LOCUS       NP_036128                388 aa            linear   ROD 14-JUN-2024
DEFINITION  carbohydrate sulfotransferase 4 [Mus musculus].
ACCESSION   NP_036128
VERSION     NP_036128.3
DBSOURCE    REFSEQ: accession NM_011998.5
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 388)
  AUTHORS   Liu,W., Xiong,W., Liu,W., Hirakawa,J. and Kawashima,H.
  TITLE     A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans
            attenuates murine allergic rhinitis by suppressing Th2 immune
            responses
  JOURNAL   Sci Rep 13 (1), 15740 (2023)
   PUBMED   37735247
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 388)
  AUTHORS   Abo,H., Muraki,A., Harusato,A., Imura,T., Suzuki,M., Takahashi,K.,
            Denning,T.L. and Kawashima,H.
  TITLE     N-acetylglucosamine-6-O sulfation on intestinal mucins prevents
            obesity and intestinal inflammation by regulating gut microbiota
  JOURNAL   JCI Insight 8 (16), e165944 (2023)
   PUBMED   37463055
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 388)
  AUTHORS   Kawakubo,M., Komura,H., Goso,Y., Okumura,M., Sato,Y., Fujii,C.,
            Miyashita,M., Arisaka,N., Harumiya,S., Yamanoi,K., Yamada,S.,
            Kakuta,S., Kawashima,H., Fukuda,M.N., Fukuda,M. and Nakayama,J.
  TITLE     Analysis of A4gnt Knockout Mice Reveals an Essential Role for
            Gastric Sulfomucins in Preventing Gastritis Cystica Profunda
  JOURNAL   J Histochem Cytochem 67 (10), 759-770 (2019)
   PUBMED   31246144
REFERENCE   4  (residues 1 to 388)
  AUTHORS   Narentuya, Takeda-Uchimura,Y., Foyez,T., Zhang,Z., Akama,T.O.,
            Yagi,H., Kato,K., Komatsu,Y., Kadomatsu,K. and Uchimura,K.
  TITLE     GlcNAc6ST3 is a keratan sulfate sulfotransferase for the
            protein-tyrosine phosphatase PTPRZ in the adult brain
  JOURNAL   Sci Rep 9 (1), 4387 (2019)
   PUBMED   30867513
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 388)
  AUTHORS   Patnode,M.L., Yu,S.Y., Cheng,C.W., Ho,M.Y., Tegesjo,L., Sakuma,K.,
            Uchimura,K., Khoo,K.H., Kannagi,R. and Rosen,S.D.
  TITLE     KSGal6ST generates galactose-6-O-sulfate in high endothelial
            venules but does not contribute to L-selectin-dependent lymphocyte
            homing
  JOURNAL   Glycobiology 23 (3), 381-394 (2013)
   PUBMED   23254996
REFERENCE   6  (residues 1 to 388)
  AUTHORS   Hemmerich,S., Bistrup,A., Singer,M.S., van Zante,A., Lee,J.K.,
            Tsay,D., Peters,M., Carminati,J.L., Brennan,T.J., Carver-Moore,K.,
            Leviten,M., Fuentes,M.E., Ruddle,N.H. and Rosen,S.D.
  TITLE     Sulfation of L-selectin ligands by an HEV-restricted
            sulfotransferase regulates lymphocyte homing to lymph nodes
  JOURNAL   Immunity 15 (2), 237-247 (2001)
   PUBMED   11520459
REFERENCE   7  (residues 1 to 388)
  AUTHORS   Hemmerich,S., Lee,J.K., Bhakta,S., Bistrup,A., Ruddle,N.R. and
            Rosen,S.D.
  TITLE     Chromosomal localization and genomic organization for the
            galactose/ N-acetylgalactosamine/N-acetylglucosamine
            6-O-sulfotransferase gene family
  JOURNAL   Glycobiology 11 (1), 75-87 (2001)
   PUBMED   11181564
REFERENCE   8  (residues 1 to 388)
  AUTHORS   Lee,J.K., Bhakta,S., Rosen,S.D. and Hemmerich,S.
  TITLE     Cloning and characterization of a mammalian
            N-acetylglucosamine-6-sulfotransferase that is highly restricted to
            intestinal tissue
  JOURNAL   Biochem Biophys Res Commun 263 (2), 543-549 (1999)
   PUBMED   10491328
REFERENCE   9  (residues 1 to 388)
  AUTHORS   Hiraoka,N., Petryniak,B., Nakayama,J., Tsuboi,S., Suzuki,M.,
            Yeh,J.C., Izawa,D., Tanaka,T., Miyasaka,M., Lowe,J.B. and Fukuda,M.
  TITLE     A novel, high endothelial venule-specific sulfotransferase
            expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed
            by CD34
  JOURNAL   Immunity 11 (1), 79-89 (1999)
   PUBMED   10435581
REFERENCE   10 (residues 1 to 388)
  AUTHORS   Bistrup,A., Bhakta,S., Lee,J.K., Belov,Y.Y., Gunn,M.D., Zuo,F.R.,
            Huang,C.C., Kannagi,R., Rosen,S.D. and Hemmerich,S.
  TITLE     Sulfotransferases of two specificities function in the
            reconstitution of high endothelial cell ligands for L-selectin
  JOURNAL   J Cell Biol 145 (4), 899-910 (1999)
   PUBMED   10330415
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124409.5.
            
            On Oct 27, 2007 this sequence version replaced NP_036128.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057886.1, AK009113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..388
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.38 cM"
     Protein         1..388
                     /product="carbohydrate sulfotransferase 4"
                     /note="LSST; glcNAc6ST-2; L-selectin ligand
                     sulfotransferase; N-acetylglucosamine 6-O-sulfotransferase
                     2; high endothelial cells N-acetylglucosamine
                     6-O-sulfotransferase;
                     galactose/N-acetylglucosamine/N-acetylglucosamine
                     6-O-sulfotransferase 3; high endothelial cell
                     GlcNAC-6-sulphotransferase; carbohydrate (chondroitin
                     6/keratan) sulfotransferase 4"
                     /calculated_mol_wt=44563
     Site            8..28
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R1I1.1)"
     Region          44..297
                     /region_name="Sulfotransfer_3"
                     /note="Sulfotransferase family; cl46325"
                     /db_xref="CDD:480665"
     Region          <181..357
                     /region_name="Sulfotransfer_1"
                     /note="Sulfotransferase domain; cl21551"
                     /db_xref="CDD:473908"
     Site            307
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1I1.1)"
     Site            328
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1I1.1)"
     Site            369
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9R1I1.1)"
     CDS             1..388
                     /gene="Chst4"
                     /gene_synonym="Gn6st-2; GST-3; HEC-GlcNAc6ST"
                     /coded_by="NM_011998.5:148..1314"
                     /db_xref="CCDS:CCDS22659.1"
                     /db_xref="GeneID:26887"
                     /db_xref="MGI:MGI:1349479"
ORIGIN      
        1 mmllkkgrll mflgsqvivv alfihmsvhr hlsqreesrr pvhvlvlssw rsgssfvgql
       61 fgqhpdvfyl mepawhvwmt ftsstawklh mavrdllrsv flcdmsvfda ymnpgprkqs
      121 slfqweqsra lcsapvcdff paheisspkh ckllcgqqpf dmvekacrsh gfvvlkevrf
      181 lslqalypll tdpslnlhvv hlvrdpravf rsrehttiel mvdshivlgq hletikeedq
      241 pyyamkiick sqvdivkaiq tlpealqqry lflryedlvr aplaqttrly kfvgldflph
      301 lqtwvynvtr gkgmgqhafh tnarnalnvs qawrwslpye kvsqlqdacg eamdllgylq
      361 vrsqqeqgnl sldllssshi lgqvfreg
//
