LOCUS       NM_001081424            2513 bp    mRNA    linear   ROD 01-JUL-2024
DEFINITION  Mus musculus cholinergic receptor, nicotinic, alpha polypeptide 10
            (Chrna10), mRNA.
ACCESSION   NM_001081424 XM_989225
VERSION     NM_001081424.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2513)
  AUTHORS   Mondul,J.A., Burke,K., Morley,B. and Lauer,A.M.
  TITLE     Alpha9alpha10 knockout mice show altered physiological and
            behavioral responses to signals in masking noise
  JOURNAL   J Acoust Soc Am 155 (5), 3183-3194 (2024)
   PUBMED   38738939
  REMARK    GeneRIF: Alpha9alpha10 knockout mice show altered physiological and
            behavioral responses to signals in masking noise.
REFERENCE   2  (bases 1 to 2513)
  AUTHORS   Richter,K., Papke,R.L., Stokes,C., Roy,D.C., Espinosa,E.S.,
            Wolf,P.M.K., Hecker,A., Liese,J., Singh,V.K., Padberg,W.,
            Schluter,K.D., Rohde,M., McIntosh,J.M., Morley,B.J.,
            Horenstein,N.A., Grau,V. and Simard,A.R.
  TITLE     Comparison of the Anti-inflammatory Properties of Two Nicotinic
            Acetylcholine Receptor Ligands, Phosphocholine and pCF3-diEPP
  JOURNAL   Front Cell Neurosci 16, 779081 (2022)
   PUBMED   35431807
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2513)
  AUTHORS   Wang,Y., Sanghvi,M., Gribizis,A., Zhang,Y., Song,L., Morley,B.,
            Barson,D.G., Santos-Sacchi,J., Navaratnam,D. and Crair,M.
  TITLE     Efferent feedback controls bilateral auditory spontaneous activity
  JOURNAL   Nat Commun 12 (1), 2449 (2021)
   PUBMED   33907194
  REMARK    GeneRIF: Efferent feedback controls bilateral auditory spontaneous
            activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2513)
  AUTHORS   Vyas,P., Wood,M.B., Zhang,Y., Goldring,A.C., Chakir,F.Z.,
            Fuchs,P.A. and Hiel,H.
  TITLE     Characterization of HA-tagged alpha9 and alpha10 nAChRs in the
            mouse cochlea
  JOURNAL   Sci Rep 10 (1), 21814 (2020)
   PUBMED   33311584
  REMARK    GeneRIF: Characterization of HA-tagged alpha9 and alpha10 nAChRs in
            the mouse cochlea.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2513)
  AUTHORS   Jagdmann,S., Dames,C., Berchtold,D., Winek,K., Weitbrecht,L.,
            Meisel,A. and Meisel,C.
  TITLE     Impact of Key Nicotinic AChR Subunits on Post-Stroke Pneumococcal
            Pneumonia
  JOURNAL   Vaccines (Basel) 8 (2), 253 (2020)
   PUBMED   32481512
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2513)
  AUTHORS   Murthy,V., Maison,S.F., Taranda,J., Haque,N., Bond,C.T.,
            Elgoyhen,A.B., Adelman,J.P., Liberman,M.C. and Vetter,D.E.
  TITLE     SK2 channels are required for function and long-term survival of
            efferent synapses on mammalian outer hair cells
  JOURNAL   Mol Cell Neurosci 40 (1), 39-49 (2009)
   PUBMED   18848895
REFERENCE   7  (bases 1 to 2513)
  AUTHORS   Osman,A.A., Schrader,A.D., Hawkes,A.J., Akil,O., Bergeron,A.,
            Lustig,L.R. and Simmons,D.D.
  TITLE     Muscle-like nicotinic receptor accessory molecules in sensory hair
            cells of the inner ear
  JOURNAL   Mol Cell Neurosci 38 (2), 153-169 (2008)
   PUBMED   18420419
REFERENCE   8  (bases 1 to 2513)
  AUTHORS   Vetter,D.E., Katz,E., Maison,S.F., Taranda,J., Turcan,S.,
            Ballestero,J., Liberman,M.C., Elgoyhen,A.B. and Boulter,J.
  TITLE     The alpha10 nicotinic acetylcholine receptor subunit is required
            for normal synaptic function and integrity of the olivocochlear
            system
  JOURNAL   Proc Natl Acad Sci U S A 104 (51), 20594-20599 (2007)
   PUBMED   18077337
  REMARK    GeneRIF: Results demonstrate that alpha9(-/-) and alpha10(-/-) mice
            have overlapping but nonidentical phenotypes.
REFERENCE   9  (bases 1 to 2513)
  AUTHORS   Akil,O., Chang,J., Hiel,H., Kong,J.H., Yi,E., Glowatzki,E. and
            Lustig,L.R.
  TITLE     Progressive deafness and altered cochlear innervation in knock-out
            mice lacking prosaposin
  JOURNAL   J Neurosci 26 (50), 13076-13088 (2006)
   PUBMED   17167097
REFERENCE   10 (bases 1 to 2513)
  AUTHORS   Elgoyhen,A.B., Vetter,D.E., Katz,E., Rothlin,C.V., Heinemann,S.F.
            and Boulter,J.
  TITLE     alpha10: a determinant of nicotinic cholinergic receptor function
            in mammalian vestibular and cochlear mechanosensory hair cells
  JOURNAL   Proc Natl Acad Sci U S A 98 (6), 3501-3506 (2001)
   PUBMED   11248107
  REMARK    GeneRIF: Co-expression of the alpha10 subunit converts the normally
            weak acetylcholine-mediated activity of alpha9 to a more robustly
            active channel with identical physiological characteristics of the
            native mammalian outer hair cell cholinergic receptor.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC118592.7 and
            AC132297.4.
            
            On Feb 6, 2007 this sequence version replaced XM_989225.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033068.1, SRR1660811.202932.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-457               AC118592.7         17630-18086         c
            458-603             AC118592.7         16342-16487         c
            604-758             AC118592.7         15598-15752         c
            759-1291            AC118592.7         14460-14992         c
            1292-1947           AC118592.7         13205-13860         c
            1948-2513           AC132297.4         152376-152941       c
FEATURES             Location/Qualifiers
     source          1..2513
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 54.71 cM"
     gene            1..2513
                     /gene="Chrna10"
                     /note="cholinergic receptor, nicotinic, alpha polypeptide
                     10"
                     /db_xref="GeneID:504186"
                     /db_xref="MGI:MGI:3609260"
     exon            1..457
                     /gene="Chrna10"
                     /inference="alignment:Splign:2.1.0"
     CDS             397..1740
                     /gene="Chrna10"
                     /codon_start=1
                     /product="neuronal acetylcholine receptor subunit alpha-10
                     precursor"
                     /protein_id="NP_001074893.1"
                     /db_xref="CCDS:CCDS40047.1"
                     /db_xref="GeneID:504186"
                     /db_xref="MGI:MGI:3609260"
                     /translation="MGTRSHHLGPGFLLLLFLPAECLGAEGRLAHKLFRDLFANYTSA
                     LRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWDPKAYGDLD
                     AIRIPSSLVWRPDIVLYNKADTQPPASASTNVVVRHDGAVRWDAPAITRSSCRVDVSA
                     FPFDAQRCGLTFGSWTHGGHQLDVRPRGTSASLADFVENVEWRVLGMPARRRVLTYGC
                     CSEPYPDVTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPADSGEKVSLGVTVLL
                     ALTVFQLILAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNAHPVPA
                     WARVLLLGHLAKGLCVRERGEPCGQSKPLESAPSLQPPAGPPAGPCHEPRCLCHQEAL
                     LHHVASIAGTFRSHRAAQRRHEDWKRLARVMDRFFLGIFFCMALVMSLLVLVQAL"
     exon            458..603
                     /gene="Chrna10"
                     /inference="alignment:Splign:2.1.0"
     exon            604..758
                     /gene="Chrna10"
                     /inference="alignment:Splign:2.1.0"
     exon            759..1291
                     /gene="Chrna10"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..2513
                     /gene="Chrna10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctgctgag agcagcaggc ttgctcagag cccaggtaca gggaatggat tgaagggggg
       61 tttgaggtgc tgtaagagga gaagaaaggg ggagagagga aagaaaacag aaaccaagac
      121 cattacagag gaagaaagca aattgagaca gagaggtaaa agacggcact agtcatatgg
      181 aaagggacgg aagatggagc cagagaggct gtgaagagca aaggagaaac tgcaggtaca
      241 aggaccaggt atagtactgc aggcaggtgc aaacaggaga ccagaaggaa agccgcaatc
      301 tctggtttcc aggtactgtc cacctcatcc gtgccagcag ggcctgttgc tttacatctc
      361 ctcaagacct gcccaccctc tggctgtggt agcgacatgg ggaccaggag ccaccacctg
      421 ggtcctgggt ttctgctcct gctctttctc cctgcagagt gcctgggagc tgagggtaga
      481 ctggctcaca agctgtttcg tgacctgttt gccaactata caagtgcctt gagaccagtg
      541 gcagacacag accagactct aaatgtgacc ctggaggtga cgttgtctca gatcattgat
      601 atggatgaac ggaaccaagt gctgaccttg tacctgtgga tccggcagga gtggacagac
      661 gcctacctac attgggaccc caaagcctac ggtgacttgg atgcaattcg aattcccagc
      721 agtctagtgt ggcgaccaga catcgtactt tacaacaagg cggacacgca gccacctgcc
      781 tcggccagca ccaacgtggt tgtgcggcac gacggcgctg tgcgctggga cgcaccggcc
      841 atcacacgca gctcgtgccg tgtggatgtc tctgccttcc catttgacgc tcagcgctgt
      901 ggcctgacct tcggctcatg gacgcacggc gggcaccagc tggatgtgcg acctcggggc
      961 acttccgcca gtctggccga cttcgtggag aacgttgaat ggcgtgtgct gggcatgcca
     1021 gcgcgcaggc gcgtgctcac ctacggctgc tgctccgagc cctacccaga cgtgaccttc
     1081 actctgctgc tgcgccgccg tgcagctgcc tatgtgtgca acctactgct gccctgtgtg
     1141 ttcatctccc tgctggcacc tctggccttc cacctgcccg ctgactccgg ggagaaggtg
     1201 tctctgggcg tcaccgtgct cctggcgctc accgtcttcc agctgatcct ggccgagagc
     1261 atgccacctg cagagagcgt tccactcatc ggaaagtact atatggccac tatgaccatg
     1321 gtcacattct ccacagcgct taccatcctc attatgaatc tgcattactg tggccctaat
     1381 gcacatccag tacctgcctg ggctcgggtc ctcctgctgg gacacctagc caaaggcctg
     1441 tgtgtgcggg aacgagggga gccctgtgga cagtccaagc cattagagtc agcccccagc
     1501 ctccagcctc ctgcaggtcc cccagcgggc ccttgtcatg agccacggtg tctatgccac
     1561 caagaagccc ttctgcatca cgtagcttcc attgccggca ccttccgcag ccaccgggct
     1621 gcccagcgcc gccatgaaga ttggaagcgc ctggccagag taatggaccg ctttttccta
     1681 ggcatcttct tctgcatggc tctggtcatg agcctcctgg tactggtgca agccctgtaa
     1741 gggccaggaa ctggatttca gggagctgtg atcacctcaa caccaccagg tggggatggc
     1801 aaagcccagg tggttgttgg tactcagaaa cactagccag tttctcccca aagtgctgct
     1861 aagagtcaga gacacctctt caggaccagc acttctgacc tcaaacccac aaacagcctt
     1921 tgtgatctgc atgccctaat ggaaggggat ctaaagcttg cctctcccct aattccaaca
     1981 tgagtgaggt caaagtacag acttggaggc taagactcag tgccagctga gcaaggtgat
     2041 ataattccag cacaaggagg ctgagacagg aagattaccc taaggtctgt agcctgagct
     2101 acagaaattt ttgtctaaaa ataaataacc accccagtgt ctacacttgg aatcatagct
     2161 attagccggt ggaatccagg ttattttcct ttgtcgagtt agagtctcgc tatgtagtcc
     2221 ttgctggcct ggaacttgct atgtagccca ggttggcttt gaactcacac agatccacat
     2281 gcctctgcct ctccaaacac aggtgccact atgcctggct tgggtgtagg ttactaatta
     2341 aagggacaaa gctacacatt tgcttgtcac ccttagcagt tgctattaca gattctcatc
     2401 ttgcttctca ctgctaggct ctcccgggag ggaactcact gtctagtttc caaaacagaa
     2461 ggctgtgcag acatttgact cggagcttcg atccataata aatgagtgct ccc
//
