LOCUS       NM_026238               2555 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cytosolic iron-sulfur assembly component 3 (Ciao3),
            mRNA.
ACCESSION   NM_026238
VERSION     NM_026238.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2555)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 2555)
  AUTHORS   Song,D. and Lee,F.S.
  TITLE     Mouse knock-out of IOP1 protein reveals its essential role in
            mammalian cytosolic iron-sulfur protein biogenesis
  JOURNAL   J Biol Chem 286 (18), 15797-15805 (2011)
   PUBMED   21367862
  REMARK    GeneRIF: knock-out of Iop1/Narfl in mice results in lethality and
            defective cytosolic iron-sulfur cluster assembly. The findings
            demonstrate an essential role for IOP1 in this pathway.
REFERENCE   3  (bases 1 to 2555)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK145408.1, AK018548.1 and AK043694.1.
            
            On Jul 30, 2009 this sequence version replaced NM_026238.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043694.1, AK018548.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AK145408.1         4-45
            43-2071             AK018548.1         14-2042
            2072-2555           AK043694.1         2049-2532
FEATURES             Location/Qualifiers
     source          1..2555
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.88 cM"
     gene            1..2555
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /note="cytosolic iron-sulfur assembly component 3"
                     /db_xref="GeneID:67563"
                     /db_xref="MGI:MGI:1914813"
     exon            1..112
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1477
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /note="cytosolic Fe-S cluster assembly factor NARFL; IOP1;
                     iron-only hydrogenase-like protein 1; nuclear prelamin A
                     recognition factor-like protein"
                     /codon_start=1
                     /product="cytosolic iron-sulfur assembly component 3"
                     /protein_id="NP_080514.3"
                     /db_xref="CCDS:CCDS50034.1"
                     /db_xref="GeneID:67563"
                     /db_xref="MGI:MGI:1914813"
                     /translation="MASPFSGALQLTDLDDFIGPSQNCIKPVKVAKKPGSGIAKIHIE
                     DDGSYFQVNQDGRTQKLEKAKVSLNDCLACSGCVTSAETVLITQQSHEELRKVLDANK
                     EAAPGQQRLVVVSISPQSRASLAARFRLDPTDTARKLTSFFKKIGVHFVFDTAFARNF
                     SLLESQKEFVQRFREQANSREALPVLASACPGWICYAEKTHGNFILPYISTARSPQQV
                     MGSLVKDFFAQQQLLTPDKIYHVTVMPCYDKKLEASRPDFFNQEYQTRDVDCVLTTGE
                     VFRLLEEEGVSLTELEPAPLDGLTSSVSAEEPSSHRGGGSGGYLEHVFRHAAQELFGI
                     HVAEVTYQPLRNKDFQEVTLEREGQVLLRFAVAYGFRNIQNLVQKLKRGRCPYHYVEV
                     MACPSGCLNGGGQLKAPDTEGSELLQQLERLYSMVRTEAPEDAPGVQELYQHWLQGED
                     SERASRLLHTQYHAVEKPSSGLSIRW"
     exon            113..208
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /inference="alignment:Splign:2.1.0"
     exon            209..352
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /inference="alignment:Splign:2.1.0"
     exon            353..485
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /inference="alignment:Splign:2.1.0"
     exon            486..620
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /inference="alignment:Splign:2.1.0"
     exon            621..739
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /inference="alignment:Splign:2.1.0"
     exon            740..869
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /inference="alignment:Splign:2.1.0"
     exon            870..942
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1080
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1238
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..2555
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1992..1997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /note="hexamer: AATAAA"
     polyA_site      2042
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /note="major polyA site"
     polyA_site      2071
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
     regulatory      2494..2499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /note="hexamer: AATAAA"
     polyA_site      2521
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
     regulatory      2532..2537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
                     /note="hexamer: AATAAA"
     polyA_site      2555
                     /gene="Ciao3"
                     /gene_synonym="9030612I22Rik; Narfl; PRN"
ORIGIN      
        1 cattttgcga cacccccgtg tgacactcgg cggcagtgag gctgtcatgg cgtcgccctt
       61 cagtggggca ctacagctga ccgacttgga cgacttcatc gggccatctc agaattgcat
      121 caagcctgta aaggtggcta agaagccagg aagtggcata gccaagatcc acattgaaga
      181 cgatggcagt tacttccaag tgaaccaaga cggaagaacc cagaagctgg agaaggccaa
      241 ggtctccctg aatgactgcc tggcgtgcag cggctgtgtc acctcagcag agacagtact
      301 catcacccag cagagtcacg aggaactgcg gaaggttcta gatgctaata aggaggcagc
      361 acctggtcag cagcggctgg tggtcgtttc catatcgccg cagtccagag catcactggc
      421 tgccaggttt cggctggacc ccacagacac tgccaggaaa ttaacttcat tcttcaaaaa
      481 aataggggtc cactttgtct ttgatactgc cttcgcgagg aacttcagcc ttttggaaag
      541 ccaaaaagag tttgtgcagc gcttccgaga gcaagccaac tccagagagg ccttgcctgt
      601 gctggcttcc gcctgcccag gctggatctg ctatgctgag aagacacatg gcaacttcat
      661 cctcccctac atcagtacag cccggtcccc acagcaggtt atgggctccc tggtcaaaga
      721 cttcttcgca caacagcagc ttctgactcc tgacaagatc taccatgtaa cagtgatgcc
      781 ctgctatgat aaaaagctag aagcatccag acctgacttc ttcaaccagg agtaccagac
      841 ccgtgatgtg gactgtgtcc ttacaacagg agaagtcttc aggctgctgg aggaagaagg
      901 agtctccctc acggagctgg agcctgcgcc cctggatggc ttaaccagta gtgtgtctgc
      961 tgaggagccc agcagccatc ggggcggagg ctcaggaggc tacctggagc atgtgttccg
     1021 gcacgcagcc caagagctct ttggaatcca cgtggctgaa gtcacctatc aacccttgag
     1081 gaacaaggac ttccaggaag tgacactgga aagggaaggc caggtactgt tgcgctttgc
     1141 tgtggcctat ggtttccgta atatccagaa cctcgtgcag aagttgaaac gaggccgctg
     1201 tccctaccat tacgtggaag taatggcctg cccttcaggt tgcttgaatg gagggggcca
     1261 gctcaaggct ccggatacag agggcagcga gctccttcag cagctggaaa gactgtacag
     1321 catggtgagg actgaggcgc ccgaagatgc accgggggtc caggagctgt accagcactg
     1381 gctgcaagga gaggactcag agcgggccag ccgcctgctg cacacacaat accatgccgt
     1441 ggagaagccc agctcaggcc tgagcatcag gtggtaggag gccttgagtc tgtgagaccc
     1501 ccggggccag caccaagact cacggaaaga ctagactgtg tgggtatctg aaacaaagcc
     1561 cacaggatac gcccgagacc ctcaattcaa ggagagctcc aaggatgtgt tggactctgt
     1621 gctccagtgg ggcactggct gcacgtgggt ccttggagat gcgtgaccca tgtctctggc
     1681 tggtaatgtt gcctgcagcc cacataaagt gcaggcagga tcagaagtag ccaagtaggt
     1741 tcactgaggt tccagactct tccactggcc tggggccatg gacatcttgt gagccctgcc
     1801 ctctggctgt agttgtctga gtgtgagggg tttcatttct atggctaatc cccaaagctg
     1861 taacacatag ggcaggtacc tactgaggca cccaggcttc taaaaactgt tctcaggacc
     1921 ttgggctctg ggcagtctgt cagtaccaag cctttatgcc tatgagaact ccatagctgg
     1981 gtctcaccac taataaacag acctgcacct ctggaaggat ccactgtgtg tctggtacca
     2041 cactgggcct ttcaaagttt tattcaccct cctcagtccc caggatatgt ctctggaccc
     2101 acaagagctc ctacagatcc cacttatagg gctccatgag cagtagagac aagacaccac
     2161 ttgctggttc ttcaaagcag ggtggcaggg gtccctgggg gagtgtgggg acaagccggt
     2221 tccccacata gttcactttt tctggtgtgt gctcagaagc ccccactgta aggccaggag
     2281 tgcccgaacc tgcggctgtg gtggctccac agcaggctgg aagcgcgctc gctccctgca
     2341 gagggcctcc aggacctggg ctggggccac ctggcctgtg aacgcacgga ctgcatcctc
     2401 tctgcaggga agaatatgct ggggaattgt ggggctggcc agctgcccat gggggtgggg
     2461 cccagcaggg cggtggatgg aaggagggcc cttaataaat gaccttctct ggtgccaggg
     2521 acattcagct caataaatag tccctagata ccctc
//
