LOCUS       NM_019769               2626 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus calcineurin-like EF hand protein 1 (Chp1), mRNA.
ACCESSION   NM_019769 XM_917493
VERSION     NM_019769.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2626)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2626)
  AUTHORS   Dong,Y., Gao,Y., Ilie,A., Kim,D., Boucher,A., Li,B., Zhang,X.C.,
            Orlowski,J. and Zhao,Y.
  TITLE     Structure and mechanism of the human NHE1-CHP1 complex
  JOURNAL   Nat Commun 12 (1), 3474 (2021)
   PUBMED   34108458
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2626)
  AUTHORS   Janzen,E., Wolff,L., Mendoza-Ferreira,N., Hupperich,K., Delle
            Vedove,A., Hosseinibarkooie,S., Kye,M.J. and Wirth,B.
  TITLE     PLS3 Overexpression Delays Ataxia in Chp1 Mutant Mice
  JOURNAL   Front Neurosci 13, 993 (2019)
   PUBMED   31607845
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2626)
  AUTHORS   Janzen,E., Mendoza-Ferreira,N., Hosseinibarkooie,S., Schneider,S.,
            Hupperich,K., Tschanz,T., Grysko,V., Riessland,M.,
            Hammerschmidt,M., Rigo,F., Bennett,C.F., Kye,M.J., Torres-Benito,L.
            and Wirth,B.
  TITLE     CHP1 reduction ameliorates spinal muscular atrophy pathology by
            restoring calcineurin activity and endocytosis
  JOURNAL   Brain 141 (8), 2343-2361 (2018)
   PUBMED   29961886
REFERENCE   5  (bases 1 to 2626)
  AUTHORS   Liu,Y., Zaun,H.C., Orlowski,J. and Ackerman,S.L.
  TITLE     CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje
            cell axon homeostasis
  JOURNAL   J Neurosci 33 (31), 12656-12669 (2013)
   PUBMED   23904602
  REMARK    GeneRIF: This study demonistrated that CHP1-mediated NHE1
            biosynthetic maturation is required for Purkinje cell axon
            homeostasis.
REFERENCE   6  (bases 1 to 2626)
  AUTHORS   Li,G.D., Zhang,X., Li,R., Wang,Y.D., Wang,Y.L., Han,K.J.,
            Qian,X.P., Yang,C.G., Liu,P., Wei,Q., Chen,W.F., Zhang,J. and
            Zhang,Y.
  TITLE     CHP2 activates the calcineurin/nuclear factor of activated T cells
            signaling pathway and enhances the oncogenic potential of HEK293
            cells
  JOURNAL   J Biol Chem 283 (47), 32660-32668 (2008)
   PUBMED   18815128
  REMARK    GeneRIF: CHP2 has a role in tumorigenesis and as an activator of
            the calcineurin/NFAT signaling pathway
REFERENCE   7  (bases 1 to 2626)
  AUTHORS   Yu,X., Bauer,K., Wernhoff,P., Koczan,D., Moller,S., Thiesen,H.J.
            and Ibrahim,S.M.
  TITLE     Fine mapping of collagen-induced arthritis quantitative trait loci
            in an advanced intercross line
  JOURNAL   J Immunol 177 (10), 7042-7049 (2006)
   PUBMED   17082620
REFERENCE   8  (bases 1 to 2626)
  AUTHORS   Hahn,J.S.
  TITLE     Regulation of Nod1 by Hsp90 chaperone complex
  JOURNAL   FEBS Lett 579 (20), 4513-4519 (2005)
   PUBMED   16083881
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY268484.1, AK166219.1 and BC054733.1.
            
            On Aug 3, 2006 this sequence version replaced NM_019769.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054733.1, AK045920.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               BY268484.1         1-121
            122-678             AK166219.1         83-639
            679-2626            BC054733.1         589-2536
FEATURES             Location/Qualifiers
     source          1..2626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.97 cM"
     gene            1..2626
                     /gene="Chp1"
                     /gene_synonym="1500003O03Rik; Cahp; Chp; p24; Sid470p;
                     vac"
                     /note="calcineurin-like EF hand protein 1"
                     /db_xref="GeneID:56398"
                     /db_xref="MGI:MGI:1927185"
     exon            1..211
                     /gene="Chp1"
                     /gene_synonym="1500003O03Rik; Cahp; Chp; p24; Sid470p;
                     vac"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..732
                     /gene="Chp1"
                     /gene_synonym="1500003O03Rik; Cahp; Chp; p24; Sid470p;
                     vac"
                     /note="calcium-binding protein p22; sid 470;
                     calcium-binding protein CHP; calcineurin homologous
                     protein; calcium binding protein P22; calcineurin B-like
                     protein; EF-hand calcium-binding domain-containing protein
                     p22"
                     /codon_start=1
                     /product="calcineurin B homologous protein 1"
                     /protein_id="NP_062743.1"
                     /db_xref="CCDS:CCDS16604.1"
                     /db_xref="GeneID:56398"
                     /db_xref="MGI:MGI:1927185"
                     /translation="MGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENG
                     TLSREDFQRIPELAINPLGDRIINAFFSEGEDQVNFRGFMRTLAHFRPIEDNEKSKDV
                     NGPEPLNSRSNKLHFAFRLYDLDKDDKISRDELLQVLRMMVGVNISDEQLGSIADRTI
                     QEADQDGDSAISFTEFVKVLEKVDVEQKMSIRFLH"
     exon            212..284
                     /gene="Chp1"
                     /gene_synonym="1500003O03Rik; Cahp; Chp; p24; Sid470p;
                     vac"
                     /inference="alignment:Splign:2.1.0"
     exon            285..365
                     /gene="Chp1"
                     /gene_synonym="1500003O03Rik; Cahp; Chp; p24; Sid470p;
                     vac"
                     /inference="alignment:Splign:2.1.0"
     exon            366..493
                     /gene="Chp1"
                     /gene_synonym="1500003O03Rik; Cahp; Chp; p24; Sid470p;
                     vac"
                     /inference="alignment:Splign:2.1.0"
     exon            494..555
                     /gene="Chp1"
                     /gene_synonym="1500003O03Rik; Cahp; Chp; p24; Sid470p;
                     vac"
                     /inference="alignment:Splign:2.1.0"
     exon            556..678
                     /gene="Chp1"
                     /gene_synonym="1500003O03Rik; Cahp; Chp; p24; Sid470p;
                     vac"
                     /inference="alignment:Splign:2.1.0"
     exon            679..2596
                     /gene="Chp1"
                     /gene_synonym="1500003O03Rik; Cahp; Chp; p24; Sid470p;
                     vac"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2570..2575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Chp1"
                     /gene_synonym="1500003O03Rik; Cahp; Chp; p24; Sid470p;
                     vac"
                     /note="hexamer: AATAAA"
     polyA_site      2596
                     /gene="Chp1"
                     /gene_synonym="1500003O03Rik; Cahp; Chp; p24; Sid470p;
                     vac"
                     /note="major polyA site"
ORIGIN      
        1 gcgctccacc ccttgtttct ctccccgggc cgcaagagaa acagtgccct ctcccttctt
       61 gacccctggc ccttccctcc ctccttccct tctgccgctg ctgcttctgg cgctgccgct
      121 cccggaggag ctcccgtcac ggtgatgggg tctcgggcct ccacgttatt gcgggacgaa
      181 gagctcgagg agatcaagaa ggagactggc ttttcccaca gtcagatcac gcgcctgtac
      241 agccgcttca ccagcctgga caaaggggag aacgggactc tcagccggga agatttccag
      301 aggattccag aacttgccat caacccactg ggggaccgga tcatcaatgc cttcttctca
      361 gagggagagg atcaggtaaa cttccgagga ttcatgagaa cattggctca tttccgaccc
      421 attgaggata acgaaaagag caaagatgtg aatggcccgg aacccctcaa cagccggagc
      481 aacaagctgc actttgcttt cagactctat gatttggata aagatgacaa gatctcccgt
      541 gatgagctgt tacaggtact gcgaatgatg gttggagtga atatctcgga tgagcagctg
      601 ggcagtattg cggacaggac catccaggag gctgaccaag atggagatag tgccatatct
      661 tttacagaat tcgttaaggt tttggaaaaa gtggatgtag aacagaagat gagcatccga
      721 tttcttcact aaagggcaga gaccaaatta ttcttgcttt ctagtattta agaactgaaa
      781 cttgtgtcct ccagccccac cccatcctgt catccccttt tcccagaata ctacagctct
      841 tgcatgacaa cctgaagtct ctcctgtcca tacaaacttg cctttggtgt ataaacaggg
      901 cgttacagaa tggtaccctc tgtctgcttc tgttcagtat ccacccacca ggtccttagt
      961 tgtcagtacc atcttcccct gttagctgct gagtgccatg catccatcct gtctggggaa
     1021 atgaaccagc cagcaaagct cccactggat ggggactata tccatgctgc cttccatccc
     1081 tgcatcgagc ctccaccatg tttctgtgac cttgtgtcct tttgtccttg tgtctgttac
     1141 ttcctacctc tcagtcatcc aaccttctct ccattcagtt tttcagctgc cctcctgtcg
     1201 ttgagattcc ctgcatttta cttgattctg ggctctgggc tctgctgtta agcctgtttc
     1261 tgatgtggca ggatagttag tggtgtggtg agttatagct accttctaat gtgtctctgg
     1321 gacgttgcct atccaggagc ttttcagcaa gcagtactgc tcttggaagc atgtgactcc
     1381 cttggtcccc tgtattgctc tgttgtcgaa gggcttatga gcagacatgt tcttaaaagg
     1441 tggtcatggt gaggcttgta gagccatgtt tcctaggtgg cttcccaggt ctctctacct
     1501 ctgacttttt attttcaaac atatttatgt ggcttttctg ggtacagtgt tgacattcat
     1561 tagaaaatat tctaatgcct gccagtttgc ttctctttgg aacattgtca ccacccaagt
     1621 ggctcttctg acaatgtggt agagggcctt cttgtagttt tctgaacaag gctaggcacc
     1681 ctggagagct ggccacattt gctctacagc atgggtcatg cctcagtgtt ctgtacactg
     1741 gaagagtctt cacatttcca aacagaaaga ctagtgttac agaagtgcct gacttatctc
     1801 agtcctaaag aattagattg tcctcagtgt cttaaagttt cgcacaaaac tctgaatgaa
     1861 ttttatactt ggcaaatttt aatgctggac gatgtgcagt cagttcatag tcctggtcca
     1921 ggcctttagt gtattgtctc atgagcctcc tgatggcgtg accttcctag ctccctgtgt
     1981 atactacgca gatcccatag aagcatgggg ccaaggattg gtggcaccaa ctgaggtgac
     2041 atttagaggt ctttgagtga cccagctcaa cttctctgcc aatgtcagct tgatttagat
     2101 ctcactgaat caggctgctt ctgtcctgtg tccctgtgaa tctgctcttg gctggctttc
     2161 tctgatgtcg cttccttgct tgcttgcttc gttgctttgg aaggctatcc aaggtgtgta
     2221 aacaattctt tagtaaataa attgctatta acccaaacaa acaaaaacac tgcaaagagg
     2281 atgggtaaag gtgagcaaca ggggaatggc tgggatagat ggctggggct acatgaactg
     2341 gggattcttt acgaaatatc tgttagactt tgtgatcaaa tgatgtgata aaagaattgt
     2401 ataaagggaa taattgtctg atactgatct gtttgagaag tattgagaag cttctcaatt
     2461 taaatattta aactttctaa gcttatgccc ccttggctgt gtatagcaaa ctgtttttat
     2521 ccacagttgt gccttattgt cccattaaag ttgtattcct caattcatca ataaatcaat
     2581 tgttgttaaa acaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
