LOCUS       NM_021369               2921 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus cholinergic receptor, nicotinic, alpha polypeptide 6
            (Chrna6), mRNA.
ACCESSION   NM_021369
VERSION     NM_021369.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2921)
  AUTHORS   Lee,B.R., Budzillo,A., Hadley,K., Miller,J.A., Jarsky,T., Baker,K.,
            Hill,D., Kim,L., Mann,R., Ng,L., Oldre,A., Rajanbabu,R., Trinh,J.,
            Vargas,S., Braun,T., Dalley,R.A., Gouwens,N.W., Kalmbach,B.E.,
            Kim,T.K., Smith,K.A., Soler-Llavina,G., Sorensen,S., Tasic,B.,
            Ting,J.T., Lein,E., Zeng,H., Murphy,G.J. and Berg,J.
  TITLE     Scaled, high fidelity electrophysiological, morphological, and
            transcriptomic cell characterization
  JOURNAL   Elife 10, e65482 (2021)
   PUBMED   34387544
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2921)
  AUTHORS   Moen,J.K., DeBaker,M.C., Myjak,J.E., Wickman,K. and Lee,A.M.
  TITLE     Bidirectional sex-dependent regulation of alpha6 and beta3
            nicotinic acetylcholine receptors by protein kinase Cepsilon
  JOURNAL   Addict Biol 26 (3), e12954 (2021)
   PUBMED   32776643
  REMARK    GeneRIF: Bidirectional sex-dependent regulation of alpha6 and beta3
            nicotinic acetylcholine receptors by protein kinase Cepsilon.
REFERENCE   3  (bases 1 to 2921)
  AUTHORS   Jager,P., Moore,G., Calpin,P., Durmishi,X., Salgarella,I.,
            Menage,L., Kita,Y., Wang,Y., Kim,D.W., Blackshaw,S., Schultz,S.R.,
            Brickley,S., Shimogori,T. and Delogu,A.
  TITLE     Dual midbrain and forebrain origins of thalamic inhibitory
            interneurons
  JOURNAL   Elife 10, e59272 (2021)
   PUBMED   33522480
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2921)
  AUTHORS   Avelar,A.J., Akers,A.T., Baumgard,Z.J., Cooper,S.Y., Casinelli,G.P.
            and Henderson,B.J.
  TITLE     Why flavored vape products may be attractive: Green apple tobacco
            flavor elicits reward-related behavior, upregulates nAChRs on VTA
            dopamine neurons, and alters midbrain dopamine and GABA neuron
            function
  JOURNAL   Neuropharmacology 158, 107729 (2019)
   PUBMED   31369741
REFERENCE   5  (bases 1 to 2921)
  AUTHORS   Yan,Y., Peng,C., Arvin,M.C., Jin,X.T., Kim,V.J., Ramsey,M.D.,
            Wang,Y., Banala,S., Wokosin,D.L., McIntosh,J.M., Lavis,L.D. and
            Drenan,R.M.
  TITLE     Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate
            Excitatory Transmission
  JOURNAL   Cell Rep 23 (8), 2236-2244 (2018)
   PUBMED   29791835
REFERENCE   6  (bases 1 to 2921)
  AUTHORS   Even,N., Cardona,A., Soudant,M., Corringer,P.J., Changeux,J.P. and
            Cloez-Tayarani,I.
  TITLE     Regional differential effects of chronic nicotine on brain alpha
            4-containing and alpha 6-containing receptors
  JOURNAL   Neuroreport 19 (15), 1545-1550 (2008)
   PUBMED   18797314
REFERENCE   7  (bases 1 to 2921)
  AUTHORS   Champtiaux,N., Gotti,C., Cordero-Erausquin,M., David,D.J.,
            Przybylski,C., Lena,C., Clementi,F., Moretti,M., Rossi,F.M., Le
            Novere,N., McIntosh,J.M., Gardier,A.M. and Changeux,J.P.
  TITLE     Subunit composition of functional nicotinic receptors in
            dopaminergic neurons investigated with knock-out mice
  JOURNAL   J Neurosci 23 (21), 7820-7829 (2003)
   PUBMED   12944511
REFERENCE   8  (bases 1 to 2921)
  AUTHORS   Kuo,Y., Lucero,L., Michaels,J., DeLuca,D. and Lukas,R.J.
  TITLE     Differential expression of nicotinic acetylcholine receptor
            subunits in fetal and neonatal mouse thymus
  JOURNAL   J Neuroimmunol 130 (1-2), 140-154 (2002)
   PUBMED   12225896
REFERENCE   9  (bases 1 to 2921)
  AUTHORS   Champtiaux,N., Han,Z.Y., Bessis,A., Rossi,F.M., Zoli,M.,
            Marubio,L., McIntosh,J.M. and Changeux,J.P.
  TITLE     Distribution and pharmacology of alpha 6-containing nicotinic
            acetylcholine receptors analyzed with mutant mice
  JOURNAL   J Neurosci 22 (4), 1208-1217 (2002)
   PUBMED   11850448
REFERENCE   10 (bases 1 to 2921)
  AUTHORS   Drescher,D.G., Khan,K.M., Green,G.E., Morley,B.J., Beisel,K.W.,
            Kaul,H., Gordon,D., Gupta,A.K., Drescher,M.J. and Barretto,R.L.
  TITLE     Analysis of nicotinic acetylcholine receptor subunits in the
            cochlea of the mouse
  JOURNAL   Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 112 (3),
            267-273 (1995)
   PUBMED   8838678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031985.1.
            
            On Jun 9, 2003 this sequence version replaced NM_021369.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031985.1, AK149262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2921              BC031985.1         1-2921
FEATURES             Location/Qualifiers
     source          1..2921
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 16.02 cM"
     gene            1..2921
                     /gene="Chrna6"
                     /gene_synonym="Acra6; Nica6"
                     /note="cholinergic receptor, nicotinic, alpha polypeptide
                     6"
                     /db_xref="GeneID:11440"
                     /db_xref="MGI:MGI:106213"
     exon            1..321
                     /gene="Chrna6"
                     /gene_synonym="Acra6; Nica6"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1727
                     /gene="Chrna6"
                     /gene_synonym="Acra6; Nica6"
                     /note="nicotinic acetylcholine receptor subunit alpha 6;
                     neuronal acetylcholine receptor subunit alpha-6;
                     acetylcholine receptor alpha 6 neural; alpha6 nAChR"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit alpha-6
                     precursor"
                     /protein_id="NP_067344.2"
                     /db_xref="CCDS:CCDS40312.1"
                     /db_xref="GeneID:11440"
                     /db_xref="MGI:MGI:106213"
                     /translation="MLNSRDQGNLHSGLCLWLCGFLALFKGSTGCESEEQLFHRLFAH
                     YNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHIWKDYRLRWDPTEY
                     DGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPM
                     DITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDI
                     KYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCI
                     SVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPAT
                     HTMPKWVKTIFLQAFPSILMMRKPLDKTKEAGGVKDPKSHTKRPAKVKFTHRGESKLL
                     KECHHCQKSSDIAPGKRRSSQQPARWVAENSEHSSDVEDVIESVQFIAENMKSHNETN
                     EVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQPLLGNTGKS"
     exon            322..461
                     /gene="Chrna6"
                     /gene_synonym="Acra6; Nica6"
                     /inference="alignment:Splign:2.1.0"
     exon            462..506
                     /gene="Chrna6"
                     /gene_synonym="Acra6; Nica6"
                     /inference="alignment:Splign:2.1.0"
     exon            507..616
                     /gene="Chrna6"
                     /gene_synonym="Acra6; Nica6"
                     /inference="alignment:Splign:2.1.0"
     exon            617..1595
                     /gene="Chrna6"
                     /gene_synonym="Acra6; Nica6"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..2906
                     /gene="Chrna6"
                     /gene_synonym="Acra6; Nica6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2883..2888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrna6"
                     /gene_synonym="Acra6; Nica6"
                     /note="hexamer: AATAAA"
     polyA_site      2906
                     /gene="Chrna6"
                     /gene_synonym="Acra6; Nica6"
                     /note="major polyA site"
ORIGIN      
        1 gacaggacat gtgacagcca gccgagtgaa gcagcagggt tggcttccct tgcccttcac
       61 atctgtttca gcctgggatg cagggagcag ttgcatgatg tcccgtgttt tcacttcaca
      121 gaagatctgt gtgagcttcc aggagcttcc cggggctttc aatatctgat tctggcagct
      181 gacagacagc tgtgtcttcc acagccctcc gtgtagaaat cggaattcag agagctttta
      241 tcatgctgaa cagccgggac cagggaaacc tgcactccgg tttatgtctg tggctatgtg
      301 gattcctggc tctctttaaa ggcagtacag gctgtgaatc tgaagagcag ctcttccaca
      361 ggctgtttgc tcactacaac cgcttcatcc ggccggtgga gaatgtctcc gatcccgtca
      421 cggtgcattt tgaattggca atcacgcaac tggccaatgt ggatgaagtc aaccagatta
      481 tggagaccaa tctgtggctg cgtcacatct ggaaggacta cagattgcgt tgggatccaa
      541 cggagtatga tggcatcgag acacttcgag ttccagcaga caacatctgg aagcctgaca
      601 tcgttctgta taacaatgct gtcggcgact tccaggtcga aggcaagacc aaagctcttc
      661 tcaagtatga cggtgtgata acctggaccc caccagccat ctttaagagc tcctgcccaa
      721 tggacatcac cttcttcccg tttgaccatc aaaactgctc cctgaagttt ggttcctgga
      781 cttatgacaa ggcagaaatc gaccttctca tcattggctc taaagtagac atgaacgact
      841 tttgggaaaa cagtgaatgg gaaattgtcg acgcctctgg ctataagcat gacatcaagt
      901 acaactgctg tgaagagatt tacacggaca taacctactc cttctacatc aggaggttgc
      961 ccatgtttta caccatcaac ctcatcatcc cctgcctctt catttccttc ctcacggtgc
     1021 tggtttttta ccttccctcc gactgtggcg agaaagtgac tctttgcatc tccgttctgc
     1081 tttctctcac tgtctttttg ctggtgatta cagagaccat cccatccaca tctctcgtga
     1141 tcccactggt gggtgagtat ctactgttca ccatgatctt tgtcacgctg tccattgtgg
     1201 tgaccgtgtt cgtgctgaac atacactaca ggaccccagc aacgcatacc atgcccaagt
     1261 gggtgaagac catcttcctt caggccttcc cctcgattct gatgatgagg aaacctctgg
     1321 acaagacaaa ggaggcagga ggtgttaagg accccaaaag ccataccaag aggcctgcca
     1381 aggtcaaatt tactcatcga ggagaatcca aacttctaaa ggaatgccac cactgccaaa
     1441 aatcaagtga catagcacct ggaaagagaa gatcaagcca gcagcctgca cggtgggtgg
     1501 cagagaattc agagcactcg tccgatgttg aagatgtcat cgagagtgtt caattcatag
     1561 cagaaaacat gaagagccac aatgaaacaa acgaggtaga agacgactgg aaatacatgg
     1621 ctatggtggt ggacagagtc ttcctttggg tatttataat tgtctgtgtg tttggaactg
     1681 tggggctatt tctgcagcca ctgcttggga acacaggaaa gtcttaattg gtattgtccc
     1741 tttaccttct gaatctttta gatgttgtgt tttttcccga gctagtcccc acaagaaaaa
     1801 gccaagtaca cagactccta aaccaagaca agaagggagt gggcattgct gcagccttag
     1861 gagcctgaat acctgtcttc cttacactgg gtgttttatc accttggagc ccagagctgg
     1921 cagttgtcct aggctaggag gactgagtca gcttctctat aatttgcatt ctttgtttca
     1981 agaaacacaa atggtccctc gtagagctag gccccatagt caagagtcag tccactctga
     2041 aaggtgattg gcttgtatcc gaagctcctg ctggttattg caagtgatgt gtatggttat
     2101 caagaaactc gggagcgctg ctgacacttg caacacacct gtctgctact ttcttgtgca
     2161 tgtccctgtg atgtagctca cactcatatc tgacatgtgc aatggtcaaa gaagaaagca
     2221 gatagcatct ctcttagcag actattcaat tcgtggtgca atgggttttc tgtccgtgtg
     2281 aaaatcactg aactgatagg cgtaaaagga tgacgtttat atgagctcat ggatttggag
     2341 gactctgccc atgatcacta ggtcccattg cctctgggcc tttgatgagg caaagcatca
     2401 tgcctagaag aggatggctg cccacttaaa gatagctaca aagaaagcaa acagagagga
     2461 aggctctgga gtgccaatat tcctttcaca gtcacagccc aatgacttca tgtcttccta
     2521 caagaccttc catcctagaa gctccactac ctcctgatag cgtggaggaa tcagtctcta
     2581 acacttgtcc ttggggctga tccaaaccac agcagtattg tcctggcagg acatttggct
     2641 ggctccagta ctgtgctagg tgctacaagg ggatacataa gagtctttcc cttataaagt
     2701 tacagccttt tagaaaagcc gtatatgcaa agagccacag gatcaggtag tagaggatat
     2761 agctagagca acccaaatgg gagaaactaa tcggacaaac ctaaactcac tcttgtgttt
     2821 caaacagata tctgtgtagc tttttcccac gagcccttct ctagctcact gcatggagat
     2881 gaaataaaat cgatatgaaa ttttaaaaaa aaaaaaaaaa a
//
