LOCUS       NP_001360830             467 aa            linear   ROD 05-OCT-2024
DEFINITION  neuronal acetylcholine receptor subunit alpha-5 isoform 1 precursor
            [Mus musculus].
ACCESSION   NP_001360830 XP_006510836
VERSION     NP_001360830.1
DBSOURCE    REFSEQ: accession NM_001373901.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 467)
  AUTHORS   Tsuzuki,A., Yamasaki,M., Konno,K., Miyazaki,T., Takei,N.,
            Tomita,S., Yuzaki,M. and Watanabe,M.
  TITLE     Abundant extrasynaptic expression of alpha3beta4-containing
            nicotinic acetylcholine receptors in the medial
            habenula-interpeduncular nucleus pathway in mice
  JOURNAL   Sci Rep 14 (1), 14193 (2024)
   PUBMED   38902419
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 467)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 467)
  AUTHORS   Yang,K., McLaughlin,I., Shaw,J.K., Quijano-Carde,N., Dani,J.A. and
            De Biasi,M.
  TITLE     CHRNA5 gene variation affects the response of VTA dopaminergic
            neurons during chronic nicotine exposure and withdrawal
  JOURNAL   Neuropharmacology 235, 109547 (2023)
   PUBMED   37116611
  REMARK    GeneRIF: CHRNA5 gene variation affects the response of VTA
            dopaminergic neurons during chronic nicotine exposure and
            withdrawal.
REFERENCE   4  (residues 1 to 467)
  AUTHORS   Brynildsen,J.K., Yang,K., Lemchi,C., Dani,J.A., De Biasi,M. and
            Blendy,J.A.
  TITLE     A common SNP in Chrna5 enhances morphine reward in female mice
  JOURNAL   Neuropharmacology 218, 109218 (2022)
   PUBMED   35973602
  REMARK    GeneRIF: A common SNP in Chrna5 enhances morphine reward in female
            mice.
REFERENCE   5  (residues 1 to 467)
  AUTHORS   Quijano Carde,N.A., Shaw,J., Carter,C., Kim,S., Stitzel,J.A.,
            Venkatesh,S.K., Ramchandani,V.A. and De Biasi,M.
  TITLE     Mutation of the alpha5 nicotinic acetylcholine receptor subunit
            increases ethanol and nicotine consumption in adolescence and
            impacts adult drug consumption
  JOURNAL   Neuropharmacology 216, 109170 (2022)
   PUBMED   35752273
  REMARK    GeneRIF: Mutation of the alpha5 nicotinic acetylcholine receptor
            subunit increases ethanol and nicotine consumption in adolescence
            and impacts adult drug consumption.
REFERENCE   6  (residues 1 to 467)
  AUTHORS   Miner,L.L. and Marley,R.J.
  TITLE     Chromosomal mapping of the psychomotor stimulant effects of cocaine
            in BXD recombinant inbred mice
  JOURNAL   Psychopharmacology (Berl) 122 (3), 209-214 (1995)
   PUBMED   8748389
REFERENCE   7  (residues 1 to 467)
  AUTHORS   Drescher,D.G., Khan,K.M., Green,G.E., Morley,B.J., Beisel,K.W.,
            Kaul,H., Gordon,D., Gupta,A.K., Drescher,M.J. and Barretto,R.L.
  TITLE     Analysis of nicotinic acetylcholine receptor subunits in the
            cochlea of the mouse
  JOURNAL   Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 112 (3),
            267-273 (1995)
   PUBMED   8838678
REFERENCE   8  (residues 1 to 467)
  AUTHORS   Nagavarapu,U. and Boyd,R.T.
  TITLE     Distribution of neuronal nicotinic acetylcholine receptor gene
            restriction fragment length polymorphisms in inbred and partially
            inbred mice
  JOURNAL   Pharmacogenetics 5 (5), 326-331 (1995)
   PUBMED   8563774
REFERENCE   9  (residues 1 to 467)
  AUTHORS   Anand,R. and Lindstrom,J.
  TITLE     Chromosomal localization of seven neuronal nicotinic acetylcholine
            receptor subunit genes in humans
  JOURNAL   Genomics 13 (4), 962-967 (1992)
   PUBMED   1505988
REFERENCE   10 (residues 1 to 467)
  AUTHORS   Eng,C.M., Kozak,C.A., Beaudet,A.L. and Zoghbi,H.Y.
  TITLE     Mapping of multiple subunits of the neuronal nicotinic
            acetylcholine receptor to chromosome 15 in man and chromosome 9 in
            mouse
  JOURNAL   Genomics 9 (2), 278-282 (1991)
   PUBMED   2004777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161264.2.
            
            On Oct 28, 2019 this sequence version replaced XP_006510836.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ318788.1, SRR11927933.2222185.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..467
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.84 cM"
     Protein         1..467
                     /product="neuronal acetylcholine receptor subunit alpha-5
                     isoform 1 precursor"
                     /note="neuronal acetylcholine receptor subunit alpha-5;
                     nicotinic acetylcholine receptor alpha5 subunit"
                     /calculated_mol_wt=50218
     sig_peptide     1..29
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q2MKA5.1)"
                     /calculated_mol_wt=3248
     mat_peptide     30..467
                     /product="Neuronal acetylcholine receptor subunit alpha-5.
                     /id=PRO_0000304938"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MKA5.1)"
                     /calculated_mol_wt=50218
     Region          45..251
                     /region_name="LGIC_ECD"
                     /note="extracellular domain (ECD) of Cys-loop
                     neurotransmitter-gated ion channels (also known as
                     ligand-gated ion channel (LGIC)); cl28912"
                     /db_xref="CDD:475126"
     Site            order(82,84,90..91,98,120,122,131..132,134,136..137,
                     147..149,151,161,163,165,169,191,249)
                     /site_type="other"
                     /note="pentamer interface [polypeptide binding]"
                     /db_xref="CDD:349787"
     Site            155
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q2MKA5.1)"
     Site            183
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q2MKA5.1)"
     Site            229
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q2MKA5.1)"
     Site            255..275
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MKA5.1)"
     Region          257..446
                     /region_name="Neur_chan_memb"
                     /note="Neurotransmitter-gated ion-channel transmembrane
                     region; pfam02932"
                     /db_xref="CDD:460753"
     Site            284..304
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MKA5.1)"
     Site            317..337
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MKA5.1)"
     Site            430..450
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q2MKA5.1)"
     CDS             1..467
                     /gene="Chrna5"
                     /gene_synonym="Acra-5; Acra5"
                     /coded_by="NM_001373901.1:129..1532"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="GeneID:110835"
                     /db_xref="MGI:MGI:87889"
ORIGIN      
        1 maargsrrra lrlllmvqll agrwrpagaa rgargglpel ssaakhedsl frdlfedyek
       61 wvrpvehlsd kikikfglai sqlvdvdekn qlmttnvwlk qewidvklrw npddyggiki
      121 irvpsdslwi pdivlfdnad grfegastkt vvryngtvtw tqpanykssc tidvtffpfd
      181 lqncsmkfgs wtydgsqvdi iledqdvdrt dffdngewei msamgskgnr tdsccwypci
      241 tysfvikrlp lfytlfliip ciglsfltvv vfylpsnege kislctsvlv sltvfllvie
      301 eiipssskvi pligeylvft mifvtlsimv tvfainihhr sssthnamap wvrkiflhkl
      361 pkllcmrsha dryftqreea ekdggpksrn tleaaldcir yitrhvvken dvrevvedwk
      421 fiaqvldrmf lwtfllvsii gtlglfvpvi ykwaniivpv higntik
//
