LOCUS       NM_009604               1721 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus cholinergic receptor, nicotinic, gamma polypeptide
            (Chrng), transcript variant 1, mRNA.
ACCESSION   NM_009604 XM_978270
VERSION     NM_009604.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1721)
  AUTHORS   Dos Santos,M., Shah,A.M., Zhang,Y., Bezprozvannaya,S., Chen,K.,
            Xu,L., Lin,W., McAnally,J.R., Bassel-Duby,R., Liu,N. and Olson,E.N.
  TITLE     Opposing gene regulatory programs governing myofiber development
            and maturation revealed at single nucleus resolution
  JOURNAL   Nat Commun 14 (1), 4333 (2023)
   PUBMED   37468485
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1721)
  AUTHORS   Liu,J., Chanumolu,S.K., White,K.M., Albahrani,M., Otu,H.H. and
            Nawshad,A.
  TITLE     Transcriptional analysis of cleft palate in TGFbeta3 mutant mice
  JOURNAL   Sci Rep 10 (1), 14940 (2020)
   PUBMED   32913205
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1721)
  AUTHORS   Sakakibara,I., Wurmser,M., Dos Santos,M., Santolini,M.,
            Ducommun,S., Davaze,R., Guernec,A., Sakamoto,K. and Maire,P.
  TITLE     Six1 homeoprotein drives myofiber type IIA specialization in soleus
            muscle
  JOURNAL   Skelet Muscle 6 (1), 30 (2016)
   PUBMED   27597886
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1721)
  AUTHORS   Anderson,D.M., Cannavino,J., Li,H., Anderson,K.M., Nelson,B.R.,
            McAnally,J., Bezprozvannaya,S., Liu,Y., Lin,W., Liu,N.,
            Bassel-Duby,R. and Olson,E.N.
  TITLE     Severe muscle wasting and denervation in mice lacking the
            RNA-binding protein ZFP106
  JOURNAL   Proc Natl Acad Sci U S A 113 (31), E4494-E4503 (2016)
   PUBMED   27418600
REFERENCE   5  (bases 1 to 1721)
  AUTHORS   Roux,I., Wu,J.S., McIntosh,J.M. and Glowatzki,E.
  TITLE     Assessment of the expression and role of the alpha1-nAChR subunit
            in efferent cholinergic function during the development of the
            mammalian cochlea
  JOURNAL   J Neurophysiol 116 (2), 479-492 (2016)
   PUBMED   27098031
REFERENCE   6  (bases 1 to 1721)
  AUTHORS   Vidal,S.M., Epstein,D.J., Malo,D., Weith,A., Vekemans,M. and
            Gros,P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   7  (bases 1 to 1721)
  AUTHORS   Cole,T.J., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Schutz,G. and
            Ruppert,S.
  TITLE     The mouse CREB (cAMP responsive element binding protein) gene:
            structure, promoter analysis, and chromosomal localization
  JOURNAL   Genomics 13 (4), 974-982 (1992)
   PUBMED   1387109
REFERENCE   8  (bases 1 to 1721)
  AUTHORS   Traut,W., Seldin,M.F. and Winking,H.
  TITLE     Genetic mapping and assignment of a long-range repeat cluster to
            band D of chromosome 1 in Mus musculus and M. spretus
  JOURNAL   Cytogenet Cell Genet 60 (2), 128-130 (1992)
   PUBMED   1611911
REFERENCE   9  (bases 1 to 1721)
  AUTHORS   Malo,D., Schurr,E., Epstein,D.J., Vekemans,M., Skamene,E. and
            Gros,P.
  TITLE     The host resistance locus Bcg is tightly linked to a group of
            cytoskeleton-associated protein genes that include villin and
            desmin
  JOURNAL   Genomics 10 (2), 356-364 (1991)
   PUBMED   1676979
REFERENCE   10 (bases 1 to 1721)
  AUTHORS   Copeland,N.G., Silan,C.M., Kingsley,D.M., Jenkins,N.A.,
            Cannizzaro,L.A., Croce,C.M., Huebner,K. and Sims,J.E.
  TITLE     Chromosomal location of murine and human IL-1 receptor genes
  JOURNAL   Genomics 9 (1), 44-50 (1991)
   PUBMED   1672292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102611.10.
            
            On Sep 7, 2022 this sequence version replaced NM_009604.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK047974.1, M30514.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC102611.10        164078-164146
            70-209              AC102611.10        164342-164481
            210-254             AC102611.10        164735-164779
            255-364             AC102611.10        164917-165026
            365-520             AC102611.10        165654-165809
            521-618             AC102611.10        166475-166572
            619-819             AC102611.10        167282-167482
            820-934             AC102611.10        167694-167808
            935-1049            AC102611.10        168031-168145
            1050-1266           AC102611.10        168791-169007
            1267-1400           AC102611.10        169170-169303
            1401-1721           AC102611.10        169582-169902
FEATURES             Location/Qualifiers
     source          1..1721
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.07 cM"
     gene            1..1721
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /note="cholinergic receptor, nicotinic, gamma polypeptide"
                     /db_xref="GeneID:11449"
                     /db_xref="MGI:MGI:87895"
     exon            1..69
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1574
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; acetylcholine receptor subunit gamma; nicotinic
                     acetylcholine receptor gamma subunit"
                     /codon_start=1
                     /product="acetylcholine receptor subunit gamma isoform 1
                     precursor"
                     /protein_id="NP_033734.3"
                     /db_xref="CCDS:CCDS35651.1"
                     /db_xref="GeneID:11449"
                     /db_xref="MGI:MGI:87895"
                     /translation="MQGGQRPQLLLLLLAVCLGAQSRNQEERLLADLMRNYDPHLRPA
                     ERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPKDYEGLWILRV
                     PSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSSCSISVTYFPFD
                     WQNCSLVFQSQTYSTSEINLQLSQEDGQAIEWIFIDPEAFTENGEWAIRHRPAKMLLD
                     SVAPAEEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIYFLPAKAGGQKCTV
                     ATNVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLRSP
                     HTHSMARGVRKVFLRLLPQLLRMHVRPLAPAAVQDARFRLQNGSSSGWPIMAREEGDL
                     CLPRSELLFRQRQRNGLVQAVLEKLENGPEVRQSQEFCGSLKQASPAIQACVDACNLM
                     ARARRQQSHFDSGNEEWLLVGRVLDRVCFLAMLSLFICGTAGIFLMAHYNQVPDLPFP
                     GDPRPYLPLPD"
     exon            70..209
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /inference="alignment:Splign:2.1.0"
     exon            210..254
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /inference="alignment:Splign:2.1.0"
     exon            255..364
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /inference="alignment:Splign:2.1.0"
     exon            365..520
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /inference="alignment:Splign:2.1.0"
     exon            521..618
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /inference="alignment:Splign:2.1.0"
     exon            619..819
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /inference="alignment:Splign:2.1.0"
     exon            820..934
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1049
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1266
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1400
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1721
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1702..1707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /note="hexamer: AATAAA"
     polyA_site      1721
                     /gene="Chrng"
                     /gene_synonym="Achr-3; Acrg"
                     /note="major polyA site"
ORIGIN      
        1 agaactgagg caccatgcaa gggggccaga gacctcagct cctcttgctg ctgttggctg
       61 tctgcctggg ggcccagagc cgcaaccaag aggagcgtct gcttgcggac ctgatgcgaa
      121 actacgaccc ccacctgcgg ccggctgagc gcgactcaga tgtggtcaat gtcagcctga
      181 agcttacctt gaccaacctc atctccctga atgaacgaga ggaggccctc acaactaacg
      241 tctggataga gatgcaatgg tgcgactatc gcctgcgctg ggacccaaaa gactacgaag
      301 gcctgtggat attgagggtg ccatctacta tggtctggcg gccagatatc gtcctggaga
      361 acaatgtgga cggtgtcttc gaggtggctc tctactgcaa tgtcctcgtg tcccccgacg
      421 gttgtatcta ctggctgccg cctgccatct tccgctcctc ctgctccatc tctgtcacct
      481 acttcccctt cgattggcag aactgttccc tcgtcttcca atcccagact tacagcacca
      541 gtgagatcaa cttgcagctg agccaggagg atgggcaagc cattgagtgg atcttcattg
      601 acccggaggc tttcacagag aatggggagt gggccatccg gcaccgaccg gctaaaatgc
      661 tcctggactc cgtggctcct gcagaggagg cgggccacca gaaggtggtg ttctacctgc
      721 ttatccagcg caagcccctc ttctacgtca tcaacatcat cgccccctgt gtgctcatct
      781 cctcagtcgc catcctcatc tacttccttc ctgctaaggc gggcgggcag aaatgcacag
      841 tggccaccaa cgtgctcctg gcccagactg tcttcctttt ccttgtggct aagaaggtgc
      901 ctgagacctc ccaggcagtg ccactcatca gcaagtacct gaccttcctc atggtggtga
      961 ccatcctcat cgtcgtgaac tctgtggtcg tgctcaatgt gtccttgcgg tccccccaca
     1021 cacactccat ggcccgtggg gtccgcaagg tgttcctgag gctcctgccc cagctgttac
     1081 ggatgcatgt gcgcccacta gctccagctg ctgtccagga tgcccggttc cgactccaga
     1141 atggctcttc ctcagggtgg cccatcatgg ctcgagagga aggggacctc tgtctgcctc
     1201 gaagcgaact cctctttagg caaaggcagc gcaatggatt agtgcaggca gtattggaga
     1261 agctagagaa tggtccagaa gtgaggcaga gccaggagtt ctgtggcagc ctgaagcaag
     1321 cctccccagc catccaggcc tgtgtggatg cctgtaacct catggctcgt gcccgacgcc
     1381 agcagagtca ctttgacagt gggaacgagg agtggttgct ggtgggccga gtgctggacc
     1441 gagtctgctt cctagccatg ctctccctct tcatctgtgg cactgctggc atcttcctca
     1501 tggcccacta caaccaagtg cctgacctgc cgttccccgg agacccccgc ccctacctgc
     1561 ctttgccaga ctgagccaac caatccctcc tgggccctgg agtcagctat gagggccatg
     1621 ctgtttgtag agctgtatcc cgtgttgatg ctgagtgtgc tcttggggaa atacccaagg
     1681 cttcctggga gaagatagag aaataaagag acagaggggg a
//
