LOCUS       NM_001416766            3267 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus chordin (Chrd), transcript variant 5, mRNA.
ACCESSION   NM_001416766 XM_030248948
VERSION     NM_001416766.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3267)
  AUTHORS   Escuin,S., Rose Raza-Knight,S., Savery,D., Gaston-Massuet,C.,
            Galea,G.L., Greene,N.D.E. and Copp,A.J.
  TITLE     Dual mechanism underlying failure of neural tube closure in the
            Zic2 mutant mouse
  JOURNAL   Dis Model Mech 16 (3) (2023)
   PUBMED   36916392
REFERENCE   2  (bases 1 to 3267)
  AUTHORS   Kim,J., Muraoka,M., Okada,H., Toyoda,A., Ajima,R. and Saga,Y.
  TITLE     The RNA helicase DDX6 controls early mouse embryogenesis by
            repressing aberrant inhibition of BMP signaling through
            miRNA-mediated gene silencing
  JOURNAL   PLoS Genet 18 (10), e1009967 (2022)
   PUBMED   36197846
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3267)
  AUTHORS   Dennison,B.J.C., Larson,E.D., Fu,R., Mo,J. and Fantauzzo,K.A.
  TITLE     Srsf3 mediates alternative RNA splicing downstream of PDGFRalpha
            signaling in the facial mesenchyme
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34184034
REFERENCE   4  (bases 1 to 3267)
  AUTHORS   Wang,C.N., Gong,S.N., Guan,W., Wang,J.L., Gao,T.T., Wang,Y., Sun,F.
            and Jiang,B.
  TITLE     Hippocampal overexpression of chordin protects against the chronic
            social defeat stress-induced depressive-like effects in mice
  JOURNAL   Brain Res Bull 158, 31-39 (2020)
   PUBMED   32105677
  REMARK    GeneRIF: Hippocampal overexpression of chordin protects against the
            chronic social defeat stress-induced depressive-like effects in
            mice.
REFERENCE   5  (bases 1 to 3267)
  AUTHORS   Mzoughi,S., Di Tullio,F., Low,D.H.P., Motofeanu,C.M., Ong,S.L.M.,
            Wollmann,H., Wun,C.M., Kruszka,P., Muenke,M., Hildebrandt,F.,
            Dunn,N.R., Messerschmidt,D.M. and Guccione,E.
  TITLE     PRDM15 loss of function links NOTCH and WNT/PCP signaling to
            patterning defects in holoprosencephaly
  JOURNAL   Sci Adv 6 (2), eaax9852 (2020)
   PUBMED   31950080
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3267)
  AUTHORS   Clark,T.G., Conway,S.J., Scott,I.C., Labosky,P.A., Winnier,G.,
            Bundy,J., Hogan,B.L. and Greenspan,D.S.
  TITLE     The mammalian Tolloid-like 1 gene, Tll1, is necessary for normal
            septation and positioning of the heart
  JOURNAL   Development 126 (12), 2631-2642 (1999)
   PUBMED   10331975
REFERENCE   7  (bases 1 to 3267)
  AUTHORS   Pappano,W.N., Scott,I.C., Clark,T.G., Eddy,R.L., Shows,T.B. and
            Greenspan,D.S.
  TITLE     Coding sequence and expression patterns of mouse chordin and
            mapping of the cognate mouse chrd and human CHRD genes
  JOURNAL   Genomics 52 (2), 236-239 (1998)
   PUBMED   9782094
REFERENCE   8  (bases 1 to 3267)
  AUTHORS   Treier,M., Gleiberman,A.S., O'Connell,S.M., Szeto,D.P.,
            McMahon,J.A., McMahon,A.P. and Rosenfeld,M.G.
  TITLE     Multistep signaling requirements for pituitary organogenesis in
            vivo
  JOURNAL   Genes Dev 12 (11), 1691-1704 (1998)
   PUBMED   9620855
REFERENCE   9  (bases 1 to 3267)
  AUTHORS   Shawlot,W., Deng,J.M. and Behringer,R.R.
  TITLE     Expression of the mouse cerberus-related gene, Cerr1, suggests a
            role in anterior neural induction and somitogenesis
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6198-6203 (1998)
   PUBMED   9600941
REFERENCE   10 (bases 1 to 3267)
  AUTHORS   Rhinn,M., Dierich,A., Shawlot,W., Behringer,R.R., Le Meur,M. and
            Ang,S.L.
  TITLE     Sequential roles for Otx2 in visceral endoderm and neuroectoderm
            for forebrain and midbrain induction and specification
  JOURNAL   Development 125 (5), 845-856 (1998)
   PUBMED   9449667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010490.10.
            
            On Feb 16, 2023 this sequence version replaced XM_030248948.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.20795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               CT010490.10        78370-78535
            167-270             CT010490.10        78771-78874
            271-400             CT010490.10        79247-79376
            401-529             CT010490.10        79513-79641
            530-629             CT010490.10        79727-79826
            630-717             CT010490.10        79926-80013
            718-859             CT010490.10        80357-80498
            860-988             CT010490.10        80611-80739
            989-1071            CT010490.10        80821-80903
            1072-1219           CT010490.10        80986-81133
            1220-1326           CT010490.10        81277-81383
            1327-1446           CT010490.10        81504-81623
            1447-1603           CT010490.10        82149-82305
            1604-1824           CT010490.10        82582-82802
            1825-1938           CT010490.10        83434-83547
            1939-2202           CT010490.10        83793-84056
            2203-2296           CT010490.10        84144-84237
            2297-2350           CT010490.10        84351-84404
            2351-2454           CT010490.10        84647-84750
            2455-2557           CT010490.10        85194-85296
            2558-2709           CT010490.10        86433-86584
            2710-2809           CT010490.10        86736-86835
            2810-3267           CT010490.10        87165-87622
FEATURES             Location/Qualifiers
     source          1..3267
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.51 cM"
     gene            1..3267
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /note="chordin"
                     /db_xref="GeneID:12667"
                     /db_xref="MGI:MGI:1313268"
     exon            1..166
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2862
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /note="isoform 5 precursor is encoded by transcript
                     variant 5"
                     /codon_start=1
                     /product="chordin isoform 5 precursor"
                     /protein_id="NP_001403695.1"
                     /db_xref="GeneID:12667"
                     /db_xref="MGI:MGI:1313268"
                     /translation="MPSLPAPPAPRLLLGLLLLGSRPASGTGPEPPALPIRSEKEPLP
                     VRGAAGCSFGGKVYALDETWHPDLGEPFGVMRCVLCACEAPQWARRGRGPGRVSCKNI
                     KPQCPTLACRQPRQLPGHCCQTCPQERSNLDPQPAGLVFEYPRDPEHRSYSDRGEPGV
                     GERTRADGHTDFVALLTGPRSQAVARARVSLLRSSLRFSVSYQRLDRPSRVRFTDPTG
                     NILFEHPATPTQDGLVCGVWRAVPRLSVRLLRAEQLRVALVTSTHPSGEVWGPLIWQG
                     ALAAETFSAILTLEDPLQRGVGGIALLTLSDTEDSLHFLLLFRGLLGGLAQAPLKLQI
                     LHQGQLLRELQANTSAQEPGFAEVLPSLTDQEMDWLELGELQMVLEKAGGPELRISGY
                     ITTRQSCDVLQSVLCGADALIPVQTGAAGSASFILLGNGSLIYQVQVVGTGSEVVAMT
                     LETKPQRKNQRTVLCHMAGLQPGGHMAVGMCSGLGARGAHMLLQNELFLNVGTKDFPD
                     GELRGHVTALCYSGHSARYDRLPVPLAGALVLPPVRSQAAGHAWLSLDTHCHLHYEVL
                     LAGLGGSEQGTVTAHLLGPPGMPGPQRLLKGFYGSEAQGVVKDLEPVLLRHLAQGTAS
                     LLITTKSSPRGELRGQVHIASQCEAGGLRLASEGVQMPLAPNGEAATSPMLPAGPGPE
                     APVPAKHGSPGRPRDPNTCFFEGQQRPHGARWAPNYDPLCSLCICQRRTVICDPVVCP
                     PPSCPHPVQALDQCCPVCPEKQRSRDLPSLPNLEPGEGCYFDGDRSWRAAGTRWHPVV
                     PPFGLIKCAVCTCKGATGEVHCEKVQCPRLACAQPVRANPTDCCKQCPGSGTNAKLGD
                     PMQADGPRGCRFAGQWFPENQSWHPSVPPFGEMSCITCRCGAGVPHCERDDCSPPLSC
                     GSGKESRCCSHCTAQRSSETRTLPELEKEAEHS"
     exon            167..270
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            271..400
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            401..529
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            530..629
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            630..717
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            718..859
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            860..988
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1071
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1219
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1326
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1446
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1603
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1824
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1938
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2202
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2296
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2350
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            2351..2454
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2557
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2709
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2809
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..3267
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3245..3250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /note="hexamer: ATTAAA"
     polyA_site      3267
                     /gene="Chrd"
                     /gene_synonym="Chd"
                     /note="major polyA site"
ORIGIN      
        1 agctgtctgc tccgcgtcat gccgagcctc ccggccccgc cggccccgcg gctgctcctc
       61 gggctgctgc tgctcggctc gcggccggcc agtggcactg gccctgagcc cccagcactg
      121 cccatccgtt ccgagaagga gccgctgcct gtccggggag cggcaggctg ctccttcggc
      181 gggaaggtct atgccttgga cgagacgtgg cacccggacc tgggggagcc ttttggggtg
      241 atgcgctgcg tgctgtgcgc ctgtgaagcg cctcagtggg ctcgccgtgg gaggggtcct
      301 ggcagggtca gctgcaagaa catcaaacct cagtgcccca ccctggcctg caggcagccg
      361 cgccagctgc caggacactg ctgccagacc tgcccgcagg agcgcagcaa tctagatcca
      421 cagcccgctg gcctggtctt cgagtatcca agggatccag agcatcgcag ttacagtgat
      481 cgaggggaac ccggcgttgg ggagcggacc cgtgctgatg gccacacaga ctttgtggcg
      541 ctgctgacag gaccgaggtc gcaggcggta gctcgtgctc gagtctcttt gctgcgctca
      601 agtttacgct tctctgtctc ctaccagcgg ctggaccgtc ccagcagggt tcgtttcaca
      661 gatcccacag gcaacatcct gtttgaacac cctgcaaccc ccacccagga tggcctggtc
      721 tgtggggtgt ggcgggcagt gcctcggctg tctgtgaggc tcctgagggc agagcagctt
      781 cgggtagccc ttgtgacatc cactcaccct tcaggagaag tctgggggcc tctcatttgg
      841 cagggtgctc tcgctgcaga gaccttcagt gccatcctga ccctggaaga cccactgcag
      901 cggggtgtgg ggggcatagc cctgctcacc ctcagtgaca cagaagattc cttgcatttt
      961 ttgctgctct tccggggtct gctgggagga ctagctcagg ctcccttgaa gcttcagatt
     1021 ctccaccagg gacagctact tcgggagctc caggccaaca cctccgctca ggagccaggt
     1081 tttgctgagg tgctgcccag ccttacagac caagagatgg actggttgga gctgggggag
     1141 ctgcagatgg tcctagagaa ggcgggtggg ccagagctac gcatcagtgg atacatcacc
     1201 accaggcaga gctgtgatgt ccttcaaagt gtcctttgtg gggctgatgc cctgatccca
     1261 gtccagacgg gtgctgctgg gtcagccagc ttcatattgc taggaaatgg ctcccttatc
     1321 tatcaggtgc aagtggtagg tacaggtagc gaggtggtgg ccatgacact ggagaccaag
     1381 cctcagcgga agaaccagcg cactgtcctg tgccacatgg ctggactcca gccgggagga
     1441 cacatggctg tgggtatgtg ctctgggctg ggtgcccgag gggctcatat gctgctacag
     1501 aacgagctgt tcctgaatgt tggtaccaag gacttcccag atggagagct tcgggggcat
     1561 gtgactgccc tatgctacag tgggcacagt gcccgctatg acagattgcc tgtgcctctg
     1621 gcaggggcac tagtgctgcc ccctgtgcgg agtcaggcag cagggcacgc ctggctctcc
     1681 ttggatacac attgtcactt acactatgaa gttctattgg ctgggcttgg tggctcagag
     1741 caaggaactg tcactgccca cctccttggg cctcctggga tgccagggcc ccagcggctg
     1801 ctgaagggat tctatggctc agaggctcag ggcgtggtaa aagatctgga gcctgtgctg
     1861 ctgcggcacc tggcacaggg cactgcctcc ctgctcatca ccaccaagag tagccccaga
     1921 ggagaactac gtgggcaggt gcacattgcc agtcagtgtg aggcgggagg cctgcgtctg
     1981 gcctcagaag gagtgcagat gcccttggct ccaaatggag aggcggctac gtcacccatg
     2041 ctgcctgctg gccctggccc tgaagcccca gtaccagcca aacatggcag ccctgggaga
     2101 ccccgagatc ctaacacatg tttcttcgag gggcagcagc ggccccacgg ggctcgctgg
     2161 gcacccaact atgacccact ctgctccctc tgcatctgcc agagacgaac agtgatctgt
     2221 gaccctgtag tatgcccacc accaagctgt ccccacccgg tgcaggcact ggaccagtgc
     2281 tgtcccgtgt gtccagagaa acaacgcagt agagacctcc ccagcctacc aaatctggag
     2341 ccaggagagg gctgctattt tgatggtgac cggagctgga gggcagcggg tacccgatgg
     2401 caccctgttg tgcccccctt tggcctaatt aagtgtgctg tctgcacctg caagggggcc
     2461 acgggagagg tgcactgtga gaaggtgcag tgtcctcgcc tggcctgtgc tcagcctgtc
     2521 cgtgccaacc ccaccgactg ctgcaaacag tgtccagggt cagggactaa tgccaagctg
     2581 ggagacccca tgcaggctga tgggcctcgg gggtgtcgct ttgctgggca gtggttccca
     2641 gagaatcaga gctggcaccc atcagtgccc ccctttgggg agatgagctg tattacctgc
     2701 agatgtgggg caggggtacc ccactgtgag cgggacgatt gttcaccgcc gctatcctgt
     2761 ggctcaggga aggagagtcg atgctgttcc cactgcacag cccaaaggtc ctctgagact
     2821 agaacccttc cagagctgga gaaagaagcg gagcactcct agggagcatc cagaaggcca
     2881 tatgaccaag aggatgggcc tgagctggga gaaggagtgg tgctgaggac cccgactctc
     2941 ctgtgggaac ccagtgcctt tcgtgcctct gctctgcttc ttctcctccc ccactacctc
     3001 tgggaaccac aagtctacaa ggggaaagac tgctgggtca gaccaaggcc atatccatgc
     3061 gaactcctgc cctgttttct tttggcctct gtcccacaag cttaactctt ttcttctgta
     3121 cagaacacca ctggcttatt gggattcttt aatttatcct cactcagcac caagggttcc
     3181 ctcacaccat tcctgctacc cctgagctga gcagagtcat tattagagat ttttttttgt
     3241 atttattaaa acatcttttt ttcagtc
//
