LOCUS       NM_205783               1746 bp    mRNA    linear   ROD 31-MAY-2023
DEFINITION  Mus musculus cholinergic receptor, muscarinic 5 (Chrm5), mRNA.
ACCESSION   NM_205783 XM_141500
VERSION     NM_205783.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1746)
  AUTHORS   Shindo Y, Nakamura HM, Nakai J, Wakamori M and Nakamura T.
  TITLE     A parasympathetic neurotransmitter induces myoepithelial cell
            differentiation during salivary gland development
  JOURNAL   Exp Cell Res 416 (1), 113137 (2022)
   PUBMED   35427599
REFERENCE   2  (bases 1 to 1746)
  AUTHORS   Hollenhorst MI, Jurastow I, Nandigama R, Appenzeller S, Li L, Vogel
            J, Wiederhold S, Althaus M, Empting M, Altmuller J, Hirsch AKH,
            Flockerzi V, Canning BJ, Saliba AE and Krasteva-Christ G.
  TITLE     Tracheal brush cells release acetylcholine in response to bitter
            tastants for paracrine and autocrine signaling
  JOURNAL   FASEB J 34 (1), 316-332 (2020)
   PUBMED   31914675
REFERENCE   3  (bases 1 to 1746)
  AUTHORS   Lemos JC, Shin JH and Alvarez VA.
  TITLE     Striatal Cholinergic Interneurons Are a Novel Target of
            Corticotropin Releasing Factor
  JOURNAL   J Neurosci 39 (29), 5647-5661 (2019)
   PUBMED   31109960
REFERENCE   4  (bases 1 to 1746)
  AUTHORS   Laspas P, Zhutdieva MB, Brochhausen C, Musayeva A, Zadeh JK,
            Pfeiffer N, Xia N, Li H, Wess J and Gericke A.
  TITLE     The M1 muscarinic acetylcholine receptor subtype is important for
            retinal neuron survival in aging mice
  JOURNAL   Sci Rep 9 (1), 5222 (2019)
   PUBMED   30914695
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1746)
  AUTHORS   Deckmann K, Rafiq A, Erdmann C, Illig C, Durschnabel M, Wess J,
            Weidner W, Bschleipfer T and Kummer W.
  TITLE     Muscarinic receptors 2 and 5 regulate bitter response of urethral
            brush cells via negative feedback
  JOURNAL   FASEB J 32 (6), 2903-2910 (2018)
   PUBMED   29401598
REFERENCE   6  (bases 1 to 1746)
  AUTHORS   Forster GL, Yeomans JS, Takeuchi J and Blaha CD.
  TITLE     M5 muscarinic receptors are required for prolonged accumbal
            dopamine release after electrical stimulation of the pons in mice
  JOURNAL   J Neurosci 22 (1), RC190 (2002)
   PUBMED   11756520
REFERENCE   7  (bases 1 to 1746)
  AUTHORS   Yamada M, Lamping KG, Duttaroy A, Zhang W, Cui Y, Bymaster FP,
            McKinzie DL, Felder CC, Deng CX, Faraci FM and Wess J.
  TITLE     Cholinergic dilation of cerebral blood vessels is abolished in M(5)
            muscarinic acetylcholine receptor knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (24), 14096-14101 (2001)
   PUBMED   11707605
REFERENCE   8  (bases 1 to 1746)
  AUTHORS   Thach DC, Kleeberger SR, Tucker PC and Griffin DE.
  TITLE     Genetic control of neuroadapted sindbis virus replication in female
            mice maps to chromosome 2 and associates with paralysis and
            mortality
  JOURNAL   J Virol 75 (18), 8674-8680 (2001)
   PUBMED   11507212
REFERENCE   9  (bases 1 to 1746)
  AUTHORS   Matsui M, Araki Y, Karasawa H, Matsubara N, Taketo MM and Seldin
            MF.
  TITLE     Mapping of five subtype genes for muscarinic acetylcholine receptor
            to mouse chromosomes
  JOURNAL   Genes Genet Syst 74 (1), 15-21 (1999)
   PUBMED   10549128
REFERENCE   10 (bases 1 to 1746)
  AUTHORS   Lammerding-Koppel M, Greiner-Schroder A and Drews U.
  TITLE     Muscarinic receptors in the prenatal mouse embryo. Comparison of
            M35-immunohistochemistry with [3H]quinuclidinyl benzylate
            autoradiography
  JOURNAL   Histochem Cell Biol 103 (4), 301-310 (1995)
   PUBMED   7648406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731840.17.
            
            [WARNING] On Oct 5, 2023 this sequence was replaced by NM_205783.3.
            
            On Jul 24, 2009 this sequence version replaced NM_205783.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC120615.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1746              AL731840.17        14060-15805         c
FEATURES             Location/Qualifiers
     source          1..1746
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 57.02 cM"
     gene            1..1746
                     /gene="Chrm5"
                     /gene_synonym="AChR-M5; m5; M5R"
                     /note="cholinergic receptor, muscarinic 5"
                     /db_xref="GeneID:213788"
                     /db_xref="MGI:MGI:109248"
     exon            1..1746
                     /gene="Chrm5"
                     /gene_synonym="AChR-M5; m5; M5R"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1647
                     /gene="Chrm5"
                     /gene_synonym="AChR-M5; m5; M5R"
                     /note="muscarinic acetylcholine receptor 5"
                     /codon_start=1
                     /product="muscarinic acetylcholine receptor M5"
                     /protein_id="NP_991352.2"
                     /db_xref="CCDS:CCDS16556.1"
                     /db_xref="GeneID:213788"
                     /db_xref="MGI:MGI:109248"
                     /translation="MEGESYHNETTVNGTPVNHQALERHGLWEVITIAAVTAVVSLMT
                     IVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLA
                     CDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFI
                     LWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYR
                     ETEKRTKDLADLQGSDSVAEVKKRKPAHRTLLRSFFSCPRPSLAQRVRNQASWSSSRR
                     STSTTGKPTQATDLSADWEKAEQVTNCSSCPSSEDEAKATTDPVFQVVCKNEAKESPG
                     KEFNTQETKETFVSPRTENNDYDTPKYFLSPGAAHRLKSQKCVAYKFRLVVKADGTQE
                     TNNGCRKVKIMPCSFPVSKDPSTKGLDPHLSHQMTKRKRMVLVKERKAAQTLSAILLA
                     FIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKL
                     LLLCRWKKKKVEEKLYWQGNSKLP"
ORIGIN      
        1 gtagcgccaa accttggacc aaatctgagt gtaatttctt gagccaggat ggaaggggag
       61 tcttatcaca atgaaaccac tgtcaacggc accccagtaa atcaccaggc tttggaacgc
      121 catggactgt gggaagtcat tactattgca gctgtgaccg ctgtggtcag tctgatgacc
      181 attgtcggca atgtcttggt catgatctcc ttcaaagtca acagtcagct caagacagtt
      241 aacaactatt acctgctcag cttggcctgt gcagacctca tcattggcat cttctccatg
      301 aacctctaca cgacctacat cctcatggga cgctgggttc tcgggagtct ggcctgtgac
      361 ctttggcttg cactcgacta tgtagccagc aacgcttctg tcatgaacct tctggtgatt
      421 agctttgatc gttacttttc catcacaaga ccactgacat accgagccaa gcgtacccca
      481 aagagggctg gcatcatgat cggcttggca tggctggtct ccttcatcct ctgggcgcca
      541 gccatcctct gctggcagta cttggtcggg aagcggacag taccacctga tgagtgccag
      601 atccagttcc tctctgagcc caccatcact tttgggaccg ccattgccgc tttctatatc
      661 cctgtctccg tcatgaccat actctactgc cggatctacc gggaaacaga gaaacgaacc
      721 aaggacctgg ctgacctcca aggttccgat tctgtggcag aagtcaagaa gagaaaaccg
      781 gctcacagga ccctgctcag atctttcttt agctgcccta gacccagcct ggcccagaga
      841 gtacggaacc aggcctcctg gtcatcctcc cgtagaagca cctcaacaac gggaaagcca
      901 acccaggcca ctgatctaag tgctgactgg gaaaaggctg agcaggttac caactgtagc
      961 agctgcccct cttcagagga cgaagccaag gccaccactg accctgtctt tcaagtggtc
     1021 tgcaagaatg aggccaagga aagcccgggg aaggaattca atacccaaga gaccaaggaa
     1081 acgtttgtga gccctcggac tgaaaacaat gactatgaca ctcccaagta cttcctgtct
     1141 ccaggtgctg ctcacagact caagagtcag aagtgtgttg cctataagtt ccgattggtg
     1201 gtaaaagctg acgggaccca ggagacaaac aatggctgtc gtaaggtgaa aatcatgccc
     1261 tgttccttcc cagtgtccaa agacccttca acaaaaggcc tggatcccca cctcagccat
     1321 caaatgacca aacgaaagag aatggtccta gtcaaagaga ggaaagcggc gcagaccttg
     1381 agcgccattc tcctggcctt catcatcaca tggactcctt ataacatcat ggtcctggtt
     1441 tccaccttct gtgacaagtg tgtccctgtc accctgtggc acttgggtta ctggctgtgc
     1501 tatgtcaaca gcaccatcaa ccccatctgt tacgctctct gcaacagaac cttcaggaag
     1561 acctttaagc tgctgcttct ctgccggtgg aaaaagaaaa aagtagaaga gaaattgtat
     1621 tggcaaggca acagcaagct accctgaatc cttagcaact cctctggaaa gaacaatgat
     1681 cacagtctgg tttgcttgtt aaaggaatgt catctgccat tctgagtccc tgaaggcttg
     1741 tcaagg
//
