LOCUS       NP_033731                501 aa            linear   ROD 14-JUN-2024
DEFINITION  acetylcholine receptor subunit beta isoform 1 precursor [Mus
            musculus].
ACCESSION   NP_033731
VERSION     NP_033731.3
DBSOURCE    REFSEQ: accession NM_009601.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 501)
  AUTHORS   Xiao,Y., Zhang,J., Shu,X., Bai,L., Xu,W., Wang,A., Chen,A.,
            Tu,W.Y., Wang,J., Zhang,K., Luo,B. and Shen,C.
  TITLE     Loss of mitochondrial protein CHCHD10 in skeletal muscle causes
            neuromuscular junction impairment
  JOURNAL   Hum Mol Genet 29 (11), 1784-1796 (2020)
   PUBMED   31261376
  REMARK    GeneRIF: Loss of mitochondrial protein CHCHD10 in skeletal muscle
            causes neuromuscular junction impairment.
REFERENCE   2  (residues 1 to 501)
  AUTHORS   Zoupa,M., Xavier,G.M., Bryan,S., Theologidis,I., Arno,M. and
            Cobourne,M.T.
  TITLE     Gene expression profiling in the developing secondary palate in the
            absence of Tbx1 function
  JOURNAL   BMC Genomics 19 (1), 429 (2018)
   PUBMED   29866044
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 501)
  AUTHORS   Remedio,L., Gribble,K.D., Lee,J.K., Kim,N., Hallock,P.T.,
            Delestree,N., Mentis,G.Z., Froemke,R.C., Granato,M. and Burden,S.J.
  TITLE     Diverging roles for Lrp4 and Wnt signaling in neuromuscular synapse
            development during evolution
  JOURNAL   Genes Dev 30 (9), 1058-1069 (2016)
   PUBMED   27151977
REFERENCE   4  (residues 1 to 501)
  AUTHORS   Watson,J.A., Bhattacharyya,B.J., Vaden,J.H., Wilson,J.A., Icyuz,M.,
            Howard,A.D., Phillips,E., DeSilva,T.M., Siegal,G.P., Bean,A.J.,
            King,G.D., Phillips,S.E., Miller,R.J. and Wilson,S.M.
  TITLE     Motor and Sensory Deficits in the teetering Mice Result from
            Mutation of the ESCRT Component HGS
  JOURNAL   PLoS Genet 11 (6), e1005290 (2015)
   PUBMED   26115514
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 501)
  AUTHORS   Tezuka,T., Inoue,A., Hoshi,T., Weatherbee,S.D., Burgess,R.W.,
            Ueta,R. and Yamanashi,Y.
  TITLE     The MuSK activator agrin has a separate role essential for
            postnatal maintenance of neuromuscular synapses
  JOURNAL   Proc Natl Acad Sci U S A 111 (46), 16556-16561 (2014)
   PUBMED   25368159
REFERENCE   6  (residues 1 to 501)
  AUTHORS   Nonaka,M., Matsuda,Y., Shiroishi,T., Moriwaki,K., Nonaka,M. and
            Natsuume-Sakai,S.
  TITLE     Molecular cloning of mouse beta 2-glycoprotein I and mapping of the
            gene to chromosome 11
  JOURNAL   Genomics 13 (4), 1082-1087 (1992)
   PUBMED   1339387
REFERENCE   7  (residues 1 to 501)
  AUTHORS   Takahashi,Y., Shimizu,A., Sakai,T., Endo,Y., Osawa,N., Shisa,H. and
            Honjo,T.
  TITLE     Mapping of the nu gene using congenic nude strains and in situ
            hybridization
  JOURNAL   J Exp Med 175 (3), 873-876 (1992)
   PUBMED   1346798
REFERENCE   8  (residues 1 to 501)
  AUTHORS   Cornall,R.J., Friedman,J.M. and Todd,J.A.
  TITLE     Mouse microsatellites from a flow-sorted 4:6 Robertsonian
            chromosome
  JOURNAL   Mamm Genome 3 (11), 620-624 (1992)
   PUBMED   1450512
REFERENCE   9  (residues 1 to 501)
  AUTHORS   Todd,J.A., Aitman,T.J., Cornall,R.J., Ghosh,S., Hall,J.R.,
            Hearne,C.M., Knight,A.M., Love,J.M., McAleer,M.A., Prins,J.B. et
            al.
  TITLE     Genetic analysis of autoimmune type 1 diabetes mellitus in mice
  JOURNAL   Nature 351 (6327), 542-547 (1991)
   PUBMED   1675432
REFERENCE   10 (residues 1 to 501)
  AUTHORS   Hearne,C.M., McAleer,M.A., Love,J.M., Aitman,T.J., Cornall,R.J.,
            Ghosh,S., Knight,A.M., Prins,J.B. and Todd,J.A.
  TITLE     Additional microsatellite markers for mouse genome mapping
  JOURNAL   Mamm Genome 1 (4), 273-282 (1991)
   PUBMED   1794058
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL603707.5.
            
            On Nov 16, 2007 this sequence version replaced NP_033731.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023318.1, M14537.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..501
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.87 cM"
     Protein         1..501
                     /product="acetylcholine receptor subunit beta isoform 1
                     precursor"
                     /note="acetylcholine receptor subunit beta; AChR beta;
                     acetylcholine receptor beta; cholinergic receptor,
                     nicotinic, beta polypeptide 1 (muscle)"
                     /calculated_mol_wt=54774
     sig_peptide     1..23
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2175
     mat_peptide     24..501
                     /product="acetylcholine receptor subunit beta isoform 1"
                     /calculated_mol_wt=54774
     Region          24..488
                     /region_name="LIC"
                     /note="Cation transporter family protein; cl42365"
                     /db_xref="CDD:455710"
     Region          27..245
                     /region_name="LGIC_ECD_nAChR_B1"
                     /note="extracellular domain of nicotinic acetylcholine
                     receptor subunit beta 1 (CHRNB1); cd19024"
                     /db_xref="CDD:349825"
     Site            order(62,64,70..71,78,100,102,111..112,114,116..117,121,
                     123..124,128..130,132,142,144,146,150,172,244)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349825"
     Region          151..165
                     /region_name="Cys-loop"
                     /note="Cys-loop [structural motif]"
                     /db_xref="CDD:349825"
     Site            164
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P09690.1)"
     Site            245..269
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P09690.1)"
     Site            277..295
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P09690.1)"
     Site            311..332
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P09690.1)"
     Region          362..382
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P09690.1)"
     Site            390
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by Tyr-kinases.
                     /evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (P09690.1)"
     Site            470..488
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P09690.1)"
     CDS             1..501
                     /gene="Chrnb1"
                     /gene_synonym="Achr-2; Acrb"
                     /coded_by="NM_009601.5:38..1543"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS24910.1"
                     /db_xref="GeneID:11443"
                     /db_xref="MGI:MGI:87890"
ORIGIN      
        1 malgalllll gvlgtplapg argseaegql ikklfsnyds svrparevgd rvgvsigltl
       61 aqlislnekd eemstkvyld lewtdyrlsw dpaehdgids lritaesvwl pdvvllnnnd
      121 gnfdvaldin vvvsfegsvr wqppglyrss csiqvtyfpf dwqnctmvfs sysydssevs
      181 lktgldpege erqevyiheg tfiengqwei ihkpsrliql pgdqrggkeg hheevifyli
      241 irrkplfylv nviapcilit llaifvfylp pdagekmgls ifalltltvf lllladkvpe
      301 tslavpiiik ylmftmvlvt fsvilsvvvl nlhhrsphth qmpfwvrqif ihklppylgl
      361 krpkperdql pephhslspr sgwgrgtdey firkppsdfl fpklnrfqpe ssapdlrrfi
      421 dgptravglp qelrevissi symarqlqeq edhdalkedw qfvamvvdrl flwtfivfts
      481 vgtlviflda tyhlpppepf p
//
