LOCUS       NM_001411781             711 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus calcium and integrin binding family member 3 (Cib3),
            transcript variant 1, mRNA.
ACCESSION   NM_001411781 XM_006509668
VERSION     NM_001411781.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 711)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 711)
  AUTHORS   Wang,X., Liu,S., Cheng,Q., Qu,C., Ren,R., Du,H., Li,N., Yan,K.,
            Wang,Y., Xiong,W. and Xu,Z.
  TITLE     CIB2 and CIB3 Regulate Stereocilia Maintenance and
            Mechanoelectrical Transduction in Mouse Vestibular Hair Cells
  JOURNAL   J Neurosci 43 (18), 3219-3231 (2023)
   PUBMED   37001993
  REMARK    GeneRIF: CIB2 and CIB3 Regulate Stereocilia Maintenance and
            Mechanoelectrical Transduction in Mouse Vestibular Hair Cells.
REFERENCE   3  (bases 1 to 711)
  AUTHORS   Giese,A.P.J., Tang,Y.Q., Sinha,G.P., Bowl,M.R., Goldring,A.C.,
            Parker,A., Freeman,M.J., Brown,S.D.M., Riazuddin,S., Fettiplace,R.,
            Schafer,W.R., Frolenkov,G.I. and Ahmed,Z.M.
  TITLE     CIB2 interacts with TMC1 and TMC2 and is essential for
            mechanotransduction in auditory hair cells
  JOURNAL   Nat Commun 8 (1), 43 (2017)
   PUBMED   28663585
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 711)
  AUTHORS   Hager,M., Bigotti,M.G., Meszaros,R., Carmignac,V., Holmberg,J.,
            Allamand,V., Akerlund,M., Kalamajski,S., Brancaccio,A., Mayer,U.
            and Durbeej,M.
  TITLE     Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2
            chain-deficient muscular dystrophy
  JOURNAL   J Biol Chem 283 (36), 24760-24769 (2008)
   PUBMED   18611855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158898.7.
            
            On Sep 1, 2022 this sequence version replaced XM_006509668.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849383
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC158898.7         46919-47043
            126-160             AC158898.7         47189-47223
            161-272             AC158898.7         49483-49594
            273-420             AC158898.7         52693-52840
            421-616             AC158898.7         54209-54404
            617-711             AC158898.7         55537-55631
FEATURES             Location/Qualifiers
     source          1..711
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.88 cM"
     gene            1..711
                     /gene="Cib3"
                     /gene_synonym="C730014M21Rik; Gm1107; KIP3"
                     /note="calcium and integrin binding family member 3"
                     /db_xref="GeneID:234421"
                     /db_xref="MGI:MGI:2685953"
     exon            1..125
                     /gene="Cib3"
                     /gene_synonym="C730014M21Rik; Gm1107; KIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..638
                     /gene="Cib3"
                     /gene_synonym="C730014M21Rik; Gm1107; KIP3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="calcium and integrin-binding family member 3
                     isoform 1"
                     /protein_id="NP_001398710.1"
                     /db_xref="GeneID:234421"
                     /db_xref="MGI:MGI:2685953"
                     /translation="MGNKQTVFSHEQLEEYQDCTFFTRKEIMRLFYRYQDLAPQLVPL
                     DYTTSPKVKVPYELIGSMPELKDNPFRQRIAQVFSQDGDGHMTLENFLDMFSVMSEMA
                     PRDLKAYYAFKIYDFNNDNYICAWDLEQTVTRLTRGELSAEEVTLVCEKVLDEADGDQ
                     DGRLSLEDFQNMILRAPDFLSTFHIRI"
     exon            126..160
                     /gene="Cib3"
                     /gene_synonym="C730014M21Rik; Gm1107; KIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            161..272
                     /gene="Cib3"
                     /gene_synonym="C730014M21Rik; Gm1107; KIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            273..420
                     /gene="Cib3"
                     /gene_synonym="C730014M21Rik; Gm1107; KIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..616
                     /gene="Cib3"
                     /gene_synonym="C730014M21Rik; Gm1107; KIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            617..711
                     /gene="Cib3"
                     /gene_synonym="C730014M21Rik; Gm1107; KIP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      690..695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cib3"
                     /gene_synonym="C730014M21Rik; Gm1107; KIP3"
                     /note="hexamer: AATAAA"
     polyA_site      711
                     /gene="Cib3"
                     /gene_synonym="C730014M21Rik; Gm1107; KIP3"
                     /note="major polyA site"
ORIGIN      
        1 attatgagca cgggtgctcc cgaggagcca cctgtaattt cagttccagt gtattcaagg
       61 ctgcagtctg cagcatgggc aacaagcaga ctgtgtttag tcacgagcag ctggaggaat
      121 accaggactg tactttcttc acgaggaagg agatcatgag gctgttctat cgataccagg
      181 acctggcccc tcagttggtg cctcttgact acacgaccag tcccaaggtg aaggtgccct
      241 atgaactgat tggcagcatg ccagagctga aggataaccc tttccgccag agaattgcgc
      301 aggtcttctc gcaagatggg gatggtcaca tgaccttaga gaatttcttg gatatgttct
      361 cagtgatgag tgagatggct ccacgggacc tgaaggccta ctatgccttc aagatttatg
      421 acttcaacaa tgacaactac atctgtgcat gggacctgga gcagaccgtg accaggctga
      481 ctcgtgggga actgagtgct gaggaagtga ccctggtctg tgagaaggtg ctggatgaag
      541 cagatggaga ccaagacggg cgactgtccc tggaggactt ccaaaatatg atcctgcgag
      601 ctccagactt cctcagcacc ttccacatcc gcatctgaca tgctcagagg acaagacctg
      661 gccctcaccc atctctactc tgctctctga ataaatagga atcaaaactg c
//
