LOCUS       NM_029935               4827 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus carbohydrate sulfotransferase 15 (Chst15), transcript
            variant 1, mRNA.
ACCESSION   NM_029935
VERSION     NM_029935.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4827)
  AUTHORS   Ye,J., Suizu,F., Yamakawa,K., Mukai,Y., Kato,M., Yoneyama,H.,
            Yahagi,N. and Matsuda,Y.
  TITLE     Silencing of tumoral carbohydrate sulfotransferase 15 reactivates
            lymph node pancreatic cancer T cells in mice
  JOURNAL   Eur J Immunol 53 (9), e2250160 (2023)
   PUBMED   37248998
  REMARK    GeneRIF: Silencing of tumoral carbohydrate sulfotransferase 15
            reactivates lymph node pancreatic cancer T cells in mice.
REFERENCE   2  (bases 1 to 4827)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4827)
  AUTHORS   Schaberg,E., Theocharidis,U., May,M., Lessmann,K., Schroeder,T. and
            Faissner,A.
  TITLE     Sulfation of Glycosaminoglycans Modulates the Cell Cycle of
            Embryonic Mouse Spinal Cord Neural Stem Cells
  JOURNAL   Front Cell Dev Biol 9, 643060 (2021)
   PUBMED   34169071
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4827)
  AUTHORS   Bachvarova,V., Dierker,T., Esko,J., Hoffmann,D., Kjellen,L. and
            Vortkamp,A.
  TITLE     Chondrocytes respond to an altered heparan sulfate composition with
            distinct changes of heparan sulfate structure and increased levels
            of chondroitin sulfate
  JOURNAL   Matrix Biol 93, 43-59 (2020)
   PUBMED   32201365
REFERENCE   5  (bases 1 to 4827)
  AUTHORS   Nadanaka,S., Miyata,S., Yaqiang,B., Tamura,J.I., Habuchi,O. and
            Kitagawa,H.
  TITLE     Reconsideration of the Semaphorin-3A Binding Motif Found in
            Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice
  JOURNAL   Biomolecules 10 (11), 1499 (2020)
   PUBMED   33143303
  REMARK    GeneRIF: Reconsideration of the Semaphorin-3A Binding Motif Found
            in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4827)
  AUTHORS   Ohtake,S., Kondo,S., Morisaki,T., Matsumura,K., Kimata,K. and
            Habuchi,O.
  TITLE     Expression of sulfotransferases involved in the biosynthesis of
            chondroitin sulfate E in the bone marrow derived mast cells
  JOURNAL   Biochim Biophys Acta 1780 (4), 687-695 (2008)
   PUBMED   18237557
REFERENCE   7  (bases 1 to 4827)
  AUTHORS   Akita,K., von Holst,A., Furukawa,Y., Mikami,T., Sugahara,K. and
            Faissner,A.
  TITLE     Expression of multiple chondroitin/dermatan sulfotransferases in
            the neurogenic regions of the embryonic and adult central nervous
            system implies that complex chondroitin sulfates have a role in
            neural stem cell maintenance
  JOURNAL   Stem Cells 26 (3), 798-809 (2008)
   PUBMED   18079434
REFERENCE   8  (bases 1 to 4827)
  AUTHORS   Salgueiro,A.M., Filipe,M. and Belo,J.A.
  TITLE     N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase expression
            during early mouse embryonic development
  JOURNAL   Int J Dev Biol 50 (8), 705-708 (2006)
   PUBMED   17051481
  REMARK    GeneRIF: GalNAc4S-6ST has a role during early mouse development
REFERENCE   9  (bases 1 to 4827)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (bases 1 to 4827)
  AUTHORS   Verkoczy,L.K., Marsden,P.A. and Berinstein,N.L.
  TITLE     hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane
            glycoprotein potentially involved in the regulation of
            recombination activating gene 1 (RAG1)
  JOURNAL   Eur J Immunol 28 (9), 2839-2853 (1998)
   PUBMED   9754571
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB842314.1, AK082318.1, AC101690.7 and AW491120.1.
            
            On Feb 13, 2018 this sequence version replaced NM_029935.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083614.1, AK082318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BB842314.1         1-43
            44-3494             AK082318.1         37-3487
            3495-4430           AC101690.7         90728-91663         c
            4431-4827           AW491120.1         1-397               c
FEATURES             Location/Qualifiers
     source          1..4827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 76.29 cM"
     gene            1..4827
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /note="carbohydrate sulfotransferase 15"
                     /db_xref="GeneID:77590"
                     /db_xref="MGI:MGI:1924840"
     exon            1..182
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /inference="alignment:Splign:2.1.0"
     exon            183..1179
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /inference="alignment:Splign:2.1.0"
     CDS             634..2319
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /EC_number="2.8.2.33"
                     /note="GalNAc 4-sulfate 6-O-sulfotransferase; B-cell
                     RAG-associated gene protein; N-acetylgalactosamine
                     4-sulfate 6-O-sulfotransferase; carbohydrate
                     (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 15"
                     /protein_id="NP_084211.2"
                     /db_xref="CCDS:CCDS21922.1"
                     /db_xref="GeneID:77590"
                     /db_xref="MGI:MGI:1924840"
                     /translation="MRHCINCCVQLFPEDTHKQQVACQGGPHHSHQACPTCKGENKIL
                     FRVDSKQMNLLAVLEVRTEGNENWGGFLRFRKGKRCSLVFGLIIMTLVMASYILSGAH
                     QELLISSPFHYGGFPSNPSVMDGENPSDVKEHHYQPSVNNISYVKDYPSIKLIIDSIA
                     ARIEFTTRQLPDLQDLKRQELHMFSVIPSKFLPTSKSPCWYEEFSGRNTTDPYLTNSY
                     VLYSKRFRSTFDALRKVFWGHLSHVQGKHFRLRCLPHFYIIGQPKCGTTDLYDRLRLH
                     PEVKFSAIKEPHWWTRKRFGIVRLRDGLRDRYPVEDYLDLFDLAAHQIHQGLQAASAE
                     QPSKMNKIIIGEASASTMWDNNAWTFFYDNSTDGEPPFLTQDFIHAFQPEAKLIVMLR
                     DPVERLYSDYLYFASSNKSADDFHEKVTEALQLFENCMLDYSLRACVYNNTLNNAMPV
                     RLQVGLYAVYLLDWLTVFSKEQFLILRLEDHASNVKYTMHKVFQFLNLGPLSEKQEAL
                     MTKSPASNTRRPEDRSLGPMWPITQKILREFYGPFNTRLAQVLDDEAFAWKTT"
     exon            1180..1519
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1666
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1823
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..1980
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2128
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..4813
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4758..4763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /note="hexamer: ATTAAA"
     polyA_site      4778
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
     polyA_site      4812
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /note="major polyA site"
ORIGIN      
        1 gggggagggt tctgttcaga ggtttcattc gccatctgca agtcactccc aaacttttcc
       61 tcccagcgct cggggagtca ggttgacgcg ccctgggtgc ggggtgctag gcgcggggct
      121 gggcgcgcgc tcccgcggag tcggagctgc agaggcttcc gagatcgtct tgggcttttc
      181 aggtcaccta gcattggtat gaatctgctc ctcaagaaga gaaaatattc tgaaggcatg
      241 tccgtttacc tgtcaacgag gaacccataa tgtcttctca tctccagtgt ggctccatgc
      301 tctctcctga tgctactcca actttctttg gtgccatggg aaaaacctga agcacgagca
      361 gagtcacctc caaatctgtg ctcacttcat tttgttgcat ggctggtgcg gaacagacta
      421 ttggaatttg ctcctgtgtg ttgcccttcg tacctgaacc aaagactgtg cctcattctc
      481 tagtgcattg ctgcctgctg tcttcctcgt tcatttctgt tgcttgtgcc ttcctactgt
      541 cttctgtcat cacaggacac ccttaaagtt tctcactgga ctcctcgagg gctggcccat
      601 ggctctctaa gccagctgtc caaggtctct accatgaggc attgcattaa ttgctgcgtc
      661 cagctgttcc ccgaagacac acacaaacag caagttgcct gccaaggagg cccccatcac
      721 agtcatcagg cgtgccccac ttgcaaagga gaaaacaaaa ttctgtttcg tgtggacagt
      781 aagcagatga acttgcttgc tgttctcgaa gtgaggactg agggcaatga aaactggggt
      841 gggtttttgc gcttcaggaa ggggaagcga tgtagcctgg tctttggatt gataataatg
      901 accttggtga tggcttctta catcctttcc ggggctcatc aggaacttct gatttcctcc
      961 cctttccatt atgggggctt tcccagcaac cccagcgtga tggatggtga gaaccccagt
     1021 gatgtgaaag agcatcacta ccagccttct gtaaataaca tctcctatgt aaaggactat
     1081 ccgagcatta aactgattat cgacagcatt gctgccagga ttgagttcac aaccaggcag
     1141 ctcccggact tacaagatct caagagacaa gagttgcata tgttttctgt aatccccagc
     1201 aaattcctcc cgactagcaa gagcccttgt tggtatgagg agttctcggg caggaacacc
     1261 actgacccct acctgaccaa ttcctacgtg ctctactcca agcggttccg ctctaccttt
     1321 gacgctctgc gcaaggtttt ctggggccac ctgtcccacg tgcagggcaa gcacttccgc
     1381 ctgcgctgcc tgccccactt ctacatcatt gggcagccca agtgtggaac cactgacctg
     1441 tacgaccgcc tccggctgca tccagaagtg aaattctcag ccatcaagga gccgcactgg
     1501 tggacccgga agcgctttgg aattgtccgc ctgcgggacg gactacgaga ccgctaccct
     1561 gtggaagatt acctggacct ctttgacttg gctgcacacc agatccatca aggactgcag
     1621 gctgcctctg cagagcagcc cagcaagatg aataagatca ttattggaga ggccagcgcc
     1681 tctacaatgt gggataacaa tgcctggacc ttcttctatg acaacagcac agacggcgag
     1741 ccaccattcc tgacccaaga cttcatccat gcctttcaac cagaagccaa gctcattgtt
     1801 atgctcaggg atcctgtgga gaggttgtac tcagactatc tctacttcgc aagttccaat
     1861 aaatctgcag atgacttcca cgagaaagtg acggaggctc tgcagctgtt tgaaaattgc
     1921 atgctggatt attcactgcg cgcctgcgtc tacaacaaca ccctgaacaa tgccatgccc
     1981 gtgaggctcc aggttggcct gtatgctgtg tacctcctgg attggctgac tgtcttcagt
     2041 aaggagcagt tcctcattct ccgtctggaa gaccacgcat ccaatgtcaa gtataccatg
     2101 cacaaggtct tccagtttct aaacctgggg cctctgagtg agaagcagga agctctgatg
     2161 accaagagcc ctgcatccaa cacacggcgt cctgaggatc gtagtctggg acccatgtgg
     2221 cccatcaccc agaagattct gcgtgaattc tatgggcctt tcaacacaag gctggcacag
     2281 gtcttggatg acgaagcatt tgcctggaag acaacgtgag agctgagtcc cttctgcaga
     2341 agctgggccc actgactctg tcattgccat gactttaaaa gtctccaggc ggagaactgt
     2401 cacccacagc gtggagaaag ccgctggagc cccacccaat cctcttctca tgtccaaggc
     2461 acctggtgtg ggaactattt taaagctttc cttgccatgt tcagcagctc tgctcttgat
     2521 tgcaaggctc gtccacctga agccttggaa acgacactgg gggtaggctt ctgtctgttc
     2581 ccagagtgcc ttggatctca ggagggcagt ggatctctgg cacccagtgg gtaggaagag
     2641 gaagctacgg gaggccatag accagccttg ccttccttcc tccaggagag tttgtctggg
     2701 tgtagggttg gacagctctg ggatccgatt aaggccatgt tctggggctg cccctcacgt
     2761 gttatatccc agcaggcctt gcataaatcg acaaccccat gtggacagag aacagagctg
     2821 cttggagaat ggaggctctt tcgtttttgt tcgtattccc aagtcagccc ttcggtgaca
     2881 tcagaaatga gccctgttcc ctttgctgtg ctcagaagaa actcagaagt cagcttttgg
     2941 cagtaggctc gtctctctga cctattctgc ccatacactt tgtttatgcc cagcgtagag
     3001 aaggagcgtt ttaaaacaaa ctgcttctcg catttgactg gccctgcctc tcttttctgc
     3061 tcccttggat gttttcctta aggacttcag tttatatttg gaaagggaag ttttgctgtt
     3121 aatgccagaa cagaacacct caaggcatcg aacagtggaa aaggaaggaa gtgaagccct
     3181 ccccatttgt gggggtcact ggagagtgtg gggatgtttt tggttctggc tggttacagg
     3241 ctcccccctg tcttcctgtt ggaggaatct ttatccacat tctctgtcat gtgcagccaa
     3301 agttctgtaa ctcactaagg gtgagtctca agacaccctt agaatgtcct cagaaacaca
     3361 tctcacaaac taagctcggg ccacatgtgg tgtcactagg agatagcttt gatttttatg
     3421 aacctttcca ggcctgctag cagcttggtt cgcaaaggat atgctgaaag tcttgtcatt
     3481 ttaaaaaaaa aaaaagaccc cagggaatac cagagagaac aacttaaacc cacttggcac
     3541 acaggacaag gtggggatgt cacaaagctt ttcattggag cgttgccaag ggatgctgcc
     3601 tgtgaagctg tgttctcagg tcaggatcct gttcaccagc gtcagaaagt gtacacacca
     3661 catgcccgac tgtcacttgg acgtgtgaga aaagctgggc tttggcagca ggaggctgtg
     3721 cagttgctcg actgtgtgag ttctgctgcg gtccaccctt gttggagatg ggactctcag
     3781 ctcattggaa ggttccggga gagctctggg catcagcatg gactgggctc gttctgctac
     3841 tgaaggggct gtgtgtcatg tggcctgtgt tccaggacaa ttctcccttc tctcacggtg
     3901 gccacttggc tcggcagcca gtgggaaaat ctagcctgag tacaaggatg ctttgggaag
     3961 aaatgacgag agagagagag agagagagag agagagagag agagagagag agagagcgag
     4021 agagagcgca agctcaagcg caagcgtgtg agaaagagca cgagagagta tttatttgga
     4081 ataccgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgcgtgcg
     4141 cgcgcgagtg tgcgcgcgaa cactcgtgct tatactgagc agggccctct cagctgtctt
     4201 gttgatgggg cttctcctcc attagagaca tgatgccttt atgaattaat ttctccaacc
     4261 cttcgcctgt catttccagg acatatctta ctgccccaca ccaaccacga ctctaagaga
     4321 ttttttctga cgcactccta tgcatgtgaa taacatgtcg cgtgattctg cttcttacag
     4381 aagtattgcc aaaggtatta tttccaatat tatttggttc attgctgatc tttttttata
     4441 cgtgcagccc cttcctttcc gccatgcgtg gccatccgga cccagtcttc tctctattgc
     4501 tccctccccg ggggtcaccg gcactgcctt tgcttttgct cggttggagc cccctcttgt
     4561 tgagagcaca ggcagtgttt tgggtgatgg ctcttgagcc tgtcacccca aaccaaagcg
     4621 aaacacagac ctggtaccga agacacttcg tattcccaaa gccgtgtgcc agggtgtatg
     4681 acaccttccc tcccttgtcg tgtaaggtat gatatgcgag tcacatttat tctgtacttt
     4741 tactcatatt taaaataatt aaagatggac ccacacaact ggtgcctgcc aagagtgagt
     4801 cctccttcac aagaaaaaaa aaaaaaa
//
