LOCUS       NM_011998               2000 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus carbohydrate sulfotransferase 4 (Chst4), mRNA.
ACCESSION   NM_011998
VERSION     NM_011998.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2000)
  AUTHORS   Narentuya, Takeda-Uchimura Y, Foyez T, Zhang Z, Akama TO, Yagi H,
            Kato K, Komatsu Y, Kadomatsu K and Uchimura K.
  TITLE     GlcNAc6ST3 is a keratan sulfate sulfotransferase for the
            protein-tyrosine phosphatase PTPRZ in the adult brain
  JOURNAL   Sci Rep 9 (1), 4387 (2019)
   PUBMED   30867513
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2000)
  AUTHORS   Patnode ML, Yu SY, Cheng CW, Ho MY, Tegesjo L, Sakuma K, Uchimura
            K, Khoo KH, Kannagi R and Rosen SD.
  TITLE     KSGal6ST generates galactose-6-O-sulfate in high endothelial
            venules but does not contribute to L-selectin-dependent lymphocyte
            homing
  JOURNAL   Glycobiology 23 (3), 381-394 (2013)
   PUBMED   23254996
REFERENCE   3  (bases 1 to 2000)
  AUTHORS   Ohmichi Y, Hirakawa J, Imai Y, Fukuda M and Kawashima H.
  TITLE     Essential role of peripheral node addressin in lymphocyte homing to
            nasal-associated lymphoid tissues and allergic immune responses
  JOURNAL   J Exp Med 208 (5), 1015-1025 (2011)
   PUBMED   21518796
REFERENCE   4  (bases 1 to 2000)
  AUTHORS   Arata-Kawai H, Singer MS, Bistrup A, Zante Av, Wang YQ, Ito Y, Bao
            X, Hemmerich S, Fukuda M and Rosen SD.
  TITLE     Functional contributions of N- and O-glycans to L-selectin ligands
            in murine and human lymphoid organs
  JOURNAL   Am J Pathol 178 (1), 423-433 (2011)
   PUBMED   21224079
REFERENCE   5  (bases 1 to 2000)
  AUTHORS   Hirakawa J, Tsuboi K, Sato K, Kobayashi M, Watanabe S, Takakura A,
            Imai Y, Ito Y, Fukuda M and Kawashima H.
  TITLE     Novel anti-carbohydrate antibodies reveal the cooperative function
            of sulfated N- and O-glycans in lymphocyte homing
  JOURNAL   J Biol Chem 285 (52), 40864-40878 (2010)
   PUBMED   20929857
REFERENCE   6  (bases 1 to 2000)
  AUTHORS   Hemmerich S, Bistrup A, Singer MS, van Zante A, Lee JK, Tsay D,
            Peters M, Carminati JL, Brennan TJ, Carver-Moore K, Leviten M,
            Fuentes ME, Ruddle NH and Rosen SD.
  TITLE     Sulfation of L-selectin ligands by an HEV-restricted
            sulfotransferase regulates lymphocyte homing to lymph nodes
  JOURNAL   Immunity 15 (2), 237-247 (2001)
   PUBMED   11520459
REFERENCE   7  (bases 1 to 2000)
  AUTHORS   Hemmerich S, Lee JK, Bhakta S, Bistrup A, Ruddle NR and Rosen SD.
  TITLE     Chromosomal localization and genomic organization for the
            galactose/ N-acetylgalactosamine/N-acetylglucosamine
            6-O-sulfotransferase gene family
  JOURNAL   Glycobiology 11 (1), 75-87 (2001)
   PUBMED   11181564
REFERENCE   8  (bases 1 to 2000)
  AUTHORS   Lee JK, Bhakta S, Rosen SD and Hemmerich S.
  TITLE     Cloning and characterization of a mammalian
            N-acetylglucosamine-6-sulfotransferase that is highly restricted to
            intestinal tissue
  JOURNAL   Biochem Biophys Res Commun 263 (2), 543-549 (1999)
   PUBMED   10491328
REFERENCE   9  (bases 1 to 2000)
  AUTHORS   Hiraoka N, Petryniak B, Nakayama J, Tsuboi S, Suzuki M, Yeh JC,
            Izawa D, Tanaka T, Miyasaka M, Lowe JB and Fukuda M.
  TITLE     A novel, high endothelial venule-specific sulfotransferase
            expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed
            by CD34
  JOURNAL   Immunity 11 (1), 79-89 (1999)
   PUBMED   10435581
REFERENCE   10 (bases 1 to 2000)
  AUTHORS   Bistrup A, Bhakta S, Lee JK, Belov YY, Gunn MD, Zuo FR, Huang CC,
            Kannagi R, Rosen SD and Hemmerich S.
  TITLE     Sulfotransferases of two specificities function in the
            reconstitution of high endothelial cell ligands for L-selectin
  JOURNAL   J Cell Biol 145 (4), 899-910 (1999)
   PUBMED   10330415
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK009113.1, AI614882.1 and AA672072.1.
            
            [WARNING] On Oct 11, 2023 this sequence was replaced by
            NM_011998.5.
            
            On Oct 27, 2007 this sequence version replaced NM_011998.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057886.1, AK009113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1047              AK009113.1         2-1048
            1048-1238           AI614882.1         24-214
            1239-1921           AK009113.1         1240-1922
            1922-2000           AA672072.1         199-277
FEATURES             Location/Qualifiers
     source          1..2000
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.38 cM"
     gene            1..2000
                     /gene="Chst4"
                     /gene_synonym="Gn6st-2; GST-3; HEC-GlcNAc6ST"
                     /note="carbohydrate sulfotransferase 4"
                     /db_xref="GeneID:26887"
                     /db_xref="MGI:MGI:1349479"
     exon            1..93
                     /gene="Chst4"
                     /gene_synonym="Gn6st-2; GST-3; HEC-GlcNAc6ST"
                     /inference="alignment:Splign:2.1.0"
     exon            94..2000
                     /gene="Chst4"
                     /gene_synonym="Gn6st-2; GST-3; HEC-GlcNAc6ST"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1261
                     /gene="Chst4"
                     /gene_synonym="Gn6st-2; GST-3; HEC-GlcNAc6ST"
                     /note="LSST; glcNAc6ST-2; L-selectin ligand
                     sulfotransferase; N-acetylglucosamine 6-O-sulfotransferase
                     2; high endothelial cells N-acetylglucosamine
                     6-O-sulfotransferase;
                     galactose/N-acetylglucosamine/N-acetylglucosamine
                     6-O-sulfotransferase 3; high endothelial cell
                     GlcNAC-6-sulphotransferase; carbohydrate (chondroitin
                     6/keratan) sulfotransferase 4"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 4"
                     /protein_id="NP_036128.3"
                     /db_xref="CCDS:CCDS22659.1"
                     /db_xref="GeneID:26887"
                     /db_xref="MGI:MGI:1349479"
                     /translation="MMLLKKGRLLMFLGSQVIVVALFIHMSVHRHLSQREESRRPVHV
                     LVLSSWRSGSSFVGQLFGQHPDVFYLMEPAWHVWMTFTSSTAWKLHMAVRDLLRSVFL
                     CDMSVFDAYMNPGPRKQSSLFQWEQSRALCSAPVCDFFPAHEISSPKHCKLLCGQQPF
                     DMVEKACRSHGFVVLKEVRFLSLQALYPLLTDPSLNLHVVHLVRDPRAVFRSREHTTI
                     ELMVDSHIVLGQHLETIKEEDQPYYAMKIICKSQVDIVKAIQTLPEALQQRYLFLRYE
                     DLVRAPLAQTTRLYKFVGLDFLPHLQTWVYNVTRGKGMGQHAFHTNARNALNVSQAWR
                     WSLPYEKVSQLQDACGEAMDLLGYLQVRSQQEQGNLSLDLLSSSHILGQVFREG"
ORIGIN      
        1 gtgggccctg aggaagccta aggtaagaag agaattcctt ggggagcagc tatcacgaag
       61 ggcattatcc cagctacagg atcagtgtat caggatgatg ctgttgaaga aagggaggct
      121 gctgatgttc ctgggttccc aggtcatcgt tgtagctctc ttcatccata tgtccgtcca
      181 cagacacctt tcccagaggg aggagtccag gaggcccgtg catgtgctgg tgctgtcttc
      241 ctggcggtca ggatcctctt ttgtgggaca gcttttcggg cagcacccgg atgtgttcta
      301 cctgatggag cctgcctggc atgtgtggat gactttcacc agcagcacag cctggaagct
      361 gcacatggct gtgcgggatc ttctgcgttc cgtcttcctg tgtgacatga gcgtctttga
      421 tgcctacatg aacccaggcc cccggaaaca gtccagcctc ttccagtggg agcaaagccg
      481 ggccctgtgc tcagcgcctg tgtgtgactt cttccctgcc cacgagatca gctcacccaa
      541 gcactgcaag ctgctctgcg gtcagcagcc ctttgatatg gtggagaagg cctgccgctc
      601 tcacggcttc gtggtactca aggaggtgcg ttttctcagc ctgcaggccc tctatccact
      661 actcacggac ccttccctca acctgcacgt cgtgcacctg gtccgagacc cccgggccgt
      721 gttccgatcc cgggagcaca ccaccataga actcatggtt gacagtcata ttgtgctagg
      781 gcagcatttg gaaacgatca aggaggaaga ccagccctat tatgccatga agatcatctg
      841 caaaagccag gtggacatag tcaaggccat ccaaaccctc cctgaagctc tgcagcagcg
      901 ctacctgttc ctgaggtatg aggacctggt tcgggcaccc ctggcccaga cgaccagact
      961 atataaattt gtggggttgg attttttgcc ccacctccaa acatgggttt acaatgtcac
     1021 ccgcggcaag ggcatgggtc agcatgcctt ccatactaac gccaggaacg ccctcaacgt
     1081 ctctcaggcg tggcgttggt ccttacctta cgaaaaggtt tcccagcttc aagatgcctg
     1141 cggtgaggct atggatttgc tgggatacct ccaggtcaga tctcaacaag aacaaggcaa
     1201 cctgtccctg gatcttctgt cctcctccca tatcttgggg caggtcttcc gagaaggtta
     1261 aggaggtctg tctgcacccc ttggttccag ccttagtcac cattaaacgc acagaagcct
     1321 taaggtataa ccaaactgag tgcccctttc tcctcagccc caagcagagg ggtctttgtg
     1381 tctatactca tgtctaccct acaactgagc ctaaaaagcc aagaaacagt atctttctgt
     1441 cttgaaaata cttaggaacc ttaagcagcc cctttgacct gtcaagcaag actttcttgt
     1501 aaccttggcc ttcttacctg tgcatacctt ggagactacg gtctggaggc atactggaca
     1561 cagcaaacag catctgtgga gtgtgtctgt aaacctccct gtccacatct ttccgaagag
     1621 aaaggggaga ataaaagcca aggaaacgcg gctcttacca aagagctccc agaaacttcc
     1681 acagagacat agaccctcaa agtttccaga ggatttgagg aagcaggagc gggggtgggt
     1741 gcttatctgt gaatctctgc ccattgtcac tatcagtaat cagaaacagg aagcaaacaa
     1801 cacaacaggg gcagagctca agttcaaggc gtgtctggta tggatggcat ctctcctcag
     1861 tgttttcctg gcattcagga tgctgacctg tggaacggcc ccgcagtaaa actatatcct
     1921 cagcttctgt cttgactttc ctatgtatgt tttctaacta cccatcgccg atgctcattc
     1981 tcacggggtt ctaacaacag
//
