LOCUS       NM_001081104            1596 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus cholinergic receptor, nicotinic, alpha polypeptide 9
            (Chrna9), transcript variant 1, mRNA.
ACCESSION   NM_001081104 XM_132045
VERSION     NM_001081104.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1596)
  AUTHORS   Mondul,J.A., Burke,K., Morley,B. and Lauer,A.M.
  TITLE     Alpha9alpha10 knockout mice show altered physiological and
            behavioral responses to signals in masking noise
  JOURNAL   J Acoust Soc Am 155 (5), 3183-3194 (2024)
   PUBMED   38738939
  REMARK    GeneRIF: Alpha9alpha10 knockout mice show altered physiological and
            behavioral responses to signals in masking noise.
REFERENCE   2  (bases 1 to 1596)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1596)
  AUTHORS   Vicencio-Jimenez,S., Delano,P.H., Madrid,N., Terreros,G.,
            Maass,J.C., Delgado,C. and Jorratt,P.
  TITLE     Maintained Spatial Learning and Memory Functions in Middle-Aged
            alpha9 Nicotinic Receptor Subunit Knock-Out Mice
  JOURNAL   Brain Sci 13 (5), 794 (2023)
   PUBMED   37239266
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1596)
  AUTHORS   Yazawa,T., Imamichi,Y., Kitano,T., Islam,M.S., Khan,M.R.I.,
            Takahashi,S., Sekiguchi,T., Suzuki,N., Umezawa,A. and Uwada,J.
  TITLE     Expression of Chrna9 is regulated by Tbx3 in undifferentiated
            pluripotent stem cells
  JOURNAL   Sci Rep 13 (1), 1611 (2023)
   PUBMED   36709241
  REMARK    GeneRIF: Expression of Chrna9 is regulated by Tbx3 in
            undifferentiated pluripotent stem cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1596)
  AUTHORS   Richter,K., Papke,R.L., Stokes,C., Roy,D.C., Espinosa,E.S.,
            Wolf,P.M.K., Hecker,A., Liese,J., Singh,V.K., Padberg,W.,
            Schluter,K.D., Rohde,M., McIntosh,J.M., Morley,B.J.,
            Horenstein,N.A., Grau,V. and Simard,A.R.
  TITLE     Comparison of the Anti-inflammatory Properties of Two Nicotinic
            Acetylcholine Receptor Ligands, Phosphocholine and pCF3-diEPP
  JOURNAL   Front Cell Neurosci 16, 779081 (2022)
   PUBMED   35431807
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1596)
  AUTHORS   May,B.J., Prosen,C.A., Weiss,D. and Vetter,D.
  TITLE     Behavioral investigation of some possible effects of the central
            olivocochlear pathways in transgenic mice
  JOURNAL   Hear Res 171 (1-2), 142-157 (2002)
   PUBMED   12204358
REFERENCE   7  (bases 1 to 1596)
  AUTHORS   Prosen,C.A., Bath,K.G., Vetter,D.E. and May,B.J.
  TITLE     Behavioral assessments of auditory sensitivity in transgenic mice
  JOURNAL   J Neurosci Methods 97 (1), 59-67 (2000)
   PUBMED   10771076
REFERENCE   8  (bases 1 to 1596)
  AUTHORS   Vetter,D.E., Liberman,M.C., Mann,J., Barhanin,J., Boulter,J.,
            Brown,M.C., Saffiote-Kolman,J., Heinemann,S.F. and Elgoyhen,A.B.
  TITLE     Role of alpha9 nicotinic ACh receptor subunits in the development
            and function of cochlear efferent innervation
  JOURNAL   Neuron 23 (1), 93-103 (1999)
   PUBMED   10402196
  REMARK    GeneRIF: description of the role of alpha9 nAChR subunit in the
            development of the olivocochlear system and efferent function
REFERENCE   9  (bases 1 to 1596)
  AUTHORS   .
  TITLE     British Society of Audiology short papers meeting on experimental
            studies of hearing and deafness. Cambridge, United Kingdom, 22-23
            September 1996. Abstracts
  JOURNAL   Br J Audiol 31 (2), 73-132 (1997)
   PUBMED   9183385
REFERENCE   10 (bases 1 to 1596)
  AUTHORS   Glowatzki,E., Wild,K., Brandle,U., Fakler,G., Fakler,B.,
            Zenner,H.P. and Ruppersberg,J.P.
  TITLE     Cell-specific expression of the alpha 9 n-ACh receptor subunit in
            auditory hair cells revealed by single-cell RT-PCR
  JOURNAL   Proc Biol Sci 262 (1364), 141-147 (1995)
   PUBMED   8524909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115293.5.
            
            On Apr 1, 2022 this sequence version replaced NM_001081104.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010496.1, SRR15390195.739751.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC115293.5         186388-186528
            142-287             AC115293.5         186799-186944
            288-442             AC115293.5         188132-188286
            443-975             AC115293.5         189833-190365
            976-1596            AC115293.5         195723-196343
FEATURES             Location/Qualifiers
     source          1..1596
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 33.84 cM"
     gene            1..1596
                     /gene="Chrna9"
                     /gene_synonym="2410015I05Rik; Acra9; EG666827; Gm8311"
                     /note="cholinergic receptor, nicotinic, alpha polypeptide
                     9"
                     /db_xref="GeneID:231252"
                     /db_xref="MGI:MGI:1202403"
     exon            1..141
                     /gene="Chrna9"
                     /gene_synonym="2410015I05Rik; Acra9; EG666827; Gm8311"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1517
                     /gene="Chrna9"
                     /gene_synonym="2410015I05Rik; Acra9; EG666827; Gm8311"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit alpha-9
                     isoform a"
                     /protein_id="NP_001074573.1"
                     /db_xref="CCDS:CCDS39101.1"
                     /db_xref="GeneID:231252"
                     /db_xref="MGI:MGI:1202403"
                     /translation="MNRPHPCISFCWMYFAASGIKAVETANGKYAQKLFSDLFEDYSN
                     ALRPVEDTDAVLNVTLQVTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDRDQYDGL
                     DSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDSPAITKSSCVVDVT
                     YFPFDSQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVQGMPAVKNVISYG
                     CCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTIL
                     LAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVP
                     HWAKVVILKYMSRILFVYDVGESCLSPRHSQEPEQITKVYGKLPGSNLKASRNKDLSR
                     KKELRKLLKNDLGYQGGIPQNTDSYCARYEALTKNIEYIAKCLKDHKATNSKGSEWKK
                     VAKVIDRFFMWIFFAMVFVMTVLIIARAD"
     exon            142..287
                     /gene="Chrna9"
                     /gene_synonym="2410015I05Rik; Acra9; EG666827; Gm8311"
                     /inference="alignment:Splign:2.1.0"
     exon            288..442
                     /gene="Chrna9"
                     /gene_synonym="2410015I05Rik; Acra9; EG666827; Gm8311"
                     /inference="alignment:Splign:2.1.0"
     exon            443..975
                     /gene="Chrna9"
                     /gene_synonym="2410015I05Rik; Acra9; EG666827; Gm8311"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1596
                     /gene="Chrna9"
                     /gene_synonym="2410015I05Rik; Acra9; EG666827; Gm8311"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1573..1578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrna9"
                     /gene_synonym="2410015I05Rik; Acra9; EG666827; Gm8311"
                     /note="hexamer: AATAAA"
     polyA_site      1596
                     /gene="Chrna9"
                     /gene_synonym="2410015I05Rik; Acra9; EG666827; Gm8311"
                     /note="major polyA site"
ORIGIN      
        1 gtggcagtga gggtgctttg tagacagaag tgggagtcct cgctgtctgg ctgggacgtt
       61 ctacatgttg ggaaaggatg aaccggcccc atccctgcat ctccttttgc tggatgtatt
      121 ttgctgcttc tggaatcaaa gccgtagaga cagcaaatgg aaagtatgcc cagaaattgt
      181 ttagcgatct ttttgaagac tactccaatg ctctgcgtcc agtagaagat acggacgcgg
      241 tgctgaacgt cactctgcag gtcacgctct cccagataaa ggacatggac gagagaaatc
      301 agattctgac agcctacctg tggatccgcc aaacttggca cgatgcgtac ctcacgtggg
      361 atcgagacca gtatgacggg ctggactcca tcaggattcc cagcgatctg gtgtggaggc
      421 cggacattgt cctctacaac aaggccgatg acgagtcttc agagccggtg aacaccaacg
      481 tggtcctgcg gtacgatggg ctcatcacct gggactcacc agccatcacc aaaagctcct
      541 gtgtggtgga tgtcacctat ttccccttcg acagccagca gtgcaacctg acctttggtt
      601 cctggaccta caatgggaac caggtggaca tattcaatgc cctggacagt ggtgacctct
      661 ctgacttcat tgaagacgtg gaatgggagg ttcagggcat gcctgccgtg aagaacgtca
      721 tctcctacgg ctgctgctcg gagccttacc cagacgtcac cttcactctc cttctgaaga
      781 ggaggtcttc cttttacatt gtcaacctcc tcatcccttg cgtcctcata tcgttcctcg
      841 ctccgctgag tttctacctc ccagcagcct ccggggagaa ggtctctctg ggagtgacca
      901 tcctattggc catgactgta tttcagctaa tggtggcaga gatcatgcca gcctcagaaa
      961 acgtccctct gataggaaaa tactacatag ctaccatggc cttgatcacc gcctccacag
     1021 cccttaccat catggtgatg aatatccact tctgtggggc ggaagcccgg ccagtaccac
     1081 actgggccaa ggtggtcatc ctgaaataca tgtccaggat cttgtttgtc tacgatgtgg
     1141 gtgagagctg ccttagcccc cgtcacagcc aggagccaga acaaatcacg aaggtttatg
     1201 gcaaacttcc agggtccaac ctgaaagcat ccagaaacaa agacctttcc agaaagaagg
     1261 aactgagaaa actcctaaag aatgacctag ggtaccaggg tgggatcccc cagaatactg
     1321 acagctactg tgcacgctat gaagcactga caaaaaatat tgaatacatt gccaaatgtc
     1381 tcaaggacca caaggccacc aactccaagg gcagcgagtg gaagaaggtc gccaaggtca
     1441 tagaccgttt cttcatgtgg attttcttcg ctatggtgtt tgtcatgacc gtcttgatca
     1501 tagcaagagc agattagaaa gaaagaggag gagtgggttg gtaggcattc gatatttgga
     1561 gaaaaaaaaa tcaataaatt tcacgtgtga tctcca
//
