LOCUS       NP_001398249             375 aa            linear   ROD 13-JUN-2024
DEFINITION  circadian-associated transcriptional repressor isoform 1 [Mus
            musculus].
ACCESSION   NP_001398249
VERSION     NP_001398249.1
DBSOURCE    REFSEQ: accession NM_001411320.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 375)
  AUTHORS   Ono,D., Honma,K.I., Schmal,C., Takumi,T., Kawamoto,T., Fujimoto,K.,
            Kato,Y. and Honma,S.
  TITLE     CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression
            of coherent circadian rhythm but not in generation of circadian
            oscillation in the neonatal mouse SCN
  JOURNAL   Sci Rep 11 (1), 19240 (2021)
   PUBMED   34584158
  REMARK    GeneRIF: CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in
            expression of coherent circadian rhythm but not in generation of
            circadian oscillation in the neonatal mouse SCN.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 375)
  AUTHORS   Anafi,R.C., Lee,Y., Sato,T.K., Venkataraman,A., Ramanathan,C.,
            Kavakli,I.H., Hughes,M.E., Baggs,J.E., Growe,J., Liu,A.C., Kim,J.
            and Hogenesch,J.B.
  TITLE     Machine learning helps identify CHRONO as a circadian clock
            component
  JOURNAL   PLoS Biol 12 (4), e1001840 (2014)
   PUBMED   24737000
  REMARK    GeneRIF: CHRONO interferes with the ability of BMAL1 to recruit
            CBP, a bona fide histone acetylase and key transcriptional
            coactivator of the circadian clock.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 375)
  AUTHORS   Goriki,A., Hatanaka,F., Myung,J., Kim,J.K., Yoritaka,T., Tanoue,S.,
            Abe,T., Kiyonari,H., Fujimoto,K., Kato,Y., Todo,T., Matsubara,A.,
            Forger,D. and Takumi,T.
  TITLE     A novel protein, CHRONO, functions as a core component of the
            mammalian circadian clock
  JOURNAL   PLoS Biol 12 (4), e1001839 (2014)
   PUBMED   24736997
  REMARK    GeneRIF: Chrono binds to the regulatory region of clock genes and
            its occupancy oscillates in a circadian manner.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 375)
  AUTHORS   Annayev,Y., Adar,S., Chiou,Y.Y., Lieb,J.D., Sancar,A. and Ye,R.
  TITLE     Gene model 129 (Gm129) encodes a novel transcriptional repressor
            that modulates circadian gene expression
  JOURNAL   J Biol Chem 289 (8), 5013-5024 (2014)
   PUBMED   24385426
  REMARK    GeneRIF: The GM129 protein contributes to the transcriptional
            feedback loop by modulating CLOCK.BMAL1 activity as a
            transcriptional repressor.
REFERENCE   5  (residues 1 to 375)
  AUTHORS   Nishiguchi,S., Sakuma,R., Nomura,M., Zou,Z., Jearanaisilavong,J.,
            Joh,T., Yasunaga,T. and Shimada,K.
  TITLE     A catalogue of genes in mouse embryonal carcinoma F9 cells
            identified with expressed sequence tags
  JOURNAL   J Biochem 119 (4), 749-767 (1996)
   PUBMED   8743579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092855.39.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784649.785622.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..375
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.42 cM"
     Protein         1..375
                     /product="circadian-associated transcriptional repressor
                     isoform 1"
                     /note="circadian-associated transcriptional repressor;
                     chIP-derived repressor of network oscillator;
                     computationally highlighted repressor of the network
                     oscillator"
                     /calculated_mol_wt=40277
     Region          1..102
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TQ03.1)"
     Region          85..360
                     /region_name="Ciart"
                     /note="Circadian-associated transcriptional repressor;
                     pfam15673"
                     /db_xref="CDD:464794"
     Region          192..218
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TQ03.1)"
     Region          351..375
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TQ03.1)"
     CDS             1..375
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /coded_by="NM_001411320.1:531..1658"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /db_xref="GeneID:229599"
                     /db_xref="MGI:MGI:2684975"
ORIGIN      
        1 mdspssvssy sssslspsfs tssvnsdfsf psdneregkg thelrpdtvg qrggsrpspg
       61 pircrhrprv ssnqhtaphl eqqgsevkrs rdgeqetsln tqgcttegdl lfaqkckelq
      121 gfirpltdll nglkmgrfdr glssfqqsva mdriqrivgv lqkpqmgery lgtllqvegm
      181 lktwfphiaa qksssggsrh qiskhfpshh gdpgaaspap llekmgqtql ghlvlkpkqp
      241 whltgwpamn ltwihstpic npplssqgsa sghspigtga sigvilvlqk ggqpfthsap
      301 gtpvpptpls pvvpgdlkkl pgeeprchsl pvtlpsdwsc ilcppvlptt dremtkghpe
      361 pqmtshppva pdpqp
//
