LOCUS       NM_134141               4327 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cytokine induced apoptosis inhibitor 1 (Ciapin1),
            mRNA.
ACCESSION   NM_134141 NM_173730 XM_991838
VERSION     NM_134141.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4327)
  AUTHORS   Hamanaka,Y., Tanimura,A., Yokota,T., Ezoe,S., Ichii,M., Nagate,Y.,
            Oritani,K., Kanakura,Y., Hosen,N. and Shibayama,H.
  TITLE     Impaired B cell terminal differentiation in B cell-specific
            knockout mice of cell death-defying factor anamorsin
  JOURNAL   Biochem Biophys Res Commun 603, 1-6 (2022)
   PUBMED   35259639
REFERENCE   2  (bases 1 to 4327)
  AUTHORS   Park,K.A., Yun,N. and Oh,Y.J.
  TITLE     Anamorsin attenuates cupric chloride-induced dopaminergic neuronal
            cell death
  JOURNAL   Biochem Biophys Res Commun 520 (1), 99-106 (2019)
   PUBMED   31582212
  REMARK    GeneRIF: anamorsin exerts a neuroprotective effect by reducing
            intracellular ROS levels and subsequently attenuating activated
            stress-activated MAP kinases pathways
REFERENCE   3  (bases 1 to 4327)
  AUTHORS   Yeo,H.J., Shin,M.J., Yeo,E.J., Choi,Y.J., Kim,D.W., Kim,D.S.,
            Eum,W.S. and Choi,S.Y.
  TITLE     Tat-CIAPIN1 inhibits hippocampal neuronal cell damage through the
            MAPK and apoptotic signaling pathways
  JOURNAL   Free Radic Biol Med 135, 68-78 (2019)
   PUBMED   30818058
  REMARK    GeneRIF: Tat-CIAPIN1 protein transduced into HT-22cells and
            significantly inhibited cell death, DNA fragmentation, and reactive
            oxygen species (ROS) generation.
REFERENCE   4  (bases 1 to 4327)
  AUTHORS   Yun,N., Lee,Y.M., Kim,C., Shibayama,H., Tanimura,A., Hamanaka,Y.,
            Kanakura,Y., Park,I.S., Jo,A., Shin,J.H., Ju,C., Kim,W.K. and
            Oh,Y.J.
  TITLE     Anamorsin, a novel caspase-3 substrate in neurodegeneration
  JOURNAL   J Biol Chem 289 (32), 22183-22195 (2014)
   PUBMED   24973211
  REMARK    GeneRIF: Among 46 putative substrates identified in MN9D neuronal
            cells, we further evaluated whether caspase-3-mediated cleavage of
            anamorsin, a recently recognized cell death-defying factor in
            hematopoiesis, is a general feature of apoptosis.
REFERENCE   5  (bases 1 to 4327)
  AUTHORS   Tanimura,A., Shibayama,H., Hamanaka,Y., Fujita,N., Ishibashi,T.,
            Sudo,T., Yokota,T., Ezoe,S., Tanaka,H., Matsumura,I., Oritani,K.
            and Kanakura,Y.
  TITLE     The anti-apoptotic gene Anamorsin is essential for both autonomous
            and extrinsic regulation of murine fetal liver hematopoiesis
  JOURNAL   Exp Hematol 42 (5), 410-422 (2014)
   PUBMED   24440520
  REMARK    GeneRIF: AM was essential for both autonomous and extrinsic
            regulation of fetal liver hematopoiesis. This study provided new
            insight into the molecular regulation of hematopoiesis.
REFERENCE   6  (bases 1 to 4327)
  AUTHORS   Saito,Y., Shibayama,H., Tanaka,H., Tanimura,A. and Kanakura,Y.
  TITLE     A cell-death-defying factor, anamorsin mediates cell growth through
            inactivation of PKC and p38MAPK
  JOURNAL   Biochem Biophys Res Commun 405 (2), 303-307 (2011)
   PUBMED   21219862
  REMARK    GeneRIF: These data suggest that PKCtheta;, PKCdelta, and p38MAPK
            activation lead to cell cycle retardation in AM KO MEF cells, and
            that AM may negatively regulate novel PKCs and p38MAPK in MEF
            cells.
REFERENCE   7  (bases 1 to 4327)
  AUTHORS   Hao,Z., Li,X., Qiao,T., Du,R., Zhang,G. and Fan,D.
  TITLE     Subcellular localization of CIAPIN1
  JOURNAL   J Histochem Cytochem 54 (12), 1437-1444 (2006)
   PUBMED   16957168
  REMARK    GeneRIF: CIAPIN1 was localized in both the cytoplasm and the
            nucleus and was accumulated in the nucleolus. Bioinformatic
            prediction disclosed a putative nuclear localization signal and a
            putative nuclear export signal within mouse CIAPIN1.
REFERENCE   8  (bases 1 to 4327)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4327)
  AUTHORS   Shibayama,H., Takai,E., Matsumura,I., Kouno,M., Morii,E.,
            Kitamura,Y., Takeda,J. and Kanakura,Y.
  TITLE     Identification of a cytokine-induced antiapoptotic molecule
            anamorsin essential for definitive hematopoiesis
  JOURNAL   J Exp Med 199 (4), 581-592 (2004)
   PUBMED   14970183
  REMARK    GeneRIF: Anamorsin is considered to be a necessary molecule for
            hematopoiesis that mediates antiapoptotic effects of various
            cytokines.
REFERENCE   10 (bases 1 to 4327)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129606.4.
            
            On Nov 17, 2006 this sequence version replaced NM_134141.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136821.1, AK088757.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC129606.4         90866-90954         c
            90-275              AC129606.4         85129-85314         c
            276-428             AC129606.4         84387-84539         c
            429-505             AC129606.4         81768-81844         c
            506-668             AC129606.4         80891-81053         c
            669-742             AC129606.4         79249-79322         c
            743-858             AC129606.4         77830-77945         c
            859-937             AC129606.4         76267-76345         c
            938-4327            AC129606.4         72432-75821         c
FEATURES             Location/Qualifiers
     source          1..4327
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 46.86 cM"
     gene            1..4327
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /note="cytokine induced apoptosis inhibitor 1"
                     /db_xref="GeneID:109006"
                     /db_xref="MGI:MGI:1922083"
     exon            1..89
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /inference="alignment:Splign:2.1.0"
     exon            90..275
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1048
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /note="fe-S cluster assembly protein DRE2 homolog"
                     /codon_start=1
                     /product="anamorsin"
                     /protein_id="NP_598902.1"
                     /db_xref="CCDS:CCDS22549.1"
                     /db_xref="GeneID:109006"
                     /db_xref="MGI:MGI:1922083"
                     /translation="MEEFGISPGQLVAVFWDKSSPEEALKKLVARLQELTGSEGQVFM
                     ENVTQLLQSSHKESSFDVILSGVVPGSTSLHSAEVLAEMARILRPGGCLFLKEPVETA
                     EVNNDKMKTASKLCSALTLSGLVEIKELQREALSPEEVQSVQEHLGYHSDSLRSVRVT
                     GKKPNFEVGSSSQLKLPNKKSSSVKPVVDPAAAKLWTLSANDMEDDSVDLIDSDELLD
                     PEDLKRPDPASLKAPSCGEGKKRKACKNCTCGLAEELEREQSKAQSSQPKSACGNCYL
                     GDAFRCANCPYLGMPAFKPGEQVLLSNSNLQDA"
     exon            276..428
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /inference="alignment:Splign:2.1.0"
     exon            429..505
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /inference="alignment:Splign:2.1.0"
     exon            506..668
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /inference="alignment:Splign:2.1.0"
     exon            669..742
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /inference="alignment:Splign:2.1.0"
     exon            743..858
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /inference="alignment:Splign:2.1.0"
     exon            859..937
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /inference="alignment:Splign:2.1.0"
     exon            938..4327
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1561..1566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /note="hexamer: ATTAAA"
     polyA_site      1584
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /note="major polyA site"
     regulatory      2106..2111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
                     /note="hexamer: ATTAAA"
     polyA_site      2126
                     /gene="Ciapin1"
                     /gene_synonym="2810413N20Rik; anamorsin"
ORIGIN      
        1 taggactcag gtgttgtgcg gcgtcttctc gcgagagacc aggacgagaa gccggcgtcc
       61 gcggagcggg ttttcaggct acgaggaagt accatttagg tccagcagcg cggcaggaat
      121 ggaggagttt gggatctccc ctggccagct tgtggcagtg ttctgggaca agtcatctcc
      181 tgaggaagcc ctaaaaaagc tggtggctag actgcaagag ttaactggca gcgagggcca
      241 ggtattcatg gaaaacgtca cccagctgtt gcagtcttcg cataaggaat ccagcttcga
      301 tgtcattctg tcgggtgtag tcccaggaag cacctctctg cacagtgctg aggttctggc
      361 tgagatggcc cggatcctcc ggccaggggg ctgtcttttt ctgaaagaac cagtggagac
      421 agctgaagtt aacaatgaca aaatgaagac ggcctctaag ctatgttcag ccctgactct
      481 ttctggcctc gtggaaataa aagagttgca gagggaggcc ttaagccctg aggaggtaca
      541 gtccgtgcag gagcacctgg gctaccacag tgacagcctg cgctcagtcc gtgtcactgg
      601 caagaagcca aactttgaag tgggttcttc tagccagcta aagcttccca acaagaagtc
      661 ttcttcagtg aagcctgttg tggatcctgc tgctgccaag ctctggaccc tctcagcaaa
      721 tgacatggag gatgacagtg tggatctcat tgactcagac gagctgcttg atccagagga
      781 tttgaagagg cctgacccag cctccctgaa ggctccttca tgtggggaag ggaaaaagag
      841 gaaggcctgt aagaactgca cctgtggcct cgcagaggaa ctggagcggg agcagtccaa
      901 ggcgcagagc tctcagccca agtcagcctg tggaaattgc tacctgggtg acgctttccg
      961 ctgtgccaac tgcccctacc tcgggatgcc agccttcaag cctggcgagc aggtgctcct
     1021 gagcaatagc aatctccagg atgcctagga gggacctcaa gcccacacac ctcctcctcc
     1081 agcaactcct gtcctcagct cctcccacgg cctcctccca cctctggatt caggcgctct
     1141 gaaaacactc acagggagag gcttgcagcc gagcgagcga gcgaagctgc tgtgggcagt
     1201 ggggtggggt gctgctgtgt cttgaaagac caaggattga ggggacctgt ctcttagtgt
     1261 taggggaaga gggtggatgc gcctaaggaa ctctgctcct ggtgttacag tgctgtccct
     1321 ctccaccctt gagtatttat gctgagtaag ctccaggctc cgctcagtga tgctgccacc
     1381 tgctggactt cctcaggatg tagttcttgg agccatgggt tagctgtcaa agggcctcag
     1441 gggcaccaaa gaagtcactc ccccagttgt gatccatctt gtgtccctct gcctttctca
     1501 cctcaccccg ttttactgta gtgttgtatc tgtgtcctgt tgtcatttct gttaaatggt
     1561 attaaacttt tgtgttttta tgtctccctt ttactgtgag tgtgtctttg tgtctgtgtg
     1621 tggtagtgaa gggttgtctg tcacccatcc acattcagct tggactatga aaattgtttt
     1681 tgaagaagtc atcgtcacac aggagtgggg ccagaactgc ccactagcta ggactaggat
     1741 ctgtcttcac ctcctgtagg agccaggtgg agaatgcagg ttagggcagg ctggaccagc
     1801 agcaggaagt atcagagcag gaggccctct tcagtctccc tcctgcctct gcccacatcc
     1861 ctgttatcca tcatgcctgc tgttacctgt ccttgttact tgatctgctt agctagcttc
     1921 tgctgctatg ggtgtggtga aaagcccttt gagaagcaga atttctgttg accccagtga
     1981 cccttgcctt gtgttacctc ccctccaatt acagcaaacc ctgaaaacct ctggtgtttc
     2041 tcttctgagt ggaagaggct ttgctaagtg aaagggtttt acagatggac ccacagtccc
     2101 tgctgattaa agttaattag acgggagatt atccttggcc cattctcttg atcctttaaa
     2161 agaattagaa aacaaaggct ttgttttgct gcctgtgcac aagctagtgg tgaagtttta
     2221 ggaggtgtgt acctcttagc cctactaaga aagtgggagc caggcagtgg tggtgtatgc
     2281 ctttaacccc agcacttggc agccagaggc agccggattt ctgagttcaa ggctagccta
     2341 gtctacagag tgagttccag gacagccagg gctacacaga gaaaccctgt tttgggggga
     2401 aaaaaagggt ggtggtgggg tggtggtggt tacagcccca cagcaaggag cttggttctg
     2461 tcatcactgt gccagcttga aagaggactc gctttcaaat gagaacacag cctgtgcctg
     2521 aattaatggc tgggatccat ggatggaaca cttgggtatg cacaaagcct tgtttttgat
     2581 tcctagtacc aaaaccaaaa aaggttttct caggccagag caattgacag aaaagccaag
     2641 ataataagtg ggggtgtggc tgactgattt gtcacacagc aacaaaaact cagccccaga
     2701 tgggtttagg tttagctgac caactggccc agtcacagac ctgttgtcgg cctctactgc
     2761 agttacctag gtgagggaca aacacttgag cctctaggag gaggagatgc tcctggacca
     2821 gagcttcctt gtgggcttag taaacgccac aagcccttca gacctgcttg ttgattgcta
     2881 gctatgactg gcacgaagga taatgatttg gttggcttgg ttaatagggc cctggcgtca
     2941 gtctttgtgt ccttccacaa gggccagaag gagcatatcc agtttagtca gtcctaggct
     3001 ggtggagaga atccttgccc agagcacatg taggcctctg cctggctgct gctgcacacc
     3061 aaggaatttg cagtggtagg ggcacagcta tttgtctggc cagactcttg agtctgtgac
     3121 catagcctaa ggaggagttt cagccattgg taagcttaca gtatagaacc caaaaacaaa
     3181 ttcaacctaa actcccatgg atacatgtgt gggcctggaa gccttggttt tgtagtaagt
     3241 gtaatggttt ctttgtgttt atgtgtatac aggcacacgt gccatggtgc acctggaggt
     3301 cacggaataa cttgccagag ctggttctcc ttccaccacg tgggtcccag ggatcaaagc
     3361 caggtcctca ggctaggcag ccattacctt cccgcactga gccatctcat tggttcttgt
     3421 cttttgtttt tgtgagactg ggttacatgg aagctgggct ctcctccatc tccctccctc
     3481 cccctctctt cccctgtctg aaacaaactc tggttatcgt agcctgaatc tcaccgtgta
     3541 gcccaaacta gcctgcacct catggggctc ctcaggctcc cgaatactgg cattgcaagc
     3601 atgtcccatc atgctaaacc tggcttttaa aaaaatgtgg tttttttttt tcattttatg
     3661 tgtatgtatg catatatgtc tgtgtaccag gtttgtgcag tgcccaggga gcccagagag
     3721 ggtgtcagcc cccctgggat tggacttaga gctgtgagcc actatatggg tgctgggaat
     3781 caaacaggtt ctctgtaaaa gcagctaagt tctcttaacc attgaggaat cttccagctc
     3841 cctggcttct tagctctatg gagtctttgg cttagaatct ggtattgtgg catctagttt
     3901 cccctcgttc tgaaatcact tggttagtat aggcagcaga ggcaggccac atctttcctg
     3961 ggctttggtg acagctgggc cttaaggggt cttggagctg aagcatgagg gggtgtgagt
     4021 gagacaggtt gcagaggtga aggccctcgg gctttgcaga tactcctggt tgagctgagt
     4081 ctacagggaa gcctgccatt gcttgaagct gatagttctc tgatgttaca aaatactgct
     4141 tcacccagta tgtggtgatg gcgattcgga aggcgaagca gaagccctac cagataagag
     4201 tgaaggcgtg gccagatggg gacacagcag gatttgtttg gacagttcaa cactggctga
     4261 ccattggaat cactgggcag cttccaaaaa taaaaacaac ctcctgtgcc tgggtgttat
     4321 ttacaaa
//
