LOCUS       NM_007390               2091 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus cholinergic receptor, nicotinic, alpha polypeptide 7
            (Chrna7), mRNA.
ACCESSION   NM_007390
VERSION     NM_007390.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2091)
  AUTHORS   Fritz,M., Rosa,P.B., Wilhelms,D., Jaarola,M., Ruud,J., Engblom,D.
            and Klawonn,A.M.
  TITLE     Nicotinic alpha7 receptors on cholinergic neurons in the striatum
            mediate cocaine-reinforcement, but not food reward
  JOURNAL   Front Mol Neurosci 17, 1418686 (2025)
   PUBMED   39906479
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2091)
  AUTHORS   Yang,Y., Eguchi,A., Mori,C. and Hashimoto,K.
  TITLE     Splenic nerve denervation attenuates depression-like behaviors in
            Chrna7 knock-out mice via the spleen-gut-brain axis
  JOURNAL   J Affect Disord 362, 114-125 (2024)
   PUBMED   38944290
  REMARK    GeneRIF: Splenic nerve denervation attenuates depression-like
            behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.
REFERENCE   3  (bases 1 to 2091)
  AUTHORS   Shen,L., Zhong,X., Ji,H., Yang,S., Jin,J., Lyu,C., Ren,Y., Xiao,Y.,
            Zhang,Y., Fang,S., Lin,N., Tou,J., Shu,Q. and Lai,D.
  TITLE     Macrophage alpha7nAChR alleviates the inflammation of neonatal
            necrotizing enterocolitis through mTOR/NLRP3/IL-1beta pathway
  JOURNAL   Int Immunopharmacol 139, 112590 (2024)
   PUBMED   38996778
  REMARK    GeneRIF: Macrophage alpha7nAChR alleviates the inflammation of
            neonatal necrotizing enterocolitis through mTOR/NLRP3/IL-1beta
            pathway.
REFERENCE   4  (bases 1 to 2091)
  AUTHORS   Zhao,C., Chen,J., Liu,Z., Liang,H., Chen,X., Cheng,L., Xie,S.,
            Lin,Z., Wu,R., Zhao,Q., Xue,Y., Lai,X., Jin,X., Xu,J.F. and Su,X.
  TITLE     Activation of nicotinic acetylcholine receptor alpha7 subunit
            limits Zika viral infection via promoting autophagy and ferroptosis
  JOURNAL   Mol Ther 32 (8), 2641-2661 (2024)
   PUBMED   38822526
  REMARK    GeneRIF: Activation of nicotinic acetylcholine receptor alpha7
            subunit limits Zika viral infection via promoting autophagy and
            ferroptosis.
REFERENCE   5  (bases 1 to 2091)
  AUTHORS   Mihara,T. and Hori,M.
  TITLE     Nicotine aggravates liver fibrosis via alpha7 nicotinic
            acetylcholine receptor expressed on activated hepatic stellate
            cells in mice
  JOURNAL   Hepatol Commun 8 (6), e0457 (2024)
   PUBMED   38836815
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2091)
  AUTHORS   Marks,M.J., Pauly,J.R., Grun,E.U. and Collins,A.C.
  TITLE     ST/b and DBA/2 mice differ in brain alpha-bungarotoxin binding and
            alpha 7 nicotinic receptor subunit mRNA levels: a quantitative
            autoradiographic analysis
  JOURNAL   Brain Res Mol Brain Res 39 (1-2), 207-222 (1996)
   PUBMED   8804729
REFERENCE   7  (bases 1 to 2091)
  AUTHORS   Drescher,D.G., Khan,K.M., Green,G.E., Morley,B.J., Beisel,K.W.,
            Kaul,H., Gordon,D., Gupta,A.K., Drescher,M.J. and Barretto,R.L.
  TITLE     Analysis of nicotinic acetylcholine receptor subunits in the
            cochlea of the mouse
  JOURNAL   Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 112 (3),
            267-273 (1995)
   PUBMED   8838678
REFERENCE   8  (bases 1 to 2091)
  AUTHORS   Nagavarapu,U. and Boyd,R.T.
  TITLE     Distribution of neuronal nicotinic acetylcholine receptor gene
            restriction fragment length polymorphisms in inbred and partially
            inbred mice
  JOURNAL   Pharmacogenetics 5 (5), 326-331 (1995)
   PUBMED   8563774
REFERENCE   9  (bases 1 to 2091)
  AUTHORS   Orr-Urtreger,A., Seldin,M.F., Baldini,A. and Beaudet,A.L.
  TITLE     Cloning and mapping of the mouse alpha 7-neuronal nicotinic
            acetylcholine receptor
  JOURNAL   Genomics 26 (2), 399-402 (1995)
   PUBMED   7601470
REFERENCE   10 (bases 1 to 2091)
  AUTHORS   Schultz,J.R., Gong,E.L., McCall,M.R., Nichols,A.V., Clift,S.M. and
            Rubin,E.M.
  TITLE     Expression of human apolipoprotein A-II and its effect on high
            density lipoproteins in transgenic mice
  JOURNAL   J Biol Chem 267 (30), 21630-21636 (1992)
   PUBMED   1400473
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK034208.1, AK157809.1 and BY727569.1.
            
            On Sep 5, 2007 this sequence version replaced NM_007390.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF225980.1, AK157809.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK034208.1         45-48
            5-1719              AK157809.1         2-1716
            1720-2091           BY727569.1         107-478
FEATURES             Location/Qualifiers
     source          1..2091
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 34.47 cM"
     gene            1..2091
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /note="cholinergic receptor, nicotinic, alpha polypeptide
                     7"
                     /db_xref="GeneID:11441"
                     /db_xref="MGI:MGI:99779"
     exon            1..105
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1559
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /note="neuronal acetylcholine receptor subunit alpha-7;
                     acetylcholine receptor alpha 7 neural; alpha7 nicotinic
                     receptor; alpha7-nAChR"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit alpha-7
                     precursor"
                     /protein_id="NP_031416.3"
                     /db_xref="CCDS:CCDS21329.1"
                     /db_xref="GeneID:11441"
                     /db_xref="MGI:MGI:99779"
                     /translation="MCGRRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPV
                     ANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRF
                     PDGQIWKPDILLYNSADERFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFD
                     VQQCKLKFGSWSYGGWSLDLQMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYP
                     DVTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFM
                     LLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRII
                     LLNWCAWFLRMKRPGEDKVRPACQHKPRRCSLASVELSAGAGPPTSNGNLLYIGFRGL
                     EGMHCAPTPDSGVVCGRLACSPTHDEHLMHGTHPSDGDPDLAKILEEVRYIANRFRCQ
                     DESEVICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA"
     exon            106..245
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            246..290
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            291..400
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            401..480
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            481..648
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            649..843
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            844..930
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1040
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..2091
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1703..1708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /note="hexamer: ACTAAA"
     polyA_site      1720
                     /gene="Chrna7"
                     /gene_synonym="Acra7; alpha7; nAchR"
                     /note="major polyA site"
ORIGIN      
        1 cggcagctcg gccccggcgg acggcgggac acggcggctg ctccggcgac atgtgcggcc
       61 ggcggggagg catctggctg gctctggccg cggcgctgct gcacgtgtcc ctgcaaggcg
      121 agttccagag gaggctgtac aaggagctgg tcaagaacta caacccgctg gagaggccgg
      181 tggccaacga ctcgcagccg ctcaccgtgt acttctccct gagcctcctg cagatcatgg
      241 atgtggatga gaagaaccaa gttttaacca ccaacatttg gctacaaatg tcttggacag
      301 atcactattt gcagtggaac atgtctgagt accccggagt gaaaaatgtt cgttttccag
      361 atggccagat ttggaaacca gacattctcc tctataacag tgcagatgaa cgctttgatg
      421 ccacattcca caccaacgtc ttggtgaatg catctgggca ttgccagtat ctccctccag
      481 gcatattcaa gagctcctgc tacatcgatg tacgctggtt cccttttgat gtgcagcagt
      541 gcaaactgaa gtttgggtcc tggtcctatg gagggtggtc cttggacctg cagatgcaag
      601 aggcagatat cagcagctat atccccaatg gagaatggga tctcatggga atccctggca
      661 aaaggaatga gaagttctat gaatgctgca aagagccata cccagatgtc acctacacag
      721 taaccatgcg ccgtaggaca ctctactatg gcctcaacct gctcattcct tgtgtgctca
      781 tttcagccct ggctttgctg gtattcttgc tgcctgcaga ctctggagag aaaatctctc
      841 ttggaataac tgtcttactt tctctgactg tcttcatgct gcttgtggct gagatcatgc
      901 cagcaacatc tgattccgtg cccttgatag cacagtactt cgccagcacc atgatcatcg
      961 tgggcctctc agtggtcgtg acagtgattg tgctgcgata tcaccaccat gaccctgatg
     1021 gtggcaaaat gcctaagtgg accaggatca ttcttctgaa ttggtgtgca tggtttctgc
     1081 gcatgaagag gccgggagag gacaaggtgc ggccggcttg tcagcacaag cctcggcgct
     1141 gcagcctggc cagtgtggag ctgagcgcag gtgcggggcc acccaccagc aatggcaacc
     1201 tgctctacat tggcttccga ggcctggagg gcatgcactg tgccccaact ccagactctg
     1261 gggtcgtgtg tggtcgtttg gcctgctccc caacacatga tgagcacctc atgcatggta
     1321 cacacccctc tgatggggac cccgacctgg ccaagatcct ggaggaggtc cgctacatcg
     1381 ccaaccgctt ccgctgccag gatgagagtg aggtgatctg cagtgagtgg aagtttgcgg
     1441 cctgtgtggt ggaccgcttg tgcctcatgg ccttttcggt ttttaccatc atctgcacca
     1501 tcggcatcct catgtcagcc ccaaactttg tggaggctgt gtccaaagac tttgcttaat
     1561 gttatcatgt aggagatgca cagataagaa gagaatctgg aggacgagaa ttggggtcct
     1621 aactctacat tgtgataaat ggaagaactc tgaggtatcc ctgtagctgt cggtcttgag
     1681 atttattttc ctggttactt taactaaaaa gatcccagca gcttctgttt acttttctta
     1741 cacccatcac cggcatatca ttgtactcgg caggggcacc atgtggtcat ttgcccactc
     1801 tggatagccc tacagggtag atcttagtgg ctctagtagg ccagtagaga ggcctgtcca
     1861 gtttgtggcg catgcctgca tgccccttgt catgggctca cccgataggc tgtctgcctt
     1921 tgccatgcac agacccaggc tgaaaccaat ccagagcact tcccactgga tccatttcaa
     1981 cagctgcctt gcaaaaggaa gtcaaattca aatacaaact acaaacccct ctgctactta
     2041 cattctctgt gatttaactt acatctaact atatctatct atctatctgt c
//
