gcctggacag cctggctggg agggggctcc ccagccctca
     7561 ccacctccct ctggcccttc cacagctgcc acaggcaggt gaggggccct tgttaaagac
     7621 cccaggaccc acagtacccc cccctcagga tatggacagt atatagatgg caggaattgg
     7681 gggccagaca gtgggatagt taccgcctcc ccaggaagcc atttgtcctt tccagttcgg
     7741 cgcggaatgt ggcctgttcc cttgtatata tattccctcc ctgtgctggg ggcagcaggg
     7801 gcagataccc tccactgagc tcttgtagat aacctgaagt gtgtgacctt cagagctttt
     7861 cacttgtact ttatgcagaa tggctcctgt gagggctgca agctggaggg tagtatgagc
     7921 cttgggccac agggagaaga tgcctgtgga gtagtgggga gttcatgcac cccccttttt
     7981 ccccagaggg gctggactca ggttagtttg gggtgggggg gttcctgcac tttgccacag
     8041 gcatggggag gattctcccc accctctgcc ctcccaactt gggttgtact ttctaagaag
     8101 gtgattcccc ctaccattgt ccccattccc agaacaaaac atgttgatca tgtgcaatat
     8161 ttcttactgt gccgagaagc cgcaatgacc gagattaaag ctgtttaaca cacgtgtggg
     8221 ctgctgaaaa aaaaaaaaaa aaaa
//
