LOCUS       NM_007389               4320 bp    mRNA    linear   ROD 10-OCT-2024
DEFINITION  Mus musculus cholinergic receptor nicotinic alpha 1 subunit
            (Chrna1), mRNA.
ACCESSION   NM_007389 XM_911658
VERSION     NM_007389.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4320)
  AUTHORS   Ohkawara,B., Kurokawa,M., Kanai,A., Imamura,K., Chen,G., Zhang,R.,
            Masuda,A., Higashi,K., Mori,H., Suzuki,Y., Kurokawa,K. and Ohno,K.
  TITLE     Transcriptome profile of subsynaptic myonuclei at the neuromuscular
            junction in embryogenesis
  JOURNAL   J Neurochem 168 (4), 342-354 (2024)
   PUBMED   37994470
REFERENCE   2  (bases 1 to 4320)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4320)
  AUTHORS   Eguchi,T., Tezuka,T., Watanabe,Y., Inoue-Yamauchi,A., Sagara,H.,
            Ozawa,M. and Yamanashi,Y.
  TITLE     Calcium-binding protein 7 expressed in muscle negatively regulates
            age-related degeneration of neuromuscular junctions in mice
  JOURNAL   iScience 27 (2), 108997 (2024)
   PUBMED   38327785
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4320)
  AUTHORS   Chen,J.F., Lin,M., Li,X. and Lin,J.B.
  TITLE     PAI1 inhibits the pathogenesis of primary focal hyperhidrosis by
            targeting CHRNA1
  JOURNAL   Orphanet J Rare Dis 18 (1), 205 (2023)
   PUBMED   37542348
  REMARK    GeneRIF: PAI1 inhibits the pathogenesis of primary focal
            hyperhidrosis by targeting CHRNA1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4320)
  AUTHORS   Dellisanti,C.D., Yao,Y., Stroud,J.C., Wang,Z.Z. and Chen,L.
  TITLE     Crystal structure of the extracellular domain of nAChR alpha1 bound
            to alpha-bungarotoxin at 1.94 A resolution
  JOURNAL   Nat Neurosci 10 (8), 953-962 (2007)
   PUBMED   17643119
  REMARK    Erratum:[Nat Neurosci. 2007 Sep;10(9):1222]
REFERENCE   6  (bases 1 to 4320)
  AUTHORS   MacGregor,T.M., Copeland,N.G., Jenkins,N.A. and Giguere,V.
  TITLE     The murine gene for cellular retinoic acid-binding protein type II.
            Genomic organization, chromosomal localization, and
            post-transcriptional regulation by retinoic acid
  JOURNAL   J Biol Chem 267 (11), 7777-7783 (1992)
   PUBMED   1313808
REFERENCE   7  (bases 1 to 4320)
  AUTHORS   Pilz,A., Moseley,H., Peters,J. and Abbott,C.
  TITLE     Comparative mapping of mouse chromosome 2 and human chromosome 9q:
            the genes for gelsolin and dopamine beta-hydroxylase map to mouse
            chromosome 2
  JOURNAL   Genomics 12 (4), 715-719 (1992)
   PUBMED   1315305
REFERENCE   8  (bases 1 to 4320)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
REFERENCE   9  (bases 1 to 4320)
  AUTHORS   Taylor,B.A. and Rowe,L.
  TITLE     Localization of the gene encoding the alpha-subunit of the
            acetylcholine receptor on chromosome 2 of the mouse
  JOURNAL   Cytogenet Cell Genet 52 (1-2), 102-103 (1989)
   PUBMED   2558853
REFERENCE   10 (bases 1 to 4320)
  AUTHORS   Merlie,J.P., Sebbane,R., Gardner,S. and Lindstrom,J.
  TITLE     cDNA clone for the alpha subunit of the acetylcholine receptor from
            the mouse muscle cell line BC3H-1
  JOURNAL   Proc Natl Acad Sci U S A 80 (12), 3845-3849 (1983)
   PUBMED   6344089
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL928889.14, AK029177.1 and
            AL928813.10.
            
            On Nov 30, 2012 this sequence version replaced NM_007389.4.
            
            Summary: This gene encodes an alpha subunit of the muscle-derived
            nicotinic acetylcholine receptor, a pentameric neurotransmitter
            receptor and member of the ligand-gated ion channel superfamily.
            The alpha subunit plays a role in substrate binding and channel
            gating. [provided by RefSeq, Nov 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029177.1, BC137678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AL928889.14        3375-3406           c
            33-2689             AK029177.1         2-2658
            2690-4320           AL928813.10        135556-137186       c
FEATURES             Location/Qualifiers
     source          1..4320
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 43.76 cM"
     gene            1..4320
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /note="cholinergic receptor nicotinic alpha 1 subunit"
                     /db_xref="GeneID:11435"
                     /db_xref="MGI:MGI:87885"
     exon            1..94
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1425
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /note="acetylcholine receptor subunit alpha; cholinergic
                     receptor, nicotinic, alpha polypeptide 1 (muscle)"
                     /codon_start=1
                     /product="acetylcholine receptor subunit alpha precursor"
                     /protein_id="NP_031415.2"
                     /db_xref="CCDS:CCDS16132.1"
                     /db_xref="GeneID:11435"
                     /db_xref="MGI:MGI:87885"
                     /translation="MELSTVLLLLGLCSAGLVLGSEHETRLVAKLFEDYSSVVRPVED
                     HREIVQVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPS
                     EKIWRPDVVLYNNADGDFAIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQ
                     NCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKEARGWKHWVFYSCCPTTPY
                     LDITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLPTDSGEKMTLSISVLLSLTVF
                     LLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHIMPEWVRK
                     VFIDTIPNIMFFSTMKRPSRDKQEKRIFTEDIDISDISGKPGPPPMGFHSPLIKHPEV
                     KSAIEGVKYIAETMKSDQESNNAAEEWKYVAMVMDHILLGVFMLVCLIGTLAVFAGRL
                     IELHQQG"
     exon            95..240
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /inference="alignment:Splign:2.1.0"
     exon            241..285
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /inference="alignment:Splign:2.1.0"
     exon            286..395
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /inference="alignment:Splign:2.1.0"
     exon            396..591
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /inference="alignment:Splign:2.1.0"
     exon            592..829
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1053
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1293
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..4320
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1662..1667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /note="hexamer: AATAAA"
     polyA_site      1682
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /note="major polyA site"
     regulatory      1784..1789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /note="hexamer: AATAAA"
     polyA_site      1803
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
     regulatory      3551..3556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /note="hexamer: AATAAA"
     polyA_site      3570
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
     regulatory      4291..4296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
                     /note="hexamer: TATAAA"
     polyA_site      4309
                     /gene="Chrna1"
                     /gene_synonym="Achr-1; Acra"
ORIGIN      
        1 ggagtaggac cggcagcaag ccgctggcgg ccacagcggc acccacagcc catggagctc
       61 tcgactgttc tcctgctgct aggcctctgc tccgctggcc ttgttctggg ctccgaacat
      121 gagacgcgtc tggtggcaaa gctctttgaa gactacagca gtgtagtccg gccagtggag
      181 gaccaccgtg agattgtaca agtcaccgtg ggtctacagc tgatccagct tatcaatgtg
      241 gatgaagtaa atcagattgt gacaaccaat gtacgtctga aacagcaatg ggtcgattac
      301 aacttgaaat ggaatccaga tgactatgga ggagtgaaaa aaattcacat cccctcggaa
      361 aagatctggc ggccggacgt cgttctctat aacaacgcag acggcgactt tgccattgtc
      421 aaattcacca aggtgctcct ggactacacc ggccacatca cctggacacc gccagccatc
      481 tttaaaagct actgtgagat cattgtcact cactttccct tcgatgagca gaactgcagc
      541 atgaagctgg gcacctggac ctatgacggc tctgtggtgg ccattaaccc ggaaagtgac
      601 cagcccgacc tgagtaactt catggagagc ggggagtggg tgatcaagga agctcggggc
      661 tggaagcact gggtgttcta ctcctgctgc cccaccactc cctacctgga catcacctac
      721 cacttcgtca tgcagcgcct gcccctctac ttcattgtca acgtcatcat tccctgcctg
      781 ctcttctcct tcttaaccag cctggtgttc tacctgccca cagactcagg ggagaagatg
      841 acgctgagca tctctgtctt actgtccctg accgtgttcc ttctggtcat tgtggagcta
      901 atcccttcca cctccagcgc tgtgcccctg atcgggaagt atatgttgtt caccatggtc
      961 tttgtcattg cgtccatcat catcaccgtc atcgtcatca acacacacca ccgttcgccc
     1021 agcacccaca tcatgcccga gtgggtgcgg aaggttttta tcgacactat cccaaacatc
     1081 atgtttttct ccacaatgaa aagaccatcc agagataaac aagagaaaag gatttttaca
     1141 gaagacatag atatatctga catctctggg aagccgggtc ctccacctat gggctttcac
     1201 tctccgctga tcaagcaccc tgaggtgaaa agcgccatcg agggcgtgaa gtacattgca
     1261 gagaccatga agtcagacca ggagtccaat aacgccgctg aggaatggaa gtatgttgcc
     1321 atggtgatgg atcacatcct cctcggagtc tttatgctgg tgtgtctcat cgggacgctg
     1381 gctgtgtttg caggtcggct cattgagtta catcaacaag gatgagcaga ggctgagcta
     1441 agcctacctc tgtcccagcc atagccatcg ctaggaaaga tggaagagag gaaggtctgt
     1501 ctccttgaat cctttcacac ttaccaaaca tgcagtgttc tacatgtcct acatgttaat
     1561 gagagtgatc tctgctcaca cggctgtatt cttgaagtgt ctcccctttg cttctgcttt
     1621 taacactatg ggcctcctta aagggcgaac cctttgaagt aaataaaagt gagccctcaa
     1681 aagaagtgtt tgcttctaaa tggcccctgg gagagttttg cttggatact caaggttttc
     1741 tgtttgtatt gccatggcta gttgtttttg ttttctttcc tttaataaat ataattgtac
     1801 ttatatgagt gatccgccta cgtgtatgtc tcacatacac gcctagtgtc catgaaggtc
     1861 agaagaaggt atcccatctc ctagaactgg aactacaaat ggttgtgagc gtccacatgg
     1921 aacctgggaa tcaggccctc tggaagagca cccagtgttc ttaaccactg aaccacccac
     1981 ctatcgggct cagttaattt ttatttttaa agtgctgaga gtcccttact taagacacac
     2041 ggtttcatac ctactagaaa agtcgtgtct accagattcc ccagatttga tgtggacaca
     2101 aaggaagtgg tagaaaggaa attaggtaac tttaaactta aaaaaaaatt gtgtgtgtgt
     2161 gtgtgtgtgt gtgtgtgtgt gtgtgtacat actcgcacac attgatgaaa ttgggggaca
     2221 acttttagga gttagttctc atcttttatc tcatttgagg caaagtatct tgtgatttct
     2281 gccgctgtgt tacattctca tgtaaagctt cctggggcat tttcctttct atacttctcg
     2341 gcccatgaac agagtgcagg gattccagat gcatgccgcc atctccagct tttcataggt
     2401 cctaggatag aatttaggtc gttaggtttg tccagcaaaa aactactttt acctgcttaa
     2461 tccatttcac tggcccaaag gtaattttag ggcgatcaca tacaaatagt atcaaaacct
     2521 catggtttaa agtagacttc tgaaaccagg agagggagaa tgctttctta agtgatttct
     2581 gtttgagagg ccttcttgaa agggcgcttg ggattccttg ggattgtacc tagagctttg
     2641 cacacagagc tataactgag cctcagctct cccaacttaa cggagcccct ggattttgtt
     2701 ctcaggaccc gaggaagggc agatcccatc ctcatcaagg gtgtgcctct gaccccatga
     2761 gaatcgtctc gcccgcatgg gtttatttta tccaaattgt tttacacagt ctccataatg
     2821 tccctaattt acaaatggaa aaaaaaattt ttggggaaag ttaaactctg ctccatctag
     2881 aagtagaaga actgagatct gaacccagac agaacttaag attctaaaac aggggctgga
     2941 gagatggctc tatggttaag atcattccca gcaaccacag ggtgcatggt ggctcacaac
     3001 catctacagt gggatctgat gccctctgct ggtgtgcagg tgtgcatata caaagcactc
     3061 acacataaat acataaacaa acaaacaaat attttttaaa gatttattta tttattatat
     3121 gtaaatacac tgtagctgtc ttcagacact ccagaagagg gcatcagatc ttgttacaga
     3181 tggttgtgag ccaccatgtg gttgctggga tttgaactct ggaccttcag aagaacagtc
     3241 gggtgctctt acccactgag ccatctcacc agccccaaat atttttttta aaagtcaaaa
     3301 agaaaaggga ttctaaaccg acttgcagct gatggggtca cctgctccct gctctcccag
     3361 catgcctggc gtgatctaag tagttctggt ctgtgttggt ggggactctg tgatatccta
     3421 tttcctgcct tctcaattaa aacccctggc ttttccttca gtccttggac gcaatcatgt
     3481 ttggagttca ggccctatga atggaaccag aaacgtatgc acacaccatc accatttctg
     3541 aaatctgaaa aataaattct ctgtgccaaa ctctaggctc tagtacaatt tacccagacc
     3601 aagaagccgt gtggctctgg acgcagaaaa ggcctttgaa tcacaaacac atctgatccg
     3661 tcatctccag ggagagctat aaactgcata accaggaggc cagtgcgagc ccaggtggct
     3721 tcaatctcct gagggacttc ccatcacccc tgcaccagtg ctgggctctt tcatctcaaa
     3781 tagtttgcac tttaaagtgg aaacaattgg cagtttctca gaaagtcaca ctcgggtcac
     3841 caagtcactc agcagtccca ttcccaggta gagagccaaa gaaatcgaaa gaaagactta
     3901 cacaatttgt atgagaacgc gcacagaagg caagagccag agaaagcggt ctaggctcca
     3961 acccacagac gacaagcaaa agggatgtgg agaatgggtt ttggggtgta tgtgtgtagg
     4021 cctggggggc catcgccttt ttgttttgtt gttgtttttg agatagagtt tctcactggc
     4081 ctggaacttg ccaagtagtt taggctggct aggcaggcca ttccgagatc tgcctgtctc
     4141 ctctttctgc aaacaattta gttggcatgg gttctggggc tcttactcag atctaaaaac
     4201 aagcattttg tcagttgatc taattcttta gctttttcta ctcacgacca ctttttgctt
     4261 gagaaatgtt atgtagaaat ataaaatatg tataaaaata aataacaaag aaatttaatt
//
