LOCUS       NM_028117               2089 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus carbohydrate sulfotransferase 14 (Chst14), mRNA.
ACCESSION   NM_028117
VERSION     NM_028117.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2089)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2089)
  AUTHORS   Hirose,T., Mizumoto,S., Hashimoto,A., Takahashi,Y., Yoshizawa,T.,
            Nitahara-Kasahara,Y., Takahashi,N., Nakayama,J., Takehana,K.,
            Okada,T., Nomura,Y., Yamada,S., Kosho,T. and Watanabe,T.
  TITLE     Systematic investigation of the skin in Chst14-/- mice: A model for
            skin fragility in musculocontractural Ehlers-Danlos syndrome caused
            by CHST14 variants (mcEDS-CHST14)
  JOURNAL   Glycobiology 31 (2), 137-150 (2021)
   PUBMED   32601684
  REMARK    GeneRIF: Systematic investigation of the skin in Chst14-/- mice: A
            model for skin fragility in musculocontractural Ehlers-Danlos
            syndrome caused by CHST14 variants (mcEDS-CHST14).
REFERENCE   3  (bases 1 to 2089)
  AUTHORS   Shimada,S., Yoshizawa,T., Takahashi,Y., Nitahara-Kasahara,Y.,
            Okada,T., Nomura,Y., Yamanaka,H., Kosho,T. and Matsumoto,K.
  TITLE     Backcrossing to an appropriate genetic background improves the
            birth rate of carbohydrate sulfotransferase 14 gene-deleted mice
  JOURNAL   Exp Anim 69 (4), 407-413 (2020)
   PUBMED   32522905
REFERENCE   4  (bases 1 to 2089)
  AUTHORS   Li,Q., Wu,X., Na,X., Ge,B., Wu,Q., Guo,X., Ntim,M., Zhang,Y.,
            Sun,Y., Yang,J., Xiao,Z., Zhao,J. and Li,S.
  TITLE     Impaired Cognitive Function and Altered Hippocampal Synaptic
            Plasticity in Mice Lacking Dermatan Sulfotransferase Chst14/D4st1
  JOURNAL   Front Mol Neurosci 12, 26 (2019)
   PUBMED   30853887
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2089)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2089)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 2089)
  AUTHORS   Ishii,M. and Maeda,N.
  TITLE     Oversulfated chondroitin sulfate plays critical roles in the
            neuronal migration in the cerebral cortex
  JOURNAL   J Biol Chem 283 (47), 32610-32620 (2008)
   PUBMED   18819920
  REMARK    GeneRIF: analysis of the three CS sulfotransferases in the
            developing neocortex: uronyl 2-O-sulfotransferase (UST),
            N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (4,6-ST) and
            dermatan 4-O-sulfotransferase-1 (D4-ST)
REFERENCE   8  (bases 1 to 2089)
  AUTHORS   Akita,K., von Holst,A., Furukawa,Y., Mikami,T., Sugahara,K. and
            Faissner,A.
  TITLE     Expression of multiple chondroitin/dermatan sulfotransferases in
            the neurogenic regions of the embryonic and adult central nervous
            system implies that complex chondroitin sulfates have a role in
            neural stem cell maintenance
  JOURNAL   Stem Cells 26 (3), 798-809 (2008)
   PUBMED   18079434
REFERENCE   9  (bases 1 to 2089)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 2089)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845164.5.
            
            On Jul 21, 2009 this sequence version replaced NM_028117.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC085479.1, AK154555.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2089              AL845164.5         17768-19856
FEATURES             Location/Qualifiers
     source          1..2089
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.73 cM"
     gene            1..2089
                     /gene="Chst14"
                     /gene_synonym="2600016L03Rik; D4ST-1; D4st1"
                     /note="carbohydrate sulfotransferase 14"
                     /db_xref="GeneID:72136"
                     /db_xref="MGI:MGI:1919386"
     exon            1..2089
                     /gene="Chst14"
                     /gene_synonym="2600016L03Rik; D4ST-1; D4st1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1286
                     /gene="Chst14"
                     /gene_synonym="2600016L03Rik; D4ST-1; D4st1"
                     /EC_number="2.8.2.35"
                     /note="dermatan 4-sulfotransferase 1; carbohydrate
                     (N-acetylgalactosamine 4-0) sulfotransferase 14"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 14"
                     /protein_id="NP_082393.3"
                     /db_xref="CCDS:CCDS16587.1"
                     /db_xref="GeneID:72136"
                     /db_xref="MGI:MGI:1919386"
                     /translation="MFPRPLTPLAAPKSAETLGRTPRRAPLGRARAGLGGPPLLLPSM
                     LMFAVIVASSGLLLMIERGILSEMKPLPLHPPSHKGAAWSGTDPKPRGLSLDAGDSDL
                     QVREDIRNRTLRAVCGQPGMPRDPWDLPVGQRRTLLRHILVSDRYRFLYCYVPKVACS
                     NWKRVLKVLAGILNNVDVRLKMDHRSDLVFLADLRPEEIRYRLQHYFKFLFVRDPLER
                     LLSAYRNKFGEIREYQQRYGAEIVRRYRAGAGPSPAGDDVTFPEFLRYLVDEDPEHMN
                     EHWMPVYHLCQPCAVHYDFVGSYERLEADANQVLEWVRAPPHVRFPARQAWYRPASPE
                     SLHYHLCNVPRALLQDVLPKYILDFSLFAYPLPNVTKEACHQ"
     regulatory      2066..2071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chst14"
                     /gene_synonym="2600016L03Rik; D4ST-1; D4st1"
                     /note="hexamer: AATAAA"
     polyA_site      2089
                     /gene="Chst14"
                     /gene_synonym="2600016L03Rik; D4ST-1; D4st1"
                     /note="major polyA site"
ORIGIN      
        1 ggagagaaga gcggccgggc gggacatccg gccctggtcc ctgcctgcac cccgggagct
       61 ggccacccac tatccctccc ctcccgagac ctccagcccc tgctgcagtc acctcccctg
      121 cagcctcgag gtcggcgagg tctggccgca gcaccatgtt tccccgccct ctgaccccac
      181 tggctgcccc gaaaagcgcg gagaccctgg gccgcacgcc aaggcgggcc ccattgggcc
      241 gggcccgggc tgggctcggg gggccgcccc tgctgctgcc gtccatgctg atgttcgctg
      301 taatcgtggc ctccagcgga ctgctgctca tgatcgagcg aggcatccta tcggagatga
      361 aaccccttcc cctgcaccct cccagccaca aaggcgcggc ctggagcggg acagatccta
      421 agcctagagg cctatccttg gatgctgggg actcggactt gcaagtgagg gaggacatcc
      481 gaaaccggac cttgagggcc gtgtgcggac aaccaggcat gccccgggac ccctgggact
      541 tgccggtggg acagcggcgc accctgctgc gccacattct cgtaagtgac cgctaccgct
      601 tcctctactg ctatgtcccc aaagtggcct gctctaactg gaaacgtgtg ctgaaggtgc
      661 tggctggcat cctgaacaac gtggatgtcc gcctcaagat ggaccaccgc agtgacttgg
      721 tgtttctggc agacctgcgg cctgaggaga ttcgctaccg tctgcagcac tacttcaagt
      781 tcctgtttgt gcgagacccc ttggaacgcc tcctgtctgc ttaccgtaac aagtttggag
      841 agatccgaga gtaccagcag cgatatgggg ccgaaattgt caggcgctac agggctggag
      901 ctggccccag ccctgcaggg gacgatgtca ccttcccaga gttcctgaga tacctggtgg
      961 atgaggatcc tgaacatatg aatgagcatt ggatgcctgt gtaccacctg tgccaaccat
     1021 gtgctgtgca ctacgacttc gtgggttcct atgagaggct ggaggctgat gccaaccagg
     1081 tgctggagtg ggtgcgggcc ccaccccatg tccggttccc agctcgccag gcctggtacc
     1141 ggccagccag cccagaaagt ctgcattacc acttgtgcaa tgttccacgg gccctgcttc
     1201 aagatgtgct acctaagtat atcctggact tctccctctt tgcttaccca ctgcccaatg
     1261 tcaccaagga agcctgtcac caatgacagt aggccagcac cttttggagt ttgggtttaa
     1321 tgatatcagc tttgggatgt ctttcagaga aactcctggc tctgggtggc ttcctggttt
     1381 ctctaggtgt ctccatatct cagtggtaag gactgtcctt ggaggtcctt gtccacagtg
     1441 gctcagagga cagagctaga aaggaggcct gctgctttca ctggtgaact gcctctctta
     1501 ggggcctgtg gtatccgtgt ctgcagggca ccagtggtta ttaaagccat atgtttgatc
     1561 gaaagactga cttcagcccc ctggctgctg ggtctatgca gtccacctgg tctgttgtaa
     1621 tttaacctgt ggccaaatcc caaatatgac actagccaag cacatgatca tgcctaggac
     1681 caatggctgt gaccccctat tcacccatcc catggacctc aggactggag tgagctgtgg
     1741 tgccttagaa atgaaatgtg tgcaattcta ctccagactt ttacatttcc tcctcttgct
     1801 aggtctgaat catttttcta aggaaagaga aacggaagtg gggcccttac ctcgaagctc
     1861 taaagcccag cccctcaagc atccaaagac gcctgtgcct gacctcttcc tagggctcct
     1921 ggagcatctt caataagcct cccttcccta caaacctttg gagactatgt gagactgtac
     1981 agcccatata tctggctgtc acttgtctaa tgcatttatt taaaatgtgt atattttaat
     2041 aggatccttg taagggctaa cttttaataa agctttttca tatacaaaa
//
