LOCUS       NM_021600               3003 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus cholinergic receptor, nicotinic, delta polypeptide
            (Chrnd), mRNA.
ACCESSION   NM_021600
VERSION     NM_021600.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3003)
  AUTHORS   Ohkawara,B., Kurokawa,M., Kanai,A., Imamura,K., Chen,G., Zhang,R.,
            Masuda,A., Higashi,K., Mori,H., Suzuki,Y., Kurokawa,K. and Ohno,K.
  TITLE     Transcriptome profile of subsynaptic myonuclei at the neuromuscular
            junction in embryogenesis
  JOURNAL   J Neurochem 168 (4), 342-354 (2024)
   PUBMED   37994470
REFERENCE   2  (bases 1 to 3003)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3003)
  AUTHORS   Watson,J.A., Bhattacharyya,B.J., Vaden,J.H., Wilson,J.A., Icyuz,M.,
            Howard,A.D., Phillips,E., DeSilva,T.M., Siegal,G.P., Bean,A.J.,
            King,G.D., Phillips,S.E., Miller,R.J. and Wilson,S.M.
  TITLE     Motor and Sensory Deficits in the teetering Mice Result from
            Mutation of the ESCRT Component HGS
  JOURNAL   PLoS Genet 11 (6), e1005290 (2015)
   PUBMED   26115514
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3003)
  AUTHORS   Rudell,J.C., Borges,L.S., Rudell,J.B., Beck,K.A. and Ferns,M.J.
  TITLE     Determinants in the beta and delta subunit cytoplasmic loop
            regulate Golgi trafficking and surface expression of the muscle
            acetylcholine receptor
  JOURNAL   J Biol Chem 289 (1), 203-214 (2014)
   PUBMED   24240098
  REMARK    GeneRIF: These findings identify novel Golgi retention signals in
            the beta and delta subunit loops that regulate surface trafficking
            of assembled AChR and may help prevent surface expression of
            unassembled subunits.
REFERENCE   5  (bases 1 to 3003)
  AUTHORS   Gu,Y., Franco,A. Jr., Gardner,P.D., Lansman,J.B., Forsayeth,J.R.
            and Hall,Z.W.
  TITLE     Properties of embryonic and adult muscle acetylcholine receptors
            transiently expressed in COS cells
  JOURNAL   Neuron 5 (2), 147-157 (1990)
   PUBMED   2383398
REFERENCE   6  (bases 1 to 3003)
  AUTHORS   Crowder,C.M. and Merlie,J.P.
  TITLE     Stepwise activation of the mouse acetylcholine receptor delta- and
            gamma-subunit genes in clonal cell lines
  JOURNAL   Mol Cell Biol 8 (12), 5257-5267 (1988)
   PUBMED   3244354
REFERENCE   7  (bases 1 to 3003)
  AUTHORS   Baldwin,T.J. and Burden,S.J.
  TITLE     Isolation and characterization of the mouse acetylcholine receptor
            delta subunit gene: identification of a 148-bp cis-acting region
            that confers myotube-specific expression
  JOURNAL   J Cell Biol 107 (6 Pt 1), 2271-2279 (1988)
   PUBMED   3198687
REFERENCE   8  (bases 1 to 3003)
  AUTHORS   Heidmann,O., Buonanno,A., Geoffroy,B., Robert,B., Guenet,J.L.,
            Merlie,J.P. and Changeux,J.P.
  TITLE     Chromosomal localization of muscle nicotinic acetylcholine receptor
            genes in the mouse
  JOURNAL   Science 234 (4778), 866-868 (1986)
   PUBMED   3022377
REFERENCE   9  (bases 1 to 3003)
  AUTHORS   LaPolla,R.J., Mayne,K.M. and Davidson,N.
  TITLE     Isolation and characterization of a cDNA clone for the complete
            protein coding region of the delta subunit of the mouse
            acetylcholine receptor
  JOURNAL   Proc Natl Acad Sci U S A 81 (24), 7970-7974 (1984)
   PUBMED   6096870
REFERENCE   10 (bases 1 to 3003)
  AUTHORS   Porter,C.W., Barnard,E.A. and Chiu,T.H.
  TITLE     The ultrastructural localization and quantitation of cholinergic
            receptors at the mouse motor endplate
  JOURNAL   J Membr Biol 14 (4), 383-402 (1973)
   PUBMED   4781450
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC102611.10 and BC052153.1.
            
            On Dec 1, 2012 this sequence version replaced NM_021600.2.
            
            Summary: This gene encodes the delta subunit of the muscle-derived
            nicotinic acetylcholine receptor, a pentameric neurotransmitter
            receptor and member of the ligand-gated ion channel superfamily.
            The delta subunit together with the alpha subunit forms the
            ligand-binding site. [provided by RefSeq, Nov 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052153.1, K02582.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC102611.10        148864-148918
            56-3003             BC052153.1         1-2948
FEATURES             Location/Qualifiers
     source          1..3003
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.07 cM"
     gene            1..3003
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /note="cholinergic receptor, nicotinic, delta polypeptide"
                     /db_xref="GeneID:11447"
                     /db_xref="MGI:MGI:87893"
     exon            1..146
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /inference="alignment:Splign:2.1.0"
     exon            147..301
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /inference="alignment:Splign:2.1.0"
     exon            302..346
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /inference="alignment:Splign:2.1.0"
     exon            347..456
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /inference="alignment:Splign:2.1.0"
     exon            457..612
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /inference="alignment:Splign:2.1.0"
     exon            613..722
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /inference="alignment:Splign:2.1.0"
     exon            723..923
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1035
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1150
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1355
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1474
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..2965
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1802..1807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /note="hexamer: AATAAA"
     polyA_site      1823
                     /gene="Chrnd"
                     /gene_synonym="Achr-4; Acrd"
                     /note="major polyA site"
ORIGIN      
        1 acccctaaac caccagcacc tgtccccttg cttgcctcat tccacagcca acaggctgaa
       61 gggaagacaa accctagtca gtcagaggtg ggggatggca gggcctgtgc tcacactggg
      121 gctgctggct gcccttgttg tgtgtgccct cccaggcagt tggggcctga atgaggaaca
      181 aaggctgatc cagcacctat tcaatgagaa gggctacgac aaagacctgc ggccggtggc
      241 tcgaaaggag gacaaagtgg atgtcgccct aagtctcacc ctctccaacc tcatctccct
      301 gaaagaagtg gaggagaccc tcaccaccaa cgtgtggata gatcatgcct gggtagacag
      361 ccgtctacag tgggatgcca acgacttcgg gaacatcact gtcctgcgcc tgccccctga
      421 catggtgtgg ctaccagaga ttgtactgga gaacaacaat gatggctcgt tccagatttc
      481 ttatgcctgc aatgtgcttg tctatgactc gggctatgtg acctggctgc cgcccgccat
      541 cttccgctcc tcctgcccca tctcagtcac ctacttccct ttcgactggc agaactgctc
      601 cctcaaattc agttcactca agtatacagc caaggagatc acacttagcc tgaagcagga
      661 ggaggaaaac aaccgctctt accccatcga gtggatcatc attgaccctg aaggtttcac
      721 agagaacggt gagtgggaga tagtgcatcg ggcagccaag ctcaatgtgg accccagtgt
      781 cccgatggac agcaccaacc accaagatgt caccttctac cttatcatcc gccgcaagcc
      841 cctcttctac atcatcaaca ttctggtacc ctgcgtgctc atctccttca tgatcaacct
      901 agtcttctac ctgccaggcg actgtggaga gaagacctcc gtggccatct cagtgctcct
      961 ggcccaatct gtcttcctgc tgcttatctc caagaggctg ccggccactt ccatggccat
     1021 ccccttggta ggcaagttcc tgcttttcgg catggtgctg gtcaccatgg tggtggtgat
     1081 ctgtgtcatc gtactgaaca tccacttccg gacgcccagc acccatgtgc tgtctgaggg
     1141 agtcaagaag ttcttcctgg agaccctgcc caagctcctg cacatgtccc gcccagcaga
     1201 ggaagaccca ggccccaggg ctctcatccg gagaagcagc tctctgggat acatctgcaa
     1261 agcagaggag tatttctcac ttaagtcccg cagtgacctc atgtttgaga agcaatcaga
     1321 gcggcatggg ctggcccggc gcctcaccac agcccgcagg cctccagcaa gctctgagca
     1381 ggtccaacag gagctcttca atgagatgaa gccagctgtg gatggggcaa acttcatcgt
     1441 caaccatatg agagaccaaa acagttacaa tgaggagaag gacaactgga accaggtggc
     1501 ccgcacagtg gaccgtctct gcctgtttgt ggtgacaccc gtcatggtgg tgggcacagc
     1561 ctggatcttc ctgcagggtg tctacaacca gcccccactc cagcctttcc ctggggaccc
     1621 cttctcctat agcgaacagg acaagcgctt catctagagc aggcatgagt agacagccag
     1681 gcagacagca gtctgagaac ggcacgtagt tcctgccctt gagcttgtgc ctagcgggtg
     1741 ctgtgtggct gggcagaggc catggtcggg agagctccct tccggaaaca attcctttct
     1801 aaataaagga gggagacact tgagatgggc taagggtgga cgtggtggag agggaggctc
     1861 cagggttgtg aggagaagca ggggccttgc tcagggggcc agagaggtga ccttgggact
     1921 ggcttcctgg gaacagtcct gtgagagatc ccccaacctg agctgctcct ccgcctgact
     1981 gtcttccaga gcaggtcaga attctgaact tgcaatttcc ttgccttcct tcccttacct
     2041 acctggggcc cagagagggt gactactctc cattccccag ggaaggaggt ttactgggat
     2101 ggtgggctgt ccaggttgtc atctgtcagc ccccgatgcc ttggtcgttc tgtctgagtc
     2161 cttctgagaa gcgggggact ggtgtgggag gatgacactt ggcatcaaaa gccccatcag
     2221 tgtgtgttct cacatcctag agcatcagga cccagcagcc cctctaagag acccccacat
     2281 tgagtccctt cctcctagcc ccaggctctc caaaccaggg ttgcctagca atatttgagg
     2341 tacacttggg ataaagattt atccgtcgtt catctgaagc tcaaatttaa atgtgcaccc
     2401 agtgttctta ttgagtctgg tcttcaaccc tatcctaaag gaaggcacat tcagaactat
     2461 cctgagtcct atcaatcaca ggagcaagga gactaggtct tagtgtagcc tgcaaagccc
     2521 acctctcaaa tcgtgtcttg agacagtccc tgctctctgt acctggcagt tcagagtaac
     2581 caatagaatg aggtagaaat gatgctatgc tccttcaaag aacagcttct gagatggctg
     2641 ctcctgcaga gtaatggcgc acacctataa ccccagcact taagaagccg gagcaaacag
     2701 atgagaccag cctgggttgc acacacacac acacacacac acacacacac acacacacac
     2761 acagcactgc ggcctctccc ttccactctc ccactctctt tggaagtcag ccacactgct
     2821 gagactctgt aaaagggtcc acctatcaag agccacacag gcaggtagac tagaaagggg
     2881 gtctttctac cctgggagga cctctagatg agagctgttc aggaccctca gaaactgtcg
     2941 gggataataa atacatttgg gagcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3001 aaa
//
