LOCUS       NM_033269               3168 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus cholinergic receptor, muscarinic 3, cardiac (Chrm3),
            mRNA.
ACCESSION   NM_033269
VERSION     NM_033269.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3168)
  AUTHORS   Zheng,F., Wess,J. and Alzheimer,C.
  TITLE     Long-Term-But Not Short-Term-Plasticity at the Mossy Fiber-CA3
            Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3
            Muscarinic Acetylcholine Receptor Double Knockout Mice
  JOURNAL   Cells 12 (14), 1890 (2023)
   PUBMED   37508553
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3168)
  AUTHORS   Duan,J., Grando,C., Liu,S., Chernyavsky,A., Chen,J.K., Andersen,B.
            and Grando,S.A.
  TITLE     The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal
            Differentiation
  JOURNAL   J Invest Dermatol 142 (12), 3211-3221 (2022)
   PUBMED   35870560
  REMARK    GeneRIF: The M3 Muscarinic Acetylcholine Receptor Promotes
            Epidermal Differentiation.
REFERENCE   3  (bases 1 to 3168)
  AUTHORS   Shindo,Y., Nakamura,H.M., Nakai,J., Wakamori,M. and Nakamura,T.
  TITLE     A parasympathetic neurotransmitter induces myoepithelial cell
            differentiation during salivary gland development
  JOURNAL   Exp Cell Res 416 (1), 113137 (2022)
   PUBMED   35427599
REFERENCE   4  (bases 1 to 3168)
  AUTHORS   Wan,J., Wang,J., Wagner,L.E. 2nd, Wang,O.H., Gui,F., Chen,J.,
            Zhu,X., Haddock,A.N., Edenfield,B.H., Haight,B., Mukhopadhyay,D.,
            Wang,Y., Yule,D.I., Bi,Y. and Ji,B.
  TITLE     Pancreas-specific CHRM3 activation causes pancreatitis in mice
  JOURNAL   JCI Insight 6 (17), e132585 (2021)
   PUBMED   34314386
  REMARK    GeneRIF: Pancreas-specific CHRM3 activation causes pancreatitis in
            mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3168)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3168)
  AUTHORS   Matsui,M., Motomura,D., Karasawa,H., Fujikawa,T., Jiang,J.,
            Komiya,Y., Takahashi,S. and Taketo,M.M.
  TITLE     Multiple functional defects in peripheral autonomic organs in mice
            lacking muscarinic acetylcholine receptor gene for the M3 subtype
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9579-9584 (2000)
   PUBMED   10944224
REFERENCE   7  (bases 1 to 3168)
  AUTHORS   Matsui,M., Araki,Y., Karasawa,H., Matsubara,N., Taketo,M.M. and
            Seldin,M.F.
  TITLE     Mapping of five subtype genes for muscarinic acetylcholine receptor
            to mouse chromosomes
  JOURNAL   Genes Genet Syst 74 (1), 15-21 (1999)
   PUBMED   10549128
REFERENCE   8  (bases 1 to 3168)
  AUTHORS   Lammerding-Koppel,M., Greiner-Schroder,A. and Drews,U.
  TITLE     Muscarinic receptors in the prenatal mouse embryo. Comparison of
            M35-immunohistochemistry with [3H]quinuclidinyl benzylate
            autoradiography
  JOURNAL   Histochem Cell Biol 103 (4), 301-310 (1995)
   PUBMED   7648406
REFERENCE   9  (bases 1 to 3168)
  AUTHORS   Andre,C., Dos Santos,G. and Koulakoff,A.
  TITLE     Cultured neurons from mouse brain reproduce the muscarinic receptor
            profile of their tissue of origin
  JOURNAL   Eur J Neurosci 6 (11), 1691-1701 (1994)
   PUBMED   7874308
REFERENCE   10 (bases 1 to 3168)
  AUTHORS   Shapiro,R.A., Scherer,N.M., Habecker,B.A., Subers,E.M. and
            Nathanson,N.M.
  TITLE     Isolation, sequence, and functional expression of the mouse M1
            muscarinic acetylcholine receptor gene
  JOURNAL   J Biol Chem 263 (34), 18397-18403 (1988)
   PUBMED   2848036
  REMARK    Erratum:[J Biol Chem 1989 Apr 15;264(11):6596]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK080950.1 and AK051841.1.
            
            [WARNING] On Mar 11, 2024 this sequence was replaced by
            NM_033269.5.
            
            On Dec 11, 2007 this sequence version replaced NM_033269.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080950.1, BC129892.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-441               AK080950.1         2-442
            442-716             AK051841.1         487-761
            717-3168            AK080950.1         719-3170
FEATURES             Location/Qualifiers
     source          1..3168
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 3.72 cM"
     gene            1..3168
                     /gene="Chrm3"
                     /gene_synonym="Chrm-3; M3; M3R"
                     /note="cholinergic receptor, muscarinic 3, cardiac"
                     /db_xref="GeneID:12671"
                     /db_xref="MGI:MGI:88398"
     exon            1..540
                     /gene="Chrm3"
                     /gene_synonym="Chrm-3; M3; M3R"
                     /inference="alignment:Splign:2.1.0"
     exon            541..653
                     /gene="Chrm3"
                     /gene_synonym="Chrm-3; M3; M3R"
                     /inference="alignment:Splign:2.1.0"
     exon            654..716
                     /gene="Chrm3"
                     /gene_synonym="Chrm-3; M3; M3R"
                     /inference="alignment:Splign:2.1.0"
     exon            717..763
                     /gene="Chrm3"
                     /gene_synonym="Chrm-3; M3; M3R"
                     /inference="alignment:Splign:2.1.0"
     exon            764..3168
                     /gene="Chrm3"
                     /gene_synonym="Chrm-3; M3; M3R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3144..3149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrm3"
                     /gene_synonym="Chrm-3; M3; M3R"
                     /note="putative"
ORIGIN      
        1 acttggagcg ccttctgtct gcttttggag aaaagaataa aacatataca aagaggcaga
       61 gaaaaggaat gagaagtgag agagcaggag ggtaaaaaaa aaaaaaatta aggcgagatc
      121 agagagggct ggggtgggca ggggcgcgca ggacgcgggg gcggactaac cgagccccag
      181 tgcggtcgcc cgggcaggtg ccacggctgc tgccgagagg cggcatgtga cgcgcggccg
      241 cagctgcccg cgggcggagc gcgctcggac ccgggagcgc aaccgcgggc caagtcggct
      301 gcagccggga gccccgcact cgcgaccggc cgggaggagc ccgcagctgc gcttgcaccc
      361 agaagccggg cgatgcagac aagggcggct ccgaggcacg agcgaacctg aggacagtcg
      421 ctgtctccga actccctgct gcgagagacc gaggttcggt agagcggact ggacagtccg
      481 ggagattcgg ggaggcgcgg aggactggag tgggacagcc acctggagca cggctgccag
      541 atatgaccag caatggcatc tacttcactt ctgacttgct cagtggactg tggattgagt
      601 gaaccatatc ctttcccatc atgatacaca ccacagagac tctcctcttg aagtgctgcg
      661 ttctgaccaa gtgaccaagc acgtgacatt ctgaacttca gcaaaggtac aataagggct
      721 gactacttaa tcttggataa ccagttggtg tgttcttcct tggactatgt cagagagtca
      781 caatgacctt gcacagtaac agtacaacct cgcctttgtt tcccaacatc agctcttcct
      841 gggtgcacag tccctcagag gcggggctgc ccttggggac agtctctcaa ttggacagct
      901 acaacatttc ccaaacctct gggaatttct cctcaaatga cacctccagt gaccctctag
      961 ggggccacac catctggcaa gtggtcttca ttgcattctt gactggcttc ctggcattgg
     1021 tgaccatcat cggcaacatc cttgtcattg tggcatttaa ggtcaacaaa cagctgaaga
     1081 cagtcaacaa ctacttcctc ttaagcctgg cctgcgcaga tctgatcatc ggggtcattt
     1141 ccatgaacct gttcacgacc tacatcatta tgaaccgctg ggctctgggg aacttagcct
     1201 gtgacctctg gctttccatt gactatgtgg ccagcaatgc ttctgtcatg aatctgctgg
     1261 tgatcagctt tgacaggtac ttttctatta ccaggccact cacttaccga gccaaacgaa
     1321 caacaaaacg agccggtgtg atgattggtc tggcttgggt catctccttt gtcctgtggg
     1381 ctcctgccat cttgttctgg caatactttg tagggaagag aactgtgccc cccggagaat
     1441 gtttcattca gtttctaagt gagcccacca tcaccttcgg cacggcgatc gctgcctttt
     1501 acatgcctgt caccatcatg actattttat actggagaat ctataaggag actgagaaac
     1561 gtaccaaaga gctggctggg ctacaggcct ctgggacaga agcggaagca gaaaactttg
     1621 tccaccccac aggcagttct cgaagctgta gcagctatga gctacaacag caaggcacga
     1681 aacggtcatc taggaggaag tatggtggct gtcacttctg gttcacaact aagagctgga
     1741 agcccagtgc tgagcagatg gaccaagacc acagtagcag tgacagttgg aataacaacg
     1801 atgctgctgc ctccctggaa aactctgctt cttctgatga agaggatatt ggctcagaga
     1861 ccagagccat ctattccatt gtactcaagc tgccgggtca tagcaccatc ctcaactcta
     1921 ccaagctacc ctcctcagat aacctgcagg tgccagacaa ggacctgggg actatggatg
     1981 tagagagaaa tgcccataag cttcaggccc agaagagtat ggatgaccgt gacaactgtc
     2041 agaaggactt ctccaagctc cccatccagt tagagtctgc cgtggacaca gccaagacct
     2101 ctgacaccaa ctcctcggtg gacaagacca cggccgctct acctctgtcc ttcaaagaag
     2161 ccacgctggc taagaggttt gctctcaaga ccagaagtca gatcaccaag cggaaaagga
     2221 tgtcgctcat caaggagaag aaggccgccc agacactcag tgccatcttg ctggctttca
     2281 tcatcacgtg gaccccctac aacatcatgg tcctggtgaa caccttctgt gacagctgca
     2341 tacccaaaac ctattggaat ctgggctact ggctgtgcta tatcaacagc accgtgaacc
     2401 ccgtgtgcta tgccctgtgc aacaagacat tcagaaccac cttcaagatg cttctcttat
     2461 gccagtgtga caagaggaag cggcgcaaac agcagtacca gcagagacag tccgtcattt
     2521 ttcacaagcg agtgcctgag caggccttgt agaaaagggg tttatcaata gcagtgaccc
     2581 atacacacac gtcagcccac agcctagcag gagtctggcg caggtgggag gccattcctg
     2641 atggtgataa aaggggtttt tttgtcaacc acacaggaga gaagctgcct atttactgat
     2701 ccactgaata cctgattttg gtccaatgcc aattcagcag gaaagaagga gaagtgtact
     2761 gctaaattta aagaaatgta ttctgaaaca gacttttaag tggatttttt aagagaaaaa
     2821 aaatattgtc tcagaacaag aatcctcaga aattggtctg cctgggtctt ttaattctta
     2881 ttagctctgg aatcactggt gagcctcaat gtgctggttg ccatgtgttc tccctagggg
     2941 tcctaaagtg tccacccaga tcccacgtga agcacggcag gcttgaagta tctgtggttc
     3001 tgagttattt tgtatattgc aaagctgaca ccacttgtcc ccgatcagct tctgtcctcc
     3061 ctcggtgtgc tgttaaactc cattcgtgga tttgactctt ggttcttgca aagtactgtt
     3121 ttgtgcagtt caagtttcat acaaataaaa ttgtacatga atacctgc
//
