LOCUS       NM_011870               1055 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus calcium and integrin binding 1 (calmyrin) (Cib1),
            transcript variant 1, mRNA.
ACCESSION   NM_011870
VERSION     NM_011870.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1055)
  AUTHORS   Wu CJ, Li X, Sommers CL, Kurima K, Huh S, Bugos G, Dong L, Li W,
            Griffith AJ and Samelson LE.
  TITLE     Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in
            lymphocytes is regulated by each of the components
  JOURNAL   J Biol Chem 295 (47), 16086-16099 (2020)
   PUBMED   32917726
  REMARK    GeneRIF: Expression of a TMC6-TMC8-CIB1 heterotrimeric complex in
            lymphocytes is regulated by each of the components.
REFERENCE   2  (bases 1 to 1055)
  AUTHORS   Chiu YW, Hori Y, Ebinuma I, Sato H, Hara N, Ikeuchi T and Tomita T.
  TITLE     Identification of calcium and integrin-binding protein 1 as a novel
            regulator of production of amyloid beta peptide using
            CRISPR/Cas9-based screening system
  JOURNAL   FASEB J 34 (6), 7661-7674 (2020)
   PUBMED   32307772
  REMARK    GeneRIF: Identification of calcium and integrin-binding protein 1
            as a novel regulator of production of amyloid beta peptide using
            CRISPR/Cas9-based screening system.
REFERENCE   3  (bases 1 to 1055)
  AUTHORS   Patel P, Naik MU, Golla K, Shaik NF and Naik UP.
  TITLE     Calcium-induced dissociation of CIB1 from ASK1 regulates
            agonist-induced activation of the p38 MAPK pathway in platelets
  JOURNAL   Biochem J 476 (19), 2835-2850 (2019)
   PUBMED   31530712
REFERENCE   4  (bases 1 to 1055)
  AUTHORS   Miura T, Takeo S, Ntege EH, Otsuki H, Sawasaki T, Ishino T,
            Takashima E and Tsuboi T.
  TITLE     The malaria parasite RhopH protein complex interacts with
            erythrocyte calmyrin identified from a comprehensive erythrocyte
            protein library
  JOURNAL   Biochem Biophys Res Commun 500 (2), 261-267 (2018)
   PUBMED   29653104
  REMARK    GeneRIF: mouse erythrocyte calmyrin is an interacting molecule of
            the rodent malaria parasite Plasmodium yoelii RhopH complex.
REFERENCE   5  (bases 1 to 1055)
  AUTHORS   Wang Y, Li J, Yao X, Li W, Du H, Tang M, Xiong W, Chai R and Xu Z.
  TITLE     Loss of CIB2 Causes Profound Hearing Loss and Abolishes
            Mechanoelectrical Transduction in Mice
  JOURNAL   Front Mol Neurosci 10, 401 (2017)
   PUBMED   29255404
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1055)
  AUTHORS   Henderson MJ, Russell AJ, Hird S, Munoz M, Clancy JL, Lehrbach GM,
            Calanni ST, Jans DA, Sutherland RL and Watts CK.
  TITLE     EDD, the human hyperplastic discs protein, has a role in
            progesterone receptor coactivation and potential involvement in DNA
            damage response
  JOURNAL   J Biol Chem 277 (29), 26468-26478 (2002)
   PUBMED   12011095
REFERENCE   7  (bases 1 to 1055)
  AUTHORS   Hattori A, Seki N, Hayashi A, Kozuma S and Saito T.
  TITLE     Genomic structure of mouse and human genes for DNA-PKcs interacting
            protein (KIP)
  JOURNAL   DNA Seq 10 (6), 415-418 (2000)
   PUBMED   10826701
REFERENCE   8  (bases 1 to 1055)
  AUTHORS   Stabler SM, Ostrowski LL, Janicki SM and Monteiro MJ.
  TITLE     A myristoylated calcium-binding protein that preferentially
            interacts with the Alzheimer's disease presenilin 2 protein
  JOURNAL   J Cell Biol 145 (6), 1277-1292 (1999)
   PUBMED   10366599
REFERENCE   9  (bases 1 to 1055)
  AUTHORS   Saito T, Seki N, Hattori A, Hayashi A, Abe M, Araki R, Fujimori A,
            Fukumura R, Kozuma S and Matsuda Y.
  TITLE     Structure, expression profile, and chromosomal location of a mouse
            gene homologous to human DNA-PKcs interacting protein (KIP) gene
  JOURNAL   Mamm Genome 10 (3), 315-317 (1999)
   PUBMED   10051332
REFERENCE   10 (bases 1 to 1055)
  AUTHORS   Seki N, Hayashi A, Abe M, Araki R, Fujimori A, Fukumura R, Hattori
            A, Kozuma S, Ohhira M, Hori T and Saito T.
  TITLE     Chromosomal assignment of the gene for human DNA-PKcs interacting
            protein (KIP) on chromosome 15q25.3-q26.1 by somatic hybrid
            analysis and fluorescence in situ hybridization
  JOURNAL   J Hum Genet 43 (4), 275-277 (1998)
   PUBMED   9852683
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF104297.1, AK152805.1 and BP770454.1.
            
            [WARNING] On May 30, 2023 this sequence was replaced by
            NM_011870.6.
            
            On Apr 1, 2014 this sequence version replaced NM_011870.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV055722.1, CK020088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               CF104297.1         9-177
            170-1027            AK152805.1         2-859
            1028-1055           BP770454.1         1-28                c
FEATURES             Location/Qualifiers
     source          1..1055
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..1055
                     /gene="Cib1"
                     /gene_synonym="Cibkip; Kip; Prkdcip"
                     /note="calcium and integrin binding 1 (calmyrin)"
                     /db_xref="GeneID:23991"
                     /db_xref="MGI:MGI:1344418"
     exon            1..296
                     /gene="Cib1"
                     /gene_synonym="Cibkip; Kip; Prkdcip"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..821
                     /gene="Cib1"
                     /gene_synonym="Cibkip; Kip; Prkdcip"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein kinase, DNA activated, catalytic polypeptide
                     interacting protein; calcium and integrin binding, protein
                     kinase interacting protein; calmyrin; calcium and
                     integrin-binding protein 1; CIB; kinase-interacting
                     protein; DNA-PKcs-interacting protein"
                     /codon_start=1
                     /product="calcium and integrin-binding protein 1 isoform
                     1"
                     /protein_id="NP_036000.1"
                     /db_xref="CCDS:CCDS21392.1"
                     /db_xref="GeneID:23991"
                     /db_xref="MGI:MGI:1344418"
                     /translation="MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPPEQRT
                     VEESLHTRVSFEQILSLPELKANPFKERICMVFSTSPTRDSLSFEDFLDLLSVFSDTA
                     TPDIKSHYAFRIFDFDDDGTLDREDLSQLVNCLTGEGEDTRLSASEMKQLIDNILEES
                     DIDRDGTINLSEFQHVISRSPDFASSFKIVL"
     exon            297..331
                     /gene="Cib1"
                     /gene_synonym="Cibkip; Kip; Prkdcip"
                     /inference="alignment:Splign:2.1.0"
     exon            332..440
                     /gene="Cib1"
                     /gene_synonym="Cibkip; Kip; Prkdcip"
                     /inference="alignment:Splign:2.1.0"
     exon            441..591
                     /gene="Cib1"
                     /gene_synonym="Cibkip; Kip; Prkdcip"
                     /inference="alignment:Splign:2.1.0"
     exon            592..710
                     /gene="Cib1"
                     /gene_synonym="Cibkip; Kip; Prkdcip"
                     /inference="alignment:Splign:2.1.0"
     exon            711..799
                     /gene="Cib1"
                     /gene_synonym="Cibkip; Kip; Prkdcip"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1030
                     /gene="Cib1"
                     /gene_synonym="Cibkip; Kip; Prkdcip"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccccgatgc gtccggctcc tccccgggcc ctccctccag ctctcctggg cccgcgggga
       61 gccgggagcc ggcccgctga gcggcgctaa gggtggcggg gcactgtagg caggggcggg
      121 cccgggggcg gaggccaggc agcggttgct acggggactg ggcggggacg cggccccgag
      181 gacggaagtg agaaagttgc cggcgtcccg gggagagttg gcctagctgt gcgcgcaccg
      241 cggcgatggg aggttcgggc agtcgcctgt ctaaggagct gctggccgag taccaggacc
      301 tgacgttcct gaccaagcag gagatcctcc tagcccacag acgcttttgt gagctgcttc
      361 ccccagagca gcggaccgtg gaggagtcac tgcacacccg agtatcgttt gagcagatcc
      421 tcagcctccc agagctcaag gctaaccctt tcaaggagcg aatctgcatg gtcttctcca
      481 catcacctac cagagacagc ctgagctttg aggacttcct ggacctcctg agtgtcttca
      541 gtgacacagc aaccccagac atcaagtcac actatgcctt ccgcatcttt gactttgatg
      601 acgatggaac cctggacaga gaagacctga gccagcttgt gaattgcctc acgggagagg
      661 gcgaggacac tcggctcagt gcttctgaga tgaagcagct gattgacaat atcctggaag
      721 agtcagacat tgacagggat gggaccatca atctttccga gttccagcat gtcatctcgc
      781 gctcaccaga ctttgccagc tcctttaaga ttgtcctgtg atgtcttcta agtaccaaca
      841 tcctgtccaa gacctggcca ctgctgagat gtggccaagg ttatgcctgc ggtgtcaggg
      901 ccagtgccgg cccagcctgg agagggcgct gcagagtctg gccccctggc aggggaggac
      961 cctccccctt gtcactgctg ttgtcatcac tgtgtttact aattggtaat aaaggtttag
     1021 aaatgtttga aaaaaaaaaa aaaaaaaaaa aaaaa
//
