LOCUS       NM_001114385            4060 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus chordin-like 1 (Chrdl1), transcript variant 1, mRNA.
ACCESSION   NM_001114385
VERSION     NM_001114385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4060)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4060)
  AUTHORS   Sun,H., Wang,S., Yang,Z., Tian,L., Li,X., Zhou,J. and Wang,B.
  TITLE     Chordin Like-1 Regulates Osteoblast and Adipocyte Differentiation
            Through Stabilizing Insulin-Like Growth Factor Binding Protein 3
  JOURNAL   Stem Cells 41 (4), 400-414 (2023)
   PUBMED   36682027
  REMARK    GeneRIF: Chordin Like-1 Regulates Osteoblast and Adipocyte
            Differentiation Through Stabilizing Insulin-Like Growth Factor
            Binding Protein 3.
REFERENCE   3  (bases 1 to 4060)
  AUTHORS   Escuin,S., Rose Raza-Knight,S., Savery,D., Gaston-Massuet,C.,
            Galea,G.L., Greene,N.D.E. and Copp,A.J.
  TITLE     Dual mechanism underlying failure of neural tube closure in the
            Zic2 mutant mouse
  JOURNAL   Dis Model Mech 16 (3) (2023)
   PUBMED   36916392
REFERENCE   4  (bases 1 to 4060)
  AUTHORS   Ahn,J., Suh,Y. and Lee,K.
  TITLE     Chordin-like 1, a Novel Adipokine, Markedly Promotes Adipogenesis
            and Lipid Accumulation
  JOURNAL   Cells 12 (4), 624 (2023)
   PUBMED   36831292
  REMARK    GeneRIF: Chordin-like 1, a Novel Adipokine, Markedly Promotes
            Adipogenesis and Lipid Accumulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4060)
  AUTHORS   Blanco-Suarez,E. and Allen,N.J.
  TITLE     Astrocyte-secreted chordin-like 1 regulates spine density after
            ischemic injury
  JOURNAL   Sci Rep 12 (1), 4176 (2022)
   PUBMED   35264691
  REMARK    GeneRIF: Astrocyte-secreted chordin-like 1 regulates spine density
            after ischemic injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4060)
  AUTHORS   Chandra,A., Itakura,T., Yang,Z., Tamakoshi,T., Xue,X., Wang,B.,
            Ueki,T., Sato,K., Uezato,T. and Miura,N.
  TITLE     Neurogenesin-1 differentially inhibits the osteoblastic
            differentiation by bone morphogenetic proteins in C2C12 cells
  JOURNAL   Biochem Biophys Res Commun 344 (3), 786-791 (2006)
   PUBMED   16630536
REFERENCE   7  (bases 1 to 4060)
  AUTHORS   Nakayama,N., Han,C.Y., Cam,L., Lee,J.I., Pretorius,J., Fisher,S.,
            Rosenfeld,R., Scully,S., Nishinakamura,R., Duryea,D., Van,G.,
            Bolon,B., Yokota,T. and Zhang,K.
  TITLE     A novel chordin-like BMP inhibitor, CHL2, expressed preferentially
            in chondrocytes of developing cartilage and osteoarthritic joint
            cartilage
  JOURNAL   Development 131 (1), 229-240 (2004)
   PUBMED   14660436
REFERENCE   8  (bases 1 to 4060)
  AUTHORS   Sakuta,H., Suzuki,R., Takahashi,H., Kato,A., Shintani,T.,
            Iemura,Si., Yamamoto,T.S., Ueno,N. and Noda,M.
  TITLE     Ventroptin: a BMP-4 antagonist expressed in a double-gradient
            pattern in the retina
  JOURNAL   Science 293 (5527), 111-115 (2001)
   PUBMED   11441185
REFERENCE   9  (bases 1 to 4060)
  AUTHORS   Nakayama,N., Han,C.E., Scully,S., Nishinakamura,R., He,C., Zeni,L.,
            Yamane,H., Chang,D., Yu,D., Yokota,T. and Wen,D.
  TITLE     A novel chordin-like protein inhibitor for bone morphogenetic
            proteins expressed preferentially in mesenchymal cell lineages
  JOURNAL   Dev Biol 232 (2), 372-387 (2001)
   PUBMED   11401399
REFERENCE   10 (bases 1 to 4060)
  AUTHORS   Coffinier,C., Tran,U., Larrain,J. and De Robertis,E.M.
  TITLE     Neuralin-1 is a novel Chordin-related molecule expressed in the
            mouse neural plate
  JOURNAL   Mech Dev 100 (1), 119-122 (2001)
   PUBMED   11118896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX119959.7, AF321853.1 and AL713920.14.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.615852.1,
                                           SRR17784644.834737.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               BX119959.7         86205-86653         c
            450-524             BX119959.7         82477-82551         c
            525-2297            AF321853.1         1-1773
            2298-4060           AL713920.14        132251-134013       c
FEATURES             Location/Qualifiers
     source          1..4060
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 64.24 cM"
     gene            1..4060
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /note="chordin-like 1"
                     /db_xref="GeneID:83453"
                     /db_xref="MGI:MGI:1933172"
     exon            1..449
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            450..603
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     CDS             525..1868
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; ventroptin-beta; chordin-like protein 1;
                     neuralin-1; neurogenesin-1; ventroptin-alpha"
                     /codon_start=1
                     /product="chordin-like protein 1 isoform 1 precursor"
                     /protein_id="NP_001107857.1"
                     /db_xref="CCDS:CCDS53208.1"
                     /db_xref="GeneID:83453"
                     /db_xref="MGI:MGI:1933172"
                     /translation="MDGMKYIISLFFIFVFLEGSKTEQVKHSDTYCVFQDKKYRVGEK
                     WHPYLEPYGLVYCVNCICSENGNVLCSRVRCPSLHCLSPVHIPHLCCPRCPDSLPPVN
                     NKVTSKSCEYNGTTYQHGELFIAEGLFQNRQPNQCSQCSCSEGNVYCGLKTCPKLTCA
                     FPVSVPDSCCRVCRGDAELSWEHADGDIFRQPANREARHSYLRSPYDPPPNRQAGGLP
                     RFPGSRSHRGAVIDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFG
                     IVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPEEPPSQNFDSKGSFCG
                     EETMPVYESVFMEDGETTRKVALETERPPQVEVHVWTIQKGILQHFHIEKISKRMFGE
                     LHHFKLVTRTTLNQWKLFTEGEAQLSQMCSSQVCRTELEDLVQVLYLGRPEKDHC"
     exon            604..716
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            717..810
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            811..953
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1047
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1115
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1284
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1479
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1647
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1737
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..4060
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4035..4040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /note="hexamer: AATAAA"
     polyA_site      4058
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /note="major polyA site"
ORIGIN      
        1 gtgtggtggg ggcgctgcgt gatgggaaag tgccggctga gccgcacact ttctccccgg
       61 tttgtaactt tcgggtctgg gatgtatcaa taaagcccgg tgctaggacc aagaaggggt
      121 gcgtgtttgc agcggctggg ctgcttgctg gagaacttcc cgccagcgcc gggtagccgg
      181 gccaagtagg gagcggacag gcgggcgggc aggtggcccc gggccgccgc gcccgcgcct
      241 tggctctgcc ccctggagcc aagcgagcct ctgctccctc gtggtgcgag ggcggtgatg
      301 tttttcctcc cacccacttt tgagtccccc ctcccccttc gcgcgcactc aagttctcgc
      361 cacaacctgc gagccccaga cctcggagga gcgccccagg gagctcagag cttgtgcaag
      421 cgtggcagca ggaggaggcc agtgcccagc tttagtccac cgctcctctc cttggagccc
      481 ctgaattgca ttttgcagta gctcgaagga gaaaaaagta gaagatggat ggcatgaaat
      541 acatcatttc cttatttttc atctttgttt tcctagaagg aagcaaaaca gaacaagtaa
      601 aacactcaga cacatattgc gtgtttcaag acaagaagta tagagtgggt gagaaatggc
      661 atccctacct ggaaccgtat ggactggttt actgtgtgaa ctgcatctgc tctgagaatg
      721 ggaatgtgct ttgcagccga gtcagatgtc caagtcttca ttgcctttca cccgtgcata
      781 ttcctcatct ctgttgcccc cgctgcccag actccttacc accagtgaac aataaggtga
      841 ccagcaagtc atgcgaatac aatggaacca cttaccaaca tggagaactg ttcatagctg
      901 aagggctctt tcagaaccgg caacccaatc agtgcagtca gtgtagctgc tcggagggga
      961 atgtatactg tggtctcaag acttgcccca aactgacctg tgcattccca gtctctgttc
     1021 cagattcttg ctgccgagta tgcagagggg atgcagaatt atcgtgggaa catgcggatg
     1081 gtgatatctt ccggcaacct gccaacagag aagcaagaca ttcttacctc cgttccccct
     1141 acgatcctcc accaaacaga caagctggag gtcttccccg ctttcctggg agcagaagtc
     1201 accggggagc tgttatagat tcccagcaag catccgggac catcgtgcag attgtcatca
     1261 ataacaagca caaacatgga caagtgtgtg tttccaatgg aaagacctac tctcatggag
     1321 agtcctggca cccaaatcta cgagcatttg gcattgtgga atgtgtacta tgcacttgta
     1381 atgtcaccaa gcaagaatgt aagaaaatcc actgccccaa tcgatacccc tgcaagtatc
     1441 ctcaaaaaat agatggaaag tgctgcaagg tgtgcccaga agaacctcca agccaaaact
     1501 ttgacagcaa aggttccttt tgtggagaag aaaccatgcc tgtatatgag tctgtgttca
     1561 tggaggatgg agagacaacc agaaaagtag cactggagac cgagagacca cctcaagtag
     1621 aggtccacgt ttggactatt caaaagggca ttctccagca cttccacatt gagaagattt
     1681 ccaagaggat gtttggggag ctccatcatt tcaagctagt tactcggacc accttgaacc
     1741 agtggaagct cttcactgaa ggagaagctc agctcagcca gatgtgctca agtcaggtgt
     1801 gcagaacaga gctggaagat ttagtccagg ttttgtacct ggggagacct gaaaaggacc
     1861 actgttagac acaacagcca ggattgcaca gtatcaatca aggaaaccca agctgcagcg
     1921 ctccaaaacc caaaagtcaa cctcagtcaa attatccacg ccagccacag cataccttgt
     1981 tcctctatgt gccgctgtgt gccagccctc aaacatctcc tgtaaagaga acagaggagt
     2041 ctttaatggt ttctggaagg agaagggata ggactttgtg gtacagctct agtttctgtg
     2101 agaatccctt ttatttgcag tttaaagtaa gaaaaaacaa acaaacactt ttagagatcc
     2161 tctgtagaaa gtcacaggaa agagaaagat attgttcagc ttgagttggg tcatgccaaa
     2221 cagtcattta tttggtgggt agaaatacag tcaggtggtt atagagcaca tacctagcat
     2281 atgtgaagcc atgggttcta ttctcagaac tgaaaaaaaa aaaaattcca tcctcgtatc
     2341 tcatgtgtac acatatgaac acacacactg cacatgtaac tgcccttctt ctttctggct
     2401 cctaaacgcc tttgagcttg ttggtaccca gagaaataaa ctaaaattgt atgaaaaaaa
     2461 aactctgcct tcaagccttt aaggcaggtt tttaagtcat cagccatagt cctagggtga
     2521 agaactccat ttgtgggcct tgttcccttt gaagtgctaa attcattttg cctaataata
     2581 ctacttctct ttccttatct gaatctctaa cacctccatt agaaaagtag agtttggaga
     2641 aatcatcaga aactattttt attccaaaca aaataaccgt agaagaatac aactgataaa
     2701 aataaaataa cccatttgtt cacagttcta aaactaactg gttaataggc taatgatgtt
     2761 cactcattct ttgaggcagt agttacctag gcagacactt taggttggta cttttattct
     2821 aaaagccttt ttaagggtaa tcttccttct ctgattacag gagctgaaat ttgacttttc
     2881 taacaggctc agtccttacg agcttctcaa cactggttct tctgttaaga gtgactgttc
     2941 attcagggag ctgagaattc tggcacagat ctttgtccca agccttccta ctattcttgc
     3001 cttattctta gtatgcgttg catcggggat tttagaccag gctgcctctg aaatggttat
     3061 ttgcagccca attcctcagt gtcaatgatc ctttctgagg cttggcttta gaaataacct
     3121 tttggaacaa actataaata tttcctagca aggatcataa gcccaatttc cggatttgcc
     3181 cctctgagaa gcatgaatga gctcacatta gtactgagaa gtttgaagac caagaaatcc
     3241 tgtatttcct actctaggtg agacaatgtg agaggacaaa gtatgaagag tctggttttt
     3301 actagaacct gacagagaag ggaaggtttc tataaaaaga gacaccaggc tttgggggcc
     3361 agggcttcat gagacaaact tcttgccagc caatcacaca ttcttctcag aagagaggca
     3421 tagagcatcc tgggttgcaa agccacagaa cattattgaa catgtgatgg ggcagtgaca
     3481 aacctctgct gcttccctct tggaggatac agtaatacca gagtgtggag atcagtaacc
     3541 atatcctgag gaaagtggtg attcccctgc tagatgattc acccacaaac cttcccaccc
     3601 aggtgttctc tgaaagctta gcctcaaggg aacacctaaa gagctcccct acatagactc
     3661 ctgcctccag gtgcaggaac acaccttcct aaagtgctgt gggaggccaa actggggagc
     3721 tgtgctaagt caatgtagaa attctcgagt attttggtgt tggatagaat atagaacata
     3781 ggggaaagag accaaactgc ctgtagttag taacgaagta tgtatgttgt tcttttgtgt
     3841 atttatttgt atcataaaca catgggaaag caaagaccat aagcaccatt ttgcagttct
     3901 atcttttttt ccagttagcc tatgtaacca agtatgcata acataacagt attacccttt
     3961 cactcttctc acaggacatg tacccaaata tggtacttat ttatgtagtc actgtgtttc
     4021 tggaatttta tgttaataaa attttaattt aaaaaggcta
//
