LOCUS       NM_145142               3117 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus carbohydrate sulfotransferase 10 (Chst10), transcript
            variant 1, mRNA.
ACCESSION   NM_145142
VERSION     NM_145142.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3117)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3117)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3117)
  AUTHORS   Vernon,C.G., Copits,B.A., Stolz,J.R., Guzman,Y.F. and Swanson,G.T.
  TITLE     N-glycan content modulates kainate receptor functional properties
  JOURNAL   J Physiol 595 (17), 5913-5930 (2017)
   PUBMED   28714086
REFERENCE   4  (bases 1 to 3117)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3117)
  AUTHORS   Suzuki-Anekoji,M., Suzuki,A., Wu,S.W., Angata,K., Murai,K.K.,
            Sugihara,K., Akama,T.O., Khoo,K.H., Nakayama,J., Fukuda,M.N. and
            Fukuda,M.
  TITLE     In vivo regulation of steroid hormones by the Chst10
            sulfotransferase in mouse
  JOURNAL   J Biol Chem 288 (7), 5007-5016 (2013)
   PUBMED   23269668
  REMARK    GeneRIF: Chst10 likely functions in widespread regulation of
            steroid hormones in vivo
REFERENCE   6  (bases 1 to 3117)
  AUTHORS   Gurevicius,K., Gureviciene,I., Sivukhina,E., Irintchev,A.,
            Schachner,M. and Tanila,H.
  TITLE     Increased hippocampal and cortical beta oscillations in mice
            deficient for the HNK-1 sulfotransferase
  JOURNAL   Mol Cell Neurosci 34 (2), 189-198 (2007)
   PUBMED   17157030
  REMARK    GeneRIF: These findings reveal alterations in ST-/- mice that
            differ from EEG abnormalities of mice deficient in the HNK-1
            carrier molecule tenascin-R.
REFERENCE   7  (bases 1 to 3117)
  AUTHORS   Sykova,E., Vorisek,I., Mazel,T., Antonova,T. and Schachner,M.
  TITLE     Reduced extracellular space in the brain of tenascin-R- and
            HNK-1-sulphotransferase deficient mice
  JOURNAL   Eur J Neurosci 22 (8), 1873-1880 (2005)
   PUBMED   16262627
  REMARK    GeneRIF: This study conclude that in ST-/- mice which show
            morphological, electrophysiological and behavioural abnormalities,
            the ECS is reduced and its geometry altered.
REFERENCE   8  (bases 1 to 3117)
  AUTHORS   Chou,D.K., Zhang,J., Smith,F.I., McCaffery,P. and Jungalwala,F.B.
  TITLE     Developmental expression of receptor for advanced glycation end
            products (RAGE), amphoterin and sulfoglucuronyl (HNK-1)
            carbohydrate in mouse cerebellum and their role in neurite
            outgrowth and cell migration
  JOURNAL   J Neurochem 90 (6), 1389-1401 (2004)
   PUBMED   15341523
REFERENCE   9  (bases 1 to 3117)
  AUTHORS   Chou,D.K., Schachner,M. and Jungalwala,F.B.
  TITLE     HNK-1 sulfotransferase null mice express glucuronyl glycoconjugates
            and show normal cerebellar granule neuron migration in vivo and in
            vitro
  JOURNAL   J Neurochem 82 (5), 1239-1251 (2002)
   PUBMED   12358771
REFERENCE   10 (bases 1 to 3117)
  AUTHORS   Senn,C., Kutsche,M., Saghatelyan,A., Bosl,M.R., Lohler,J.,
            Bartsch,U., Morellini,F. and Schachner,M.
  TITLE     Mice deficient for the HNK-1 sulfotransferase show alterations in
            synaptic efficacy and spatial learning and memory
  JOURNAL   Mol Cell Neurosci 20 (4), 712-729 (2002)
   PUBMED   12213450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101277.16 and AC124699.4.
            
            [WARNING] On Jul 23, 2024 this sequence was replaced by
            NM_145142.4.
            
            On Apr 8, 2021 this sequence version replaced NM_145142.2.
            
            CCDS Note: The coding region has been updated to start at a
            downstream in-frame start codon that is supported by conservation
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046415.1, AF360543.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-268               AC101277.16        151246-151513
            269-388             AC101277.16        153347-153466
            389-520             AC101277.16        164922-165053
            521-612             AC124699.4         174461-174552       c
            613-847             AC124699.4         172113-172347       c
            848-953             AC124699.4         168493-168598       c
            954-3117            AC124699.4         164384-166547       c
FEATURES             Location/Qualifiers
     source          1..3117
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 17.24 cM"
     gene            1..3117
                     /gene="Chst10"
                     /gene_synonym="Hnk-1st; ST"
                     /note="carbohydrate sulfotransferase 10"
                     /db_xref="GeneID:98388"
                     /db_xref="MGI:MGI:2138283"
     exon            1..268
                     /gene="Chst10"
                     /gene_synonym="Hnk-1st; ST"
                     /inference="alignment:Splign:2.1.0"
     exon            269..388
                     /gene="Chst10"
                     /gene_synonym="Hnk-1st; ST"
                     /inference="alignment:Splign:2.1.0"
     exon            389..520
                     /gene="Chst10"
                     /gene_synonym="Hnk-1st; ST"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..1491
                     /gene="Chst10"
                     /gene_synonym="Hnk-1st; ST"
                     /EC_number="2.8.2.-"
                     /note="HNK-1 sulfotransferase; HNK1ST"
                     /codon_start=1
                     /product="carbohydrate sulfotransferase 10"
                     /protein_id="NP_660124.3"
                     /db_xref="CCDS:CCDS14901.1"
                     /db_xref="GeneID:98388"
                     /db_xref="MGI:MGI:2138283"
                     /translation="MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDGYSAKQEFVFL
                     TTMPEAEKLRGEKHFPEVPKPTGKMLSDSRPDQPPVYLERLELIRNTCKEEALRNLSH
                     TEVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFSSIEEIPENVVHDHE
                     KNGLPRLSSFSKIGIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIA
                     PGIIRKYRKNRTETRGIQFEDFVRYLGDPNRRWLDLQFGDHIIHWVTYVELCAPCEIK
                     YSVVGHHETLEADAPYILKEAGIDHLVSYPTIPPGITMYNRTKVEQYFLGISKRDIRR
                     LYARFEGDFKLFGYQKPDFLLN"
     exon            521..612
                     /gene="Chst10"
                     /gene_synonym="Hnk-1st; ST"
                     /inference="alignment:Splign:2.1.0"
     exon            613..847
                     /gene="Chst10"
                     /gene_synonym="Hnk-1st; ST"
                     /inference="alignment:Splign:2.1.0"
     exon            848..953
                     /gene="Chst10"
                     /gene_synonym="Hnk-1st; ST"
                     /inference="alignment:Splign:2.1.0"
     exon            954..3117
                     /gene="Chst10"
                     /gene_synonym="Hnk-1st; ST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2789..2794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chst10"
                     /gene_synonym="Hnk-1st; ST"
                     /note="hexamer: AATAAG"
     polyA_site      2813
                     /gene="Chst10"
                     /gene_synonym="Hnk-1st; ST"
                     /note="major polyA site"
ORIGIN      
        1 gtgcacagcg gtggcggcga cgacgcgcag gaccaggccc acactcccgg gcggcagtgg
       61 gcggcggtct tgcaccccga agctcgcacg cgcccggctt cctccttccg gcgtggctgc
      121 acccctgcac cctgcaggag ggtaggcggg tagcggtgcg gaggtctggg cagagcccgc
      181 ctccggggct ccggggacgc ccacaggccc cgcgaggccc gagcagagcg ccagcggctg
      241 ggaggagcgc gagcgccgat gtacgaggac catcccacac agtgacagag ggaccataaa
      301 cctcaagagg aacaagtcca gcttggcaat gtgacgcctc caaacccagg ccgcagatgg
      361 tccgtgatgg aaaatgtgaa cccatcagga aggatcatcg aatggcccct gtctgacaac
      421 atgcaccatc agtggctcct gctggctgca tgcttttggg tgattttcat gttcatggtg
      481 gccagcaagt tcatcacgtt gacctttaag gatccggatg ggtatagtgc caaacaggag
      541 tttgtgttcc tgacgaccat gccggaagca gagaagctaa gaggagagaa gcattttcct
      601 gaagtcccga agccaactgg gaagatgctt tcggacagcc gtcctgatca gcccccggtt
      661 tatctggagc ggctggagct cattagaaac acctgcaagg aggaggctct gcggaacctc
      721 tcacacaccg aggtctcgaa gttcgtcctg gatcgaatat ttgtctgtga caagcacaag
      781 attcttttct gtcagactcc caaggtgggc aacacccagt ggaagaaagt gctgatcgtc
      841 ctaaatggag cattttcttc cattgaagag attcctgaaa atgtagtcca tgaccatgag
      901 aaaaatggcc ttccacgcct ctcttccttc agcaaaatag gaattcagaa gcgattgaaa
      961 acatacttca agttttttat tgtgagagat ccctttgaaa gactgatttc tgcctttaag
     1021 gataagtttg ttcacaatcc tcgattcgag ccttggtaca ggcatgagat agccccaggc
     1081 attattagaa agtaccggaa gaaccggaca gagacccggg ggatccagtt tgaagatttt
     1141 gtgcgctacc tgggtgatcc aaaccgcagg tggttagacc ttcagtttgg ggaccatatc
     1201 atccactggg tgacctacgt tgaactctgt gcgccctgtg agatcaagta cagtgtggtc
     1261 ggacaccatg agaccctgga ggcagatgcc ccgtacatcc tgaaagaagc tggcatagac
     1321 catctggtgt cataccccac catccctccg ggcatcacca tgtacaacag aaccaaggta
     1381 gaacagtact tcctgggcat cagcaaacga gacatccggc gtctctatgc ccgctttgaa
     1441 ggggacttca agctctttgg gtatcagaaa ccagatttct tgctaaatta atgtgtcaga
     1501 cccttgaata ttgccagatc aggggttggc taggtgagat gtgagcacag aaacggtact
     1561 tcctctatcg tgtcccatgg ttccgttcac ggatgatgtt gggctctgat tacctgctca
     1621 ggtgacagat gctctgatga ccccctcccc agcctgtgtc acccccataa aaggttagga
     1681 aagactggat atttgcagac agatggacgg accaggagga cgtgttagga gcctgcttcc
     1741 ttcagctgtc atgtcatcgg caccgtgcca gctagccagt gttagggtag tgtcacccgt
     1801 gacctgtgga ttgtacagac ccagcacttt caagagagat gggatgctga gtggctgcaa
     1861 aggttactgg gacccatgca gtgtcgaatc taagccagaa tgatacctct ttctttcacc
     1921 ttgacacagc agtagccata gatacagatc atactctcct tgagcttgag gccctgtgac
     1981 atttggtggt cataatcaca aaacagtttg agaagtctga cctttcagga cccaggctag
     2041 cccattcttt gggacctctg accctacaag cacctgcttc attcttctct tctggaaagt
     2101 gagggtgtta taggaacatc acctttgagg acttagaact tggcacaggg aaagaggagg
     2161 aaccagccgg tcctgggaac tcaggctgct gtgaaatcgg gtactgttgt ctttgacccc
     2221 tgcttttgtc ttcgactatc ccatcagtgt gagcagcagg ggcatttcca cctgtctcct
     2281 gaatgaacct ccctgtcctg agaggggagt gaagaaaaca aagcatttcc agcggataga
     2341 gacatgcact tgctgacgtg tcaggacaac acacaggcgt gccatgcctg ttttgccgag
     2401 tccagtgctg tttacagact gccaagtccg ttcatgtcgc aagatgggat cctgtggccc
     2461 tgagcctaat agtgccacca tcctcgactg aaagaccaca agttggataa tcagattcat
     2521 cagcaataaa atcctgggtg aggccacctc tggtgatgtc atacaggtaa caagtcacca
     2581 atcatggcac tgaggccagc cccagcaaga agaaagccac agccgcagtc tcggctgcca
     2641 accagcagca aagggctatt aaagatgatg gggcagtttc tcccagtgag tccctggccc
     2701 agggttgcga ggaatcgtgc tagcttctcc tcaaggctac agccctagtc tcaaaaagcc
     2761 tttcccgaac ttgtaaatgt gaaagtaaaa taagatttaa aatgtgtgcc aaatctgacc
     2821 catgatcccc aggggagggg gctccaggac ccctggtaac tcttgaggcc agggatcggg
     2881 ctacagactg gaaggaggct cagcccttcc ttgtgaactg ataaactgta aacgtgatgt
     2941 tgggttattt gttagtgaag ttttagcaaa gcctacttaa aaatccctcc cggcctgaat
     3001 ttgctgatca gaaatctctt tcctgttttt ttgacaggca acagtgtcaa taatgtgtgt
     3061 gtgtgaggtt aaggtcttca agtcaatctt gattaaagca gcattttctc tcagaaa
//
