LOCUS       NM_019686               1421 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus calcium and integrin binding family member 2 (Cib2),
            mRNA.
ACCESSION   NM_019686
VERSION     NM_019686.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1421)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1421)
  AUTHORS   Lee,J.H., Perez-Flores,M.C., Park,S., Kim,H.J., Chen,Y., Kang,M.,
            Kersigo,J., Choi,J., Thai,P.N., Woltz,R.L., Perez-Flores,D.C.,
            Perkins,G., Sihn,C.R., Trinh,P., Zhang,X.D., Sirish,P., Dong,Y.,
            Feng,W.W., Pessah,I.N., Dixon,R.E., Sokolowski,B., Fritzsch,B.,
            Chiamvimonvat,N. and Yamoah,E.N.
  TITLE     The Piezo channel is a mechano-sensitive complex component in the
            mammalian inner ear hair cell
  JOURNAL   Nat Commun 15 (1), 526 (2024)
   PUBMED   38228630
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1421)
  AUTHORS   Wang,Y., Wang,J., Shi,L., Chen,X., Li,D., Cui,C., Yang,K., Lu,M.,
            Huang,J., Zhang,L., Li,F., Wang,J., Chen,B., Wang,B., Hall,D.D.,
            Pan,Z., Hong,J., Song,L.S., Song,L. and Zhao,S.
  TITLE     CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling
  JOURNAL   Circulation 147 (23), 1758-1776 (2023)
   PUBMED   37128899
  REMARK    GeneRIF: CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling.
REFERENCE   4  (bases 1 to 1421)
  AUTHORS   Wang,X., Liu,S., Cheng,Q., Qu,C., Ren,R., Du,H., Li,N., Yan,K.,
            Wang,Y., Xiong,W. and Xu,Z.
  TITLE     CIB2 and CIB3 Regulate Stereocilia Maintenance and
            Mechanoelectrical Transduction in Mouse Vestibular Hair Cells
  JOURNAL   J Neurosci 43 (18), 3219-3231 (2023)
   PUBMED   37001993
  REMARK    GeneRIF: CIB2 and CIB3 Regulate Stereocilia Maintenance and
            Mechanoelectrical Transduction in Mouse Vestibular Hair Cells.
REFERENCE   5  (bases 1 to 1421)
  AUTHORS   Yoo,D., Park,J., Lee,C., Song,I., Lee,Y.H., Yun,T., Lee,H.,
            Heguy,A., Han,J.Y., Dasen,J.S., Kim,H. and Baek,M.
  TITLE     Little skate genome provides insights into genetic programs
            essential for limb-based locomotion
  JOURNAL   Elife 11, e78345 (2022)
   PUBMED   36288084
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1421)
  AUTHORS   Cosgrove,D. and Zallocchi,M.
  TITLE     Usher protein functions in hair cells and photoreceptors
  JOURNAL   Int J Biochem Cell Biol 46, 80-89 (2014)
   PUBMED   24239741
  REMARK    Review article
REFERENCE   7  (bases 1 to 1421)
  AUTHORS   Riazuddin,S., Belyantseva,I.A., Giese,A.P., Lee,K.,
            Indzhykulian,A.A., Nandamuri,S.P., Yousaf,R., Sinha,G.P., Lee,S.,
            Terrell,D., Hegde,R.S., Ali,R.A., Anwar,S., Andrade-Elizondo,P.B.,
            Sirmaci,A., Parise,L.V., Basit,S., Wali,A., Ayub,M., Ansar,M.,
            Ahmad,W., Khan,S.N., Akram,J., Tekin,M., Riazuddin,S., Cook,T.,
            Buschbeck,E.K., Frolenkov,G.I., Leal,S.M., Friedman,T.B. and
            Ahmed,Z.M.
  TITLE     Alterations of the CIB2 calcium- and integrin-binding protein cause
            Usher syndrome type 1J and nonsyndromic deafness DFNB48
  JOURNAL   Nat Genet 44 (11), 1265-1271 (2012)
   PUBMED   23023331
REFERENCE   8  (bases 1 to 1421)
  AUTHORS   Sherwood,R.I., Maehr,R., Mazzoni,E.O. and Melton,D.A.
  TITLE     Wnt signaling specifies and patterns intestinal endoderm
  JOURNAL   Mech Dev 128 (7-10), 387-400 (2011)
   PUBMED   21854845
REFERENCE   9  (bases 1 to 1421)
  AUTHORS   Hager,M., Bigotti,M.G., Meszaros,R., Carmignac,V., Holmberg,J.,
            Allamand,V., Akerlund,M., Kalamajski,S., Brancaccio,A., Mayer,U.
            and Durbeej,M.
  TITLE     Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2
            chain-deficient muscular dystrophy
  JOURNAL   J Biol Chem 283 (36), 24760-24769 (2008)
   PUBMED   18611855
  REMARK    GeneRIF: Cib2 binds integrin alpha7Bbeta1D and is reduced in
            laminin alpha2 chain-deficient muscular dystrophy
REFERENCE   10 (bases 1 to 1421)
  AUTHORS   Seki,N., Hattori,A., Hayashi,A., Kozuma,S., Ohira,M., Hori,T. and
            Saito,T.
  TITLE     Structure, expression profile and chromosomal location of an isolog
            of DNA-PKcs interacting protein (KIP) gene
  JOURNAL   Biochim Biophys Acta 1444 (1), 143-147 (1999)
   PUBMED   9931475
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN175059.1, AB016080.1, AK013240.1 and AI842389.1.
            
            On Jun 19, 2018 this sequence version replaced NM_019686.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK013240.1, BY705508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-111               DN175059.1         6-116
            112-847             AB016080.1         1-736
            848-1235            AK013240.1         846-1233
            1236-1421           AI842389.1         1-186               c
FEATURES             Location/Qualifiers
     source          1..1421
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.7 cM"
     gene            1..1421
                     /gene="Cib2"
                     /gene_synonym="2810434I23Rik; KIP 2; KIP2"
                     /note="calcium and integrin binding family member 2"
                     /db_xref="GeneID:56506"
                     /db_xref="MGI:MGI:1929293"
     exon            1..223
                     /gene="Cib2"
                     /gene_synonym="2810434I23Rik; KIP 2; KIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..736
                     /gene="Cib2"
                     /gene_synonym="2810434I23Rik; KIP 2; KIP2"
                     /note="kinase-interacting protein 2; calcium binding
                     protein Kip2"
                     /codon_start=1
                     /product="calcium and integrin-binding family member 2"
                     /protein_id="NP_062660.1"
                     /db_xref="CCDS:CCDS40642.1"
                     /db_xref="GeneID:56506"
                     /db_xref="MGI:MGI:1929293"
                     /translation="MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHARFYELAPNLVPM
                     DYRKSPIVHVPMSLIIQMPELRENPFKERIVEAFSEDGEGNLTFNDFVDMFSVLCESA
                     PRELKANYAFKIYDFNTDNFICKEDLEMTLARLTKSELEEDEVVLVCDKVIEEADLDG
                     DGKLGFADFEDMIAKAPDFLSTFHIRI"
     exon            224..258
                     /gene="Cib2"
                     /gene_synonym="2810434I23Rik; KIP 2; KIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            259..370
                     /gene="Cib2"
                     /gene_synonym="2810434I23Rik; KIP 2; KIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..518
                     /gene="Cib2"
                     /gene_synonym="2810434I23Rik; KIP 2; KIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..714
                     /gene="Cib2"
                     /gene_synonym="2810434I23Rik; KIP 2; KIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            715..1405
                     /gene="Cib2"
                     /gene_synonym="2810434I23Rik; KIP 2; KIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1381..1386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cib2"
                     /gene_synonym="2810434I23Rik; KIP 2; KIP2"
                     /note="hexamer: AATAAA"
     polyA_site      1405
                     /gene="Cib2"
                     /gene_synonym="2810434I23Rik; KIP 2; KIP2"
                     /note="major polyA site"
ORIGIN      
        1 actgaactgc gggacccagc ggagcgggcc aggctaggct ggcgacgctg cccgctcccg
       61 ggctggcaag ggccgcgggc accgggctcg gggctccaga cgccgccgat gggaagcagc
      121 actcgaaagg gcgagagacg acgccgcggc cacccatacc atcgcggtca ccatggggaa
      181 caagcagacc atcttcactg aagagcagct ggacaactac caggactgca ctttcttcaa
      241 taagaaggac atcctcaagc ttcatgcacg gttctatgag ctggctccca acctcgtccc
      301 gatggactac aggaagagtc ccatcgtcca tgtacccatg agcctcatca ttcagatgcc
      361 ggagctccgg gagaatccct tcaaagagag gattgtggag gctttctccg aggatggcga
      421 ggggaacctc accttcaatg actttgtgga catgttctct gtgctctgcg aatcagcgcc
      481 tcgggagctc aaggcaaact atgccttcaa gatctatgac ttcaacactg acaatttcat
      541 ctgtaaagaa gacttagaga tgacgctggc ccgactcacc aagtctgagt tggaagagga
      601 tgaggtagtg cttgtgtgtg acaaagtcat tgaagaggct gacctggatg gtgacggcaa
      661 gctgggcttt gctgactttg aggacatgat cgccaaggcc cctgattttc tcagcacctt
      721 ccacattcga atctgaagac actgccaagg ccgtgggggc ctagagctgc atcctctggc
      781 ctgctgtctg tgcaggtatg gtttccaagt gctccaggga aggagctgtg gcctctgggg
      841 ttctcaccca tggacatttc ctgtggccct ttcagcaaaa aaattaaaat aaaataaaat
      901 aaaataaaat aaaataaaaa tctaactgca acagggttgt gaagagcagg acccttccct
      961 gggcccccag tggcctaccc tcaagacctg tagttcccct gtgagccctc tcacgcaccc
     1021 cctgcccagt ccttttctca cctaggaggg ggaggtagaa aaacccactg ggagaggtga
     1081 ggctggattt tccgtgtgct gggcagacac cccagccacc cagggatgag tgcaaaaacc
     1141 aaccaagcaa agaaaacaga aaacagaaaa cagaacctgg ggctttaaca agctatgcaa
     1201 tcttttacca aagccaaggc tgggctgtac cacctccgcc cccgtacttt cccaatgtga
     1261 agctgtataa ggttcggtcc aaagggctct gcccctgtgt cttgaacact accccacccc
     1321 acctccctga tgacatggta tcacttatgt gtgctgacct cagatttgtg aactcctaga
     1381 aataaaacac tttttgtgtg ctgcaaaaaa aaaaaaaaaa a
//
