LOCUS       NM_144803               3527 bp    mRNA    linear   ROD 10-NOV-2023
DEFINITION  Mus musculus cholinergic receptor nicotinic alpha 2 subunit
            (Chrna2), mRNA.
ACCESSION   NM_144803
VERSION     NM_144803.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3527)
  AUTHORS   Kisseleff E, Vigouroux RJ, Hottin C, Lourdel S, Thomas L, Shah P,
            Chedotal A, Perron M, Swaroop A and Roger JE.
  TITLE     Glycogen Synthase Kinase 3 Regulates the Genesis of Displaced
            Retinal Ganglion Cells3
  JOURNAL   eNeuro 8 (5) (2021)
   PUBMED   34518365
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3527)
  AUTHORS   Jun H, Ma Y, Chen Y, Gong J, Liu S, Wang J, Knights AJ, Qiao X,
            Emont MP, Xu XZS, Kajimura S and Wu J.
  TITLE     Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat
            Activation
  JOURNAL   Dev Cell 54 (1), 106-116 (2020)
   PUBMED   32533922
  REMARK    GeneRIF: Adrenergic-Independent Signaling via CHRNA2 Regulates
            Beige Fat Activation.
REFERENCE   3  (bases 1 to 3527)
  AUTHORS   Mineur YS, Ernstsen C, Islam A, Lefoli Maibom K and Picciotto MR.
  TITLE     Hippocampal knockdown of alpha2 nicotinic or M1 muscarinic
            acetylcholine receptors in C57BL/6J male mice impairs cued fear
            conditioning
  JOURNAL   Genes Brain Behav 19 (6), e12677 (2020)
   PUBMED   32447811
  REMARK    GeneRIF: Hippocampal knockdown of alpha2 nicotinic or M1 muscarinic
            acetylcholine receptors in C57BL/6J male mice impairs cued fear
            conditioning.
            Erratum:[Genes Brain Behav. 2020 Sep;19(7):e12693. PMID: 32909690]
REFERENCE   4  (bases 1 to 3527)
  AUTHORS   Gongrich C, Krapacher FA, Munguba H, Fernandez-Suarez D, Andersson
            A, Hjerling-Leffler J and Ibanez CF.
  TITLE     ALK4 coordinates extracellular and intrinsic signals to regulate
            development of cortical somatostatin interneurons
  JOURNAL   J Cell Biol 219 (1) (2020)
   PUBMED   31676717
REFERENCE   5  (bases 1 to 3527)
  AUTHORS   Jun H, Yu H, Gong J, Jiang J, Qiao X, Perkey E, Kim DI, Emont MP,
            Zestos AG, Cho JS, Liu J, Kennedy RT, Maillard I, Xu XZS and Wu J.
  TITLE     An immune-beige adipocyte communication via nicotinic acetylcholine
            receptor signaling
  JOURNAL   Nat Med 24 (6), 814-822 (2018)
   PUBMED   29785025
  REMARK    GeneRIF: These results reveal a beige-selective immune-adipose
            interaction mediated through CHRNA2 and identify a novel function
            of nicotinic acetylcholine receptors in energy metabolism.
REFERENCE   6  (bases 1 to 3527)
  AUTHORS   O'Hara BF, Macdonald E, Clegg D, Wiler SW, Andretic R, Cao VH,
            Miller JD, Heller HC and Kilduff TS.
  TITLE     Developmental changes in nicotinic receptor mRNAs and responses to
            nicotine in the suprachiasmatic nucleus and other brain regions
  JOURNAL   Brain Res Mol Brain Res 66 (1-2), 71-82 (1999)
   PUBMED   10095079
REFERENCE   7  (bases 1 to 3527)
  AUTHORS   Sallinen J, Link RE, Haapalinna A, Viitamaa T, Kulatunga M, Sjoholm
            B, Macdonald E, Pelto-Huikko M, Leino T, Barsh GS, Kobilka BK and
            Scheinin M.
  TITLE     Genetic alteration of alpha 2C-adrenoceptor expression in mice:
            influence on locomotor, hypothermic, and neurochemical effects of
            dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor
            agonist
  JOURNAL   Mol Pharmacol 51 (1), 36-46 (1997)
   PUBMED   9016344
REFERENCE   8  (bases 1 to 3527)
  AUTHORS   Drescher DG, Khan KM, Green GE, Morley BJ, Beisel KW, Kaul H,
            Gordon D, Gupta AK, Drescher MJ and Barretto RL.
  TITLE     Analysis of nicotinic acetylcholine receptor subunits in the
            cochlea of the mouse
  JOURNAL   Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 112 (3),
            267-273 (1995)
   PUBMED   8838678
REFERENCE   9  (bases 1 to 3527)
  AUTHORS   Anand R and Lindstrom J.
  TITLE     Chromosomal localization of seven neuronal nicotinic acetylcholine
            receptor subunit genes in humans
  JOURNAL   Genomics 13 (4), 962-967 (1992)
   PUBMED   1505988
REFERENCE   10 (bases 1 to 3527)
  AUTHORS   Bessis A, Simon-Chazottes D, Devillers-Thiery A, Guenet JL and
            Changeux JP.
  TITLE     Chromosomal localization of the mouse genes coding for alpha 2,
            alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic
            acetylcholine receptor
  JOURNAL   FEBS Lett 264 (1), 48-52 (1990)
   PUBMED   2338144
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126272.3.
            
            [WARNING] On Nov 22, 2023 this sequence was replaced by
            NM_144803.3.
            
            On Mar 21, 2007 this sequence version replaced NM_144803.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC126272.3         171567-171612
            47-189              AC126272.3         172751-172893
            190-341             AC126272.3         173964-174115
            342-386             AC126272.3         174528-174572
            387-496             AC126272.3         177013-177122
            497-1529            AC126272.3         179394-180426
            1530-3527           AC126272.3         181558-183555
FEATURES             Location/Qualifiers
     source          1..3527
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.36 cM"
     gene            1..3527
                     /gene="Chrna2"
                     /gene_synonym="Acra-2; Acra2"
                     /note="cholinergic receptor nicotinic alpha 2 subunit"
                     /db_xref="GeneID:110902"
                     /db_xref="MGI:MGI:87886"
     exon            1..46
                     /gene="Chrna2"
                     /gene_synonym="Acra-2; Acra2"
                     /inference="alignment:Splign:2.1.0"
     exon            47..189
                     /gene="Chrna2"
                     /gene_synonym="Acra-2; Acra2"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1655
                     /gene="Chrna2"
                     /gene_synonym="Acra-2; Acra2"
                     /note="neuronal acetylcholine receptor subunit alpha-2;
                     cholinergic receptor, nicotinic, alpha polypeptide 2
                     (neuronal)"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit alpha-2
                     precursor"
                     /protein_id="NP_659052.1"
                     /db_xref="CCDS:CCDS27219.1"
                     /db_xref="GeneID:110902"
                     /db_xref="MGI:MGI:87886"
                     /translation="MAPSHPAFQFWIHLYLWCLLLMPAVLAQQGSHTHAEDRLFKHLF
                     GGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPA
                     EFGNITSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSC
                     SIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYN
                     SKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITL
                     CISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSP
                     STHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPGLKLSPTYHWLETNMDAEEREE
                     TEEEEEEEEDENICMCAGLPDSSMGVLYGHGSLHLRAMGPEAKTPSQASEILLSPQIQ
                     KALEGVHYIADHLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFL
                     AGMI"
     exon            190..341
                     /gene="Chrna2"
                     /gene_synonym="Acra-2; Acra2"
                     /inference="alignment:Splign:2.1.0"
     exon            342..386
                     /gene="Chrna2"
                     /gene_synonym="Acra-2; Acra2"
                     /inference="alignment:Splign:2.1.0"
     exon            387..496
                     /gene="Chrna2"
                     /gene_synonym="Acra-2; Acra2"
                     /inference="alignment:Splign:2.1.0"
     exon            497..1529
                     /gene="Chrna2"
                     /gene_synonym="Acra-2; Acra2"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..3527
                     /gene="Chrna2"
                     /gene_synonym="Acra-2; Acra2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgatatggc ctggactcaa agtcacgctt gcagactctg gatgggctgc agagagacag
       61 ggccttgaag aagccagctc cttgtagtcc aacagaaacc aggaccctct gaagccatgg
      121 ccccctccca tcctgctttc cagttctgga tacatcttta tctctggtgt ctgcttctga
      181 tgccagcagt gttggcccag caaggctcgc acacccatgc cgaggaccgc ctgttcaaac
      241 acctctttgg aggctacaat cgctgggcac ggccagtgcc caacacttcc gatgtggtca
      301 tcgtgcgctt tggactatcc attgcacagc tcatagatgt ggatgagaag aatcaaatga
      361 tgaccaccaa tgtctggcta aagcaggaat ggaatgacta caagctgcgc tgggacccgg
      421 ctgagtttgg caacatcacc tccctccgcg tcccctcaga gatgatctgg atcccagaca
      481 ttgttctcta caacaatgca gacggggagt ttgcggtgac ccacatgacc aaggcccacc
      541 tcttcttcac gggcactgtg cactgggtgc ccccagccat ctacaagagc tcctgcagca
      601 tcgacgtgac tttcttcccc ttcgaccagc agaactgcaa gatgaagttt ggctcctgga
      661 catacgacaa ggccaagatc gacctggagc agatggagcg gacggtggac ctgaaggact
      721 actgggagag cggcgagtgg gccattatca acgccaccgg aacctataac agcaagaagt
      781 acgactgctg cgcggagatc taccccgacg tcacctacta cttcgttatc cgccggctgc
      841 cgctgttcta caccatcaac ctcattatcc cgtgcctgct catctcctgc ctcaccgtgc
      901 tcgtgttcta cttgccctct gagtgtggag agaagatcac gctgtgcatc tcggtgctgc
      961 tctccctcac tgtcttcctg ctgctcatca cagaaattat cccatccacc tcactggtca
     1021 tcccactcat cggcgagtac ctgctcttca ccatgatctt cgtcaccctc tctattgtga
     1081 tcacagtctt cgtgctcaat gtccaccacc gttcccctag cacgcacaac atgcccaact
     1141 gggtgagggt ggccctgcta ggccgggtgc cccggtggct gatgatgaat cggcccctgc
     1201 cgcccatgga gctccatggc tctccaggtc tgaagctcag ccccacttat cattggctgg
     1261 agaccaacat ggatgctgaa gaaagggagg agacagagga agaggaggag gaggaagaag
     1321 atgaaaacat atgtatgtgt gcaggcctcc cagactcttc catgggtgtc ctctatggcc
     1381 atggcagcct gcatctgagg gccatggggc ctgaggccaa gactccatcc caggctagtg
     1441 agatcctgct gtcacctcaa atacagaaag cactagaagg tgtacactac attgctgacc
     1501 acctgaggtc tgaggatgct gactcttcgg tgaaggaaga ttggaagtat gtggccatgg
     1561 tggtagaccg gatcttcctc tggctgttca ttatcgtctg cttcctgggg accatcgggc
     1621 tcttcctccc tccgttcctg gctggaatga tctgacttga tgtccctcat gttggctcca
     1681 aggtggcctg gacaaccatc ttctgctctt ctgtgactgg agccatctct agaatattct
     1741 tttgacttaa tgccacctgc ctgcgatgtt tctacgaggc ccctgatcta gcctggactt
     1801 catatcctcc ttgtcaacag ttcatggtgc cattgcggtg acaagcactg agaccactca
     1861 acatgacaac tatttaggga tgctgaggaa ctagaagagg tgaaggctgc tctgtaggtg
     1921 atgacaacat ggtggtgata tggggggaga gcaagatagt tctgaaagag catataggag
     1981 ttgtctatgg caaaagggtc aaacaaaggg atggaggggt cagaccagga caaagggaaa
     2041 tagaacactg gcccaaagat gggcacaagg ggacaatggg agtgcctggt gtggaagagt
     2101 tctgcacaac actgtggatt cagaatgtca gagaggacag ccagctgggg tggggaggct
     2161 gggaggcaag ttgggatatt tttgacccag gcccaagaag aagctcagag tctgcactga
     2221 acctgtctct atgcactttg caggaaatgt cagagggaca ggggtacttc ccaaaggagt
     2281 ggggcacaaa gaaagttcta gagcagtggc tttcaacctg tgtcgtgggt tgcaaccctt
     2341 cagggagtca aacgaccctt tcacaggggt cacatatcag atatcctgca tatcagatgt
     2401 tttacatgac agtccataac aatatcaaaa ttactgttat gaagttgaaa tgaaaacaat
     2461 tttgtggttg gggtcacaac atgaggaact gtaaagggtc atagcattag gaaggttgag
     2521 aaccactgat ctaggtgccc tggtggatgc ttgaggcaga atagcaacat tgggtataag
     2581 ttgctgggcc attattcaac caaaagcact ttggagcctt caagttcccc tcagtgtcat
     2641 gtctcactgt tctatgctac aaaaaaagag gtatagcaat ttctacaagg gatcagggct
     2701 accttcaaat caagaggaca aagtaagaag gcagtctcca atgttggcac ccttcttgct
     2761 gtccacaggg acctggtcct caattcctgg ctctgtcagc atgcctcaca taggaactga
     2821 gatctttgca tcaagctctt tcaattgtgt gctccttcag ggcagagtct ctgctcttgt
     2881 tgctttcact catcctgagc tgggtgagag agctcagtag ctggaccctc catcgtgagt
     2941 agtggagaga aaccaacctg gtagctttag gctccagaac tgctacataa taccaaagct
     3001 ttgggggagg actcttcccc agtcttccca gggccccatc aggtgactaa cctgctctga
     3061 actgtcctgt gtagcttgtt cttttacttg taatattcca cgacccttca ttgcatagaa
     3121 gcccagcgga ttgggccttt cagaacattc tgcagtcccc aaggaattag gtcccagacg
     3181 ctaacagcaa tgagattcag ggtcactaag agatatagag accaagtttg ttctctgtct
     3241 tggggtgctc tccttccgaa ccccacacac agcacctcga cagacctagg agatctgctt
     3301 gtcggaggcc ttacccagac ttcctgttac cagttctaat gatacccact cagtctcagg
     3361 ccttggctcc ccctttctcc actgaatgca gccggcacct cttttctctg tgtcaaaccc
     3421 caagacatga tttcctgatg cagagatgct tgttggatga tccctacccc ccatcctcct
     3481 tgcatgtgag tgaaatgtca aaataaagct aaaatgtctg ccgtcaa
//
