LOCUS       NP_084211                561 aa            linear   ROD 05-JUN-2024
DEFINITION  carbohydrate sulfotransferase 15 [Mus musculus].
ACCESSION   NP_084211
VERSION     NP_084211.2
DBSOURCE    REFSEQ: accession NM_029935.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 561)
  AUTHORS   Ye,J., Suizu,F., Yamakawa,K., Mukai,Y., Kato,M., Yoneyama,H.,
            Yahagi,N. and Matsuda,Y.
  TITLE     Silencing of tumoral carbohydrate sulfotransferase 15 reactivates
            lymph node pancreatic cancer T cells in mice
  JOURNAL   Eur J Immunol 53 (9), e2250160 (2023)
   PUBMED   37248998
  REMARK    GeneRIF: Silencing of tumoral carbohydrate sulfotransferase 15
            reactivates lymph node pancreatic cancer T cells in mice.
REFERENCE   2  (residues 1 to 561)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 561)
  AUTHORS   Schaberg,E., Theocharidis,U., May,M., Lessmann,K., Schroeder,T. and
            Faissner,A.
  TITLE     Sulfation of Glycosaminoglycans Modulates the Cell Cycle of
            Embryonic Mouse Spinal Cord Neural Stem Cells
  JOURNAL   Front Cell Dev Biol 9, 643060 (2021)
   PUBMED   34169071
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 561)
  AUTHORS   Bachvarova,V., Dierker,T., Esko,J., Hoffmann,D., Kjellen,L. and
            Vortkamp,A.
  TITLE     Chondrocytes respond to an altered heparan sulfate composition with
            distinct changes of heparan sulfate structure and increased levels
            of chondroitin sulfate
  JOURNAL   Matrix Biol 93, 43-59 (2020)
   PUBMED   32201365
REFERENCE   5  (residues 1 to 561)
  AUTHORS   Nadanaka,S., Miyata,S., Yaqiang,B., Tamura,J.I., Habuchi,O. and
            Kitagawa,H.
  TITLE     Reconsideration of the Semaphorin-3A Binding Motif Found in
            Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice
  JOURNAL   Biomolecules 10 (11), 1499 (2020)
   PUBMED   33143303
  REMARK    GeneRIF: Reconsideration of the Semaphorin-3A Binding Motif Found
            in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 561)
  AUTHORS   Ohtake,S., Kondo,S., Morisaki,T., Matsumura,K., Kimata,K. and
            Habuchi,O.
  TITLE     Expression of sulfotransferases involved in the biosynthesis of
            chondroitin sulfate E in the bone marrow derived mast cells
  JOURNAL   Biochim Biophys Acta 1780 (4), 687-695 (2008)
   PUBMED   18237557
REFERENCE   7  (residues 1 to 561)
  AUTHORS   Akita,K., von Holst,A., Furukawa,Y., Mikami,T., Sugahara,K. and
            Faissner,A.
  TITLE     Expression of multiple chondroitin/dermatan sulfotransferases in
            the neurogenic regions of the embryonic and adult central nervous
            system implies that complex chondroitin sulfates have a role in
            neural stem cell maintenance
  JOURNAL   Stem Cells 26 (3), 798-809 (2008)
   PUBMED   18079434
REFERENCE   8  (residues 1 to 561)
  AUTHORS   Salgueiro,A.M., Filipe,M. and Belo,J.A.
  TITLE     N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase expression
            during early mouse embryonic development
  JOURNAL   Int J Dev Biol 50 (8), 705-708 (2006)
   PUBMED   17051481
  REMARK    GeneRIF: GalNAc4S-6ST has a role during early mouse development
REFERENCE   9  (residues 1 to 561)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   10 (residues 1 to 561)
  AUTHORS   Verkoczy,L.K., Marsden,P.A. and Berinstein,N.L.
  TITLE     hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane
            glycoprotein potentially involved in the regulation of
            recombination activating gene 1 (RAG1)
  JOURNAL   Eur J Immunol 28 (9), 2839-2853 (1998)
   PUBMED   9754571
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB842314.1, AK082318.1, AC101690.7 and AW491120.1.
            
            On Jun 10, 2003 this sequence version replaced NP_084211.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083614.1, AK082318.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..561
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 76.29 cM"
     Protein         1..561
                     /product="carbohydrate sulfotransferase 15"
                     /EC_number="2.8.2.33"
                     /note="GalNAc 4-sulfate 6-O-sulfotransferase; B-cell
                     RAG-associated gene protein; N-acetylgalactosamine
                     4-sulfate 6-O-sulfotransferase; carbohydrate
                     (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15"
                     /calculated_mol_wt=64855
     Site            81..101
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91XQ5.1)"
     Region          253..>505
                     /region_name="Sulfotransfer_1"
                     /note="Sulfotransferase domain; cl21551"
                     /db_xref="CDD:473908"
     Site            364
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q91XQ5.1)"
     CDS             1..561
                     /gene="Chst15"
                     /gene_synonym="4631426J05Rik; BRAG; GalNAc4S-6ST;
                     GalNAcS-6ST; MAd5; mKIAA0598"
                     /coded_by="NM_029935.6:634..2319"
                     /db_xref="CCDS:CCDS21922.1"
                     /db_xref="GeneID:77590"
                     /db_xref="MGI:MGI:1924840"
ORIGIN      
        1 mrhcinccvq lfpedthkqq vacqggphhs hqacptckge nkilfrvdsk qmnllavlev
       61 rtegnenwgg flrfrkgkrc slvfgliimt lvmasyilsg ahqellissp fhyggfpsnp
      121 svmdgenpsd vkehhyqpsv nnisyvkdyp sikliidsia ariefttrql pdlqdlkrqe
      181 lhmfsvipsk flptskspcw yeefsgrntt dpyltnsyvl yskrfrstfd alrkvfwghl
      241 shvqgkhfrl rclphfyiig qpkcgttdly drlrlhpevk fsaikephww trkrfgivrl
      301 rdglrdrypv edyldlfdla ahqihqglqa asaeqpskmn kiiigeasas tmwdnnawtf
      361 fydnstdgep pfltqdfiha fqpeaklivm lrdpverlys dylyfassnk saddfhekvt
      421 ealqlfencm ldyslracvy nntlnnampv rlqvglyavy lldwltvfsk eqflilrled
      481 hasnvkytmh kvfqflnlgp lsekqealmt kspasntrrp edrslgpmwp itqkilrefy
      541 gpfntrlaqv lddeafawkt t
//
