LOCUS       NM_145129               4352 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus cholinergic receptor, nicotinic, alpha polypeptide 3
            (Chrna3), mRNA.
ACCESSION   NM_145129
VERSION     NM_145129.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4352)
  AUTHORS   Tsuzuki,A., Yamasaki,M., Konno,K., Miyazaki,T., Takei,N.,
            Tomita,S., Yuzaki,M. and Watanabe,M.
  TITLE     Abundant extrasynaptic expression of alpha3beta4-containing
            nicotinic acetylcholine receptors in the medial
            habenula-interpeduncular nucleus pathway in mice
  JOURNAL   Sci Rep 14 (1), 14193 (2024)
   PUBMED   38902419
  REMARK    GeneRIF: Abundant extrasynaptic expression of
            alpha3beta4-containing nicotinic acetylcholine receptors in the
            medial habenula-interpeduncular nucleus pathway in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4352)
  AUTHORS   Jimenez-Pompa,A., Arribas,R.L., McIntosh,J.M. and Albillos,A.
  TITLE     Differential tyrosine and serine/threonine
            phosphorylation/dephosphorylation pathways regulate the expression
            of alpha7 versus alpha3beta4 nicotinic receptor subtypes in mouse
            hippocampal neurons
  JOURNAL   Biochem Biophys Res Commun 684, 149115 (2023)
   PUBMED   37879250
  REMARK    GeneRIF: Differential tyrosine and serine/threonine
            phosphorylation/dephosphorylation pathways regulate the expression
            of alpha7 versus alpha3beta4 nicotinic receptor subtypes in mouse
            hippocampal neurons.
REFERENCE   3  (bases 1 to 4352)
  AUTHORS   Bsharat,S., Monni,E., Singh,T., Johansson,J.K., Achanta,K.,
            Bertonnier-Brouty,L., Schmidt-Christensen,A., Holmberg,D.,
            Kokaia,Z., Prasad,R.B. and Artner,I.
  TITLE     MafB-dependent neurotransmitter signaling promotes beta cell
            migration in the developing pancreas
  JOURNAL   Development 150 (6) (2023)
   PUBMED   36897571
REFERENCE   4  (bases 1 to 4352)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4352)
  AUTHORS   Elayouby,K.S., Ishikawa,M., Dukes,A.J., Smith,A.C.W., Lu,Q.,
            Fowler,C.D. and Kenny,P.J.
  TITLE     alpha3* Nicotinic Acetylcholine Receptors in the
            Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake
  JOURNAL   J Neurosci 41 (8), 1779-1787 (2021)
   PUBMED   33380469
  REMARK    GeneRIF: alpha3* Nicotinic Acetylcholine Receptors in the
            Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake.
REFERENCE   6  (bases 1 to 4352)
  AUTHORS   Burmeister,M., Novak,J., Liang,M.Y., Basu,S., Ploder,L.,
            Hawes,N.L., Vidgen,D., Hoover,F., Goldman,D., Kalnins,V.I.,
            Roderick,T.H., Taylor,B.A., Hankin,M.H. and McInnes,R.R.
  TITLE     Ocular retardation mouse caused by Chx10 homeobox null allele:
            impaired retinal progenitor proliferation and bipolar cell
            differentiation
  JOURNAL   Nat Genet 12 (4), 376-384 (1996)
   PUBMED   8630490
REFERENCE   7  (bases 1 to 4352)
  AUTHORS   Nagavarapu,U. and Boyd,R.T.
  TITLE     Distribution of neuronal nicotinic acetylcholine receptor gene
            restriction fragment length polymorphisms in inbred and partially
            inbred mice
  JOURNAL   Pharmacogenetics 5 (5), 326-331 (1995)
   PUBMED   8563774
REFERENCE   8  (bases 1 to 4352)
  AUTHORS   Anand,R. and Lindstrom,J.
  TITLE     Chromosomal localization of seven neuronal nicotinic acetylcholine
            receptor subunit genes in humans
  JOURNAL   Genomics 13 (4), 962-967 (1992)
   PUBMED   1505988
REFERENCE   9  (bases 1 to 4352)
  AUTHORS   Eng,C.M., Kozak,C.A., Beaudet,A.L. and Zoghbi,H.Y.
  TITLE     Mapping of multiple subunits of the neuronal nicotinic
            acetylcholine receptor to chromosome 15 in man and chromosome 9 in
            mouse
  JOURNAL   Genomics 9 (2), 278-282 (1991)
   PUBMED   2004777
REFERENCE   10 (bases 1 to 4352)
  AUTHORS   Bessis,A., Simon-Chazottes,D., Devillers-Thiery,A., Guenet,J.L. and
            Changeux,J.P.
  TITLE     Chromosomal localization of the mouse genes coding for alpha 2,
            alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic
            acetylcholine receptor
  JOURNAL   FEBS Lett 264 (1), 48-52 (1990)
   PUBMED   2338144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156832.2 and AC161264.2.
            
            On Mar 21, 2019 this sequence version replaced NM_145129.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051730.1, AK080415.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849377,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC156832.2         45136-45367         c
            233-372             AC156832.2         43093-43232         c
            373-417             AC156832.2         42951-42995         c
            418-527             AC161264.2         1679-1788
            528-1539            AC161264.2         7819-8830
            1540-4352           AC161264.2         11038-13850
FEATURES             Location/Qualifiers
     source          1..4352
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.84 cM"
     gene            1..4352
                     /gene="Chrna3"
                     /gene_synonym="(a)3; A730007P14Rik; Acra-3; Acra3"
                     /note="cholinergic receptor, nicotinic, alpha polypeptide
                     3"
                     /db_xref="GeneID:110834"
                     /db_xref="MGI:MGI:87887"
     exon            1..232
                     /gene="Chrna3"
                     /gene_synonym="(a)3; A730007P14Rik; Acra-3; Acra3"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1668
                     /gene="Chrna3"
                     /gene_synonym="(a)3; A730007P14Rik; Acra-3; Acra3"
                     /note="neuronal acetylcholine receptor subunit alpha-3;
                     neuronal nicotinic acetylcholine receptor, alpha 3
                     subunit"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit alpha-3
                     precursor"
                     /protein_id="NP_660111.3"
                     /db_xref="CCDS:CCDS23199.2"
                     /db_xref="GeneID:110834"
                     /db_xref="MGI:MGI:87887"
                     /translation="MGVVLPPPPLSMLMLVLMLLPVASASEAEHRLFQYLFEDYNEII
                     RPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEF
                     MRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYF
                     PFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCC
                     EEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLS
                     LTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPT
                     WVKAVFLNLLPRVMFMTRPTSTEEDAPKTRNFYGAELSNLNCFSRADSKSCKEGYPCQ
                     DGTCGYCHHRRVKISNFSANLTRSSSSESVDAVLSLSALSPEIKEAIQSVKYIAENMK
                     AQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLMARDDT"
     exon            233..372
                     /gene="Chrna3"
                     /gene_synonym="(a)3; A730007P14Rik; Acra-3; Acra3"
                     /inference="alignment:Splign:2.1.0"
     exon            373..417
                     /gene="Chrna3"
                     /gene_synonym="(a)3; A730007P14Rik; Acra-3; Acra3"
                     /inference="alignment:Splign:2.1.0"
     exon            418..527
                     /gene="Chrna3"
                     /gene_synonym="(a)3; A730007P14Rik; Acra-3; Acra3"
                     /inference="alignment:Splign:2.1.0"
     exon            528..1539
                     /gene="Chrna3"
                     /gene_synonym="(a)3; A730007P14Rik; Acra-3; Acra3"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..4352
                     /gene="Chrna3"
                     /gene_synonym="(a)3; A730007P14Rik; Acra-3; Acra3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2896..2901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrna3"
                     /gene_synonym="(a)3; A730007P14Rik; Acra-3; Acra3"
                     /note="hexamer: AATAAA"
     polyA_site      2916
                     /gene="Chrna3"
                     /gene_synonym="(a)3; A730007P14Rik; Acra-3; Acra3"
                     /note="major polyA site"
ORIGIN      
        1 gctagcagcg cttgcctgcc tggggttcgt gcactcgggc gcgcaagtgc gcgggagctc
       61 ggcggcgcga agccgggagg aaccccgcgc tctccgtgct agcttagctg tgcttcggtg
      121 gtggtcagca ccagagtggc tccggtcctg tccatgcggt cttcagacat gggtgttgtg
      181 ctgcccccgc cgccgctgtc catgctgatg ctggtgctga tgctgctgcc agtggccagc
      241 gcctcggaag ctgagcaccg cctgttccag tacctgtttg aagattacaa cgagatcatc
      301 cggccggtgg ctaacgtgtc ccatcctgtc atcatccagt ttgaggtgtc tatgtctcag
      361 ctggtgaagg tggatgaagt aaaccagatc atggaaacca acctgtggct gaagcaaatc
      421 tggaatgact acaagctgaa atggaaaccc tctgactacc aaggggtgga gttcatgcga
      481 gtccctgcag agaagatctg gaaaccagac atcgtgcttt acaacaacgc cgatggggat
      541 ttccaagtgg atgacaaaac caaagctcta ctcaagtaca caggagaagt gacttggatc
      601 cctccggcca tctttaagag ctcatgcaaa atcgatgtga cctacttccc gtttgactac
      661 caaaactgca ccatgaagtt cggctcctgg tcctacgaca aggcaaagat cgacctggtc
      721 ctcattggct cctccatgaa cctcaaggac tattgggaaa gtggcgagtg ggccatcatt
      781 aaagccccgg gctacaaaca tgaaatcaag tacaactgct gtgaggagat ctaccaagac
      841 atcacgtact cgctatacat tcgccgcctg ccgctgttct acaccatcaa cctcatcatt
      901 ccgtgcctgc tcatctcctt cctcactgtg ctcgtcttct acctgccctc cgactgtggg
      961 gagaaggtga cgctctgcat ctccgtgctc ctctccctga cggtctttct cctcgtgatc
     1021 accgagacca tcccttccac ctcactggtc atccccttga tcggggagta cctcctcttc
     1081 actatgattt ttgtcacctt gtccatcgtc atcacagtct ttgtgctcaa cgtgcactac
     1141 agaactccga ccacacacac gatgcccact tgggtcaagg ctgtgttttt gaaccttctc
     1201 cccagggtca tgtttatgac taggccaacc agcaccgagg aagacgcccc aaagacgagg
     1261 aacttctacg gtgctgagct ctcaaacctg aactgcttca gccgtgcaga ctccaaaagc
     1321 tgcaaggaag gctacccctg ccaagatggg acatgtggct attgccacca ccgtagggta
     1381 aaaatctcaa atttcagtgc caacctcaca agaagctcca gttctgagtc tgttgatgct
     1441 gtgttgtccc tgtctgctct gtcaccagaa atcaaagaag ccatccaaag tgtgaagtat
     1501 attgctgaaa atatgaaagc acagaatgta gccaaagaga ttcaagatga ttggaagtat
     1561 gttgccatgg tgattgatcg catttttctc tgggttttca tcctggtgtg cattttagga
     1621 actgcaggat tatttctgca acccttgatg gccagagatg acacataaac tgtgacctgt
     1681 tcgccaaggc tcgctcacct gtgctgatgc aagggcactt tctcaatagc cccacacttt
     1741 atccgatcac tgcttggagt ttgctatttc aagggttatt ttccactcat cttgatcttt
     1801 ttttgttgtt gttgttaaaa agaaatgtgg gagaaaaaca tctagttatt tactaaggat
     1861 aaatgaacat ttcactatcc ccatgattga aaactagata gaaatttttt ctgttcataa
     1921 atattaaatc cattagctca gaatctctat agaactcatt tgttcagccc ataaactact
     1981 tgaagttata aagtattcca gcagcacccc atcacttcca ttctttacta ttttttcaaa
     2041 ggcttccacc tcaattttgt tgctgctaaa ccccacatat cataccctga gatgtgacgc
     2101 ctggtctcac actcattgtt agtaaactac catagtctgt tcaagttgct aatttagaaa
     2161 aacatcccat agagccctga aagacttttt aatcccagca ctcaagaggt agagtcagag
     2221 gcaggttgga tctctgtgaa ttccaggcca gcctggttta gttagtgagc cccagcccaa
     2281 ccatggctgc agagtgaaac actgtctcaa aaccacaaga ccacaaacac tggacaacta
     2341 aacgcaaagt tatttctcat agtttaggag cttgagacgt ctaggatcaa ggtgccagca
     2401 agactatctg gggaggagtc ttcttcataa agcatacctt ccagtgcgtc accacgtggc
     2461 tgaaagggcg agtgtttctg gaatcttggt tccctttgtc aaggcatgcc ctcatgacct
     2521 catgacctcc caaacagcat tgcacggtag gttcacacgc gagctgcagg gagtcatcca
     2581 gaccctagga tgtcagggta aggcttcact attatagcac tagggtttgt gctcccgact
     2641 cgagttggga tgagagatgt gtggacttcg gcagccgatg gttcctgccc actaggatgc
     2701 caataacagg cctgtgtgcc tcggttgtca gagcacccag aatgcaggac gttgtcaaaa
     2761 ttagttatgc ttgagaagct atttgaacga attgagtttc ccatattaca tttccaaatc
     2821 taaaccacaa ctcctagagt ccacagagac cattttgagt attctcacta gttttttttt
     2881 ttttttctgt gcaaaaataa aacctgacaa ttgcaattca ctgtggctca tatttcacta
     2941 agtcaaaagg aagtgtgttc tatgaagttt gttggcttac aaatatctca acagtgattg
     3001 agatataaga gatgagggat atacacaaac taagatagct aacagcaatt tacattaaac
     3061 tagtttttat tagtgtttcc tcatattgtt aagcacctga gataataaat tttaaaggag
     3121 gaaatgtgta tttgggctca tggtttcagt ccacagccac tcatgtggtc tattcctttt
     3181 gggcttgtga tgagacaata cttcatagta agaagtgtct gattcatcaa tgacattcac
     3241 ctcaaagcag cctggaagca gaaagaatgg ggaagaagct gggctcctgt ttttccaaga
     3301 aggacgcact cccaatgacc aagctccttt cttcttagag gttccacacc tctgagtagc
     3361 accgagtagg ctggtgacca aacctttgat acactggcct ttggcactta ctcagaatgt
     3421 ggcctggctt ccaaagactt atatccattt cataatttgt tttttgcaag agttcccaaa
     3481 gtcttaactg cttcagaatt gttccatagt ccatgtcaaa ctcggcagag aagctgtaaa
     3541 aagattataa atgcccagga tacattgaca ctaggtaaac atttctattc cacaaaggag
     3601 cacagatgtg tagaaaagat cagatcaaag caagagcaaa actaagcagg gcagacatct
     3661 ggcctctggc gcccacagtg gcagtatgtg aaatctcaag ggcgcaggca gtcctgctcc
     3721 tacagactcg ctgactgcat gcagcccctg tgcctctcta gggctggctg aacttacctc
     3781 acacagctct cctcagcagg cactccacag tttgtcaccc cttgctttct ggggtctcca
     3841 ttttagattc agcttcacac tcttgtttcc aacatattgc cagtttgaga gctgataacc
     3901 tctgaaatct ttgtggaaaa ctccaggact ccacaactct ttcactttgc atgtctgtaa
     3961 aatcggcatt atgtggatga tggccaggtt tgcacaagct atatatggcc tacccgagta
     4021 tctgcagatg aggaaggagc ttcagggcaa cattttctag attgccttat ggaaggaggc
     4081 tgtcctgggt ctatttagga aaaatgtctg aattctttga gcttgcacag gcacaagtct
     4141 gaataattct tgaggcacct tcacagtatt gtattaacct ggtgccaagc acttgacttc
     4201 ccctttaaaa tatattttta ctcattgaga atttcataca tattttgatc atactcatcc
     4261 cctcctctta ccacttccca gacacatcct ctcttcttga ctcattcaac tttgtgtcct
     4321 ttaaaagtga ttaattaaaa aatacattta tc
//
