LOCUS       NM_001112697            6301 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus cholinergic receptor, muscarinic 1, CNS (Chrm1),
            transcript variant 1, mRNA.
ACCESSION   NM_001112697
VERSION     NM_001112697.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6301)
  AUTHORS   Gu,Z., Stevanovic,K.D., Cushman,J.D. and Yakel,J.L.
  TITLE     Cholinergic-Sensitive Theta Oscillations in Memory Encoding in Mice
  JOURNAL   J Neurosci 44 (12), e1313232024 (2024)
   PUBMED   38331584
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6301)
  AUTHORS   Sabbir,M.G.
  TITLE     Cholinergic Receptor Muscarinic 1 Co-Localized with Mitochondria in
            Cultured Dorsal Root Ganglion Neurons, and Its Deletion Disrupted
            Mitochondrial Ultrastructure in Peripheral Neurons: Implications in
            Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 98 (1), 247-264 (2024)
   PUBMED   38427478
  REMARK    GeneRIF: Cholinergic Receptor Muscarinic 1 Co-Localized with
            Mitochondria in Cultured Dorsal Root Ganglion Neurons, and Its
            Deletion Disrupted Mitochondrial Ultrastructure in Peripheral
            Neurons: Implications in Alzheimer's Disease.
REFERENCE   3  (bases 1 to 6301)
  AUTHORS   Zheng,F., Wess,J. and Alzheimer,C.
  TITLE     Long-Term-But Not Short-Term-Plasticity at the Mossy Fiber-CA3
            Pyramidal Cell Synapse in Hippocampus Is Altered in M1/M3
            Muscarinic Acetylcholine Receptor Double Knockout Mice
  JOURNAL   Cells 12 (14), 1890 (2023)
   PUBMED   37508553
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6301)
  AUTHORS   Sabbir,M.G., Swanson,M., Speth,R.C. and Albensi,B.C.
  TITLE     Hippocampal versus cortical deletion of cholinergic receptor
            muscarinic 1 in mice differentially affects post-translational
            modifications and supramolecular assembly of respiratory
            chain-associated proteins, mitochondrial ultrastructure, and
            respiration: implications in Alzheimer's disease
  JOURNAL   Front Cell Dev Biol 11, 1179252 (2023)
   PUBMED   37293125
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6301)
  AUTHORS   Sabbir,M.G., Swanson,M. and Albensi,B.C.
  TITLE     Loss of cholinergic receptor muscarinic 1 impairs cortical
            mitochondrial structure and function: implications in Alzheimer's
            disease
  JOURNAL   Front Cell Dev Biol 11, 1158604 (2023)
   PUBMED   37274741
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6301)
  AUTHORS   Fernandes,M., Lespinasse,F., Rotomondo,F., Poirier,C., Guenet,J.L.,
            Gaudray,P. and Carle,G.F.
  TITLE     Comparative mapping of two adjacent regions of MMU19 with their
            human counterpart on HSA11q13
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 237-246 (1998)
   PUBMED   9730611
REFERENCE   7  (bases 1 to 6301)
  AUTHORS   Hamilton,S.E., Loose,M.D., Qi,M., Levey,A.I., Hille,B.,
            McKnight,G.S., Idzerda,R.L. and Nathanson,N.M.
  TITLE     Disruption of the m1 receptor gene ablates muscarinic
            receptor-dependent M current regulation and seizure activity in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 94 (24), 13311-13316 (1997)
   PUBMED   9371842
REFERENCE   8  (bases 1 to 6301)
  AUTHORS   Lammerding-Koppel,M., Greiner-Schroder,A. and Drews,U.
  TITLE     Muscarinic receptors in the prenatal mouse embryo. Comparison of
            M35-immunohistochemistry with [3H]quinuclidinyl benzylate
            autoradiography
  JOURNAL   Histochem Cell Biol 103 (4), 301-310 (1995)
   PUBMED   7648406
REFERENCE   9  (bases 1 to 6301)
  AUTHORS   Shapiro,R.A., Palmer,D. and Cislo,T.
  TITLE     A deletion mutation in the third cytoplasmic loop of the mouse m1
            muscarinic acetylcholine receptor unmasks cryptic G-protein binding
            sites
  JOURNAL   J Biol Chem 268 (29), 21734-21738 (1993)
   PUBMED   8408028
REFERENCE   10 (bases 1 to 6301)
  AUTHORS   Shapiro,R.A., Scherer,N.M., Habecker,B.A., Subers,E.M. and
            Nathanson,N.M.
  TITLE     Isolation, sequence, and functional expression of the mouse M1
            muscarinic acetylcholine receptor gene
  JOURNAL   J Biol Chem 263 (34), 18397-18403 (1988)
   PUBMED   2848036
  REMARK    Erratum:[J Biol Chem 1989 Apr 15;264(11):6596]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK138282.1, BY062993.1, BB848456.1, BC094242.1, AC025794.9 and
            AW495047.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.75422.1,
                                           SRR1660817.114101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-369               AK138282.1         3-371
            370-520             BY062993.1         2-152
            521-745             BB848456.1         119-343
            746-3058            BC094242.1         638-2950
            3059-6153           AC025794.9         143146-146240
            6154-6301           AW495047.1         1-148               c
FEATURES             Location/Qualifiers
     source          1..6301
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.44 cM"
     gene            1..6301
                     /gene="Chrm1"
                     /gene_synonym="Chrm-1; M1; M1R"
                     /note="cholinergic receptor, muscarinic 1, CNS"
                     /db_xref="GeneID:12669"
                     /db_xref="MGI:MGI:88396"
     exon            1..453
                     /gene="Chrm1"
                     /gene_synonym="Chrm-1; M1; M1R"
                     /inference="alignment:Splign:2.1.0"
     exon            454..545
                     /gene="Chrm1"
                     /gene_synonym="Chrm-1; M1; M1R"
                     /inference="alignment:Splign:2.1.0"
     exon            546..6290
                     /gene="Chrm1"
                     /gene_synonym="Chrm-1; M1; M1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             617..1999
                     /gene="Chrm1"
                     /gene_synonym="Chrm-1; M1; M1R"
                     /note="m1 muscarinic acetylcholine receptor protein; AChR
                     M1"
                     /codon_start=1
                     /product="muscarinic acetylcholine receptor M1"
                     /protein_id="NP_001106167.1"
                     /db_xref="CCDS:CCDS29539.1"
                     /db_xref="GeneID:12669"
                     /db_xref="MGI:MGI:88396"
                     /translation="MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNL
                     LVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWL
                     ALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPA
                     ILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENR
                     ARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKE
                     EEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPKSSPNTVKRPTKKGR
                     DRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCK
                     DCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPG
                     SVHRTPSRQC"
     regulatory      3030..3035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrm1"
                     /gene_synonym="Chrm-1; M1; M1R"
                     /note="hexamer: AATAAA"
     polyA_site      3061
                     /gene="Chrm1"
                     /gene_synonym="Chrm-1; M1; M1R"
                     /note="major polyA site"
     regulatory      4527..4532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrm1"
                     /gene_synonym="Chrm-1; M1; M1R"
                     /note="hexamer: AATAAG"
     polyA_site      4548
                     /gene="Chrm1"
                     /gene_synonym="Chrm-1; M1; M1R"
                     /note="major polyA site"
     regulatory      5053..5058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrm1"
                     /gene_synonym="Chrm-1; M1; M1R"
                     /note="hexamer: AATAAA"
     polyA_site      5075
                     /gene="Chrm1"
                     /gene_synonym="Chrm-1; M1; M1R"
ORIGIN      
        1 gtgtgtgtgt gtgccgccag tctgtgtgca gtgggtgtgg gtgtttgtct ccctgtatcc
       61 gccttctctc tcctcttgga cttttagctt tcctgggctc tctttcctca tgtcctgcct
      121 cctccctctc gaggctcaaa gtgggtgccc ttgtggacaa ggggggcaca ctccaggact
      181 tagtccaacc ccagatgctg cctgaggctt ccctcctgct ccccctccct ttctttcctc
      241 cctttcctcc ctccctctct ttcccttcct ccctcccccc caaggctggc gtgccagggg
      301 gtgggacatg ccaatcactg gctgtgcctc tccggctgcc agcacagggc gcagctcccc
      361 ccgggagcca ggtgtttggg tcccaggaga cactgcaggc ccccggagaa gcactgaagc
      421 tgaggaccct acagacccct ctccggtccc atggaaaccc tgaatcctac ctcccctatc
      481 caccttcagc cccccaagat ggattgaatg aggctgctgg ccagatggac aagctggatg
      541 ccaaggtgat gcccttactc tgagaaaaat cttgtgactg gaggaagggg ctgccccttc
      601 attccacctg gctgcaatga acacctcagt gccccctgct gtcagtccca acatcaccgt
      661 cttggcacca ggaaagggtc cctggcaagt ggcattcatc gggatcacca caggcctcct
      721 gtctctggct acagtgacag gcaacctgct ggtgctcatc tccttcaagg tcaacacaga
      781 gctcaagaca gtcaacaact acttcctgct gagcctggcc tgtgctgatc tcatcattgg
      841 cactttctcc atgaacctct ataccacata cctgctcatg ggccactggg ctctgggcac
      901 actggcctgt gacctctggc tggccctgga ctatgtggcc agcaacgcct ctgtcatgaa
      961 tcttctgctc atcagctttg accgttactt ctcagtgacc cgacccctga gctaccgagc
     1021 caagcgcact ccccgcaggg cagctctgat gattggcctc gcgtggttgg tttccttcgt
     1081 tctctgggcc ccagccatcc tcttctggca atacctagtt ggggagcgga cagtgctggc
     1141 tgggcagtgc tacatccagt tcctctccca acccatcatc acttttggca cagccatggc
     1201 cgccttctac ctccctgtca cagtcatgtg tacgctgtac tggcgcatct accgggagac
     1261 agaaaaccga gcccgggagc tagcagccct acagggctct gagacaccag gcaaaggtgg
     1321 tggcagcagc agcagctcag agaggtcaca gccaggagct gaaggctcac ccgagtcacc
     1381 tccaggccgc tgctgtcgct gttgccgggc acccagactt ctgcaggcct acagctggaa
     1441 agaagaagag gaagaggatg aaggctccat ggagtccctc acatcctctg aaggtgagga
     1501 gcctggctca gaagtggtga tcaagatgcc tatggtagat cctgaggcac aggcacccac
     1561 caagcagcct cccaaaagct ccccaaatac agtcaagagg cccaccaaga aaggccgaga
     1621 ccgaggcggc aaaggccaaa aaccccgagg gaaggaacaa ctggccaaga gaaagacctt
     1681 ctcactggtc aaggagaaga aggcagctcg gaccctgagt gccatcctgc tggccttcat
     1741 cctcacctgg acaccatata acatcatggt gctggtgtct acattctgca aggactgtgt
     1801 tccagaaacc ctatgggagc tgggctactg gctttgctac gtcaacagca ctgtcaaccc
     1861 catgtgctac gcactctgca acaaagcctt ccgggacact ttccgcctgc tgttgctctg
     1921 ccgctgggac aagcggcgct ggcgcaaaat ccccaagcgc cctggctctg tgcaccgcac
     1981 cccctcccgc caatgctaat ggcccccttc tcctgcatcc ttccaccctc agctccaggg
     2041 agaggccggt ggaaagtgtc ccggaaaatg ggctgcatct tcagccccaa agccctgctc
     2101 aggactcctc tggcttccca ggcccctggg tcaccttcct ggacagccca gagagacttt
     2161 gccgctttcc aaactttgct gttcccagac agagagtgaa acccggggaa ctggtttttc
     2221 tgatccctgc tgtgtgggaa tgggcccagc aggaggatcc gggctttggt ctgtttgcgt
     2281 ttaggcagga agtcaggagc caacagggcg ggccagtagt ttaaaggtgc agtcttcctt
     2341 ggcccattag ggggcctgga ttgcagtggt gatagcacct gctgcagctt catatgggag
     2401 atcacaccaa gcacagagag aaaagtctgg aagaggaggg aggtggtgaa ccctggctgg
     2461 aaatcccctc cctacacagg cagaactcat ccaggtaggc cctaggcaca ctctccagga
     2521 ttgtccaact tccctacaaa tgtccccagg tcagccctat gtggtcacct ccaaggcaaa
     2581 tgtccaagcg taagcaggac aacaacacca gaggagacca gcttggttaa atacaccaag
     2641 tcccaaagca gcatcaagga ccagatgtca ggtgtcctaa ccagtcctct atgccatttt
     2701 cctgggggtg ggggtgggag ttgagggggt aaggtgcctg ccatccaatc ccacacccat
     2761 tcttctctct ccctacccta aagtgacctc ggtcccaccc tcctggctca cagccgttac
     2821 ctgggtggat ctgctctggg cagatctagc cagacctcct gcatgctgcc tgcctccagc
     2881 cttgccccac atgggtctgt cccagccagc agattctctt ctgtaaactc cttaatccaa
     2941 tccgtgcatg gctgccctgc caccctactc tccaggccct gcctggcccc tgttcttttc
     3001 ttccatcctc agcatatgct gagtctgtga ataaaagcca cgtaactagt gggcactata
     3061 aggaattcct ccctgttttg gccccaaggc caggaatgca aggacaggga aggcacaaga
     3121 actacaatgc agaaagtgag ctgcggcttt taagatggat ccaggaaaga cagcattgaa
     3181 tggctagatc gactaaccct gcaggggggc cccagcacaa cctgtgggtc catggctcag
     3241 gtgagtggtg ctaaaccagg caggcctgac ctctgaaaca gccccatgta ctctgtacat
     3301 agcagctcta gggccttatc attcccagga ggaacagaat tcatccaaac tcctatttgt
     3361 agctggggaa actaagaccc agagacccaa gaggattctt ttggattata taacaaaaca
     3421 acacccaggc ttccacaacc tcctgacctc tagactgtag gggtgacaga cctaggatac
     3481 tcaggccaaa gcattcaatc agggaaaccc ttagggcaca acctaagcat tgttttggta
     3541 agggaagttc ccaaagccta atgaaaagga acctgaacaa attaacccca cagtcctaag
     3601 cagtggttat ccaagtatag cagtagtcgg gtgtcccaag gctcacccag atgtcagtga
     3661 tttgctggga aaacagagag ctctgcaagg ccactagagt ctgtcactgt cacagtggaa
     3721 gagttcagaa ggaaacaaca gaataaagca cacagagcag aatcccagag taaccaggca
     3781 caaaatgcca attcttttcc caggaagtca cagaatactt aattctccag caatgatgta
     3841 ggacagctta catgacattc tgccagccac aaacaccctc cagaaccatg gtgtctggtg
     3901 tttgtactag aggacaggca tagggaggaa catggctgac tgcccacacc gttggcctca
     3961 gtgtccagcc cctctagagg cttaacagat agagtgtggc ctaggacctc caccacaaac
     4021 catattctta gtatagatta tccgatgtgc tccagacaag caaagatttt cttcaatgct
     4081 ggataatcca gtggttagcc aagattgcct ggagccagac aaggcctgct aatctaacag
     4141 aagcccaaac caggaatatt gcctgcacct gggaacttaa ctaggtaaat ttctgggatc
     4201 actatggatt tagtaaaaga agaattccaa ggatggaaac cagctatctg taaccagcag
     4261 cctcaaggtg attctggtac acattaaagt ttgagagggg taaaaaaaat atcctagaag
     4321 gctgaggtcc tgggtgggga ccccccaaaa aaatccctgc aggcttggag agttggctca
     4381 gaggttaaga gtactggctg ctcttcccga ggtcctgagt tcaattccca gcaaccacgt
     4441 agtggctcac aaccctctat aatgagatct ggtgccctct tctggcctgc aggcatacat
     4501 gcagacagaa tactgtatac ataataaata agcctttttt tttttaaatc cctgtagagg
     4561 aaggggtggg attcaccccc acacatttag cttcctgaac tcccagaaac tgttggacct
     4621 tgagagctta tctagcagtt ctagctgggg tgtgcatctc ctggtatata cccttgacct
     4681 tcctccttta tctgggaagg tcttcctctt gaactgggtg tacagatttg gacaagatga
     4741 atatggaggg atgatagagg aagaagacac ctactgagcc agtcggatca gttgcatcaa
     4801 ccctattagc caatggggtg tcaaatgtct caatcacctt catcacccac aagctatgga
     4861 atggttgcaa cactgtgggc aaggatagcc cactaggtgg acaaggagaa gctggccaga
     4921 gctgcaggag atacatggga tgatcttatg taagccatgt accccgtatc accagtacag
     4981 gttgacagct gagaccctgg taagggcttc tggcttgttc atgctccctt gtagccctaa
     5041 gcccccttca gaaataaatg ccctgcctgt gtcaagggtg tggaggtgga gggcggagga
     5101 agctgagcag cactggaaga agtgaagctt tgggaccaat ggaacatcaa ggaaggaggg
     5161 gatgggacca gcatcaggaa ggatggggtg agaccagcat caggaccgga aatgagagta
     5221 gcagcccaca cctatcactt gttccctctc ctggggacct caccggggtc ctgctatgcc
     5281 ctccaccaaa taaccttggt taggcatgcc tcctgtcttc agtgtcttca tctctaaaag
     5341 aggagcaagc cctttgcagg tgtcagaggg atgcggcaaa ctggtaaaag caattgatgg
     5401 ctgtaccgtc ggtgttacca cagaagaggc tgccacaggt aatggcctgt ctagtttctc
     5461 acccaggtct taccctgtac ctctgttctg gctttgggaa gtctagagtc ctattccccc
     5521 aaaccaggaa gaagaatctt acatcccaat gtgactgggt ttgaagagtg tccagcgcac
     5581 acctgggcaa gaaggagggt aaagtccagg tggggtctgg gtcctgcagg cctctgaaga
     5641 aagagttgcc aacccaggat ggagaataac atgaggctga aggaagaggg tggttgcatg
     5701 ggcatctgtc catctcaaac acagcaccca ctcctaccct gagggagtct ctttacccca
     5761 ggaacaaagg ccttttggta gaagtaagga gagaataagg tcgctttgtg aataccacat
     5821 cttctaccaa tcccagactg gagctagcct gaggaggaac aagttagaat ccctcccaca
     5881 ctcaaagccc agccttactt ccatttccac catgacattt tagcgccacc tgctggcaat
     5941 ttaagaaacc tgacgtttaa atgctcttcc ccctgccttt tttttttttt tttttggaca
     6001 agctcttggt atgtagcctt ggctggcctg gaattcatta tatacaccag gctggccttg
     6061 aactcttaga gagctgactg cctctgtctc tgaatgctgg aagtaaagat gttcaccatc
     6121 acactggcca aattactacc tcttcttcct cttcctcttt ctcatcctcc tttttaaaac
     6181 tagtattggg actgaatcta gggtctctca tatactaggc caacactcta caaatgagct
     6241 atatgtctca tccataaact tttttattat taaaaacacg ttgcaaaaaa aaaaaaaaaa
     6301 a
//
