LOCUS       NP_001107857             447 aa            linear   ROD 30-APR-2024
DEFINITION  chordin-like protein 1 isoform 1 precursor [Mus musculus].
ACCESSION   NP_001107857
VERSION     NP_001107857.1
DBSOURCE    REFSEQ: accession NM_001114385.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 447)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 447)
  AUTHORS   Sun,H., Wang,S., Yang,Z., Tian,L., Li,X., Zhou,J. and Wang,B.
  TITLE     Chordin Like-1 Regulates Osteoblast and Adipocyte Differentiation
            Through Stabilizing Insulin-Like Growth Factor Binding Protein 3
  JOURNAL   Stem Cells 41 (4), 400-414 (2023)
   PUBMED   36682027
  REMARK    GeneRIF: Chordin Like-1 Regulates Osteoblast and Adipocyte
            Differentiation Through Stabilizing Insulin-Like Growth Factor
            Binding Protein 3.
REFERENCE   3  (residues 1 to 447)
  AUTHORS   Escuin,S., Rose Raza-Knight,S., Savery,D., Gaston-Massuet,C.,
            Galea,G.L., Greene,N.D.E. and Copp,A.J.
  TITLE     Dual mechanism underlying failure of neural tube closure in the
            Zic2 mutant mouse
  JOURNAL   Dis Model Mech 16 (3) (2023)
   PUBMED   36916392
REFERENCE   4  (residues 1 to 447)
  AUTHORS   Ahn,J., Suh,Y. and Lee,K.
  TITLE     Chordin-like 1, a Novel Adipokine, Markedly Promotes Adipogenesis
            and Lipid Accumulation
  JOURNAL   Cells 12 (4), 624 (2023)
   PUBMED   36831292
  REMARK    GeneRIF: Chordin-like 1, a Novel Adipokine, Markedly Promotes
            Adipogenesis and Lipid Accumulation.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 447)
  AUTHORS   Blanco-Suarez,E. and Allen,N.J.
  TITLE     Astrocyte-secreted chordin-like 1 regulates spine density after
            ischemic injury
  JOURNAL   Sci Rep 12 (1), 4176 (2022)
   PUBMED   35264691
  REMARK    GeneRIF: Astrocyte-secreted chordin-like 1 regulates spine density
            after ischemic injury.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 447)
  AUTHORS   Chandra,A., Itakura,T., Yang,Z., Tamakoshi,T., Xue,X., Wang,B.,
            Ueki,T., Sato,K., Uezato,T. and Miura,N.
  TITLE     Neurogenesin-1 differentially inhibits the osteoblastic
            differentiation by bone morphogenetic proteins in C2C12 cells
  JOURNAL   Biochem Biophys Res Commun 344 (3), 786-791 (2006)
   PUBMED   16630536
REFERENCE   7  (residues 1 to 447)
  AUTHORS   Nakayama,N., Han,C.Y., Cam,L., Lee,J.I., Pretorius,J., Fisher,S.,
            Rosenfeld,R., Scully,S., Nishinakamura,R., Duryea,D., Van,G.,
            Bolon,B., Yokota,T. and Zhang,K.
  TITLE     A novel chordin-like BMP inhibitor, CHL2, expressed preferentially
            in chondrocytes of developing cartilage and osteoarthritic joint
            cartilage
  JOURNAL   Development 131 (1), 229-240 (2004)
   PUBMED   14660436
REFERENCE   8  (residues 1 to 447)
  AUTHORS   Sakuta,H., Suzuki,R., Takahashi,H., Kato,A., Shintani,T.,
            Iemura,Si., Yamamoto,T.S., Ueno,N. and Noda,M.
  TITLE     Ventroptin: a BMP-4 antagonist expressed in a double-gradient
            pattern in the retina
  JOURNAL   Science 293 (5527), 111-115 (2001)
   PUBMED   11441185
REFERENCE   9  (residues 1 to 447)
  AUTHORS   Nakayama,N., Han,C.E., Scully,S., Nishinakamura,R., He,C., Zeni,L.,
            Yamane,H., Chang,D., Yu,D., Yokota,T. and Wen,D.
  TITLE     A novel chordin-like protein inhibitor for bone morphogenetic
            proteins expressed preferentially in mesenchymal cell lineages
  JOURNAL   Dev Biol 232 (2), 372-387 (2001)
   PUBMED   11401399
REFERENCE   10 (residues 1 to 447)
  AUTHORS   Coffinier,C., Tran,U., Larrain,J. and De Robertis,E.M.
  TITLE     Neuralin-1 is a novel Chordin-related molecule expressed in the
            mouse neural plate
  JOURNAL   Mech Dev 100 (1), 119-122 (2001)
   PUBMED   11118896
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX119959.7, AF321853.1 and AL713920.14.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784643.615852.1,
                                           SRR17784644.834737.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..447
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 64.24 cM"
     Protein         1..447
                     /product="chordin-like protein 1 isoform 1 precursor"
                     /note="ventroptin-beta; chordin-like protein 1;
                     neuralin-1; neurogenesin-1; ventroptin-alpha"
                     /calculated_mol_wt=48163
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2587
     mat_peptide     23..447
                     /product="chordin-like protein 1 isoform 1"
                     /calculated_mol_wt=48163
     Region          32..94
                     /region_name="VWC"
                     /note="von Willebrand factor type C domain; cl17735"
                     /db_xref="CDD:450195"
     Region          110..173
                     /region_name="VWC"
                     /note="von Willebrand factor type C domain; cl17735"
                     /db_xref="CDD:450195"
     Site            113
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q920C1.1)"
     Region          174..176
                     /region_name="Cell attachment site. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q920C1.1)"
     Region          200..224
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q920C1.1)"
     Region          255..317
                     /region_name="VWC"
                     /note="von Willebrand factor type C domain; cl17735"
                     /db_xref="CDD:450195"
     Site            286
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q920C1.1)"
     Region          328..447
                     /region_name="CHRDL_1_2_C"
                     /note="Chordin-like protein 1/2 C-terminal; pfam19548"
                     /db_xref="CDD:437380"
     CDS             1..447
                     /gene="Chrdl1"
                     /gene_synonym="CHL; CHL1; Nrln1; VOPT"
                     /coded_by="NM_001114385.1:525..1868"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS53208.1"
                     /db_xref="GeneID:83453"
                     /db_xref="MGI:MGI:1933172"
ORIGIN      
        1 mdgmkyiisl ffifvflegs kteqvkhsdt ycvfqdkkyr vgekwhpyle pyglvycvnc
       61 icsengnvlc srvrcpslhc lspvhiphlc cprcpdslpp vnnkvtsksc eyngttyqhg
      121 elfiaeglfq nrqpnqcsqc scsegnvycg lktcpkltca fpvsvpdscc rvcrgdaels
      181 wehadgdifr qpanrearhs ylrspydppp nrqagglprf pgsrshrgav idsqqasgti
      241 vqivinnkhk hgqvcvsngk tyshgeswhp nlrafgivec vlctcnvtkq eckkihcpnr
      301 ypckypqkid gkcckvcpee ppsqnfdskg sfcgeetmpv yesvfmedge ttrkvalete
      361 rppqvevhvw tiqkgilqhf hiekiskrmf gelhhfklvt rttlnqwklf tegeaqlsqm
      421 cssqvcrtel edlvqvlylg rpekdhc
//
