LOCUS       NM_001411329            1201 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus circadian associated repressor of transcription
            (Ciart), transcript variant 12, mRNA.
ACCESSION   NM_001411329 XM_036163064
VERSION     NM_001411329.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1201)
  AUTHORS   Ono,D., Honma,K.I., Schmal,C., Takumi,T., Kawamoto,T., Fujimoto,K.,
            Kato,Y. and Honma,S.
  TITLE     CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression
            of coherent circadian rhythm but not in generation of circadian
            oscillation in the neonatal mouse SCN
  JOURNAL   Sci Rep 11 (1), 19240 (2021)
   PUBMED   34584158
  REMARK    GeneRIF: CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in
            expression of coherent circadian rhythm but not in generation of
            circadian oscillation in the neonatal mouse SCN.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1201)
  AUTHORS   Anafi,R.C., Lee,Y., Sato,T.K., Venkataraman,A., Ramanathan,C.,
            Kavakli,I.H., Hughes,M.E., Baggs,J.E., Growe,J., Liu,A.C., Kim,J.
            and Hogenesch,J.B.
  TITLE     Machine learning helps identify CHRONO as a circadian clock
            component
  JOURNAL   PLoS Biol 12 (4), e1001840 (2014)
   PUBMED   24737000
  REMARK    GeneRIF: CHRONO interferes with the ability of BMAL1 to recruit
            CBP, a bona fide histone acetylase and key transcriptional
            coactivator of the circadian clock.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1201)
  AUTHORS   Goriki,A., Hatanaka,F., Myung,J., Kim,J.K., Yoritaka,T., Tanoue,S.,
            Abe,T., Kiyonari,H., Fujimoto,K., Kato,Y., Todo,T., Matsubara,A.,
            Forger,D. and Takumi,T.
  TITLE     A novel protein, CHRONO, functions as a core component of the
            mammalian circadian clock
  JOURNAL   PLoS Biol 12 (4), e1001839 (2014)
   PUBMED   24736997
  REMARK    GeneRIF: Chrono binds to the regulatory region of clock genes and
            its occupancy oscillates in a circadian manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1201)
  AUTHORS   Annayev,Y., Adar,S., Chiou,Y.Y., Lieb,J.D., Sancar,A. and Ye,R.
  TITLE     Gene model 129 (Gm129) encodes a novel transcriptional repressor
            that modulates circadian gene expression
  JOURNAL   J Biol Chem 289 (8), 5013-5024 (2014)
   PUBMED   24385426
  REMARK    GeneRIF: The GM129 protein contributes to the transcriptional
            feedback loop by modulating CLOCK.BMAL1 activity as a
            transcriptional repressor.
REFERENCE   5  (bases 1 to 1201)
  AUTHORS   Nishiguchi,S., Sakuma,R., Nomura,M., Zou,Z., Jearanaisilavong,J.,
            Joh,T., Yasunaga,T. and Shimada,K.
  TITLE     A catalogue of genes in mouse embryonal carcinoma F9 cells
            identified with expressed sequence tags
  JOURNAL   J Biochem 119 (4), 749-767 (1996)
   PUBMED   8743579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092855.39.
            
            On Aug 24, 2022 this sequence version replaced XM_036163064.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.3343652.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               AC092855.39        58878-59128         c
            252-660             AC092855.39        58104-58512         c
            661-736             AC092855.39        57906-57981         c
            737-815             AC092855.39        57558-57636         c
            816-927             AC092855.39        57332-57443         c
            928-1201            AC092855.39        56435-56708         c
FEATURES             Location/Qualifiers
     source          1..1201
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.42 cM"
     gene            1..1201
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /note="circadian associated repressor of transcription"
                     /db_xref="GeneID:229599"
                     /db_xref="MGI:MGI:2684975"
     exon            1..251
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /inference="alignment:Splign:2.1.0"
     exon            252..660
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..942
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /note="isoform 3 is encoded by transcript variant 12;
                     circadian-associated transcriptional repressor;
                     chIP-derived repressor of network oscillator;
                     computationally highlighted repressor of the network
                     oscillator"
                     /codon_start=1
                     /product="circadian-associated transcriptional repressor
                     isoform 3"
                     /protein_id="NP_001398258.1"
                     /db_xref="GeneID:229599"
                     /db_xref="MGI:MGI:2684975"
                     /translation="MDSPSSVSSYSSSSLSPSFSTSSVNSDFSFPSDNEREGKGTHEL
                     RPDTVGQRGGSRPSPGPIRCRHRPRVSSNQHTAPHLEQQGSEVKRSRDGEQETSLNTQ
                     GCTTEGDLLFAQKCKELQGFIRPLTDLLNGLKMGRFDRGLSSFQQSVAMDRIQRIVGV
                     LQKPQMGERYLGTLLQVEGMLKTWFPHIAAQKSSSGGSRHQISKGFSV"
     exon            661..736
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /inference="alignment:Splign:2.1.0"
     exon            737..815
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /inference="alignment:Splign:2.1.0"
     exon            816..927
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1201
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1173..1178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /note="hexamer: ATTAAA"
     regulatory      1178..1183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /note="hexamer: ATTAAA"
     polyA_site      1193
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
     polyA_site      1201
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /note="major polyA site"
ORIGIN      
        1 acagacagtg aagaagctgc ataccgaccg gggctgaacc gacagaccca ggtaagcgga
       61 cgagagccaa gcgctctccg gaagacgacc cggatggggt gggcatggaa gaccgcagat
      121 cggggtgttg ggaggtattg catcacctgg caggcgcgac cgtagactga ccagcgcagt
      181 gcacctgatg gtgaaggatg cgaaagcggt ggagccgggt gtctatgggg ccggaactct
      241 agggacctga gttgcaggtt ctgatctttg gtactacggg agctgctctt cagcccctct
      301 cctgctcctg gacctatgga ttctccatct agtgtttctt cttattcctc ctcctccctc
      361 tccccatcat tttccacgtc ctctgtgaac agtgacttta gcttcccttc tgataacgag
      421 agggagggca agggcaccca tgagctcagg ccagacactg tgggtcagag aggaggttcc
      481 aggcccagtc caggccctat ccgctgcaga catcgaccca gggtttctag taaccaacat
      541 acagcacctc atctggaaca gcaaggatct gaagtcaaga gatcaagaga cggtgaacag
      601 gagacgagtc tgaacaccca aggatgtact acagagggag atctgctctt tgctcaaaag
      661 tgtaaagaac tccaagggtt catacggccc ctcacagacc tactgaacgg actcaagatg
      721 ggtcgctttg acagaggatt aagtagcttc caacagagtg tggccatgga ccggatccag
      781 cgcatagtgg gtgttttaca gaagcctcag atgggagaac gttatctagg aaccttgctg
      841 caggtggaag ggatgttaaa gacttggttt cctcacatag ctgcccagaa gtcatcctca
      901 ggaggtagcc ggcaccagat aagcaagggt ttctctgtgt agtggctgac ctgcaacttg
      961 ttctgcagac ctggctagcc ttaaactcag agatgcatgt gcctcagctt cccgagtgtt
     1021 cagatgaaag gtgtgcatca tcatgcccag ctaaatccac taaagcttct agtgatatga
     1081 aaatgactga ctgaaagatt aacaggatca tgcctcataa agaactaaac acgggaaatg
     1141 agacctttca cacagaaatt aaagaaaaga aaattaaatt aaagtcattt caatttctct
     1201 g
//
