LOCUS       NM_145409               3163 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus CTF18, chromosome transmission fidelity factor 18
            (Chtf18), mRNA.
ACCESSION   NM_145409
VERSION     NM_145409.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3163)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3163)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   3  (bases 1 to 3163)
  AUTHORS   Holton,R.A., Harris,A.M., Mukerji,B., Singh,T., Dia,F. and
            Berkowitz,K.M.
  TITLE     CHTF18 ensures the quantity and quality of the ovarian
            reservedagger
  JOURNAL   Biol Reprod 103 (1), 24-35 (2020)
   PUBMED   32219340
  REMARK    GeneRIF: CHTF18 ensures the quantity and quality of the ovarian
            reservedagger.
REFERENCE   4  (bases 1 to 3163)
  AUTHORS   Sundberg,J.P., Dadras,S.S., Silva,K.A., Kennedy,V.E., Garland,G.,
            Murray,S.A., Sundberg,B.A., Schofield,P.N. and Pratt,C.H.
  TITLE     Systematic screening for skin, hair, and nail abnormalities in a
            large-scale knockout mouse program
  JOURNAL   PLoS One 12 (7), e0180682 (2017)
   PUBMED   28700664
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3163)
  AUTHORS   Ni,L., Xie,H. and Tan,L.
  TITLE     Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3
            conditional knockout mouse models
  JOURNAL   Mol Reprod Dev 83 (12), 1060-1069 (2016)
   PUBMED   27739607
REFERENCE   6  (bases 1 to 3163)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 3163)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 3163)
  AUTHORS   Berkowitz,K.M., Sowash,A.R., Koenig,L.R., Urcuyo,D., Khan,F.,
            Yang,F., Wang,P.J., Jongens,T.A. and Kaestner,K.H.
  TITLE     Disruption of CHTF18 causes defective meiotic recombination in male
            mice
  JOURNAL   PLoS Genet 8 (11), e1002996 (2012)
   PUBMED   23133398
  REMARK    GeneRIF: These findings demonstrate essential roles for CHTF18 in
            mammalian spermatogenesis and meiosis, and suggest that CHTF18 may
            function during the double-strand break repair pathway to promote
            the formation of crossovers.
REFERENCE   9  (bases 1 to 3163)
  AUTHORS   Berkowitz,K.M., Kaestner,K.H. and Jongens,T.A.
  TITLE     Germline expression of mammalian CTF18, an evolutionarily conserved
            protein required for germ cell proliferation in the fly and sister
            chromatid cohesion in yeast
  JOURNAL   Mol Hum Reprod 14 (3), 143-150 (2008)
   PUBMED   18250106
REFERENCE   10 (bases 1 to 3163)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB861615.1, AK077947.1 and BC083096.1.
            
            On Oct 6, 2007 this sequence version replaced NM_145409.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024142.1, AK077947.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                BB861615.1         11-46
            37-1611             AK077947.1         4-1578
            1612-3163           BC083096.1         2330-3881
FEATURES             Location/Qualifiers
     source          1..3163
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.83 cM"
     gene            1..3163
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /note="CTF18, chromosome transmission fidelity factor 18"
                     /db_xref="GeneID:214901"
                     /db_xref="MGI:MGI:2384887"
     exon            1..169
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2988
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /note="Chl12 homolog; CTF18, chromosome transmission
                     fidelity factor 18 homolog"
                     /codon_start=1
                     /product="chromosome transmission fidelity protein 18
                     homolog"
                     /protein_id="NP_663384.2"
                     /db_xref="CCDS:CCDS28523.1"
                     /db_xref="GeneID:214901"
                     /db_xref="MGI:MGI:2384887"
                     /translation="MEDYEEDLYGVEDDFQNQFAAELEVLAELEGTRDQAPPGTLQTP
                     ASRPPLTFEEAIAGGDTVPRPCPAGSPGNVNRNTRKNVRRDQPAPSSPMVKRPRLDVV
                     KKLNFEPDMEELLYPDSPPGDITPPPSPEVFPEMLDAGYSDANADKDLMQTLPSPRNR
                     NPVLRRPPILEDYINVTSTSGERAFLVLRADLIGPGVQNPLLDVHWRGCGQLDLLGVP
                     FASLKEQVDSKRRQQLLEDAQQLSDTLHSLRSEGEEAVLEGPPAEEPAPGQNTAQHCL
                     WVDEFAPQHYTELLSDDFTNRCLLKWLKLWDLVVFGRERPARKPRPGVETTRVGKEAT
                     APGKWKSHEQALEEMLEAELDPSQRPRQKVALLCGPPGLGKTTLAHVVARHAGYCVVE
                     MNASDDRSPEAFRTRIEAATQMESVLGVGGRPNCLVIDEIDGAPTAAINVLLGILNRK
                     GPQEADQGGTAVAAGGRRRRAEGGLLTRPIICICNDQFTPSLRQLKQQALLLHVPPTL
                     PSRLVQRLQEISLQHGMRSDPGALVALCEKTDNDIRACINTLQFLYGRGRRELSVKAV
                     QTTHVGLKDQRKGLFSVWQEVFQLPRTQRRIVGQDLMLPAHALLLSNGDKGSLTLASQ
                     RFYHILRVTTSAGEHEKVVQGLFDNFLRLRLRDSSLSTVCCALDWLAFDDLLEQAAHR
                     GQSFQLLCYLPFVPAAFHVLFASSHVPRITFPSSQQEAQTRMSQTRNHIQTLVSGMAP
                     TTRSRATPQALVLDTLCLLLDVLAPKLRPVSTQLYSAHEKQQLSCLVGTMLAYSLTYH
                     QERTPDGQYLYKLEPNVEEVCRFPELPARKPLTYQAKQLIAREIEMEKMRRAEALAWA
                     RSGPQVDQGSSGPASLWTDSGEKGTRQPVPRNHEQRLEHIMTRATVQEQPERDFFGRV
                     VIRKVAVPSREVEAPQKDADEWRMGVAVGRSEVWFRFNEGVSNAVRRSLYIRDLL"
     exon            170..349
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            350..497
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            498..672
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            673..765
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            766..818
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            819..957
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1167
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1265
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1389
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1538
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1632
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1731
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1862
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2010
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2235
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            2236..2385
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2516
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2661
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            2662..2793
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2851
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     exon            2852..3106
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3068..3073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /note="hexamer: TATAAA"
     polyA_site      3106
                     /gene="Chtf18"
                     /gene_synonym="6030457M03Rik; Chl12; CTF18"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggggt agcgcgcggt ggcggcggcg cgggaagttc tgagggactc tgagctgtgg
       61 gagttgtggt ctggctccat ggaagactac gaggaagatc tgtatggtgt ggaggatgat
      121 ttccaaaacc agttcgcagc tgagctcgaa gtgctggctg agctggaagg aacacgggac
      181 caggctcctc ctgggaccct ccaaactcca gcgagccgcc ctccgctaac cttcgaagag
      241 gccatcgctg gtggggacac tgtcccgcgt ccctgccctg cagggtcgcc aggaaatgtc
      301 aaccgcaata ctagaaagaa tgttcgtagg gaccagcccg cgccctccag ccccatggtc
      361 aaacgaccca ggttggacgt ggtgaagaag ctgaactttg agccagatat ggaggagctc
      421 ttatatccag attcccctcc tggggacatt acccctccac cgagtccaga ggtcttccct
      481 gagatgttgg atgctgggta ttcagatgct aatgctgaca aagacctcat gcagacattg
      541 ccaagtcccc gaaatcgcaa tcctgtcctg agacggcctc ctatcttaga agattatatc
      601 aatgtgacat ccacaagtgg agaacgggcc tttttggtgc ttcgggctga cctcataggc
      661 cctggggtgc agaaccctct tctagatgtc cactggcgag gctgtggcca actggacctg
      721 ctgggtgtcc ccttcgcctc cctgaaggag caagttgata gcaagagacg gcaacaactg
      781 ctggaggatg cccaacagct ttcagacact ctacacagcc tcaggtctga aggagaggag
      841 gctgtgcttg aagggccccc tgcggaggag ccagcccctg gccagaacac cgctcagcac
      901 tgcctctggg tggatgagtt tgcacctcag cattacacgg aactgctcag tgacgatttt
      961 accaaccgct gcctactcaa gtggctgaag ctatgggacc ttgtggtgtt tggccgtgag
     1021 agacctgccc ggaagcccag acctggtgta gagaccaccc gggttgggaa ggaggctaca
     1081 gcccctggca agtggaaaag ccatgagcag gcactggagg agatgctaga agctgaactg
     1141 gaccctagcc agaggcctcg gcagaaggtg gcactgttgt gtggccctcc aggactaggc
     1201 aagaccacgc tggcacatgt ggtcgcaagg catgcagggt attgcgtggt agagatgaat
     1261 gcaagtgatg accgtagccc ggaggccttc cgtacacgca ttgaagcagc tacgcaaatg
     1321 gagtcggttc tgggtgtggg tgggaggccc aactgcctgg ttattgatga gatcgacggg
     1381 gcccccacgg cggccatcaa cgttcttttg ggtatcctga atcgcaaggg tccgcaggag
     1441 gccgaccaag gaggcacagc tgtggccgca ggggggcggc ggcgcagggc cgaggggggt
     1501 ctcctaacca ggcctatcat ctgcatctgc aatgatcagt tcacaccttc tctgaggcag
     1561 ctgaagcagc aggctcttct gctccacgtc cccccaactc tgccctccag gctggtgcag
     1621 cggctccagg agatctccct gcagcatggc atgcgctctg acccgggtgc actggttgcc
     1681 ctctgtgaga agaccgacaa tgacatccgt gcctgcatca acaccctgca gtttctgtat
     1741 gggaggggcc ggcgggagct gagtgtgaag gctgtgcaga ccactcatgt cggcctgaag
     1801 gaccagcgca aggggctatt ctctgtgtgg caagaggtct tccagttgcc caggactcaa
     1861 aggagaatcg tgggccagga cctgatgctg ccagcccacg ctctcctgct cagcaatggt
     1921 gacaagggct ctctgaccct ggcctcccag cgcttttacc acatcctgcg tgtgaccacc
     1981 tctgcgggcg agcatgagaa ggttgtccag ggcctgtttg acaactttct acgccttcgg
     2041 cttcgggact ccagcttaag caccgtgtgc tgtgccctcg actggctggc ctttgatgac
     2101 ctgctggagc aggctgccca ccgtggccag agcttccagt tgctgtgcta cttgcccttc
     2161 gtgcctgcgg ccttccacgt gctctttgcc tccagccatg tgccacgaat cactttcccc
     2221 agcagccagc aggaggccca gactcggatg agccagacaa ggaaccacat acagacactg
     2281 gtgtcaggta tggcaccgac cacgcgtagc cgggccacac cacaggccct tgttctagat
     2341 actctctgcc tgctcctgga tgtcctcgca cccaagctgc gccccgtgag cacacagctg
     2401 tacagtgccc atgagaagca gcagttgtcc tgccttgtgg gtaccatgct tgcctacagt
     2461 ctcacctacc accaggagcg cacacctgat gggcagtacc tctacaagct ggagccgaat
     2521 gtggaagagg tctgccgctt ccctgaacta cctgcccgaa agcccctcac ctaccaggct
     2581 aagcagctta ttgctcggga gattgaaatg gagaagatgc gcagggcaga ggctttggcc
     2641 tgggctcgaa gtggccccca ggtggaccag ggctcctcag ggcctgcaag tctgtggaca
     2701 gacagtgggg aaaaggggac aaggcagcct gtcccacgta accatgagca gcgcctagaa
     2761 cacatcatga cgagagcaac cgtgcaggag cagcctgaga gggacttctt tggacgtgtg
     2821 gtcatcagga aagtggcagt cccgagcaga gaggttgagg ccccccagaa ggacgcggac
     2881 gagtggcgca tgggtgtggc agtgggcagg agtgaggtgt ggttccggtt caacgagggc
     2941 gtctcaaatg ctgttcggcg cagcctgtac atcagggacc tgctgtagcc ccactgcccc
     3001 aggacatcag atcgcactgg ctcccacagg gaatggacta aagcagagac acccggagaa
     3061 gtctatttat aaagtcacac cttacagaga gtgtgggtca ggctcaaaaa aaaaaaaaaa
     3121 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa
//
