LOCUS       NM_009601               2128 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus cholinergic receptor nicotinic beta 1 subunit
            (Chrnb1), transcript variant 1, mRNA.
ACCESSION   NM_009601
VERSION     NM_009601.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2128)
  AUTHORS   Xiao,Y., Zhang,J., Shu,X., Bai,L., Xu,W., Wang,A., Chen,A.,
            Tu,W.Y., Wang,J., Zhang,K., Luo,B. and Shen,C.
  TITLE     Loss of mitochondrial protein CHCHD10 in skeletal muscle causes
            neuromuscular junction impairment
  JOURNAL   Hum Mol Genet 29 (11), 1784-1796 (2020)
   PUBMED   31261376
  REMARK    GeneRIF: Loss of mitochondrial protein CHCHD10 in skeletal muscle
            causes neuromuscular junction impairment.
REFERENCE   2  (bases 1 to 2128)
  AUTHORS   Zoupa,M., Xavier,G.M., Bryan,S., Theologidis,I., Arno,M. and
            Cobourne,M.T.
  TITLE     Gene expression profiling in the developing secondary palate in the
            absence of Tbx1 function
  JOURNAL   BMC Genomics 19 (1), 429 (2018)
   PUBMED   29866044
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2128)
  AUTHORS   Remedio,L., Gribble,K.D., Lee,J.K., Kim,N., Hallock,P.T.,
            Delestree,N., Mentis,G.Z., Froemke,R.C., Granato,M. and Burden,S.J.
  TITLE     Diverging roles for Lrp4 and Wnt signaling in neuromuscular synapse
            development during evolution
  JOURNAL   Genes Dev 30 (9), 1058-1069 (2016)
   PUBMED   27151977
REFERENCE   4  (bases 1 to 2128)
  AUTHORS   Watson,J.A., Bhattacharyya,B.J., Vaden,J.H., Wilson,J.A., Icyuz,M.,
            Howard,A.D., Phillips,E., DeSilva,T.M., Siegal,G.P., Bean,A.J.,
            King,G.D., Phillips,S.E., Miller,R.J. and Wilson,S.M.
  TITLE     Motor and Sensory Deficits in the teetering Mice Result from
            Mutation of the ESCRT Component HGS
  JOURNAL   PLoS Genet 11 (6), e1005290 (2015)
   PUBMED   26115514
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2128)
  AUTHORS   Tezuka,T., Inoue,A., Hoshi,T., Weatherbee,S.D., Burgess,R.W.,
            Ueta,R. and Yamanashi,Y.
  TITLE     The MuSK activator agrin has a separate role essential for
            postnatal maintenance of neuromuscular synapses
  JOURNAL   Proc Natl Acad Sci U S A 111 (46), 16556-16561 (2014)
   PUBMED   25368159
REFERENCE   6  (bases 1 to 2128)
  AUTHORS   Nonaka,M., Matsuda,Y., Shiroishi,T., Moriwaki,K., Nonaka,M. and
            Natsuume-Sakai,S.
  TITLE     Molecular cloning of mouse beta 2-glycoprotein I and mapping of the
            gene to chromosome 11
  JOURNAL   Genomics 13 (4), 1082-1087 (1992)
   PUBMED   1339387
REFERENCE   7  (bases 1 to 2128)
  AUTHORS   Takahashi,Y., Shimizu,A., Sakai,T., Endo,Y., Osawa,N., Shisa,H. and
            Honjo,T.
  TITLE     Mapping of the nu gene using congenic nude strains and in situ
            hybridization
  JOURNAL   J Exp Med 175 (3), 873-876 (1992)
   PUBMED   1346798
REFERENCE   8  (bases 1 to 2128)
  AUTHORS   Cornall,R.J., Friedman,J.M. and Todd,J.A.
  TITLE     Mouse microsatellites from a flow-sorted 4:6 Robertsonian
            chromosome
  JOURNAL   Mamm Genome 3 (11), 620-624 (1992)
   PUBMED   1450512
REFERENCE   9  (bases 1 to 2128)
  AUTHORS   Todd,J.A., Aitman,T.J., Cornall,R.J., Ghosh,S., Hall,J.R.,
            Hearne,C.M., Knight,A.M., Love,J.M., McAleer,M.A., Prins,J.B. et
            al.
  TITLE     Genetic analysis of autoimmune type 1 diabetes mellitus in mice
  JOURNAL   Nature 351 (6327), 542-547 (1991)
   PUBMED   1675432
REFERENCE   10 (bases 1 to 2128)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603707.5.
            
            On Mar 1, 2023 this sequence version replaced NM_009601.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023318.1, M14537.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AL603707.5         175051-175145       c
            96-235              AL603707.5         174824-174963       c
            236-280             AL603707.5         174198-174242       c
            281-390             AL603707.5         173379-173488       c
            391-499             AL603707.5         173113-173221       c
            500-647             AL603707.5         172694-172841       c
            648-857             AL603707.5         171928-172137       c
            858-1081            AL603707.5         166110-166333       c
            1082-1254           AL603707.5         164936-165108       c
            1255-1402           AL603707.5         164279-164426       c
            1403-2128           AL603707.5         163265-163990       c
FEATURES             Location/Qualifiers
     source          1..2128
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.87 cM"
     gene            1..2128
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /note="cholinergic receptor nicotinic beta 1 subunit"
                     /db_xref="GeneID:11443"
                     /db_xref="MGI:MGI:87890"
     exon            1..95
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1543
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; acetylcholine receptor subunit beta; AChR beta;
                     acetylcholine receptor beta; cholinergic receptor,
                     nicotinic, beta polypeptide 1 (muscle)"
                     /codon_start=1
                     /product="acetylcholine receptor subunit beta isoform 1
                     precursor"
                     /protein_id="NP_033731.3"
                     /db_xref="CCDS:CCDS24910.1"
                     /db_xref="GeneID:11443"
                     /db_xref="MGI:MGI:87890"
                     /translation="MALGALLLLLGVLGTPLAPGARGSEAEGQLIKKLFSNYDSSVRP
                     AREVGDRVGVSIGLTLAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLR
                     ITAESVWLPDVVLLNNNDGNFDVALDINVVVSFEGSVRWQPPGLYRSSCSIQVTYFPF
                     DWQNCTMVFSSYSYDSSEVSLKTGLDPEGEERQEVYIHEGTFIENGQWEIIHKPSRLI
                     QLPGDQRGGKEGHHEEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEK
                     MGLSIFALLTLTVFLLLLADKVPETSLAVPIIIKYLMFTMVLVTFSVILSVVVLNLHH
                     RSPHTHQMPFWVRQIFIHKLPPYLGLKRPKPERDQLPEPHHSLSPRSGWGRGTDEYFI
                     RKPPSDFLFPKLNRFQPESSAPDLRRFIDGPTRAVGLPQELREVISSISYMARQLQEQ
                     EDHDALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVIFLDATYHLPPPEPFP"
     exon            96..235
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /inference="alignment:Splign:2.1.0"
     exon            236..280
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /inference="alignment:Splign:2.1.0"
     exon            281..390
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /inference="alignment:Splign:2.1.0"
     exon            391..499
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /inference="alignment:Splign:2.1.0"
     exon            500..647
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /inference="alignment:Splign:2.1.0"
     exon            648..857
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /inference="alignment:Splign:2.1.0"
     exon            858..1081
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1254
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1402
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..2128
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2100..2105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /note="hexamer: ATTAAA"
     regulatory      2106..2111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /note="hexamer: ATTAAA"
     polyA_site      2124
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /note="major polyA site"
     polyA_site      2128
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /note="major polyA site"
ORIGIN      
        1 atccggacaa acttcactga gcgaaagagg cagggccatg gccttagggg cgctgcttct
       61 gcttctaggg gtactcggga cgcccctcgc cccaggcgcc cgcgggtcgg aagccgaagg
      121 ccaactgatt aagaaacttt tctccaacta tgatagctcg gtgaggccgg cgcgggaggt
      181 gggagaccgc gtcggggtca gcatcggcct caccctggcg caactcatca gcctgaacga
      241 gaaggatgaa gaaatgagca caaaggtgta cttagacctg gagtggaccg actacaggtt
      301 aagctgggac cccgcagaac atgatggcat cgattctctc cgcatcactg ctgaatccgt
      361 ttggctccct gatgtggtgc tgctgaacaa caatgacgga aatttcgacg ttgccctgga
      421 catcaatgtt gtggtatctt tcgagggctc tgtgcgctgg caaccccctg gcctgtaccg
      481 cagcagctgc agcatccagg tcacctactt cccctttgac tggcagaact gcaccatggt
      541 gtttagttcc tacagctatg acagctctga ggtcagcctg aagacgggcc tggatcctga
      601 aggagaggag aggcaggaag tctacattca tgaagggacc ttcattgaga atggccaatg
      661 ggagattatc cacaaacctt ctaggttaat ccaacttcca ggggatcaga gaggtgggaa
      721 ggaagggcat catgaggaag ttatcttcta tctcattatt cggcggaagc ctctcttcta
      781 cctggtcaac gtcattgccc catgcatcct catcacgctc ctggccatct ttgtcttcta
      841 cctcccacca gatgcaggag agaagatggg gctctccatc tttgccctgc tgacgctcac
      901 tgtgttcttg ctgctgttgg ccgacaaagt gcctgagacc tccctggcgg tgcccatcat
      961 tatcaagtac ctcatgttta ccatggtcct tgtcaccttc tccgttatcc ttagtgttgt
     1021 ggtcctcaac ctgcatcatc gctcacccca cacccaccaa atgccctttt gggtccgcca
     1081 gatcttcatt cacaagctcc ctccatacct gggtctgaag aggcccaaac ccgagagaga
     1141 ccaactccct gaaccacatc actctctttc tccaagaagt ggctggggca gaggaactga
     1201 tgaatatttc atccggaagc ctccaagtga ttttcttttc cctaaactta acaggtttca
     1261 gcctgaatca tctgccccgg acctgcgacg atttatcgat ggtccaaccc gggctgtagg
     1321 tctgcctcag gagctacgag aggtcatttc ctcaatcagc tacatggccc gacagcttca
     1381 ggaacaggag gaccacgacg cactgaagga ggactggcag tttgtggcca tggttgtgga
     1441 ccgtcttttt ctgtggacat tcatcgtttt cacaagcgtc gggaccctag tcattttcct
     1501 agatgccacg taccatttgc cccctcctga acctttccct tgaggaccct ccggtcattt
     1561 ttgccaaatg ctgcaggtac tctcaagctc aatagcgctt ggcgcttgta agaatcttgt
     1621 ttctgggaag acgttcaagt gagacttgga ggctgagcat ggtgccttgg acccacccga
     1681 aatgtccttc tacttattat ttagagtttt gttcttctgc ggttttgttt ttgttgtttt
     1741 tgagacagag tctcactctg tggcccaggc tagcctggaa ctgtggcgtc caggctggtc
     1801 tcaaactccc aacaatgtta cttccttagc ctagcaattg ttggaatcac agacctggta
     1861 aaccagcaca cttggagttt gtttcttgaa actacataga atgtcacagc ttagatctct
     1921 agtgaaatag aattataacc aagtagtaga ctgtaagcct tttgaggaca ggagatctgt
     1981 tggctactga attatcccca gcaatgtgta caggtcctag cccataagtg cttaacattt
     2041 gttgaagaga gggaaaataa atctggaagg aaatataaat atcgcctaca attgcacgta
     2101 ttaaaattaa aatgtagaaa atgattaa
//
