LOCUS       NM_021439               5528 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Mus musculus carbohydrate sulfotransferase 11 (Chst11), mRNA.
ACCESSION   NM_021439
VERSION     NM_021439.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5528)
  AUTHORS   Tao,C., Makrides,N., Chuang,J.Z., Wu,Y., Brooks,S.E., Esko,J.D.,
            Sung,C.H. and Zhang,X.
  TITLE     Chondroitin sulfate enhances the barrier function of basement
            membrane assembled by heparan sulfate
  JOURNAL   Development 149 (12) (2022)
   PUBMED   35608020
REFERENCE   2  (bases 1 to 5528)
  AUTHORS   Rios,J.J., Denton,K., Russell,J., Kozlitina,J., Ferreira,C.R.,
            Lewanda,A.F., Mayfield,J.E., Moresco,E., Ludwig,S., Tang,M., Li,X.,
            Lyon,S., Khanshour,A., Paria,N., Khalid,A., Li,Y., Xie,X.,
            Feng,J.Q., Xu,Q., Lu,Y., Hammer,R.E., Wise,C.A. and Beutler,B.
  TITLE     Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice
  JOURNAL   J Bone Miner Res 36 (8), 1548-1565 (2021)
   PUBMED   33905568
REFERENCE   3  (bases 1 to 5528)
  AUTHORS   Schaberg,E., Theocharidis,U., May,M., Lessmann,K., Schroeder,T. and
            Faissner,A.
  TITLE     Sulfation of Glycosaminoglycans Modulates the Cell Cycle of
            Embryonic Mouse Spinal Cord Neural Stem Cells
  JOURNAL   Front Cell Dev Biol 9, 643060 (2021)
   PUBMED   34169071
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5528)
  AUTHORS   Bachvarova,V., Dierker,T., Esko,J., Hoffmann,D., Kjellen,L. and
            Vortkamp,A.
  TITLE     Chondrocytes respond to an altered heparan sulfate composition with
            distinct changes of heparan sulfate structure and increased levels
            of chondroitin sulfate
  JOURNAL   Matrix Biol 93, 43-59 (2020)
   PUBMED   32201365
REFERENCE   5  (bases 1 to 5528)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5528)
  AUTHORS   Kluppel,M., Wight,T.N., Chan,C., Hinek,A. and Wrana,J.L.
  TITLE     Maintenance of chondroitin sulfation balance by
            chondroitin-4-sulfotransferase 1 is required for chondrocyte
            development and growth factor signaling during cartilage
            morphogenesis
  JOURNAL   Development 132 (17), 3989-4003 (2005)
   PUBMED   16079159
  REMARK    GeneRIF: chondroitin 4-O-sulfation by C4st1 is required for proper
            chondroitin sulfate localization, modulation of distinct signaling
            pathways and cartilage growth plate morphogenesis
REFERENCE   7  (bases 1 to 5528)
  AUTHORS   Kluppel,M., Vallis,K.A. and Wrana,J.L.
  TITLE     A high-throughput induction gene trap approach defines C4ST as a
            target of BMP signaling
  JOURNAL   Mech Dev 118 (1-2), 77-89 (2002)
   PUBMED   12351172
  REMARK    GeneRIF: a gene was identified for Chondroitin-4-sulfotransferase
            and displays a highly specific temporal and spatial expression
            pattern during mouse embryogenesis
REFERENCE   8  (bases 1 to 5528)
  AUTHORS   Xia,G., Evers,M.R., Kang,H.G., Schachner,M. and Baenziger,J.U.
  TITLE     Molecular cloning and expression of the pituitary glycoprotein
            hormone N-acetylgalactosamine-4-O-sulfotransferase
  JOURNAL   J Biol Chem 275 (49), 38402-38409 (2000)
   PUBMED   10988300
REFERENCE   9  (bases 1 to 5528)
  AUTHORS   Okuda,T., Mita,S., Yamauchi,S., Matsubara,T., Yagi,F., Yamamori,D.,
            Fukuta,M., Kuroiwa,A., Matsuda,Y. and Habuchi,O.
  TITLE     Molecular cloning, expression, and chromosomal mapping of human
            chondroitin 4-sulfotransferase, whose expression pattern in human
            tissues is different from that of chondroitin 6-sulfotransferase
  JOURNAL   J Biochem 128 (5), 763-770 (2000)
   PUBMED   11056388
REFERENCE   10 (bases 1 to 5528)
  AUTHORS   Yamauchi,S., Mita,S., Matsubara,T., Fukuta,M., Habuchi,H.,
            Kimata,K. and Habuchi,O.
  TITLE     Molecular cloning and expression of chondroitin 4-sulfotransferase
  JOURNAL   J Biol Chem 275 (12), 8975-8981 (2000)
   PUBMED   10722746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102114.9, AC155938.6 and AC159149.10.
            
            [WARNING] On Apr 15, 2024 this sequence was replaced by
            NM_021439.4.
            
            On Oct 9, 2020 this sequence version replaced NM_021439.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.8191.1,
                                           SRR9219379.25112.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-486               AC102114.9         96089-96574         c
            487-572             AC155938.6         31368-31453
            573-5528            AC159149.10        126250-131205       c
FEATURES             Location/Qualifiers
     source          1..5528
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 40.66 cM"
     gene            1..5528
                     /gene="Chst11"
                     /gene_synonym="1110020P09Rik; C4s; C4ST; C4ST-1; C4ST1"
                     /note="carbohydrate sulfotransferase 11"
                     /db_xref="GeneID:58250"
                     /db_xref="MGI:MGI:1927166"
     exon            1..486
                     /gene="Chst11"
                     /gene_synonym="1110020P09Rik; C4s; C4ST; C4ST-1; C4ST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..1427
                     /gene="Chst11"
                     /gene_synonym="1110020P09Rik; C4s; C4ST; C4ST-1; C4ST1"
                     /EC_number="2.8.2.5"
                     /note="C4S-1; chondroitin 4-sulfotransferase 1;
                     chondroitin 4-O-sulfotransferase 1"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 11"
                     /protein_id="NP_067414.2"
                     /db_xref="CCDS:CCDS24074.1"
                     /db_xref="GeneID:58250"
                     /db_xref="MGI:MGI:1927166"
                     /translation="MKPALLEVMRMNRICRMVLATCFGSFILVIFYFQSMLHPVMRRN
                     PFGVDICCRKGSRSPLQELYNPIQLELSNTAILHQMRRDQVTDTCRANSAMSRKRRVL
                     TPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLSGRGKYSDPMEIPANEAHVSAN
                     LKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAYRNKFTQKYNTSFHKRYGTKIIR
                     RQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLV
                     GKYETLEEDSNYVLQLAGVSGYLKFPTYAKSTRTTDEMTTEFFQNISAEHQTQLYEVY
                     KLDFLMFNYSVPNYLKLD"
     exon            487..572
                     /gene="Chst11"
                     /gene_synonym="1110020P09Rik; C4s; C4ST; C4ST-1; C4ST1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..5528
                     /gene="Chst11"
                     /gene_synonym="1110020P09Rik; C4s; C4ST; C4ST-1; C4ST1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagtgcacg gcggcggcgg caccttcctt ctcgcatccc ggtcgcccgg cccgtgagga
       61 ggcagcggcg gccgcaggcg ccagcagagg aggcggcgga gcatcgagca gaggcgaggc
      121 ggaccggcag gagcgcgcgg ccggagccac gcatcctcac acttgcacac caactcctgc
      181 gcctttcacc ctctagacca gagtcggggc ctcggagagc ctcggtgaag ctagcgggag
      241 ccagctccgg agcccagcca gctctgttct gagcctcccc ggtgctggta cccccgcggc
      301 ggggtccccg cttctgcgct cgggacgcgc ctcccggaca gccgggtccc cgcggccagg
      361 acaaagccat gaagccggcg ctgctggaag tgatgaggat gaacagaatt tgccggatgg
      421 tgctggccac ttgcttcgga tcctttatct tggtcatctt ctatttccaa agtatgttgc
      481 acccagtcat gcggaggaac cccttcggtg tggacatctg ctgccggaag ggatcgagaa
      541 gtcccctgca ggagctctac aatcccatcc agctggagct atccaacact gccatcctgc
      601 accagatgag acgggaccag gtgacagaca cctgccgggc caacagtgcc atgagccgca
      661 agcgcagggt gctgaccccc aacgacctga agcacctggt ggtggatgag gaccacgaac
      721 tcatctactg ctatgtgccc aaggtagcgt gcaccaactg gaagaggctc atgatggtcc
      781 tgagtggccg gggcaagtac agcgatccca tggagatccc agccaacgaa gcccacgtgt
      841 cggccaacct gaagaccctt aaccagtaca gcatcccaga gatcaaccac cgcttgaaaa
      901 gctacatgaa gttcctgttc gtgcgggaac ccttcgagag gctggtgtct gcctaccgca
      961 acaagttcac gcagaagtac aacacctcct tccacaagcg ctacggcacc aagatcatcc
     1021 gacgccagcg gaagaacgcc acgcaggagg ccctgcgcaa gggggacgat gtcaagttcg
     1081 aggagttcgt ggcctacctc atcgaccccc acacccagcg ggaggagccc ttcaacgagc
     1141 actggcagac ggtctactct ctctgccacc cgtgccacat ccactacgac ctcgtgggca
     1201 agtatgagac actggaggag gactccaatt acgtactgca gctggccgga gtgagcggct
     1261 acctgaagtt ccccacctat gcaaagtcca cccgaactac cgacgagatg accacggagt
     1321 tcttccagaa catcagcgcc gagcaccaga cacagctgta cgaagtctac aaactggact
     1381 ttttaatgtt caactactca gtgccaaact acctgaagtt ggattagagg gctgcggagg
     1441 ggagggggag gggtggttgg gggagaggga gagaatcctg ctttttaatt taagattttt
     1501 atttgtcaaa agaattctat ggagactggg ttattttgta agttaatatg tcttcggggg
     1561 agatgctgcg agcggcatgg ttaagaatta tttaaaaatt ctccacgggg aaggacagct
     1621 gtctttgcag gggagcgggg tggaatatcc ctgtttttag aagtggatac tgcaacactg
     1681 tctccaaggt gtccttgtgt tctggtgaag tccacaaact gcattccata aagtctaatg
     1741 aatcttattt atagttattt aaacgtggtc tgtggcagca gcctgctcct gtctgtgcag
     1801 aggagagtac agtctgtgct tcgctggcta tggctcattg ggggagggga gggggttatc
     1861 tcccccactg accgtgtgta gaatcccatg gtgacagctg cgggatgtgt gcctgtggcc
     1921 attcaagaaa ccctgctaga aagaagtcaa ttgtccttgc actaagaaac agggatgaga
     1981 ctggttcaaa ccgattgcta gcaaccccaa agtcccttgt agtaaagaaa tgcaaatttt
     2041 tttaacccaa gaagagagca gatgatagcg atttctcttt accgaaatta gcaggctata
     2101 agaataggct ttctgtggaa atctttaagt ggcactttcc agtgctagcg aaggcagaat
     2161 aatggttgtt ttctagtcaa taagtattga gcatctacta ttctccaggc ttgactgcag
     2221 atagcacatt gagtgaaacc aggagccttg gccttcagca agctttatgt gaacacaggg
     2281 catccagctc aacagtgaac caacaccccc atccctttgg tcctcacaca gactttagac
     2341 tattctcaag tggtccagag ggtccaggac cctagcaaat ttgcgtattt ctacagttca
     2401 aatttgaaag ccacacattt ggatcaggcc acttaactag ctaagtagtt cattgcccaa
     2461 cacaagaaat gacagaaacc cttttgatca tgtatatcta gtgcagtgtc ttcatagtag
     2521 aagcctataa gccacaatat tctccaagcg caaggatgga ggactgctgt gattgattag
     2581 tgatgtctgc cttgactaag gaaagggagg aacatttctc aagggcctcc tactgtgatc
     2641 tccagtccac atcttgtcct gcctgccact taaaacagtg cactgcatac atttggagac
     2701 tggcggagtt caagtgtgaa ggtcaaaggt ggagtgttgg tacccacagg cacatgccca
     2761 ccctccatgt cctgcattgg cagagcatcc aggacctccc tctcctccag aaggttggaa
     2821 atttgctctt tcctgttcct tgctgatcaa tgcccaaacc tattcctcat ttctagttgt
     2881 ttctgatact ttgcggttga catttgagcc acattcccat gacagccagt gtccgggtac
     2941 gtagcagatg ctgtacatag ttctgatgat aagggagctg gtaggctgta aattttgctt
     3001 tttgtgtttt tgtggggttt tgtttgtttt gatgcagtat agagtgaagg gggtaagaat
     3061 attctgaaaa acataaaatt gagtaattta ttcacagaaa ctattaaaat ggtattgtta
     3121 ggctcacaag gaggctgggg gcagcggtaa ctgctacact gtctcgcaga ggaaattatt
     3181 ttatttaatg tgagagaaat gtgagccaga gtggctgcct gaggctattt ataaaacgca
     3241 ggtaccttcc ccaatttctc tcccctcgcc tttaataaat agatttatgt catgtgtgtg
     3301 accaagaaca gtgacagatc ttggctgtcc ctggaataga gaggcagtca tggtgctcag
     3361 gccctgggcg tggtgtagct gatgcatgtc ccaccgagcc caggctctcc aaggcatcag
     3421 tttgtggtca catatcctta gaaaacaaaa ttaagtcagg ttcctgtctg caggagtttt
     3481 cagagccttg aatacatagt ctgccttgtg aaactgggag aatgtagcat ttctgggctg
     3541 catgacctag gtatcctgta tggcagacca tgtcttagct ggtttttcac acagtagcct
     3601 tcagtgaggg tgatctagcc tgtctgaggt ctgcaaagat tgacagctgc ttcctagatc
     3661 cttccacaaa tcagcagaaa cagtgtccat ctgggaactt tatgagagtg ttgctttacc
     3721 tagttggggt gtcttcatct ggatactgcc ccagagagtg atcccgtccc tccaagcaca
     3781 gcggagggaa gcctagggtg ttatggagtg gggcaggtgg cttaaggaca ccttaaaggc
     3841 cacttggtgg ggataatggc ctcgtgggga tactcctcac ttccacccac agtttggaac
     3901 tgttcactgt gtgcttcagg agttttaaat ggagattcgt gttgatttcc atggtccgca
     3961 tctgtttgtc ttccgtctgt ggtccagtgc tgtgtgcaga tggtacttac tccctttctc
     4021 tctcttacag ggagaaagac tgtccttctg gggagagtgt atcaatacgc ttccagaatg
     4081 agggagtctt tctcctgtct tgtgttcaca cttcctagtg acaattttca aaatatgtat
     4141 cggcttgact gtttattgta gagtgtagaa aggtttctgt gttcctggct aaagacatcc
     4201 attggtgaaa tgtgcttgga aatccaagtg ttttctactg aggaaaaaaa aatgttggaa
     4261 aagctttctc ctgcatgcct cttgtgctta gctagaaagg ggagctgcca gcgtcccagc
     4321 tctgagccac tgttcaaagg tgcagctgtg ttttaggact aggtacaggc agagtgataa
     4381 ggacatgcct gcttagtgta ctcatttatc gagaaagttt agactatgag ccacaggggt
     4441 ccctgcctgc agtccctata gcctccccct gccccagtgc ctttctcagc tggtctggga
     4501 atcagggcag cccattgagg ggggctcaga caaccctttc ttcctggttc tgggagtaag
     4561 gctttctctg cagccacaag gagaacatgg gaaccagaaa cttctctttg gtcagccctt
     4621 ctgagcacac aggtttagcc catgctccaa gaatgctcct gagcattgta taagccccta
     4681 ggactcttag ctcatgtgat aatgattgca ttactatcct gctttaactg acaaaaccac
     4741 agagaatttt gcttgctttc ctactctctt cctctgccca ggcctcctcc atacgtatac
     4801 atacacacat gggcatgtat acacacacat gcacaataga catgcacaca cacatgcaca
     4861 catgggtata catatacaca catgcacaat agacatgcat atatacatat acatgcacac
     4921 attgataggc atacacacat gcacagtaga catgcacaca tgggtataca tagacacaca
     4981 tgcacagaca tgcatacaca cacatgcaca cataaatgtg cacacacaca tacacaaatt
     5041 gcccaagcct gtgcactcct ggtacccatg tcccatcctg gcccacctct ttgtcagcag
     5101 gactgactcc atcactccct caggttttgc ccaccagcac cccccagctt tcccccagca
     5161 gagctaaaca gcccctctga atagacaaca ggaccttcta gaaacagctg aacccttgga
     5221 cagcagcagg cagattttga tctgctctca tcaggtacaa aaggtggtat ccgtattctc
     5281 ttctgagcat gctcagtaag catatggaca tagaatttaa catctctgtg gagtgtgtgt
     5341 tttttacata tttgtatgca gtcgaggagg gcctgttgta gaattctctc cctgtatctt
     5401 actatactgt taaagaagct gaattctatg ttgccaacag atgcgtgaaa tgttcctcca
     5461 ggaaaagcca ttcaagcctg attatttttc taagtaactt caattaaatt gaagaagaaa
     5521 aaaaaaaa
//
