LOCUS       NM_001293776            2438 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus chromatin target of PRMT1 (Chtop), transcript variant
            1, mRNA.
ACCESSION   NM_001293776 XM_006501886
VERSION     NM_001293776.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2438)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2438)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2438)
  AUTHORS   Zhou,X., Lv,M., Duan,Z., Liu,W., Yan,F., Liu,J. and Cui,Y.
  TITLE     CHTOP Promotes Microglia-Mediated Inflammation by Regulating Cell
            Metabolism and Inflammatory Gene Expression
  JOURNAL   J Immunol 212 (4), 677-688 (2024)
   PUBMED   38117276
  REMARK    GeneRIF: CHTOP Promotes Microglia-Mediated Inflammation by
            Regulating Cell Metabolism and Inflammatory Gene Expression.
REFERENCE   4  (bases 1 to 2438)
  AUTHORS   Bhattacharjee,R., Jolly,L.A., Corbett,M.A., Wee,I.C., Rao,S.R.,
            Gardner,A.E., Ritchie,T., van Hugte,E.J.H., Ciptasari,U., Piltz,S.,
            Noll,J.E., Nazri,N., van Eyk,C.L., White,M., Fornarino,D.,
            Poulton,C., Baynam,G., Collins-Praino,L.E., Snel,M.F., Nadif
            Kasri,N., Hemsley,K.M., Thomas,P.Q., Kumar,R. and Gecz,J.
  TITLE     Compromised transcription-mRNA export factor THOC2 causes R-loop
            accumulation, DNA damage and adverse neurodevelopment
  JOURNAL   Nat Commun 15 (1), 1210 (2024)
   PUBMED   38331934
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2438)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2438)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2438)
  AUTHORS   van Dijk,T.B., Gillemans,N., Pourfarzad,F., van Lom,K., von
            Lindern,M., Grosveld,F. and Philipsen,S.
  TITLE     Fetal globin expression is regulated by Friend of Prmt1
  JOURNAL   Blood 116 (20), 4349-4352 (2010)
   PUBMED   20688955
  REMARK    GeneRIF: The recently identified chromatin factor Friend of Prmt1
            (FOP) is a critical modulator of gamma-globin gene expression.
REFERENCE   8  (bases 1 to 2438)
  AUTHORS   van Dijk,T.B., Gillemans,N., Stein,C., Fanis,P., Demmers,J., van de
            Corput,M., Essers,J., Grosveld,F., Bauer,U.M. and Philipsen,S.
  TITLE     Friend of Prmt1, a novel chromatin target of protein arginine
            methyltransferases
  JOURNAL   Mol Cell Biol 30 (1), 260-272 (2010)
   PUBMED   19858291
  REMARK    GeneRIF: Fop is tightly associated with chromatin, and that it is
            modified by both asymmetric and symmetric arginine methylation in
            vivo. Fop plays an important role in the ligand-dependent
            activation of estrogen receptor target genes, including TFF1 (pS2).
REFERENCE   9  (bases 1 to 2438)
  AUTHORS   Zullo,A.J., Michaud,M., Zhang,W. and Grusby,M.J.
  TITLE     Identification of the small protein rich in arginine and glycine
            (SRAG): a newly identified nucleolar protein that can regulate cell
            proliferation
  JOURNAL   J Biol Chem 284 (18), 12504-12511 (2009)
   PUBMED   19254951
REFERENCE   10 (bases 1 to 2438)
  AUTHORS   Chambers,D.M. and Abbott,C.M.
  TITLE     Isolation and mapping of novel mouse brain cDNA clones containing
            trinucleotide repeats, and demonstration of novel alleles in
            recombinant inbred strains
  JOURNAL   Genome Res 6 (8), 715-723 (1996)
   PUBMED   8858346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160552.13, AK047914.1 and BE852996.1.
            
            On Jun 20, 2014 this sequence version replaced XM_006501886.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047914.1, AK132769.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC160552.13        69147-69178         c
            33-2010             AK047914.1         7-1984
            2011-2438           BE852996.1         1-428               c
FEATURES             Location/Qualifiers
     source          1..2438
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.24 cM"
     gene            1..2438
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
                     /note="chromatin target of PRMT1"
                     /db_xref="GeneID:66511"
                     /db_xref="MGI:MGI:1913761"
     exon            1..308
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
                     /inference="alignment:Splign:2.1.0"
     exon            309..390
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..1075
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
                     /note="isoform 1 is encoded by transcript variant 1; small
                     protein rich in arginine and glycine; Friend of PRMT1
                     protein; small arginine- and glycine-rich protein;
                     chromatin target of PRMT1 protein"
                     /codon_start=1
                     /product="chromatin target of PRMT1 protein isoform 1"
                     /protein_id="NP_001280705.1"
                     /db_xref="CCDS:CCDS79968.1"
                     /db_xref="GeneID:66511"
                     /db_xref="MGI:MGI:1913761"
                     /translation="MAAQSAPKVVLKSTTKMSLNERFTNMLKNKQPMPVNIRASMQQQ
                     QQLASARNRRLAQQMENRPSVQAALKLKQKSLKQRLGKSNIQARLGRPIGALARGAIG
                     GRGLPIIQRGLPRGGLRGGRATRTLLRGGMSLRGQNLLRGGRAVAPRMGLRRGGVRGR
                     GGPGRGGLGRGAMGRGGIGGRGRGMIGRGRGGFGGRGRGRGRGRGALTRPVLTKEQLD
                     NQLDAYMSKTKGHLDAELDAYMAQTDPETND"
     exon            391..544
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
                     /inference="alignment:Splign:2.1.0"
     exon            545..731
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
                     /inference="alignment:Splign:2.1.0"
     exon            732..869
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
                     /inference="alignment:Splign:2.1.0"
     exon            870..2438
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1997..2002
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
                     /note="hexamer: AACAAA"
     polyA_site      2021
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
                     /note="major polyA site"
     polyA_site      2069
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
     regulatory      2420..2425
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
                     /note="hexamer: AAGAAA"
     polyA_site      2438
                     /gene="Chtop"
                     /gene_synonym="2500003M10Rik; Fop; Srag"
ORIGIN      
        1 cggtcacgct gcactggtgg gcccggcggc cattttgttt tggacaccaa gcgggagttg
       61 gcggcgccgg ctctgggggc ccagacgaaa ggcaggaaag ggcaggcttg acgagcggga
      121 ggatcggtca gctagatact caacccacaa cgaggaagcc tcacatccta ccgtttaagc
      181 atctaagcca accgcccagc tagttaaccc gagcggcccg ccgtcagctc aggttaggcc
      241 ggcctccggg ccgcccgccg cagccgtggt ggcaaccccg ggaggagcgc tggcgtccat
      301 ctccttcgat tctcgggatt tgaagatggc tgcacagtca gcgccgaaag ttgtgctaaa
      361 aagcaccacc aagatgtctc taaatgagcg ctttactaat atgctgaaga acaaacagcc
      421 gatgccagtg aatattcggg cttcgatgca gcagcagcag cagctagcca gtgccagaaa
      481 cagaagactg gcccagcaga tggagaatag accctctgtc caggcagcat taaaacttaa
      541 gcagaagagc ttaaagcagc gcctgggtaa gagtaatatc caggcacggt taggccgacc
      601 cataggtgcc ctggccaggg gagcaattgg aggaagaggc ctacccataa tccagagagg
      661 cttgccccga ggaggactac gtgggggacg tgctaccaga accctgctta ggggtgggat
      721 gtcgctccga ggtcaaaacc tgctccgagg tggacgagcc gtagctcccc gaatgggctt
      781 aagaagaggt ggtgttcgag gtcgtggagg tcctgggaga gggggcctag ggcgtggagc
      841 tatgggtcgt ggcggaatcg gtggtagagg tcggggtatg ataggtcggg gaagaggggg
      901 ctttggaggc agaggccgag gtcgtggccg agggagaggt gccctcactc gccctgtatt
      961 gaccaaggag cagctggaca accaattgga tgcatacatg tcgaaaacta aaggacacct
     1021 ggatgctgaa ttggatgcct acatggcaca gacagatcct gaaaccaatg attgaagcct
     1081 gcctgcctgc ccgcctgcct gttagactct tgttaaagtc accacatcta taaaacaacc
     1141 ttgagaaaac atgagaagaa atctgatcga tgctggaagg acctgtcaca ataggctgtg
     1201 gacttacctg ccaccagttg gtgcatttag tctgttctgt ctactttttg atactgtgtt
     1261 atatgaaacc ctattttcct ttaaatttgg ttgagtttgt tttgttgttt atccagtcac
     1321 ccagatatct gtttgaacag gaatgcgttg gccttgtgag tagaacagtt ttctagcctc
     1381 tgcctgtcat atactcttga catttttaaa tatttcctct gttgattttt atgatcccag
     1441 aaggagctag agttttcact attgggtggt ctttgggata gagttctaca tctttcttta
     1501 aaagcttctt gttaatagct ggagctaaag gtgtgtttgc tatgttgata gtgaaggtag
     1561 taaattggaa atgttggtat tgctactggg ccacagaatg ggtaacacgt ggtaccaact
     1621 ttgatttggt caaagttgat gttgcctaca ttgaaaccac atagatggta gctgacaagc
     1681 taagttggaa tttccaccct aagaaaagat ttttaagctt ataaatctct ccttttggct
     1741 ttctgtctca tgcccaagag gcttctgcac ctctcacaga gaagaagcag ctgttggtgt
     1801 agcacaagtg gcagaagaga caagagtggg aaactggtaa caaactgact gctgggaagg
     1861 gctcatgtgc tgctcgtgct gaagtgcagt taccttccac ttaactggct ttatttgacc
     1921 ctcttgaagg tttaagttca accatatttt gtcagctgtt cagtttcagt ggaatcttgt
     1981 atttctgatt cattataaca aattgttctc tcaaaattta acccaggctt tctgtttatt
     2041 tgggggggtc ttaaaatgct atataaccat ttttgtggtg tgttaatatg tcccttgtat
     2101 agttgaaaat tcctggggtg gagccaggta agagggtggt acaaaccatc tgccacttgg
     2161 gaagcagaga caggtgggtt ctaagccagc ttgatctcag aattagttac agtttagcca
     2221 gggctacacc agccctgtct caaaaaaaaa aaaagatatt aggggtagag gaaatgttgc
     2281 tttgtggtag aaaaagcttg tgttcccctt taagccttta ggaagaatta cctgcctaga
     2341 aagtactagt agactggacc gtggttgttt aggagaaaag atcacaggcc tcttactgtg
     2401 ctgtgcatta agagccagga agaaaatact gaacaaga
//
