LOCUS       NM_144807               3239 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus choline phosphotransferase 1 (Chpt1), transcript
            variant 2, mRNA.
ACCESSION   NM_144807
VERSION     NM_144807.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3239)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3239)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3239)
  AUTHORS   Jiang,D., Burger,C.A., Casasent,A.K., Albrecht,N.E., Li,F. and
            Samuel,M.A.
  TITLE     Spatiotemporal gene expression patterns reveal molecular
            relatedness between retinal laminae
  JOURNAL   J Comp Neurol 528 (5), 729-755 (2020)
   PUBMED   31609468
REFERENCE   4  (bases 1 to 3239)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (bases 1 to 3239)
  AUTHORS   Albrecht,N.E., Alevy,J., Jiang,D., Burger,C.A., Liu,B.I., Li,F.,
            Wang,J., Kim,S.Y., Hsu,C.W., Kalaga,S., Udensi,U., Asomugha,C.,
            Bohat,R., Gaspero,A., Justice,M.J., Westenskow,P.D., Yamamoto,S.,
            Seavitt,J.R., Beaudet,A.L., Dickinson,M.E. and Samuel,M.A.
  TITLE     Rapid and Integrative Discovery of Retina Regulatory Molecules
  JOURNAL   Cell Rep 24 (9), 2506-2519 (2018)
   PUBMED   30157441
REFERENCE   6  (bases 1 to 3239)
  AUTHORS   Gao,L., Rabbitt,E.H., Condon,J.C., Renthal,N.E., Johnston,J.M.,
            Mitsche,M.A., Chambon,P., Xu,J., O'Malley,B.W. and Mendelson,C.R.
  TITLE     Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal
            signaling that initiates parturition
  JOURNAL   J Clin Invest 125 (7), 2808-2824 (2015)
   PUBMED   26098214
REFERENCE   7  (bases 1 to 3239)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 3239)
  AUTHORS   Butler,P.L. and Mallampalli,R.K.
  TITLE     Cross-talk between remodeling and de novo pathways maintains
            phospholipid balance through ubiquitination
  JOURNAL   J Biol Chem 285 (9), 6246-6258 (2010)
   PUBMED   20018880
REFERENCE   9  (bases 1 to 3239)
  AUTHORS   Gohda,T., Tanimoto,M., Shiina,K., Ito,T., Kobayashi,M.,
            Hagiwara,S., Kaneko,S., Makita,Y., Funabiki,K., Horikoshi,S. and
            Tomino,Y.
  TITLE     Altered mouse cholinephosphotransferase gene expression in kidneys
            of type 2 diabetic KK/TA mouse
  JOURNAL   Metabolism 53 (7), 842-846 (2004)
   PUBMED   15254874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ177670.1, AK032497.1 and AC125486.4.
            
            On Apr 9, 2009 this sequence version replaced NM_144807.2.
            
            Transcript Variant: This variant (2) contains a different segment
            for its 3' coding region and 3' UTR versus variant 1. The resulting
            protein (isoform 2) has a shorter and distinct C-terminus when it
            is compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY445814.1, AK032497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               CJ177670.1         1-106
            107-1178            AK032497.1         2-1073
            1179-3239           AC125486.4         4163-6223
FEATURES             Location/Qualifiers
     source          1..3239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.93 cM"
     gene            1..3239
                     /gene="Chpt1"
                     /note="choline phosphotransferase 1"
                     /db_xref="GeneID:212862"
                     /db_xref="MGI:MGI:2384841"
     exon            1..386
                     /gene="Chpt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1310
                     /gene="Chpt1"
                     /EC_number="2.7.8.2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     diacylglycerol cholinephosphotransferase 1; diabetic
                     nephropathy-associated gene transcript 1"
                     /codon_start=1
                     /product="cholinephosphotransferase 1 isoform 2"
                     /protein_id="NP_659056.3"
                     /db_xref="CCDS:CCDS24112.1"
                     /db_xref="GeneID:212862"
                     /db_xref="MGI:MGI:2384841"
                     /translation="MAAGAGARPAPRWVKALGEPLSAAQLRRLEEHRYTAVGESLFEP
                     PLQLYWTWLLQWIPLWMAPNTITLIGLAINLVTTLVLIFYCPTVTEEAPYWTYLLCAL
                     GLFIYQSLDAIDGKQARRTNSCSPLGELFDHGCDSLSTVFMAIGASIAVRLGTHPDWL
                     FFCSFVGMFMFYCAHWQTYVSGVLRFGRVDVTEIQVALVIVFMLSTFGGATMWDYTIP
                     ILEIKLKIVPVLGVVGGLIFSCSNYFHVILHGGVGKNGSTIAGTSVLSPGLHIGLIII
                     LAIMIYKKSATNMFEKHPCLYTLMFGCVFAKVAQKLVIAHMTKSELYLQDTVFIGPGL
                     LFLDQYFNNFIDEYVVLWIAMVISSFDMMIYFTSLCLQISRHLHLNIFKTSCQQAPEQ
                     VYKHID"
     exon            387..534
                     /gene="Chpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            535..676
                     /gene="Chpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            677..761
                     /gene="Chpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..893
                     /gene="Chpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1052
                     /gene="Chpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1178
                     /gene="Chpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..3239
                     /gene="Chpt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3067..3072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chpt1"
                     /note="hexamer: ATTAAA"
     polyA_site      3091
                     /gene="Chpt1"
                     /note="major polyA site"
     regulatory      3159..3164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chpt1"
                     /note="hexamer: AATAAA"
     polyA_site      3182
                     /gene="Chpt1"
     regulatory      3215..3220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chpt1"
                     /note="hexamer: AATAAA"
     polyA_site      3239
                     /gene="Chpt1"
ORIGIN      
        1 taagtgagtc ccaccggcgg agctggcccg ggcgctgtgc cctcgctcgg ctctctccgc
       61 cccccgcgcg ggccgcgggc tgcgccgggt cgcggcgggc cccgcaggca gccatggcgg
      121 cgggcgccgg ggccaggccg gcgccgcgct gggtaaaggc gctaggtgag ccgctcagtg
      181 ccgcgcagct gcggcggctg gaggagcacc gctacaccgc ggtgggagag tcgctgttcg
      241 agccgccgct gcagctttac tggacctggc tgctccaatg gatcccgctc tggatggccc
      301 ccaacaccat caccctcatc ggcctcgcca tcaacctggt caccacacta gtgctcatct
      361 tctactgccc tacagtcacg gaggaggcac catactggac atacctttta tgtgccctgg
      421 gactctttat ctaccagtca ctggatgcca ttgatgggaa acaagccaga aggacaaact
      481 cttgctctcc cttaggggaa ctatttgatc atggttgtga ctctctttcc acagtattta
      541 tggccatcgg cgcttccatt gctgttcgcc taggaacaca tcctgactgg ttgtttttct
      601 gctctttcgt tgggatgttc atgttttact gtgctcattg gcagacttac gtctcaggag
      661 tgttaagatt tggaagggtg gatgtcactg agatccaggt agctttagtg atcgtcttca
      721 tgttgtcaac atttggagga gcaacaatgt gggactatac gatacctatt ctagaaataa
      781 aactgaagat tgttccggtt cttggagttg taggtggatt aatattttcc tgttcaaatt
      841 atttccatgt gatcctccat ggtggtgttg gcaagaatgg gtctactatt gcaggcacca
      901 gtgtcttgtc acctggactc cacataggat taattattat attggcaata atgatctata
      961 agaagtctgc aacaaatatg tttgaaaaac atccttgcct ttatacttta atgtttggat
     1021 gtgtctttgc taaagttgca caaaaattgg tgatagctca catgacgaaa agtgaactat
     1081 atcttcaaga cactgtcttt attgggccag gtcttttatt tttagaccaa tactttaata
     1141 attttataga tgaatatgtt gttctgtgga tagcaatggt catttcttca tttgatatga
     1201 tgatatactt tacttctttg tgcctgcaaa tttcaagaca ccttcatcta aacatcttca
     1261 agacttcatg tcaacaagca ccggaacagg tttacaagca tattgactga ctagtagccc
     1321 aaggaaaaga ggagaagcag ttaggggaac ctatgtgtga aggatatccc cctatacagg
     1381 aggctagtat actatctata aggttatgtt taagtataaa atataaatct gtagcttcca
     1441 ttatgtctac atcaataatg aatcccttgt cgttgactta tcacgtaagt tatcaatgta
     1501 atataatgta tgcattagaa acaagaacaa aaaataaatt taaatattaa ggacaatagg
     1561 aaattgtacc ccaataagtc taaatagcat tatgtctaca aaacatctat cagacttggg
     1621 gttttgattg ccaaaggatt acacaaatat tcagaactta aaagaacttc tatccatctt
     1681 gtcaatgaca tttgattgat acaacttgaa aagtgagcac ataatactaa gtatctaatg
     1741 ataatactat aactgagtca aagtcaagtg atatactgag atatttgtat gtactaacca
     1801 ttgttcaaaa gaggtatgct aactatagac atactttagt atgctatcta gatttaaaac
     1861 aatgattgtg ggattctgtt gtactaattc agcataacac gaatctttga gggtagcttg
     1921 tgccttaaac ttgtgtccaa gtaaacaatt tatttccatg ggaaaaaaat gaaccttaag
     1981 tccccaaaga caaacaaaaa agtagctcaa ataattgata ggtaaggaaa ttggtaactt
     2041 gggaaaatgg caaaaaaggt gtaagggggg aaaaataagt gtcagtattc aacactgggt
     2101 acattaggta ctgattatct tttctattct cagttgaaaa tacttaagat ttgctttata
     2161 aataccacaa ttatcttaac actcttcaga gcttatgacc catatgacct catctctaat
     2221 ttcatacaaa atctccataa gctgtatacc atataatgaa agaatcagac aaatagtgta
     2281 aatgtgtatt ttaagtattc taagcaagaa aaagagagtt gaaaaagtgt atgtttctca
     2341 aaaggtaaaa atatgtgaat acagagaaaa cactctgaag tatttatgtt gcatatctaa
     2401 ctcttgggta agattctcaa ggtttatatt ccatgttgca gacatagcta agcttaacat
     2461 gggtgaggac ccggcttgat ctactagcaa cacccacccc acccacctca aataaaaagg
     2521 aattaaagaa ttggactgtc cttttaatgt taaagctaat ggtagaaggg taatttcttc
     2581 ctagacaata aaaagagtat tatatagact tgtataaagt ttttaaaagg tgggttatag
     2641 aacaaaattt taaaaagata gttttccttc tgatatgttt tgtttttctg aatgattcat
     2701 tgaatgcagt ttcagcaaaa ctagaaagct caaatgactt taaagaaatg ctgagacaac
     2761 tcagtatgta tgaaattgtt tttataagtt tctctgtata agtgcctatt tttaaaatta
     2821 aaaacagttc aagtttagaa atgaatgtga aatcaagctt cagtatattt actgaaaatt
     2881 acaatggaaa agatacctag gaaatacata tttgaagaca gatatgaagt acttaaacca
     2941 taaatacctt tagctgtgtt tatgataatg ctcttaatca ttactagggg catgtgtcat
     3001 ttaagtatag actaggcaat taaatggtat tttgatgaac ttgcagaatg aaatataaat
     3061 ctacacatta aaaccaatac ttggaaatct tttcaggtgt ttttaaaatt attttagcat
     3121 ctataattta ttctaagaca caagcttaag ttttttttaa taaactatag attattttct
     3181 tagaattggc aatctattat tttagtaaac atataataaa gatgtacata caaaaccga
//
