LOCUS       NM_021715               2248 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus carbohydrate sulfotransferase 7 (Chst7), mRNA.
ACCESSION   NM_021715
VERSION     NM_021715.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2248)
  AUTHORS   Schaberg,E., Theocharidis,U., May,M., Lessmann,K., Schroeder,T. and
            Faissner,A.
  TITLE     Sulfation of Glycosaminoglycans Modulates the Cell Cycle of
            Embryonic Mouse Spinal Cord Neural Stem Cells
  JOURNAL   Front Cell Dev Biol 9, 643060 (2021)
   PUBMED   34169071
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2248)
  AUTHORS   Narentuya, Takeda-Uchimura,Y., Foyez,T., Zhang,Z., Akama,T.O.,
            Yagi,H., Kato,K., Komatsu,Y., Kadomatsu,K. and Uchimura,K.
  TITLE     GlcNAc6ST3 is a keratan sulfate sulfotransferase for the
            protein-tyrosine phosphatase PTPRZ in the adult brain
  JOURNAL   Sci Rep 9 (1), 4387 (2019)
   PUBMED   30867513
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2248)
  AUTHORS   Chal,J., Al Tanoury,Z., Oginuma,M., Moncuquet,P., Gobert,B.,
            Miyanari,A., Tassy,O., Guevara,G., Hubaud,A., Bera,A., Sumara,O.,
            Garnier,J.M., Kennedy,L., Knockaert,M., Gayraud-Morel,B.,
            Tajbakhsh,S. and Pourquie,O.
  TITLE     Recapitulating early development of mouse musculoskeletal
            precursors of the paraxial mesoderm in vitro
  JOURNAL   Development 145 (6) (2018)
   PUBMED   29555813
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2248)
  AUTHORS   Akita,K., von Holst,A., Furukawa,Y., Mikami,T., Sugahara,K. and
            Faissner,A.
  TITLE     Expression of multiple chondroitin/dermatan sulfotransferases in
            the neurogenic regions of the embryonic and adult central nervous
            system implies that complex chondroitin sulfates have a role in
            neural stem cell maintenance
  JOURNAL   Stem Cells 26 (3), 798-809 (2008)
   PUBMED   18079434
REFERENCE   5  (bases 1 to 2248)
  AUTHORS   Hemmerich,S., Lee,J.K., Bhakta,S., Bistrup,A., Ruddle,N.R. and
            Rosen,S.D.
  TITLE     Chromosomal localization and genomic organization for the
            galactose/ N-acetylgalactosamine/N-acetylglucosamine
            6-O-sulfotransferase gene family
  JOURNAL   Glycobiology 11 (1), 75-87 (2001)
   PUBMED   11181564
REFERENCE   6  (bases 1 to 2248)
  AUTHORS   Bhakta,S., Bartes,A., Bowman,K.G., Kao,W.M., Polsky,I., Lee,J.K.,
            Cook,B.N., Bruehl,R.E., Rosen,S.D., Bertozzi,C.R. and Hemmerich,S.
  TITLE     Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase
            2 (GST-5)
  JOURNAL   J Biol Chem 275 (51), 40226-40234 (2000)
   PUBMED   10956661
REFERENCE   7  (bases 1 to 2248)
  AUTHORS   Uchimura,K., Fasakhany,F., Kadomatsu,K., Matsukawa,T., Yamakawa,T.,
            Kurosawa,N. and Muramatsu,T.
  TITLE     Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular
            cloning of a novel enzyme with different distribution and
            specificities
  JOURNAL   Biochem Biophys Res Commun 274 (2), 291-296 (2000)
   PUBMED   10913333
REFERENCE   8  (bases 1 to 2248)
  AUTHORS   Kitagawa,H., Fujita,M., Ito,N. and Sugahara,K.
  TITLE     Molecular cloning and expression of a novel chondroitin
            6-O-sulfotransferase
  JOURNAL   J Biol Chem 275 (28), 21075-21080 (2000)
   PUBMED   10781596
REFERENCE   9  (bases 1 to 2248)
  AUTHORS   Silbert,J.E. and Freilich,L.S.
  TITLE     Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched
            preparation from cultures of mouse mastocytoma cells
  JOURNAL   Biochem J 190 (2), 307-313 (1980)
   PUBMED   6781479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB040710.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040710.1, AK011202.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..2248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 15.5 cM"
     gene            1..2248
                     /gene="Chst7"
                     /gene_synonym="2600013M07Rik; C6ST-2; glcNAc6ST-4;
                     Gn6st-4; GST5"
                     /note="carbohydrate sulfotransferase 7"
                     /db_xref="GeneID:60322"
                     /db_xref="MGI:MGI:1891767"
     exon            1..1639
                     /gene="Chst7"
                     /gene_synonym="2600013M07Rik; C6ST-2; glcNAc6ST-4;
                     Gn6st-4; GST5"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1601
                     /gene="Chst7"
                     /gene_synonym="2600013M07Rik; C6ST-2; glcNAc6ST-4;
                     Gn6st-4; GST5"
                     /EC_number="2.8.2.17"
                     /function="This enzyme catalyzes the transfer of sulfate
                     from 3'-phosphoadenosine 5'-phosphosulfate to position 6
                     of the non-reducing GlcNAc residue of oligosaccharides"
                     /note="carbohydrate (N-acetylglucosamino) sulfotransferase
                     7; chondroitin 6-sulfotransferase 2; N-acetylglucosamine
                     6-O-sulfotransferase 1;
                     galactose/N-acetylglucosamine/N-acetylglucosamine
                     6-O-sulfotransferase 5; N-acetylglucosamine
                     6-O-sulfotransferase 4"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 7 precursor"
                     /protein_id="NP_068361.1"
                     /db_xref="CCDS:CCDS30040.1"
                     /db_xref="GeneID:60322"
                     /db_xref="MGI:MGI:1891767"
                     /translation="MKGRRRRRREYCKFTLLLALYTLLLLLVPSVLDSHSEQDKGRNC
                     PGLQRSLGVWSLEAAAAGEREQGAEVRSLAEGNPDRSPGSPGNLSAVGEAVTQEKQHI
                     YVHATWRTGSSFLGELFNQHPDVFYLYEPMWHLWQALYPGDAESLQGALRDMLRSLFR
                     CDFSVLRLYAQPGDPGERAPDSANLTTAMLFRWRTNKVICSPPLCPAAPRARADVGLV
                     EDKACESTCPPVSLRALEAECRKYPVVVIKDVRLLDLGVLVPLLRDPGLNLKVVQLFR
                     DPRAVHNSRLKSRQGLLRESIQVLRTRQRGDHFHRVLLAHGVDARPGGQARALPSAPR
                     ADFFLTSALEVICEAWLRDLLFTRGAPAWLRRRYLRLRYEDLVWQPQAQLRRLLRFSG
                     LRTLAALDAFAFNMTRGSAYGADRPFHLSARDAREAVHAWRERLSQEQVRQVETACAP
                     AMRLLAYPRSGDERDRKTVREGETPLETKANWAV"
     exon            1640..2196
                     /gene="Chst7"
                     /gene_synonym="2600013M07Rik; C6ST-2; glcNAc6ST-4;
                     Gn6st-4; GST5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chst7"
                     /gene_synonym="2600013M07Rik; C6ST-2; glcNAc6ST-4;
                     Gn6st-4; GST5"
                     /note="hexamer: ATTAAA"
     polyA_site      2062
                     /gene="Chst7"
                     /gene_synonym="2600013M07Rik; C6ST-2; glcNAc6ST-4;
                     Gn6st-4; GST5"
     regulatory      2177..2182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chst7"
                     /gene_synonym="2600013M07Rik; C6ST-2; glcNAc6ST-4;
                     Gn6st-4; GST5"
                     /note="hexamer: ACTAAA"
     polyA_site      2196
                     /gene="Chst7"
                     /gene_synonym="2600013M07Rik; C6ST-2; glcNAc6ST-4;
                     Gn6st-4; GST5"
                     /note="major polyA site"
ORIGIN      
        1 caccgcccgg ctgctccact ccgctccacc caacattgag ggagacccga agaggccgga
       61 gccgaggact ttgggctggg ttttctggac agaaccagca ggcgcctact ctgctctggg
      121 tggggagagt gaggattcgg tgaactatga agggccggcg gcggcggcgc cgagagtatt
      181 gcaagttcac gctgctcttg gcgctgtaca cgcttttgct acttcttgtc ccctctgtac
      241 tggacagcca cagcgagcag gacaagggca ggaactgccc cggcctgcag cgcagcttgg
      301 gtgtgtggag cctggaggcg gcggcggccg gggaacgtga gcagggcgct gaggtgcggt
      361 ccctggccga aggaaacccg gatcgatccc ccgggtcccc cggcaacctc agcgccgtcg
      421 gtgaggcggt gacccaggaa aagcaacaca tctatgtgca tgccacctgg cgcaccggct
      481 cgtccttctt gggcgaactc ttcaaccagc acccggacgt tttctacttg tacgagccca
      541 tgtggcatct gtggcaggca ctgtatccgg gcgacgcgga gagcctgcag ggcgcactaa
      601 gagacatgct gcgctccctc ttccgctgtg atttctctgt gctgcgcctg tacgcgcagc
      661 ctggggaccc tggggagcga gcaccggact cggccaacct caccacggcc atgcttttcc
      721 gctggcggac caacaaggtc atctgctcgc cgcctctgtg ccccgccgcg ccccgggcac
      781 gcgcggacgt gggactcgtc gaggacaaag cctgcgaaag tacctgcccg cccgtttcgc
      841 tccgcgccct ggaggccgag tgccgcaagt acccggtggt ggtcatcaaa gacgtgcggc
      901 tactggacct gggagtgctg gtccctctgc tgcgtgaccc aggcctcaac ctaaaggtgg
      961 tgcaactctt ccgagaccct cgggccgtgc acaactcgcg cctcaagtcg aggcagggac
     1021 tgctgcgcga aagcatccag gtgctgcgca cgcgccagag gggcgaccac ttccaccggg
     1081 tgctgctggc gcatggagtg gatgcccgtc cgggaggcca ggcccgggct ctgccctcgg
     1141 cgccacgcgc tgatttcttc ttaaccagcg cgcttgaggt gatctgtgaa gcgtggcttc
     1201 gcgacctgct attcacccgc ggcgcgcccg cctggctgag gcgtcgctac ctgcggctgc
     1261 gttatgagga cctggtgtgg cagccccaag cccagctgcg ccgcctgctg cgcttctctg
     1321 ggttgcggac actcgccgcg cttgatgcct tcgcattcaa tatgacgcgg ggctcggcct
     1381 acggcgccga tcgtcccttc cacttgtctg cgcgggacgc ccgagaggct gtgcacgcct
     1441 ggcgcgaacg tctgagccaa gagcaggtgc gccaagtgga aaccgcctgc gcccctgcca
     1501 tgcgtctgct tgcctaccct cgaagtgggg acgaacgcga caggaagacc gtcagggaag
     1561 gggagacacc actggagacc aaggccaatt gggctgtgta ataccctgat ccctgaaccc
     1621 tgccccgggg cgtattcagg tcagtggcca taaaaaggtg aactcagcat gctgcccccg
     1681 cactggagag gctgcacggt ggaggcgatc tatcacactg tgagacactg ggactgattt
     1741 ggtatcaact gctgtgccat tctcctggtc aggagcatca caagctgtta agtaatgaca
     1801 gacaccttgg ctgagatgaa gtttccagaa aggaagtaac agtgcaatgt ggatatttgt
     1861 gaccacaaca taggaaaagc tgtacttccc aggctgaact tggctcagct tgagccattt
     1921 caacaaggca tcctcacaat aatgaagaga tgtgatctgg tttcctttca catcagcaga
     1981 tgtctggaca aaaccatcaa tgtgaataag ggccaagtgc agttgtgtct ctcttgatta
     2041 aattacttca tattaaataa aaggtctggc tggtattgtt tcctaaaggc ctcacccagc
     2101 tctccttcaa ttagcagtct tcctgtagaa ccattttcta aacaattttc tctggtgggt
     2161 aagagaggtg taataaacta aaactttgtt ttcaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2221 aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
