LOCUS       NP_598674                768 aa            linear   ROD 28-NOV-2023
DEFINITION  chondroitin sulfate glucuronyltransferase precursor [Mus musculus].
ACCESSION   NP_598674
VERSION     NP_598674.2
DBSOURCE    REFSEQ: accession NM_133913.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 768)
  AUTHORS   Shimbo M, Suzuki R, Fuseya S, Sato T, Kiyohara K, Hagiwara K, Okada
            R, Wakui H, Tsunakawa Y, Watanabe H, Kimata K, Narimatsu H, Kudo T
            and Takahashi S.
  TITLE     Postnatal lethality and chondrodysplasia in mice lacking both
            chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2
  JOURNAL   PLoS One 12 (12), e0190333 (2017)
   PUBMED   29287114
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 768)
  AUTHORS   Kozomara A and Griffiths-Jones S.
  TITLE     miRBase: integrating microRNA annotation and deep-sequencing data
  JOURNAL   Nucleic Acids Res 39 (Database issue), D152-D157 (2011)
   PUBMED   21037258
REFERENCE   3  (residues 1 to 768)
  AUTHORS   Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M,
            Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice
            DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson
            A, Zambrowicz BP and de Sauvage FJ.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (residues 1 to 768)
  AUTHORS   Izumikawa T, Koike T, Shiozawa S, Sugahara K, Tamura J and Kitagawa
            H.
  TITLE     Identification of chondroitin sulfate glucuronyltransferase as
            chondroitin synthase-3 involved in chondroitin polymerization:
            chondroitin polymerization is achieved by multiple enzyme complexes
            consisting of chondroitin synthase family members
  JOURNAL   J Biol Chem 283 (17), 11396-11406 (2008)
   PUBMED   18316376
REFERENCE   5  (residues 1 to 768)
  AUTHORS   Sakai K, Kimata K, Sato T, Gotoh M, Narimatsu H, Shinomiya K and
            Watanabe H.
  TITLE     Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a
            critical role in chondroitin sulfate synthesis in cartilage
  JOURNAL   J Biol Chem 282 (6), 4152-4161 (2007)
   PUBMED   17145758
REFERENCE   6  (residues 1 to 768)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (residues 1 to 768)
  AUTHORS   Silbert,J.E. and Freilich,L.S.
  TITLE     Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched
            preparation from cultures of mouse mastocytoma cells
  JOURNAL   Biochem J 190 (2), 307-313 (1980)
   PUBMED   6781479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK122504.1 and BC036970.1.
            
            On Oct 26, 2007 this sequence version replaced NP_598674.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.206649.1,
                                           SRR1660811.188527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..768
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     Protein         1..768
                     /product="chondroitin sulfate glucuronyltransferase
                     precursor"
                     /EC_number="2.4.1.226"
                     /calculated_mol_wt=83599
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=2076
     Region          <177..>269
                     /region_name="Galactosyl_T"
                     /note="Galactosyltransferase; cl21608"
                     /db_xref="CDD:473923"
     Region          242..755
                     /region_name="CHGN"
                     /note="Chondroitin N-acetylgalactosaminyltransferase;
                     pfam05679"
                     /db_xref="CDD:461712"
     CDS             1..768
                     /gene="Chpf2"
                     /gene_synonym="2010209O12Rik; Gm42230; mir-671; mKIAA1402"
                     /coded_by="NM_133913.2:1289..3595"
                     /db_xref="CCDS:CCDS51436.1"
                     /db_xref="GeneID:100910"
                     /db_xref="MGI:MGI:1917522"
ORIGIN      
        1 mrlssllall rpvlplilgl slgcslsllr vswiqgeged pcveavgkpg gpqnpdskng
       61 ldqgdedfrp rivpyyrdpn kpykkvlrtr yiqtelgsre rllvavltsr atlstlavav
      121 nrtvahhfpr llyftgqrga rapagmqvvs hgderpawlm setlrhlhth fgadydwffi
      181 mqddtyvqap rlaalaghls inqdlylgha eefigtgeqa rychggfgyl lsrslllrlr
      241 phldgcrgdi lsarpdewlg rclidtlgig cvsqhqgqqy rsfelaknrd pekeespafl
      301 safavhpvpe gtlmyrlhkr fsaleleray seieqlqaqi rnltvltpeg eaglswpvgl
      361 papftphsrf evlgwdyfte qhtfacadga pkcplqgasr advgdavdta leqlnrryqp
      421 rlrfrkqrll ngyrrfdpar gmeytldlll eavtqrghrr slarrvsllr plsrveilpm
      481 pyvteatrvq lvlpllvaea paalafleaf aasvlepreh alltlllvyg pregrggpdp
      541 flgvkaaaae lerrypgarl awlavraeap sqvrlmdvis kkhpvdtlff lttvwtrpgs
      601 evlnrcrmna isgwqaffpv hfqefnpals pqrsppgvpg adppspgvdp srgapvggrf
      661 drqasaegcf ynadylaara rlagelagqe eeealeglev mdvflrfsgl hlfravepgl
      721 vqkfslrdcs prlseelyhr crlsnleglg artqlamalf eqeqanst
//
