LOCUS       NP_659056                398 aa            linear   ROD 30-APR-2024
DEFINITION  cholinephosphotransferase 1 isoform 2 [Mus musculus].
ACCESSION   NP_659056
VERSION     NP_659056.3
DBSOURCE    REFSEQ: accession NM_144807.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 398)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 398)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 398)
  AUTHORS   Jiang,D., Burger,C.A., Casasent,A.K., Albrecht,N.E., Li,F. and
            Samuel,M.A.
  TITLE     Spatiotemporal gene expression patterns reveal molecular
            relatedness between retinal laminae
  JOURNAL   J Comp Neurol 528 (5), 729-755 (2020)
   PUBMED   31609468
REFERENCE   4  (residues 1 to 398)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   5  (residues 1 to 398)
  AUTHORS   Albrecht,N.E., Alevy,J., Jiang,D., Burger,C.A., Liu,B.I., Li,F.,
            Wang,J., Kim,S.Y., Hsu,C.W., Kalaga,S., Udensi,U., Asomugha,C.,
            Bohat,R., Gaspero,A., Justice,M.J., Westenskow,P.D., Yamamoto,S.,
            Seavitt,J.R., Beaudet,A.L., Dickinson,M.E. and Samuel,M.A.
  TITLE     Rapid and Integrative Discovery of Retina Regulatory Molecules
  JOURNAL   Cell Rep 24 (9), 2506-2519 (2018)
   PUBMED   30157441
REFERENCE   6  (residues 1 to 398)
  AUTHORS   Gao,L., Rabbitt,E.H., Condon,J.C., Renthal,N.E., Johnston,J.M.,
            Mitsche,M.A., Chambon,P., Xu,J., O'Malley,B.W. and Mendelson,C.R.
  TITLE     Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal
            signaling that initiates parturition
  JOURNAL   J Clin Invest 125 (7), 2808-2824 (2015)
   PUBMED   26098214
REFERENCE   7  (residues 1 to 398)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (residues 1 to 398)
  AUTHORS   Butler,P.L. and Mallampalli,R.K.
  TITLE     Cross-talk between remodeling and de novo pathways maintains
            phospholipid balance through ubiquitination
  JOURNAL   J Biol Chem 285 (9), 6246-6258 (2010)
   PUBMED   20018880
REFERENCE   9  (residues 1 to 398)
  AUTHORS   Gohda,T., Tanimoto,M., Shiina,K., Ito,T., Kobayashi,M.,
            Hagiwara,S., Kaneko,S., Makita,Y., Funabiki,K., Horikoshi,S. and
            Tomino,Y.
  TITLE     Altered mouse cholinephosphotransferase gene expression in kidneys
            of type 2 diabetic KK/TA mouse
  JOURNAL   Metabolism 53 (7), 842-846 (2004)
   PUBMED   15254874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ177670.1, AK032497.1 and AC125486.4.
            
            On Apr 9, 2009 this sequence version replaced NP_659056.2.
            
            Transcript Variant: This variant (2) contains a different segment
            for its 3' coding region and 3' UTR versus variant 1. The resulting
            protein (isoform 2) has a shorter and distinct C-terminus when it
            is compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY445814.1, AK032497.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..398
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 43.93 cM"
     Protein         1..398
                     /product="cholinephosphotransferase 1 isoform 2"
                     /EC_number="2.7.8.2"
                     /note="diacylglycerol cholinephosphotransferase 1;
                     diabetic nephropathy-associated gene transcript 1"
                     /calculated_mol_wt=44477
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q8WUD6; propagated from
                     UniProtKB/Swiss-Prot (Q8C025.1)"
     Region          19..382
                     /region_name="PRK10832"
                     /note="CDP-diacylglycerol--glycerol-3-phosphate
                     3-phosphatidyltransferase; cl00453"
                     /db_xref="CDD:469774"
     Site            63..83
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C025.1)"
     Site            94..118
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C025.1)"
     Site            126..150
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C025.1)"
     Site            129
                     /site_type="other"
                     /note="Increases basicity of active site His.
                     /evidence=ECO:0000250|UniProtKB:Q4KLV1; propagated from
                     UniProtKB/Swiss-Prot (Q8C025.1)"
     Site            161..179
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C025.1)"
     Site            191..207
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C025.1)"
     Site            223..248
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C025.1)"
     Site            266..281
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C025.1)"
     Site            294..316
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C025.1)"
     Site            330..339
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C025.1)"
     Site            347..376
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8C025.1)"
     CDS             1..398
                     /gene="Chpt1"
                     /coded_by="NM_144807.3:114..1310"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS24112.1"
                     /db_xref="GeneID:212862"
                     /db_xref="MGI:MGI:2384841"
ORIGIN      
        1 maagagarpa prwvkalgep lsaaqlrrle ehrytavges lfepplqlyw twllqwiplw
       61 mapntitlig lainlvttlv lifycptvte eapywtyllc alglfiyqsl daidgkqarr
      121 tnscsplgel fdhgcdslst vfmaigasia vrlgthpdwl ffcsfvgmfm fycahwqtyv
      181 sgvlrfgrvd vteiqvalvi vfmlstfgga tmwdytipil eiklkivpvl gvvgglifsc
      241 snyfhvilhg gvgkngstia gtsvlspglh igliiilaim iykksatnmf ekhpclytlm
      301 fgcvfakvaq klviahmtks elylqdtvfi gpgllfldqy fnnfideyvv lwiamvissf
      361 dmmiyftslc lqisrhlhln ifktscqqap eqvykhid
//
