LOCUS       NM_009602               5405 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus cholinergic receptor nicotinic beta 2 subunit
            (Chrnb2), mRNA.
ACCESSION   NM_009602
VERSION     NM_009602.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5405)
  AUTHORS   Biswas,S., Shahriar,S., Bachay,G., Arvanitis,P., Jamoul,D.,
            Brunken,W.J. and Agalliu,D.
  TITLE     Glutamatergic neuronal activity regulates angiogenesis and
            blood-retinal barrier maturation via Norrin/beta-catenin signaling
  JOURNAL   Neuron 112 (12), 1978-1996 (2024)
   PUBMED   38599212
REFERENCE   2  (bases 1 to 5405)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5405)
  AUTHORS   Zammit,M., Kao,C.M., Zhang,H.J., Tsai,H.M., Holderman,N.,
            Mitchell,S., Tanios,E., Bhuiyan,M., Freifelder,R., Kucharski,A.,
            Green,W.N., Mukherjee,J. and Chen,C.T.
  TITLE     Evaluation of an Image-Derived Input Function for Kinetic Modeling
            of Nicotinic Acetylcholine Receptor-Binding PET Ligands in Mice
  JOURNAL   Int J Mol Sci 24 (21), 15510 (2023)
   PUBMED   37958495
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5405)
  AUTHORS   Bsharat,S., Monni,E., Singh,T., Johansson,J.K., Achanta,K.,
            Bertonnier-Brouty,L., Schmidt-Christensen,A., Holmberg,D.,
            Kokaia,Z., Prasad,R.B. and Artner,I.
  TITLE     MafB-dependent neurotransmitter signaling promotes beta cell
            migration in the developing pancreas
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36897571
REFERENCE   5  (bases 1 to 5405)
  AUTHORS   Zhang,C., Yadav,S. and Speer,C.M.
  TITLE     The synaptic basis of activity-dependent eye-specific competition
  JOURNAL   Cell Rep 42 (2), 112085 (2023)
   PUBMED   36753422
REFERENCE   6  (bases 1 to 5405)
  AUTHORS   Bessis,A., Salmon,A.M., Zoli,M., Le Novere,N., Picciotto,M. and
            Changeux,J.P.
  TITLE     Promoter elements conferring neuron-specific expression of the beta
            2-subunit of the neuronal nicotinic acetylcholine receptor studied
            in vitro and in transgenic mice
  JOURNAL   Neuroscience 69 (3), 807-819 (1995)
   PUBMED   8596650
REFERENCE   7  (bases 1 to 5405)
  AUTHORS   Nagavarapu,U. and Boyd,R.T.
  TITLE     Distribution of neuronal nicotinic acetylcholine receptor gene
            restriction fragment length polymorphisms in inbred and partially
            inbred mice
  JOURNAL   Pharmacogenetics 5 (5), 326-331 (1995)
   PUBMED   8563774
REFERENCE   8  (bases 1 to 5405)
  AUTHORS   Picciotto,M.R., Zoli,M., Lena,C., Bessis,A., Lallemand,Y., Le
            Novere,N., Vincent,P., Pich,E.M., Brulet,P. and Changeux,J.P.
  TITLE     Abnormal avoidance learning in mice lacking functional
            high-affinity nicotine receptor in the brain
  JOURNAL   Nature 374 (6517), 65-67 (1995)
   PUBMED   7870173
REFERENCE   9  (bases 1 to 5405)
  AUTHORS   Anand,R. and Lindstrom,J.
  TITLE     Chromosomal localization of seven neuronal nicotinic acetylcholine
            receptor subunit genes in humans
  JOURNAL   Genomics 13 (4), 962-967 (1992)
   PUBMED   1505988
REFERENCE   10 (bases 1 to 5405)
  AUTHORS   Bessis,A., Simon-Chazottes,D., Devillers-Thiery,A., Guenet,J.L. and
            Changeux,J.P.
  TITLE     Chromosomal localization of the mouse genes coding for alpha 2,
            alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic
            acetylcholine receptor
  JOURNAL   FEBS Lett 264 (1), 48-52 (1990)
   PUBMED   2338144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY123599.1, AK051742.1 and BC065103.1.
            
            On Apr 4, 2009 this sequence version replaced NM_009602.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065103.1, AK051742.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY123599.1         1-19
            20-3974             AK051742.1         2-3956
            3975-5405           BC065103.1         3928-5358
FEATURES             Location/Qualifiers
     source          1..5405
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.19 cM"
     gene            1..5405
                     /gene="Chrnb2"
                     /gene_synonym="Acrb-2; Acrb2; C030030P04Rik; [b]2-nAchR"
                     /note="cholinergic receptor nicotinic beta 2 subunit"
                     /db_xref="GeneID:11444"
                     /db_xref="MGI:MGI:87891"
     exon            1..290
                     /gene="Chrnb2"
                     /gene_synonym="Acrb-2; Acrb2; C030030P04Rik; [b]2-nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            291..436
                     /gene="Chrnb2"
                     /gene_synonym="Acrb-2; Acrb2; C030030P04Rik; [b]2-nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            437..481
                     /gene="Chrnb2"
                     /gene_synonym="Acrb-2; Acrb2; C030030P04Rik; [b]2-nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            482..591
                     /gene="Chrnb2"
                     /gene_synonym="Acrb-2; Acrb2; C030030P04Rik; [b]2-nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            592..1561
                     /gene="Chrnb2"
                     /gene_synonym="Acrb-2; Acrb2; C030030P04Rik; [b]2-nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..5384
                     /gene="Chrnb2"
                     /gene_synonym="Acrb-2; Acrb2; C030030P04Rik; [b]2-nAchR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4069
                     /gene="Chrnb2"
                     /gene_synonym="Acrb-2; Acrb2; C030030P04Rik; [b]2-nAchR"
     regulatory      5365..5370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrnb2"
                     /gene_synonym="Acrb-2; Acrb2; C030030P04Rik; [b]2-nAchR"
                     /note="hexamer: TATAAA"
     polyA_site      5384
                     /gene="Chrnb2"
                     /gene_synonym="Acrb-2; Acrb2; C030030P04Rik; [b]2-nAchR"
                     /note="major polyA site"
ORIGIN      
        1 ggagactcct cccctagtag ttccacttgt gttccctaga agagcagccg ggaccggcaa
       61 gaagccggga cctccccctc gttccaggaa ctgccgcgca gtgggcactt cagccctgga
      121 ggccgcgagc cccacccggg tgaaggcggc tgcgcggctt cagcaccacg gacagcgctc
      181 cgtccgcagc ccttgtgtca gcgaggctcc gcgctatgca ggcggcatgg cccggtgctc
      241 caactctatg gcgctgctgt tcagctttgg cctcctttgg ctgtgttcag gggttttggg
      301 tactgacaca gaggagcggc tggtggagca tctcttggat ccttcccgct ataacaagct
      361 gatccgtcca gctactaatg gctctgagct ggtgactgta cagctcatgg tatcattggc
      421 acagctcatc agtgtgcacg agcgggagca gatcatgacc accaacgtct ggctgaccca
      481 ggagtgggaa gattatcgcc tcacatggaa gcctgaggat ttcgacaata tgaagaaagt
      541 ccgactccct tctaagcaca tctggctccc agatgtggtt ctatacaaca atgctgacgg
      601 catgtacgaa gtctccttct attccaatgc tgtggtctcc tatgatggca gcatcttttg
      661 gctaccgcct gccatctaca agagcgcatg caagattgag gtgaagcact tcccatttga
      721 ccagcagaac tgcaccatga agttccgctc ctggacctac gaccgcactg agattgacct
      781 ggtgctcaaa agcgatgtgg ccagcctgga cgacttcaca cctagtgggg agtgggacat
      841 catcgcactg ccaggccgac gcaacgagaa cccagacgac tccacctacg tggacatcac
      901 ctacgacttc atcattcgtc gcaaaccgct cttctacacc atcaacctca tcatcccctg
      961 cgtactcatc acctcgctgg ccatcctggt cttctacctg ccctcagact gtggtgaaaa
     1021 gatgacactt tgtatttctg tgctgctggc gctcacggtg ttcctgctgc tcatctccaa
     1081 gattgtgcct cccacctccc tcgacgtacc gctggtggga aagtacctca tgttcaccat
     1141 ggtgctagtc accttctcca tcgtcactag cgtgtgtgtg ctcaatgtgc accaccgttc
     1201 gcctaccacg cacaccatgg cgccctgggt caaggtggtc ttcctggaga agctgcccac
     1261 cctcctcttc ctgcagcagc cacgccaccg ctgtgcacgt caacgcctgc gcttgcgaag
     1321 gcgccagcgg gaacgtgagg gggcaggcac actattcttc cgcgaaggtc ctgcagctga
     1381 cccatgtacc tgctttgtca atcctgcatc aatgcagggc ttggctgggg ctttccaggc
     1441 tgagcccgct gcagccggtc tggggcgctc gatgggccca tgcagctgtg gcctccggga
     1501 agctgtggac ggtgtacgct tcattgcgga ccatatgcga agtgaagatg atgaccagag
     1561 tgtgagggag gattggaaat acgttgccat ggtgatcgac cgcctgttcc tctggatctt
     1621 tgtctttgtc tgtgtctttg ggaccattgg catgttcctg cagcctctct tccagaacta
     1681 cactgccacg accttccttc actctgacca ctcagctccc agctccaagt gaggtctctc
     1741 atttgcagct actcatcccg tgacccctgg ggttcagtag tattgggtgg aagatggatt
     1801 gatccccact ccactgaagt ctgcttcaca cctccattcg cacagaggcc tccagcctgg
     1861 aggctggacc agctgcctca tgttcaagca ttctccctcc cctctgagct gattcaggca
     1921 gtagtgttaa cggtgggggc caaggctggt aagtagaggc cagagatctc agagccacct
     1981 atctgatgag ggtgctagag aaggggccaa gaaagggaca gttatctatg gcttccgagt
     2041 catgggagaa gagaaggtag gatgaggagt tcagattctg tagccaggct gacaatggtg
     2101 tctcctgaga taaaaggtgc agggtatggc tagtaattgg cttaggtgga caacactggt
     2161 ctgggaagac ttgcagtttt agggagtcct cttgagagct cctacaattc tcctgggatg
     2221 cttcatccac agcctgtgcc tcagagggct ccagaaccca gccccagctt ctgccagtgc
     2281 agaattctct gtatctctag atttttctct ttcctttctc acttgggaaa ggtgaggtgt
     2341 tgggcgaacc tttgaaggtc atgagctagg tgagaagtct aggctcacag ttttagaaga
     2401 acatttacag tgctggcctt cattgggagc catgttacag attcagaaca agcctagaag
     2461 gtgggtccct tcttccttgc cccaaggcca cggactgctt aaaggacata agtgacagac
     2521 atctaaactg tgcctcagtg tcagatgaac tcatgggcat ctctgtttgg tgactggaga
     2581 gacagacctc ctactagaac aggaaattaa aggttgccgg tgtaagaccc ctctccaacc
     2641 cccataaact tccagaccca gagaaagcac cctgaagtca taagcagcac ctggctaggt
     2701 actgtccctc tggagggtag caccagtgtt ggttttccag cctctgtgag accccaccag
     2761 ctacagctag gaccactctt gactttacta cctcctgtaa ctgtctgatg tccaaattag
     2821 tcaccagcca ggactggaaa gatcagtgaa cagtttgtcc agctcctttc cgtatcctgt
     2881 tgaacatatc aggcaaacag cgcccatctt agaacctgct cccagcattt acactgtggg
     2941 aataaaggta ggcagggctg tgctgggtga aagggaccct ggcgtgtgga ggatcatggg
     3001 agcagtgctg ttcttgccat ttttagtgca gcctttggag gaagactgca gtgggggagg
     3061 ggtggtagga ggctatcatg tgtcaggatg gtttgaaccc taaaggacat tgggaggttt
     3121 tggggaaact cagtccctac cactttgggg ccttctgtct ctatccgtgc ctcctcctcc
     3181 gtggagctgt ctctagtgag aatcaggtac ctgatttggt gaacctggat gggaacctgg
     3241 gacagggtgg catgggagtg gcagtgatga aaggtgttgg ggactcgaat cagggactaa
     3301 gctccagtaa cctggcagcc gcctttgcct aggcagatgg cccacaggcc ccctgcctct
     3361 gtggagacct gcaagtctgg agcagctagt gccaagggtg tggaaagctg agaacaaaca
     3421 ggacacagga ccctccagaa ggctcgtttt ggggaaaatt gaaggggaag gacaggactt
     3481 tcttgtaaga aacaaggaca atggtggacc ggccactgtg cctatgctat gggatcccat
     3541 ctcttacagc cctgcaggga agctcttgag accaggggca gcagcagagc gagcatgact
     3601 tcccatggga cctgctcctt gcctgtcccc atggcctttg ggcaggcggg agacttccta
     3661 gggaggaaag caaagccctt tataaagagc cttctctgaa ttgttcccca agaagagtga
     3721 caggtcttcc tgttatcacc ttctgctttc tgcttctagg cagaagggac tgttgagccc
     3781 cacatgcact gaccagcttc ccactcacca actggtcaga gccaagtgtc actttgtagt
     3841 aattatccca tcatgtctga gaagtctgtc agtgtgctgg tcacttgctt tccaaaggac
     3901 ctgatcactt tgggaactgg taggacacct cacccaccca ctgcactgtc ctaggtacgt
     3961 ccttgtcttc attcctggaa tattttccat gtcccccccc caccccaccc ccgccacaaa
     4021 cttactcccc catagctgga cttatttctc ttaaaattgt ttccaaatat gttgagttac
     4081 tttgttctgt ttggggtaag gggactaacc cttccggatc agattggtag atatagaagg
     4141 ggaggatgct ggagaatctc cactcaagag agggtaaagc aaaagtcagc aagggtgaag
     4201 ggcagtgtgt actgcccagt cagtggtatc tgctcccttt gttagatgca aaagaaatgg
     4261 ccaggtggct agacccagaa gggacctctg gggaagaccc tctataagga accaccaggg
     4321 gtggtgtggg tttgggcttc ctctccagtc tgggttctaa aatatccagg cttcagtgag
     4381 ctggcagacc cccactgcac aggctgtgct cagatcctgg gatcagagtg aatctgtggg
     4441 tgagcccttg gggccttcag ctaggcttta aggaaaccat ctatctttaa atttgagggc
     4501 cagggatcaa cggaatccac ttgtacgtga tgccaattta tcctgagcaa cacttctagc
     4561 ccacaaagct ggatacaccc tcagaaactg gaatactcca ttcctcgaat ttggacccag
     4621 tggctgctgg aggacagagc cactgagact ttaggacagc aggagttgtc acctcgaact
     4681 gcctttaaaa ctgctcagct cagttaaaca gggagtgact accacatgaa gccctggact
     4741 taagtgctgt gccccaaaac atgtcactgg gtcttctgac ctcagctgac ccatctgtct
     4801 aaaggattat gagagagttc acactcagtg tctttgggta tgttgtcact gttgaaaggt
     4861 caaagatagg tcttccagga gttctgaagt aagttactaa gagctgggtt tccttaaaat
     4921 ttaagagggg gactttcgat gccatccaca aagttaaaag gtgcatctga atgtgtcgtg
     4981 gtcccagctg caactgcctt ccaaagggca cgtacaggac agtaaaggcc gaggcttgtg
     5041 gggagagcaa caccagcaag actggcagga gcagagattt ctgctgtctc cagtgctgtt
     5101 ttctcatttg gggctttgaa atctactaag ccccacaacc cccaaactag gaacaaaaga
     5161 tgacagagtg ggctcaggtg ggaaaagttt tgaagcaggg aaagtgctga ggacatagcc
     5221 gagtccccaa ctggctggca catcacactg cctgaactac agtcagactg tagaagcagt
     5281 ggggcccttg aaactactgt ggctgtggcc agagatcctg tcacaggtcc ctgttcccaa
     5341 tctcacctcc cccaagaacc aagatataaa actttgtaac agtcaaaaaa aaaaaaaaaa
     5401 aaaaa
//
