LOCUS       NM_001033302            1377 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus circadian associated repressor of transcription
            (Ciart), transcript variant 1, mRNA.
ACCESSION   NM_001033302 XM_887747 XM_897640 XM_897661 XM_897677 XM_897692
            XM_907670 XM_920513 XM_920520 XM_920527 XM_920533
VERSION     NM_001033302.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1377)
  AUTHORS   Ono,D., Honma,K.I., Schmal,C., Takumi,T., Kawamoto,T., Fujimoto,K.,
            Kato,Y. and Honma,S.
  TITLE     CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in expression
            of coherent circadian rhythm but not in generation of circadian
            oscillation in the neonatal mouse SCN
  JOURNAL   Sci Rep 11 (1), 19240 (2021)
   PUBMED   34584158
  REMARK    GeneRIF: CHRONO and DEC1/DEC2 compensate for lack of CRY1/CRY2 in
            expression of coherent circadian rhythm but not in generation of
            circadian oscillation in the neonatal mouse SCN.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1377)
  AUTHORS   Anafi,R.C., Lee,Y., Sato,T.K., Venkataraman,A., Ramanathan,C.,
            Kavakli,I.H., Hughes,M.E., Baggs,J.E., Growe,J., Liu,A.C., Kim,J.
            and Hogenesch,J.B.
  TITLE     Machine learning helps identify CHRONO as a circadian clock
            component
  JOURNAL   PLoS Biol 12 (4), e1001840 (2014)
   PUBMED   24737000
  REMARK    GeneRIF: CHRONO interferes with the ability of BMAL1 to recruit
            CBP, a bona fide histone acetylase and key transcriptional
            coactivator of the circadian clock.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1377)
  AUTHORS   Goriki,A., Hatanaka,F., Myung,J., Kim,J.K., Yoritaka,T., Tanoue,S.,
            Abe,T., Kiyonari,H., Fujimoto,K., Kato,Y., Todo,T., Matsubara,A.,
            Forger,D. and Takumi,T.
  TITLE     A novel protein, CHRONO, functions as a core component of the
            mammalian circadian clock
  JOURNAL   PLoS Biol 12 (4), e1001839 (2014)
   PUBMED   24736997
  REMARK    GeneRIF: Chrono binds to the regulatory region of clock genes and
            its occupancy oscillates in a circadian manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1377)
  AUTHORS   Annayev,Y., Adar,S., Chiou,Y.Y., Lieb,J.D., Sancar,A. and Ye,R.
  TITLE     Gene model 129 (Gm129) encodes a novel transcriptional repressor
            that modulates circadian gene expression
  JOURNAL   J Biol Chem 289 (8), 5013-5024 (2014)
   PUBMED   24385426
  REMARK    GeneRIF: The GM129 protein contributes to the transcriptional
            feedback loop by modulating CLOCK.BMAL1 activity as a
            transcriptional repressor.
REFERENCE   5  (bases 1 to 1377)
  AUTHORS   Nishiguchi,S., Sakuma,R., Nomura,M., Zou,Z., Jearanaisilavong,J.,
            Joh,T., Yasunaga,T. and Shimada,K.
  TITLE     A catalogue of genes in mouse embryonal carcinoma F9 cells
            identified with expressed sequence tags
  JOURNAL   J Biochem 119 (4), 749-767 (1996)
   PUBMED   8743579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092855.39.
            
            On Aug 24, 2022 this sequence version replaced NM_001033302.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK164001.1, SRR5189682.134051.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC092855.39        59078-59128         c
            52-460              AC092855.39        58104-58512         c
            461-536             AC092855.39        57906-57981         c
            537-615             AC092855.39        57558-57636         c
            616-727             AC092855.39        57332-57443         c
            728-1377            AC092855.39        55423-56072         c
FEATURES             Location/Qualifiers
     source          1..1377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.42 cM"
     gene            1..1377
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /note="circadian associated repressor of transcription"
                     /db_xref="GeneID:229599"
                     /db_xref="MGI:MGI:2684975"
     exon            1..51
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /inference="alignment:Splign:2.1.0"
     exon            52..460
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1243
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /note="isoform 1 is encoded by transcript variant 1;
                     circadian-associated transcriptional repressor;
                     chIP-derived repressor of network oscillator;
                     computationally highlighted repressor of the network
                     oscillator"
                     /codon_start=1
                     /product="circadian-associated transcriptional repressor
                     isoform 1"
                     /protein_id="NP_001028474.1"
                     /db_xref="CCDS:CCDS50997.1"
                     /db_xref="GeneID:229599"
                     /db_xref="MGI:MGI:2684975"
                     /translation="MDSPSSVSSYSSSSLSPSFSTSSVNSDFSFPSDNEREGKGTHEL
                     RPDTVGQRGGSRPSPGPIRCRHRPRVSSNQHTAPHLEQQGSEVKRSRDGEQETSLNTQ
                     GCTTEGDLLFAQKCKELQGFIRPLTDLLNGLKMGRFDRGLSSFQQSVAMDRIQRIVGV
                     LQKPQMGERYLGTLLQVEGMLKTWFPHIAAQKSSSGGSRHQISKHFPSHHGDPGAASP
                     APLLEKMGQTQLGHLVLKPKQPWHLTGWPAMNLTWIHSTPICNPPLSSQGSASGHSPI
                     GTGASIGVILVLQKGGQPFTHSAPGTPVPPTPLSPVVPGDLKKLPGEEPRCHSLPVTL
                     PSDWSCILCPPVLPTTDREMTKGHPEPQMTSHPPVAPDPQP"
     exon            461..536
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /inference="alignment:Splign:2.1.0"
     exon            537..615
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /inference="alignment:Splign:2.1.0"
     exon            616..727
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /inference="alignment:Splign:2.1.0"
     exon            728..1377
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1355..1360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /note="hexamer: ATTAAA"
     polyA_site      1377
                     /gene="Ciart"
                     /gene_synonym="Chrono; Gm129"
                     /note="major polyA site"
ORIGIN      
        1 acagacagtg aagaagctgc ataccgaccg gggctgaacc gacagaccca gttgcaggtt
       61 ctgatctttg gtactacggg agctgctctt cagcccctct cctgctcctg gacctatgga
      121 ttctccatct agtgtttctt cttattcctc ctcctccctc tccccatcat tttccacgtc
      181 ctctgtgaac agtgacttta gcttcccttc tgataacgag agggagggca agggcaccca
      241 tgagctcagg ccagacactg tgggtcagag aggaggttcc aggcccagtc caggccctat
      301 ccgctgcaga catcgaccca gggtttctag taaccaacat acagcacctc atctggaaca
      361 gcaaggatct gaagtcaaga gatcaagaga cggtgaacag gagacgagtc tgaacaccca
      421 aggatgtact acagagggag atctgctctt tgctcaaaag tgtaaagaac tccaagggtt
      481 catacggccc ctcacagacc tactgaacgg actcaagatg ggtcgctttg acagaggatt
      541 aagtagcttc caacagagtg tggccatgga ccggatccag cgcatagtgg gtgttttaca
      601 gaagcctcag atgggagaac gttatctagg aaccttgctg caggtggaag ggatgttaaa
      661 gacttggttt cctcacatag ctgcccagaa gtcatcctca ggaggtagcc ggcaccagat
      721 aagcaagcac tttcccagcc accacggtga ccccggggct gcttctcctg cacctctcct
      781 agagaagatg ggccaaacac agctgggaca tttagttttg aaaccaaagc agccttggca
      841 tctcactgga tggccagcta tgaacctcac ctggattcat agcactccaa tttgtaaccc
      901 tcccctcagc tcccaaggct ccgcctctgg ccacagcccc ataggcactg gagccagcat
      961 tggtgtcatc cttgtcctcc agaaaggagg acagcccttc acccattctg ccccgggcac
     1021 tccggtccca ccaactccac tgtctcctgt cgtccctggt gatctgaaga aactgcctgg
     1081 cgaggagcct cgttgccaca gtttgccagt aacactgcca tcagactgga gttgcatcct
     1141 atgtccgcct gtcctgccta ccacagacag agagatgact aaaggacacc cagagccaca
     1201 gatgactagc catcccccag ttgctccgga tcctcagccc taacccaggc tctgcttctt
     1261 tcccctgatt cccaatttgt ataaatgtat gttttatgtg tatttttttt tttactttaa
     1321 tgtatttgtg gtgaggaaat agaaatcctt tctgattaaa gacatttttt acttaaa
//
